{"id":"https://openalex.org/W2074730819","doi":"https://doi.org/10.1371/journal.pcbi.0030171","title":"Pathway Switching Explains the Sharp Response Characteristic of Hypoxia Response Network","display_name":"Pathway Switching Explains the Sharp Response Characteristic of Hypoxia Response Network","publication_year":2007,"publication_date":"2007-08-30","ids":{"openalex":"https://openalex.org/W2074730819","doi":"https://doi.org/10.1371/journal.pcbi.0030171","mag":"2074730819","pmid":"https://pubmed.ncbi.nlm.nih.gov/17784783"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.0030171","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0030171","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.0030171","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030986526","display_name":"Yihai Yu","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yihai Yu","raw_affiliation_strings":["Department of Physics, George Washington University, Washington, DC, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, George Washington University, Washington, DC, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100644047","display_name":"Guanyu Wang","orcid":"https://orcid.org/0000-0003-0849-7114"},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guanyu Wang","raw_affiliation_strings":["Department of Physics, George Washington University, Washington, D.C., United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, George Washington University, Washington, D.C., United States of America","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085312107","display_name":"Rahul Simha","orcid":"https://orcid.org/0000-0002-0689-9411"},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rahul Simha","raw_affiliation_strings":["Department of Computer Sciences, George Washington University, Washington, D.C., United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Sciences, George Washington University, Washington, D.C., United States of America","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073126483","display_name":"Weiqun Peng","orcid":"https://orcid.org/0000-0001-5521-9091"},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiqun Peng","raw_affiliation_strings":["Department of Physics, George Washington University, Washington, D.C., United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, George Washington University, Washington, D.C., United States of America","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033844916","display_name":"Frank J. Turano","orcid":null},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank Turano","raw_affiliation_strings":["Department of Biological Sciences, George Washington University, Washington, D.C., United States of America","Department of Biological Sciences, George Washington University, Washington, D. C., United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, George Washington University, Washington, D.C., United States of America","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"Department of Biological Sciences, George Washington University, Washington, D. C., United States of America","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061649532","display_name":"Chen Zeng","orcid":"https://orcid.org/0000-0001-7778-6388"},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chen Zeng","raw_affiliation_strings":["Department of Physics, George Washington University, Washington, D.C., United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, George Washington University, Washington, D.C., United States of America","institution_ids":["https://openalex.org/I193531525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5061649532"],"corresponding_institution_ids":["https://openalex.org/I193531525"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.7973,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.77154822,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"3","issue":"8","first_page":"e171","last_page":"e171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia","display_name":"Hypoxia (environmental)","score":0.7662822008132935},{"id":"https://openalex.org/keywords/oxygen","display_name":"Oxygen","score":0.5726068019866943},{"id":"https://openalex.org/keywords/limiting-oxygen-concentration","display_name":"Limiting oxygen concentration","score":0.476151704788208},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.47551968693733215},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.47144898772239685},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4632607102394104},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4331067204475403},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.4181274175643921},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.41104209423065186},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4031943678855896},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3646587133407593},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.26983094215393066}],"concepts":[{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.7662822008132935},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.5726068019866943},{"id":"https://openalex.org/C89169090","wikidata":"https://www.wikidata.org/wiki/Q593204","display_name":"Limiting oxygen