{"id":"https://openalex.org/W2028998497","doi":"https://doi.org/10.1371/journal.pcbi.0030196","title":"Alternative Splicing Events Identified in Human Embryonic Stem Cells and Neural Progenitors","display_name":"Alternative Splicing Events Identified in Human Embryonic Stem Cells and Neural Progenitors","publication_year":2007,"publication_date":"2007-10-24","ids":{"openalex":"https://openalex.org/W2028998497","doi":"https://doi.org/10.1371/journal.pcbi.0030196","mag":"2028998497","pmid":"https://pubmed.ncbi.nlm.nih.gov/17967047"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.0030196","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0030196","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0030196&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0030196&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082310752","display_name":"G Yeo","orcid":null},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gene W Yeo","raw_affiliation_strings":["Crick-Jacobs Center for Theoretical and Computational Biology, Salk Institute, La Jolla, California, USA. geneyeo@salk.edu","Crick-Jacobs Center for Theoretical and Computational Biology, Salk Institute, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Crick-Jacobs Center for Theoretical and Computational Biology, Salk Institute, La Jolla, California, USA. geneyeo@salk.edu","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"Crick-Jacobs Center for Theoretical and Computational Biology, Salk Institute, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000111949","display_name":"Xiangdong Xu","orcid":"https://orcid.org/0000-0003-2220-0890"},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiangdong Xu","raw_affiliation_strings":["Laboratory of Genetics, Salk Institute, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Genetics, Salk Institute, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083791474","display_name":"Tiffany Y Liang","orcid":"https://orcid.org/0000-0002-1986-5966"},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tiffany Y Liang","raw_affiliation_strings":["Crick-Jacobs Center for Theoretical and Computational Biology, Salk Institute, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Crick-Jacobs Center for Theoretical and Computational Biology, Salk Institute, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048323500","display_name":"Alysson R. Muotri","orcid":"https://orcid.org/0000-0003-0867-2875"},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alysson R Muotri","raw_affiliation_strings":["Laboratory of Genetics, Salk Institute, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Genetics, Salk Institute, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072155250","display_name":"Christian T. Carson","orcid":null},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian T Carson","raw_affiliation_strings":["Laboratory of Genetics, Salk Institute, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Genetics, Salk Institute, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063982721","display_name":"Nicole G. Coufal","orcid":"https://orcid.org/0000-0001-6547-1733"},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole G Coufal","raw_affiliation_strings":["Laboratory of Genetics, Salk Institute, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Genetics, Salk Institute, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072968010","display_name":"Fred H. Gage","orcid":"https://orcid.org/0000-0002-0938-4106"},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fred H Gage","raw_affiliation_strings":["Laboratory of Genetics, Salk Institute, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Genetics, Salk Institute, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I1307098950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072968010","https://openalex.org/A5082310752"],"corresponding_institution_ids":["https://openalex.org/I1307098950"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":5.5959,"has_fulltext":true,"cited_by_count":125,"citation_normalized_percentile":{"value":0.96844113,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"3","issue":"10","first_page":"e196","last_page":"e196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exon","display_name":"Exon","score":0.7914861440658569},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7872236967086792},{"id":"https://openalex.org/keywords/rna-splicing","display_name":"RNA splicing","score":0.6263129711151123},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"Alternative splicing","score":0.5811333656311035},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5388914942741394},{"id":"https://openalex.org/keywords/embryonic-stem-cell","display_name":"Embryonic stem cell","score":0.5195039510726929},{"id":"https://openalex.org/keywords/progenitor-cell","display_name":"Progenitor