{"id":"https://openalex.org/W2156682654","doi":"https://doi.org/10.1371/journal.pcbi.0030142","title":"Computationally Derived Points of Fragility of a Human Cascade Are Consistent with Current Therapeutic Strategies","display_name":"Computationally Derived Points of Fragility of a Human Cascade Are Consistent with Current Therapeutic Strategies","publication_year":2007,"publication_date":"2007-07-17","ids":{"openalex":"https://openalex.org/W2156682654","doi":"https://doi.org/10.1371/journal.pcbi.0030142","mag":"2156682654","pmid":"https://pubmed.ncbi.nlm.nih.gov/17658944"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.0030142","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0030142","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0030142&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0030142&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069187134","display_name":"Deyan Luan","orcid":"https://orcid.org/0000-0003-3987-0989"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deyan Luan","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, USA","Department of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, United States of America","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020073481","display_name":"Michael Zai","orcid":null},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Zai","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, United States of America","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003161155","display_name":"Jeffrey D. Varner","orcid":"https://orcid.org/0000-0002-2558-7026"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeffrey D Varner","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, United States of America","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5003161155"],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.3093,"has_fulltext":true,"cited_by_count":108,"citation_normalized_percentile":{"value":0.92540066,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"3","issue":"7","first_page":"e142","last_page":"e142"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.9872000217437744,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombin","display_name":"Thrombin","score":0.5937843322753906},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.5548087358474731},{"id":"https://openalex.org/keywords/coagulation","display_name":"Coagulation","score":0.5107402801513672},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.49964189529418945},{"id":"https://openalex.org/keywords/coagulation-cascade","display_name":"Coagulation cascade","score":0.46336835622787476},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"Platelet activation","score":0.446743369102478},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.43386879563331604},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.4337254464626312},{"id":"https://openalex.org/keywords/fragility","display_name":"Fragility","score":0.4204343557357788},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.4113618731498718},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.3818226456642151},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3327668011188507},{"id":"https://openalex.org/keywords/platelet","display_name":"Platelet","score":0.3219611346721649},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24554070830345154},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.22996336221694946},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.16349577903747559},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1579781472682953},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1372232437133789}],"concepts":[{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.5937843322753906},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.5548087358474731},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.5107402801513672},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49964189529418945},{"id":"https://openalex.org/C3019190606","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation cascade","level":4,"score":0.46336835622787476},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.446743369102478},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43386879563331604},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4337254464626312},{"id":"https://openalex.org/C80191262","wikidata":"https://www.wikidata.org/wiki/Q5477668","display_name":"Fragility","level":2,"score":0.4204343557357788},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4113618731498718},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3818226456642151},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3327668011188507},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.3219611346721649},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24554070830345154},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22996336221694946},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16349577903747559},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1579781472682953},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1372232437133789},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002985","descriptor_name":"Clinical