{"id":"https://openalex.org/W2080687826","doi":"https://doi.org/10.1371/journal.pcbi.0030121","title":"Evolution of Function in the \u201cTwo Dinucleotide Binding Domains\u201d Flavoproteins","display_name":"Evolution of Function in the \u201cTwo Dinucleotide Binding Domains\u201d Flavoproteins","publication_year":2007,"publication_date":"2007-07-17","ids":{"openalex":"https://openalex.org/W2080687826","doi":"https://doi.org/10.1371/journal.pcbi.0030121","mag":"2080687826","pmid":"https://pubmed.ncbi.nlm.nih.gov/17658942"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.0030121","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0030121","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0030121&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0030121&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086714072","display_name":"Sunil Ojha","orcid":"https://orcid.org/0000-0003-2240-6813"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunil Ojha","raw_affiliation_strings":["Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco, California, USA","Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109200358","display_name":"Elaine C. Meng","orcid":null},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elaine C Meng","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020002876","display_name":"Patricia C. Babbitt","orcid":"https://orcid.org/0000-0003-0375-9015"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I103922791","display_name":"QB3","ror":"https://ror.org/04n1n3n22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I103922791","https://openalex.org/I180670191","https://openalex.org/I185103710","https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patricia C Babbitt","raw_affiliation_strings":["","Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco, California, United States of America","Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America","Institute for Quantitative Biomedical Research, University of California San Francisco, San Francisco, California, United States of America"],"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Institute for Quantitative Biomedical Research, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I103922791","https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020002876"],"corresponding_institution_ids":["https://openalex.org/I103922791","https://openalex.org/I180670191"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.0757,"has_fulltext":true,"cited_by_count":65,"citation_normalized_percentile":{"value":0.75903199,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"3","issue":"7","first_page":"e121","last_page":"e121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10303","display_name":"Photosynthetic Processes and Mechanisms","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10303","display_name":"Photosynthetic Processes and Mechanisms","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flavoprotein","display_name":"Flavoprotein","score":0.8100327253341675},{"id":"https://openalex.org/keywords/flavin-adenine-dinucleotide","display_name":"Flavin adenine dinucleotide","score":0.7862551212310791},{"id":"https://openalex.org/keywords/cofactor","display_name":"Cofactor","score":0.7717764377593994},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.4633766710758209},{"id":"https://openalex.org/keywords/flavin-group","display_name":"Flavin group","score":0.4614400267601013},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.43887585401535034},{"id":"https://openalex.org/keywords/conserved-sequence","display_name":"Conserved sequence","score":0.4339355528354645},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3712056577205658},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.26358887553215027},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.20508652925491333},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.06572085618972778}],"concepts":[{"id":"https://openalex.org/C71995715","wikidata":"https://www.wikidata.org/wiki/Q78574842","display_name":"Flavoprotein","level":3,"score":0.8100327253341675},{"id":"https://openalex.org/C2775859393","wikidata":"https://www.wikidata.org/wiki/Q28746","display_name":"Flavin adenine dinucleotide","level":4,"score":0.7862551212310791},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.7717764377593994},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4633766710758209},{"id":"https://openalex.org/C33093398","wikidata":"https://www.wikidata.org/wiki/Q174337","display_name":"Flavin group","level":3,"score":0.4614400267601013},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43887585401535034},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.4339355528354645},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3712056577205658},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.26358887553215027},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.20508652925491333},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06572085618972778}],"mesh":[{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003067","descriptor_name":"Coenzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003067","descriptor_name":"Coenzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003067","descriptor_name":"Coenzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005182","descriptor_name":"Flavin-Adenine Dinucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005182","descriptor_name":"Flavin-Adenine Dinucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005182","descriptor_name":"Flavin-Adenine Dinucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015226","descriptor_name":"Dinucleoside Phosphates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015226","descriptor_name":"Dinucleoside Phosphates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015226","descriptor_name":"Dinucleoside Phosphates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044927","descriptor_name":"Electron-Transferring Flavoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044927","descriptor_name":"Electron-Transferring Flavoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044927","descriptor_name":"Electron-Transferring Flavoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044927","descriptor_name":"Electron-Transferring Flavoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044927","descriptor_name":"Electron-Transferring Flavoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044927","descriptor_name":"Electron-Transferring Flavoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044927","descriptor_name":"Electron-Transferring Flavoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044927","descriptor_name":"Electron-Transferring Flavoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044927","descriptor_name":"Electron-Transferring Flavoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.0030121","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0030121","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0030121&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:17658942","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17658942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.785.133","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.785.133","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/a6/19/pcbi.0030121.PMC1924876.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:af7a69c4537242f3ba47c4c45fb6ab97","is_oa":true,"landing_page_url":"https://doaj.org/article/af7a69c4537242f3ba47c4c45fb6ab97","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 3, Iss 7, p e121 (2007)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2622367","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC1924876","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/151934","is_oa":true,"landing_page_url":"https://figshare.com/articles/Evolution_of_Function_in_the_Two_Dinucleotide_Binding_Domains_Flavoproteins/151934","pdf_url":null,"source":{"id":"https://openalex.org/S4306400572","display_name":"OPAL (Open@LaTrobe) (La Trobe University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I196829312","host_organization_name":"La Trobe University","host_organization_lineage":["https://openalex.org/I196829312"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:1924876","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1924876","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.0030121","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0030121","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0030121&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6100000143051147,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[{"id":"https://openalex.org/G593386812","display_name":null,"funder_award_id":"Fellowship","funder_id":"https://openalex.org/F4320306799","funder_display_name":"Pharmaceutical Research and Manufacturers of America Foundation"},{"id":"https://openalex.org/G874721465","display_name":null,"funder_award_id":"GM60595","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320306799","display_name":"Pharmaceutical Research and Manufacturers of America Foundation","ror":"https://ror.org/01z88k350"},{"id":"https://openalex.org/F4320322015","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2080687826.pdf","grobid_xml":"https://content.openalex.org/works/W2080687826.