{"id":"https://openalex.org/W2011945420","doi":"https://doi.org/10.1371/journal.pcbi.0030159","title":"On State-Space Reduction in Multi-Strain Pathogen Models, with an Application to Antigenic Drift in Influenza A","display_name":"On State-Space Reduction in Multi-Strain Pathogen Models, with an Application to Antigenic Drift in Influenza A","publication_year":2007,"publication_date":"2007-08-15","ids":{"openalex":"https://openalex.org/W2011945420","doi":"https://doi.org/10.1371/journal.pcbi.0030159","mag":"2011945420","pmid":"https://pubmed.ncbi.nlm.nih.gov/17708677"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.0030159","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0030159","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.0030159","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049961627","display_name":"Sergey Kryazhimskiy","orcid":"https://orcid.org/0000-0001-9128-8705"},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sergey Kryazhimskiy","raw_affiliation_strings":["Program in Applied and Computational Mathematics, Princeton University, Princeton, New Jersey, United States of America. skryazhi@princeton.edu","Program in Applied and Computational Mathematics, Princeton University, Princeton, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Applied and Computational Mathematics, Princeton University, Princeton, New Jersey, United States of America. skryazhi@princeton.edu","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Program in Applied and Computational Mathematics, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077785558","display_name":"Ulf Dieckmann","orcid":"https://orcid.org/0000-0001-7089-0393"},"institutions":[{"id":"https://openalex.org/I1317774081","display_name":"International Institute for Applied Systems Analysis","ror":"https://ror.org/02wfhk785","country_code":"AT","type":"funder","lineage":["https://openalex.org/I1317774081"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Ulf Dieckmann","raw_affiliation_strings":["Evolution and Ecology Program, International Institute for Applied Systems Analysis, Laxenburg, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evolution and Ecology Program, International Institute for Applied Systems Analysis, Laxenburg, Austria","institution_ids":["https://openalex.org/I1317774081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077712228","display_name":"Simon A. Levin","orcid":"https://orcid.org/0000-0002-8216-5639"},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simon A Levin","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America","Department of Ecology & Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Department of Ecology & Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071611289","display_name":"Jonathan Dushoff","orcid":"https://orcid.org/0000-0003-0506-4794"},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]},{"id":"https://openalex.org/I874236823","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I874236823"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Dushoff","raw_affiliation_strings":["","Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America","Fogarty International Center, National Institute of Health, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Fogarty International Center, National Institute of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I874236823"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5049961627"],"corresponding_institution_ids":["https://openalex.org/I20089843"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.9639,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.85761879,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"3","issue":"8","first_page":"e159","last_page":"e159"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.973800003528595,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10410","display_name":"COVID-19 epidemiological studies","score":0.9524999856948853,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/state-space","display_name":"State space","score":0.5370548963546753},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5203089714050293},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5050898194313049},{"id":"https://openalex.org/keywords/antigenic-drift","display_name":"Antigenic drift","score":0.4996988773345947},{"id":"https://openalex.org/keywords/antigenic-variation","display_name":"Antigenic variation","score":0.4296364188194275},{"id":"https://openalex.org/keywords/infectivity","display_name":"Infectivity","score":0.4241916239261627},{"id":"https://openalex.org/keywords/strain","display_name":"Strain (injury)","score":0.4187653958797455},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3910279870033264},{"id":"https://openalex.org/keywords/influenza-a-virus","display_name":"Influenza A