Protocols","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D002985","descriptor_name":"Clinical Protocols","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D002985","descriptor_name":"Clinical Protocols","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D002985","descriptor_name":"Clinical Protocols","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D003661","descriptor_name":"Decision Support Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003661","descriptor_name":"Decision Support Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003661","descriptor_name":"Decision Support Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003661","descriptor_name":"Decision Support Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015944","descriptor_name":"Factor VIIIa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015944","descriptor_name":"Factor VIIIa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015944","descriptor_name":"Factor VIIIa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015944","descriptor_name":"Factor VIIIa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015949","descriptor_name":"Factor IXa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015949","descriptor_name":"Factor IXa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015949","descriptor_name":"Factor IXa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015949","descriptor_name":"Factor IXa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015951","descriptor_name":"Factor Xa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015951","descriptor_name":"Factor Xa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015951","descriptor_name":"Factor Xa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015951","descriptor_name":"Factor Xa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.0030142","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0030142","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0030142&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:17658944","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17658944","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:0030142","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.0030142","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:23fe47279dc44aa5ba269442044ea39e","is_oa":true,"landing_page_url":"https://doaj.org/article/23fe47279dc44aa5ba269442044ea39e","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 3, Iss 7, p e142 (2007)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2622365","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC1924874","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/151938","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Computationally_Derived_Points_of_Fragility_of_a_Human_Cascade_Are_Consistent_with_Current_Therapeutic_Strategies/151938","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:1924874","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1924874","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.0030142","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0030142","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0030142&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2156682654.pdf","grobid_xml":"https://content.openalex.org/works/W2156682654.grobid-xml"},"referenced_works_count":88,"referenced_works":["https://openalex.org/W50743869","https://openalex.org/W62994428","https://openalex.org/W70134621","https://openalex.org/W1489050099","https://openalex.org/W1489758714","https://openalex.org/W1511802802","https://openalex.org/W1536230526","https://openalex.org/W1565285014","https://openalex.org/W1570080274","https://openalex.org/W1578821085","https://openalex.org/W1637936532","https://openalex.org/W1811402656","https://openalex.org/W1964509762","https://openalex.org/W1970242262","https://openalex.org/W1982075427","https://openalex.org/W1990154448","https://openalex.org/W1998317810","https://openalex.org/W2000130043","https://openalex.org/W2000600286","https://openalex.org/W2004263930","https://openalex.org/W2012761317","https://openalex.org/W2018252885","https://openalex.org/W2021674783","https://openalex.org/W2026502021","https://openalex.org/W2029576247","https://openalex.org/W2033104002","https://openalex.org/W2037036397","https://openalex.org/W2041815335","https://openalex.org/W2047121032","https://openalex.org/W2050174104","https://openalex.org/W2050940330","https://openalex.org/W2051676709","https://openalex.org/W2052436426","https://openalex.org/W2054169479","https://openalex.org/W2054733175","https://openalex.org/W2055085177","https://openalex.org/W2058161894","https://openalex.org/W2059129888","https://openalex.org/W2060670576","https://openalex.org/W2062989416","https://openalex.org/W2063546834","https://openalex.org/W2063916070","https://openalex.org/W2065304353","https://openalex.org/W2067478206","https://openalex.org/W2068602646","https://openalex.org/W2073489044","https://openalex.org/W2077207459","https://openalex.org/W2083691092","https://openalex.org/W2084619