concentration","level":3,"score":0.476151704788208},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47551968693733215},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.47144898772239685},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4632607102394104},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4331067204475403},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4181274175643921},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41104209423065186},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4031943678855896},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3646587133407593},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26983094215393066},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051793","descriptor_name":"Hypoxia-Inducible Factor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051793","descriptor_name":"Hypoxia-Inducible Factor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051793","descriptor_name":"Hypoxia-Inducible Factor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.0030171","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0030171","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:17784783","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17784783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.156.6356","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.156.6356","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c9/e6/PLoS_Comput_Biol_2007_Aug_31_3(8)_e171.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:892b172439cd4c9eae858c8269318ced","is_oa":true,"landing_page_url":"https://doaj.org/article/892b172439cd4c9eae858c8269318ced","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 3, Iss 8, p e171 (2007)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1963493","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1963493","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.0030171","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0030171","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G8672844907","display_name":"ITR: A Protocol For Computational Protein Design","funder_award_id":"0313129","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309515","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67"},{"id":"https://openalex.org/F4320337367","display_name":"Division of Materials Research","ror":"https://ror.org/01pc7k308"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W339353406","https://openalex.org/W1519389642","https://openalex.org/W1597762351","https://openalex.org/W1807981783","https://openalex.org/W1937401270","https://openalex.org/W1965518203","https://openalex.org/W1980717706","https://openalex.org/W1984929987","https://openalex.org/W1990969593","https://openalex.org/W1992306474","https://openalex.org/W2018504915","https://openalex.org/W2025974453","https://openalex.org/W2027705428","https://openalex.org/W2033958147","https://openalex.org/W2037614307","https://openalex.org/W2041603328","https://openalex.org/W2051215275","https://openalex.org/W2065151681","https://openalex.org/W2077854212","https://openalex.org/W2085470258","https://openalex.org/W2091662568","https://openalex.org/W2099039198","https://openalex.org/W2103331163","https://openalex.org/W2110417622","https://openalex.org/W2131178894","https://openalex.org/W2135836641","https://openalex.org/W2144568050","https://openalex.org/W2153373497","https://openalex.org/W2157239641","https://openalex.org/W2163855763","https://openalex.org/W2165623186","https://openalex.org/W2168918345","https://openalex.org/W2172174823","https://openalex.org/W2580449060","https://openalex.org/W4237970323","https://openalex.org/W4297900680"],"related_works":["https://openalex.org/W2363341327","https://openalex.org/W2385290608","https://openalex.org/W2039240857","https://openalex.org/W4281755190","https://openalex.org/W2358039610","https://openalex.org/W2007955051","https://openalex.org/W3163378984","https://openalex.org/W2373930425","https://openalex.org/W2368718225","https://openalex.org/W2356091321"],"abstract_inverted_index":{"Hypoxia":[0],"induces":[1],"the":[2,10,22,57,88,92,101,108,125],"expression":[3],"of":[4,21,49,59,69,82,91],"genes":[5,133],"that":[6,107],"alter":[7],"metabolism":[8],"through":[9,65],"hypoxia-inducible":[11],"factor":[12],"(HIF).":[13],"A":[14],"theoretical":[15],"model":[16,47,78],"based":[17],"on":[18],"differential":[19],"equations":[20],"hypoxia":[23],"response":[24,34],"network":[25,93],"has":[26],"been":[27],"previously":[28],"proposed":[29],"in":[30,37,121,142],"which":[31,56],"a":[32,66,80],"sharp":[33,102],"to":[35,85,100,113,130],"changes":[36],"oxygen":[38,62,103],"concentration":[39],"was":[40],"observed":[41],"but":[42],"not":[43],"quantitatively":[44,96],"explained.":[45],"That":[46],"consisted":[48],"reactions":[50],"involving":[51],"23":[52],"molecular":[53],"species":[54],"among":[55],"concentrations":[58],"HIF":[60,116,129],"and":[61,94],"were":[63],"linked":[64],"complex":[67],"set":[68],"reactions.":[70],"In":[71],"this":[72,76],"paper,":[73],"we":[74],"analyze":[75],"previous":[77],"using":[79],"combination":[81],"mathematical":[83],"tools":[84],"draw":[86],"out":[87],"key":[89],"components":[90],"explain":[95],"how":[97],"they":[98],"contribute":[99],"response.":[104],"We":[105],"find":[106],"switch-like":[109],"behavior":[110],"is":[111,139],"due":[112],"pathway-switching":[114],"wherein":[115],"degrades":[117],"rapidly":[118],"under":[119,134],"normoxia":[120],"one":[122],"pathway,":[123],"while":[124],"other":[126],"pathway":[127],"accumulates":[128],"trigger":[131],"downstream":[132],"hypoxia.":[135],"The":[136],"analytic":[137],"technique":[138],"potentially":[140],"useful":[141],"studying":[143],"larger":[144],"biomedical":[145],"networks.":[146]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