virus","score":0.34479668736457825},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3017657995223999},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.29417717456817627},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.16932883858680725},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.11399242281913757},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.11227983236312866}],"concepts":[{"id":"https://openalex.org/C72434380","wikidata":"https://www.wikidata.org/wiki/Q230930","display_name":"State space","level":2,"score":0.5370548963546753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5203089714050293},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5050898194313049},{"id":"https://openalex.org/C7842527","wikidata":"https://www.wikidata.org/wiki/Q575258","display_name":"Antigenic drift","level":4,"score":0.4996988773345947},{"id":"https://openalex.org/C191942190","wikidata":"https://www.wikidata.org/wiki/Q4774739","display_name":"Antigenic variation","level":3,"score":0.4296364188194275},{"id":"https://openalex.org/C106358424","wikidata":"https://www.wikidata.org/wiki/Q1662346","display_name":"Infectivity","level":3,"score":0.4241916239261627},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.4187653958797455},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3910279870033264},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.34479668736457825},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3017657995223999},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29417717456817627},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.16932883858680725},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.11399242281913757},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.11227983236312866},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000940","descriptor_name":"Antigenic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000940","descriptor_name":"Antigenic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000940","descriptor_name":"Antigenic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040961","descriptor_name":"Genetic Drift","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040961","descriptor_name":"Genetic Drift","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040961","descriptor_name":"Genetic Drift","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1371/journal.pcbi.0030159","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0030159","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:17708677","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17708677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pure.iiasa.ac.at:8143","is_oa":true,"landing_page_url":null,"pdf_url":"http://pure.iiasa.ac.at/id/eprint/8143/1/On%20State-Space%20Reduction%20in%20Multi-Strain%20Pathogen%20Models%2C%20with%20an%20Application%20to%20Antigenic%20Drift%20in%20Influenza%20A.PDF","source":{"id":"https://openalex.org/S4306401423","display_name":"IIASA PURE (International Institute of Applied Systems Analysis)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1317774081","host_organization_name":"International Institute for Applied Systems Analysis","host_organization_lineage":["https://openalex.org/I1317774081"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.145.2175","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.145.2175","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.iiasa.ac.at/~dieckman/reprints/KryazhimskiyEtal2007.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.220.1428","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.220.1428","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.iiasa.ac.at/~dieckman/reprints/KryazhimskiyEtal2007.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:0030159","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.0030159","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:69ec146cc13b4195b916e9cfae0099f5","is_oa":true,"landing_page_url":"https://doaj.org/article/69ec146cc13b4195b916e9cfae0099f5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 3, Iss 8, p e159 (2007)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2622387","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC1949840","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/151959","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/On_State_Space_Reduction_in_Multi_Strain_Pathogen_Models_with_an_Application_to_Antigenic_Drift_in_Influenza_A/151959","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:1949840","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1949840","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.0030159","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0030159","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15","score":0.5099999904632568}],"awards":[{"id":"https://openalex.org/G1011064577","display_name":null,"funder_award_id":"P50 GM071508","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2994491871","display_name":null,"funder_award_id":"GM071508","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306133","display_name":"Burroughs Wellcome Fund","ror":"https://ror.org/01d35cw23"},{"id":"https://openalex.org/F4320321003","display_name":"Vienna Science and Technology Fund","ror":"https://ror.org/01f9mc681"},{"id":"https://openalex.org/F4320327324","display_name":"International