201","https://openalex.org/W2092309107","https://openalex.org/W2093410681","https://openalex.org/W2093717102","https://openalex.org/W2094941678","https://openalex.org/W2097210000","https://openalex.org/W2099525487","https://openalex.org/W2106970265","https://openalex.org/W2107266385","https://openalex.org/W2108182880","https://openalex.org/W2108471572","https://openalex.org/W2110070747","https://openalex.org/W2117056464","https://openalex.org/W2125074150","https://openalex.org/W2126602684","https://openalex.org/W2128005489","https://openalex.org/W2128602721","https://openalex.org/W2134908914","https://openalex.org/W2139439234","https://openalex.org/W2142072523","https://openalex.org/W2142649232","https://openalex.org/W2143784594","https://openalex.org/W2154736824","https://openalex.org/W2155252349","https://openalex.org/W2156154713","https://openalex.org/W2159553511","https://openalex.org/W2166565152","https://openalex.org/W2166945512","https://openalex.org/W2167869241","https://openalex.org/W2170498573","https://openalex.org/W2317956317","https://openalex.org/W2325632732","https://openalex.org/W2473427517","https://openalex.org/W2523223503","https://openalex.org/W4240283855","https://openalex.org/W4251742697","https://openalex.org/W4253259085","https://openalex.org/W4253436283","https://openalex.org/W4256140420","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1994499822","https://openalex.org/W2283115510","https://openalex.org/W1972959684","https://openalex.org/W4254978556","https://openalex.org/W2988087849","https://openalex.org/W2479211211","https://openalex.org/W2537496457","https://openalex.org/W2129420064","https://openalex.org/W2113136524","https://openalex.org/W1966792216"],"abstract_inverted_index":{"The":[0,80,91],"role":[1],"that":[2,34,52,251,265],"mechanistic":[3,35],"mathematical":[4,22],"modeling":[5,23],"and":[6,14,24,51,76,97,119,126,172,181,192,195,201,226,235,241],"systems":[7],"biology":[8],"will":[9],"play":[10],"in":[11,112,123,239,242],"molecular":[12],"medicine":[13],"clinical":[15],"development":[16],"remains":[17],"uncertain.":[18],"In":[19,166],"this":[20],"study,":[21],"sensitivity":[25,147],"analysis":[26],"were":[27,84,131,159,185,197],"used":[28,277],"to":[29,187],"explore":[30],"the":[31,71,88,124,151,167,218,249],"working":[32,64,263],"hypothesis":[33,65,264],"models":[36],"of":[37,49,70,94,128,140,155,169,208,220,269,271],"human":[38,272],"cascades,":[39],"despite":[40,285],"model":[41,69,286],"uncertainty,":[42],"can":[43],"be":[44,188,276],"computationally":[45,266],"screened":[46],"for":[47,210,217,231,282],"points":[48,268],"fragility,":[50],"these":[53,259],"sensitive":[54,82],"mechanisms":[55,83],"could":[56,275],"serve":[57],"as":[58,227,278],"therapeutic":[59],"targets.":[60],"We":[61],"tested":[62],"our":[63,262],"by":[66],"screening":[67],"a":[68,137,156,162,279],"well-studied":[72],"coagulation":[73,114],"cascade,":[74],"developed":[75],"validated":[77,102],"from":[78,108],"literature.":[79,90],"predicted":[81],"then":[85],"compared":[86],"with":[87,133,136],"treatment":[89,230],"model,":[92],"composed":[93],"92":[95],"proteins":[96],"148":[98],"protein-protein":[99],"interactions,":[100],"was":[101],"using":[103,161],"21":[104],"published":[105],"datasets":[106],"generated":[107],"two":[109],"different":[110],"quiescent":[111],"vitro":[113,240],"models.":[115],"Simulated":[116],"platelet":[117,183],"activation":[118,184,194],"thrombin":[120,203],"generation":[121],"profiles":[122],"presence":[125],"absence":[127,168],"natural":[129],"anticoagulants":[130],"consistent":[132],"measured":[134],"values,":[135],"mean":[138],"correlation":[139],"0.87":[141],"across":[142],"all":[143],"trials.":[144],"Overall":[145],"state":[146],"coefficients,":[148],"which":[149],"measure":[150],"robustness":[152],"or":[153],"fragility":[154,270],"given":[157],"mechanism,":[158],"calculated":[160],"Monte":[163],"Carlo":[164],"strategy.":[165],"anticoagulants,":[170],"fluid":[171],"surface":[173],"phase":[174],"factor":[175,177],"X/activated":[176],"X":[178],"(fX/FXa)":[179],"activity":[180,196,253],"thrombin-mediated":[182],"found":[186],"fragile,":[189],"while":[190],"fIX/FIXa":[191,252],"fVIII/FVIIIa":[193],"robust.":[198,255],"Both":[199,238],"anti-fX/FXa":[200,212],"direct":[202],"inhibitors":[204,213],"are":[205],"important":[206],"classes":[207],"anticoagulants;":[209],"example,":[211],"have":[214],"FDA":[215],"approval":[216],"prevention":[219],"venous":[221,233],"thromboembolism":[222],"following":[223],"surgical":[224],"intervention":[225],"an":[228],"initial":[229],"deep":[232],"thrombosis":[234],"pulmonary":[236],"embolism.":[237],"vivo":[243],"experimental":[244],"evidence":[245],"is":[246,254],"reviewed":[247],"supporting":[248],"prediction":[250],"When":[256],"taken":[257],"together,":[258],"results":[260],"support":[261],"derived":[267],"relevant":[273],"cascades":[274],"rational":[280],"basis":[281],"target":[283],"selection":[284],"uncertainty.":[287]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":8}],"updated_date":"2026-05-04T08:30:34.212998","created_date":"2025-10-10T00:00:00"}