cell","score":0.4648975431919098},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4427310824394226},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4223184883594513},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.3542057275772095},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.31491777300834656}],"concepts":[{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.7914861440658569},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7872236967086792},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.6263129711151123},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.5811333656311035},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5388914942741394},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5195039510726929},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4648975431919098},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4427310824394226},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4223184883594513},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3542057275772095},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.31491777300834656}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009424","descriptor_name":"Nervous System Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009424","descriptor_name":"Nervous System Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009424","descriptor_name":"Nervous System Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020224","descriptor_name":"Expressed Sequence Tags","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020224","descriptor_name":"Expressed Sequence Tags","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020224","descriptor_name":"Expressed Sequence Tags","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.0030196","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0030196","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0030196&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:17967047","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17967047","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.135.7887","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.135.7887","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.snl.salk.edu/~geneyeo/stuff/papers/Yeo_PlosCompBiol07.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:24b182a2e8a24c499670e239a31ce42c","is_oa":true,"landing_page_url":"https://doaj.org/article/24b182a2e8a24c499670e239a31ce42c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 3, Iss 10, Pp 1951-1967 (2007)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/151520","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Alternative_Splicing_Events_Identified_in_Human_Embryonic_Stem_Cells_and_Neural_Progenitors/151520","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2041973","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2041973","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.0030196","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0030196","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0030196&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306136","display_name":"Michael J. Fox Foundation for Parkinson's Research","ror":"https://ror.org/03arq3225"},{"id":"https://openalex.org/F4320306171","display_name":"California Institute for Regenerative Medicine","ror":"https://ror.org/033m8b439"},{"id":"https://openalex.org/F4320306485","display_name":"Christopher and Dana Reeve Foundation","ror":"https://ror.org/0430rna51"},{"id":"https://openalex.org/F4320309018","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71"},{"id":"https://openalex.org/F4320312060","display_name":"Francis Crick Institute","ror":"https://ror.org/04tnbqb63"},{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2028998497.pdf","grobid_xml":"https://content.openalex.org/works/W2028998497.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W126539919","https://openalex.org/W1491993630","https://openalex.org/W1503270785","https://openalex.org/W1532405552","https://openalex.org/W1769886694","https://openalex.org/W1822349969","https://openalex.org/W1963918734","https://openalex.org/W1965411245","https://openalex.org/W1966569961","https://openalex.org/W1970774008","https://openalex.org/W1971158461","https://openalex.org/W1974625345","https://openalex.org/W1975066377","https://openalex.org/W1976935502","https://openalex.org/W1983954245","https://openalex.org/W1988865085","https://openalex.org/W1993019240","https://openalex.org/W1995140011","https://openalex.org/W1999557137","https://openalex.org/W2001952613","https://openalex.org/W2003357682","https://openalex.org/W2019046972","https://openalex.org/W2023340322","https://openalex.org/W2024573693","https://openalex.org/W2024667339","https://openalex.org/W2034265732","https://openalex.org/W2036399606","https://openalex.org/W2038617558","https://openalex.org/W2039623436","https://openalex.org/W2039824179","https://openalex.org/W2045131720","https://openalex.org/W2045388302","https://openalex.org/W2048997388","https://openalex.org/W2049190757","https://openalex.org/W2053998703","https://openalex.org/W2056022475","https://openalex.org/W2058659886","https://openalex.org/W2061253933","https://openalex.org/W2063318299","https://openalex.org/W2063478423","https://openalex.org/W2064960897","https://openalex.org/W2065737043","https://openalex.org/W2073654740","https://openalex.org/W2078329950","https://openalex.org/W2081678861","https://openalex.org/W2083939751","https://openalex.org/W2085494823","https://openalex.org/W2086943348","https://openalex.org/W2089465951","https://openalex.org/W2092438308","https://openalex.org/W2096940705","https://openalex.org/W2097107516","https://openalex.org/W2099117011","https://openalex.org/W2101650913","https://openalex.org/W2101951137","https://openalex.org/W2102711634","https://openalex.org/W2103489088","https://openalex.org/W2105302788","https://openalex.org/W2107794882","https://openalex.org/W2109936378","https://openalex.org/W2111191613","https://openalex.org/W2111888351","https://openalex.org/W2117198101","https://openalex.org/W2117293520","https://openalex.org/W2119742125","https://openalex.org/W2121635864","https://openalex.org/W2124169580","https://openalex.org/W2126851387","https://openalex.org/W2130143018","https://openalex.org/W2139208934","https://openalex.org/W2148165244","https://openalex.org/W2148633182","https://openalex.org/W2151045225","https://openalex.org/W2154104720","https://openalex.org/W2158020008","https://openalex.org/W2162271105","https://openalex.org/W2168579634","https://openalex.org/W2168783124","https://openalex.org/W2169685494","https://openalex.org/W2336394440","https://openalex.org/W2341491220","https://openalex.org/W4206495155","https://openalex.org/W4241343595"],"related_works":["https://openalex.org/W2130439870","https://openalex.org/W2800537687","https://openalex.org/W178291922","https://openalex.org/W2147652847","https://openalex.org/W1976843764","https://openalex.org/W2000278701","https://openalex.org/W3215633333","https://openalex.org/W4225318404","https://openalex.org/W2349910028","https://openalex.org/W2151954452"],"abstract_inverted_index":{"Human":[0,83],"embryonic":[1,295],"stem":[2,92,296,303],"cells":[3,9,93,297],"(hESCs)":[4],"and":[5,20,41,80,87,162,179,202,271,298],"neural":[6,302],"progenitor":[7],"(NP)":[8],"are":[10,21,117,195],"excellent":[11],"models":[12],"for":[13,26,278],"recapitulating":[14],"early":[15],"neuronal":[16,62,81],"development":[17,79],"in":[18,77,122,197,212,223,227,232,264,269,293],"vitro,":[19],"key":[22],"to":[23,38,49,57,111,119,125,140,147,255,285,301],"establishing":[24],"strategies":[25],"the":[27,45,213,247,265,289],"treatment":[28],"of":[29,47,71,129,145,154,184,267,291],"degenerative":[30],"disorders.":[31],"While":[32],"much":[33],"effort":[34],"had":[35],"been":[36,55],"undertaken":[37],"analyze":[39],"transcriptional":[40],"epigenetic":[42],"differences":[43],"during":[44,61],"transition":[46,300],"hESC":[48,178],"NP,":[50,86],"very":[51],"little":[52],"work":[53],"has":[54],"performed":[56],"understand":[58],"post-transcriptional":[59,72],"changes":[60],"differentiation.":[63],"Alternative":[64],"RNA":[65],"splicing":[66],"(AS),":[67],"a":[68,134,143,208,275],"major":[69],"form":[70],"gene":[73,218],"regulation,":[74],"is":[75,207,220],"important":[76],"mammalian":[78],"function.":[82],"ESC,":[84],"hESC-derived":[85],"human":[88,294],"central":[89],"nervous":[90],"system":[91],"were":[94],"compared":[95,124],"using":[96,158],"Affymetrix":[97],"exon":[98,211,279],"arrays.":[99],"We":[100],"introduced":[101],"an":[102],"outlier":[103],"detection":[104],"approach,":[105],"REAP":[106,149,193],"(Regression-based":[107],"Exon":[108],"Array":[109],"Protocol),":[110],"identify":[112],"1,737":[113],"internal":[114],"exons":[115],"that":[116,171,192,219,260],"predicted":[118],"undergo":[120],"AS":[121,131,165,186,257,268,292],"NP":[123,180,228,270],"hESC.":[126,272],"Experimental":[127],"validation":[128],"REAP-predicted":[130,209],"events":[132,156],"indicated":[133],"threshold-dependent":[135],"sensitivity":[136],"ranging":[137],"from":[138],"56%":[139],"69%,":[141],"at":[142],"specificity":[144],"77%":[146],"96%.":[148],"predictions":[150,194],"significantly":[151],"overlapped":[152],"sets":[153],"alternative":[155,210],"identified":[157],"expressed":[159,175],"sequence":[160,238],"tags":[161],"evolutionarily":[163],"conserved":[164,241],"events.":[166],"Our":[167],"results":[168],"also":[169],"reveal":[170],"focusing":[172],"on":[173],"differentially":[174,221],"genes":[176,198],"between":[177],"will":[181],"overlook":[182],"14%":[183],"potential":[185],"genes.":[187],"In":[188,273],"addition,":[189],"we":[190],"found":[191],"enriched":[196],"encoding":[199],"serine/threonine":[200],"kinase":[201,216],"helicase":[203],"activities.":[204],"An":[205],"example":[206],"SLK":[214],"(serine/threonine":[215],"2)":[217],"included":[222],"hESC,":[224],"but":[225],"skipped":[226],"as":[229,231,246,252],"well":[230],"other":[233],"differentiated":[234],"tissues.":[235],"Lastly,":[236],"comparative":[237],"analysis":[239,281],"revealed":[240],"intronic":[242],"cis-regulatory":[243],"elements":[244],"such":[245],"FOX1/2":[248,261],"binding":[249],"site":[250],"GCAUG":[251],"being":[253],"proximal":[254],"candidate":[256],"exons,":[258],"suggesting":[259],"may":[262],"participate":[263],"regulation":[266],"summary,":[274],"new":[276,286],"methodology":[277],"array":[280],"was":[282],"introduced,":[283],"leading":[284],"insights":[287],"into":[288],"complexity":[290],"their":[299],"cells.":[304]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":11}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}