Institute for Applied Systems Analysis","ror":"https://ror.org/02wfhk785"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332180","display_name":"Defense Advanced Research Projects Agency","ror":"https://ror.org/02caytj08"},{"id":"https://openalex.org/F4320332815","display_name":"Advanced Research Projects Agency","ror":"https://ror.org/02caytj08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W228144990","https://openalex.org/W1512447799","https://openalex.org/W1545711005","https://openalex.org/W1546538010","https://openalex.org/W1594291410","https://openalex.org/W1606697907","https://openalex.org/W1966485460","https://openalex.org/W1971707987","https://openalex.org/W1972584579","https://openalex.org/W1973549202","https://openalex.org/W1974017602","https://openalex.org/W1974918617","https://openalex.org/W1979158913","https://openalex.org/W1984416131","https://openalex.org/W2000753862","https://openalex.org/W2001488223","https://openalex.org/W2004578687","https://openalex.org/W2005034971","https://openalex.org/W2011483524","https://openalex.org/W2015403041","https://openalex.org/W2016808064","https://openalex.org/W2020891730","https://openalex.org/W2024258404","https://openalex.org/W2025776357","https://openalex.org/W2051457177","https://openalex.org/W2053172733","https://openalex.org/W2056499793","https://openalex.org/W2069576089","https://openalex.org/W2080324298","https://openalex.org/W2081097955","https://openalex.org/W2092500478","https://openalex.org/W2093720374","https://openalex.org/W2110891892","https://openalex.org/W2125118702","https://openalex.org/W2136167138","https://openalex.org/W2137945842","https://openalex.org/W2142773663","https://openalex.org/W2148301044","https://openalex.org/W2154116964","https://openalex.org/W2157547565","https://openalex.org/W2169404894","https://openalex.org/W2173375845"],"related_works":["https://openalex.org/W2061095809","https://openalex.org/W2483343817","https://openalex.org/W1512806282","https://openalex.org/W1979537384","https://openalex.org/W2006667246","https://openalex.org/W1546752353","https://openalex.org/W134307878","https://openalex.org/W2031127338","https://openalex.org/W2054327131","https://openalex.org/W4211002388"],"abstract_inverted_index":{"Many":[0],"pathogens":[1],"exist":[2],"in":[3,134,140,173,186,204],"phenotypically":[4],"distinct":[5],"strains":[6,172],"that":[7,18,52,72,86,148,195,217],"interact":[8],"with":[9,93,170],"each":[10],"other":[11],"through":[12],"competition":[13],"for":[14,48,91,239],"hosts.":[15,131],"General":[16],"models":[17,36,92,169],"describe":[19,118],"such":[20],"multi-strain":[21,119,215,246],"systems":[22,120,216],"are":[23,32],"extremely":[24],"difficult":[25],"to":[26,75,151,156,167,180,200],"analyze":[27],"because":[28],"their":[29],"state":[30,163],"spaces":[31],"enormously":[33],"large.":[34],"Reduced":[35],"have":[37],"been":[38],"proposed,":[39],"but":[40],"so":[41],"far":[42],"all":[43],"of":[44,103,108,114,127,161,183,214,245],"them":[45],"necessarily":[46],"allow":[47],"coinfections":[49],"and":[50,85,129,165,228,232,243],"require":[51],"immunity":[53,74,115],"be":[54,76,89,138,219],"mediated":[55,77],"solely":[56],"by":[57,78,144,222],"reduced":[58,80,83,223],"infectivity,":[59],"a":[60,67,141,145,174,191,201,205,236],"potentially":[61,192],"problematic":[62],"assumption.":[63],"Here,":[64],"we":[65,189],"suggest":[66],"new":[68],"state-space":[69],"reduction":[70],"approach":[71,98],"allows":[73],"either":[79],"infectivity":[81],"or":[82,94],"susceptibility":[84],"can":[87,137,218],"naturally":[88,122],"used":[90],"without":[95],"coinfections.":[96],"Our":[97,209],"utilizes":[99],"the":[100,112,124,159,162,181,212,241],"general":[101,193],"framework":[102,210],"status-based":[104],"models.":[105,224],"The":[106],"cornerstone":[107],"our":[109,178],"method":[110,147,179],"is":[111,149],"introduction":[113],"variables,":[116],"which":[117],"more":[121],"than":[123],"traditional":[125],"tracking":[126],"susceptible":[128],"infected":[130],"Models":[132],"expressed":[133],"this":[135],"way":[136,143],"approximated":[139],"natural":[142],"truncation":[146],"akin":[150],"moment":[152],"closure,":[153],"allowing":[154],"us":[155],"sharply":[157],"reduce":[158],"size":[160],"space,":[164],"thus":[166,233],"consider":[168],"many":[171],"tractable":[175],"manner.":[176],"Applying":[177],"phenomenon":[182],"antigenic":[184],"drift":[185],"influenza":[187],"A,":[188],"propose":[190],"mechanism":[194],"could":[196],"constrain":[197],"viral":[198],"evolution":[199,242],"one-dimensional":[202],"manifold":[203],"two-dimensional":[206],"trait":[207],"space.":[208],"broadens":[211],"class":[213],"adequately":[220],"described":[221],"It":[225],"permits":[226],"computational,":[227],"even":[229],"analytical,":[230],"investigation":[231],"serves":[234],"as":[235],"useful":[237],"tool":[238],"understanding":[240],"ecology":[244],"pathogens.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-06-13T07:54:00.901334","created_date":"2025-10-10T00:00:00"}