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1493988001","https://openalex.org/W1516817503","https://openalex.org/W1572879308","https://openalex.org/W1603225698","https://openalex.org/W1967316786","https://openalex.org/W1975430468","https://openalex.org/W1985203726","https://openalex.org/W1986228073","https://openalex.org/W1995413875","https://openalex.org/W1999623718","https://openalex.org/W2008921808","https://openalex.org/W2012479504","https://openalex.org/W2016281849","https://openalex.org/W2017661263","https://openalex.org/W2029246869","https://openalex.org/W2037907257","https://openalex.org/W2038352613","https://openalex.org/W2045899523","https://openalex.org/W2050575734","https://openalex.org/W2053159677","https://openalex.org/W2054492447","https://openalex.org/W2054539028","https://openalex.org/W2058534602","https://openalex.org/W2059351613","https://openalex.org/W2062296203","https://openalex.org/W2064280448","https://openalex.org/W2070193353","https://openalex.org/W2074315963","https://openalex.org/W2075313578","https://openalex.org/W2077314545","https://openalex.org/W2078150270","https://openalex.org/W2085277871","https://openalex.org/W2089922354","https://openalex.org/W2093595338","https://openalex.org/W2109454375","https://openalex.org/W2111507825","https://openalex.org/W2112492958","https://openalex.org/W2123671636","https://openalex.org/W2125725297","https://openalex.org/W2132629607","https://openalex.org/W2144892721","https://openalex.org/W2152326664","https://openalex.org/W2154488281","https://openalex.org/W2154802584","https://openalex.org/W2158714788","https://openalex.org/W2160769697","https://openalex.org/W2164652663","https://openalex.org/W2172424935","https://openalex.org/W2266328638","https://openalex.org/W2270435927","https://openalex.org/W2411338220","https://openalex.org/W2949495582","https://openalex.org/W3145257564","https://openalex.org/W3147254695","https://openalex.org/W4247896860"],"related_works":["https://openalex.org/W2009712104","https://openalex.org/W2191822893","https://openalex.org/W2086424699","https://openalex.org/W2014054075","https://openalex.org/W1591975289","https://openalex.org/W3154083660","https://openalex.org/W1596235536","https://openalex.org/W2182012805","https://openalex.org/W2719786949","https://openalex.org/W2134700891"],"abstract_inverted_index":{"Structural":[0],"and":[1,34,42,97,103,117,248],"biochemical":[2],"constraints":[3,44,267],"force":[4],"some":[5],"segments":[6],"of":[7,18,51,57,79,106,111,120,132,171,192,202,212,221,232,257,275,282,299],"proteins":[8,211],"to":[9,182,197,215,291],"evolve":[10],"more":[11,107],"slowly":[12],"than":[13,108],"others,":[14],"often":[15],"allowing":[16],"identification":[17],"conserved":[19,144,262,283],"structural":[20,43,104],"or":[21],"sequence":[22],"motifs":[23,162],"that":[24,129,151],"can":[25],"be":[26],"associated":[27],"with":[28,157,184,207],"substrate":[29],"binding":[30,62,67,167,224],"properties,":[31],"chemical":[32,260],"mechanisms,":[33],"molecular":[35],"functions.":[36],"We":[37],"have":[38],"assessed":[39],"the":[40,49,64,112,121,133,138,175,179,187,190,195,198,208,218,222,230,258,264,266,273,302],"functional":[41],"imposed":[45],"by":[46,60,85,154],"cofactors":[47,141],"on":[48,217,279],"evolution":[50],"new":[52,115],"functions":[53],"in":[54,130,174,272],"a":[55,86,94,143,227],"superfamily":[56,113],"flavoproteins":[58,69],"characterized":[59],"two-dinucleotide":[61],"domains,":[63],"\"two":[65],"dinucleotide":[66,100,166],"domains\"":[68],"(tDBDF)":[70],"superfamily.":[71,303],"Although":[72],"these":[73,140,237],"enzymes":[74],"catalyze":[75],"many":[76],"different":[77,209,213,288],"types":[78],"oxidation/reduction":[80],"reactions,":[81],"each":[82],"is":[83,152],"initiated":[84],"stereospecific":[87,148],"hydride":[88,149],"transfer":[89,150],"reaction":[90],"between":[91],"two":[92],"cofactors,":[93],"pyridine":[95,180],"nucleotide":[96,181],"flavin":[98],"adenine":[99],"(FAD).":[101],"Sequence":[102],"analysis":[105,127],"1,600":[109],"members":[110,116],"reveals":[114],"identifies":[118],"details":[119],"evolutionary":[122],"connections":[123],"among":[124,164],"them.":[125],"Our":[126],"shows":[128],"all":[131],"highly":[134],"divergent":[135],"families":[136,214],"within":[137],"superfamily,":[139,265],"adopt":[142],"configuration":[145,173],"optimal":[146],"for":[147],"stabilized":[153],"specific":[155,255],"interactions":[156,206],"amino":[158],"acids":[159],"from":[160,186,194],"several":[161],"distributed":[163],"both":[165],"domains.":[168,225],"The":[169],"conservation":[170],"cofactor":[172,223],"active":[176],"site":[177],"restricts":[178],"interact":[183],"FAD":[185],"re-side,":[188],"limiting":[189],"flow":[191,204],"electrons":[193],"re-side":[196],"si-side.":[199],"This":[200],"directionality":[201],"electron":[203,244,294],"constrains":[205],"partner":[210],"occur":[216],"same":[219],"face":[220],"As":[226],"result,":[228],"superimposing":[229],"structures":[231],"tDBDFs":[233],"aligns":[234],"not":[235,252],"only":[236,253],"interacting":[238],"proteins,":[239],"but":[240],"also":[241],"their":[242],"constituent":[243],"acceptors,":[245,295],"including":[246],"heme":[247],"iron-sulfur":[249],"clusters.":[250],"Thus,":[251],"are":[254,270],"aspects":[256],"cofactor-directed":[259],"mechanism":[261],"across":[263,301],"they":[268],"impose":[269],"manifested":[271],"mode":[274],"protein-protein":[276],"interactions.":[277],"Overlaid":[278],"this":[280],"foundation":[281],"interactions,":[284],"nature":[285],"has":[286],"conscripted":[287],"protein":[289],"partners":[290],"serve":[292],"as":[293],"thereby":[296],"generating":[297],"diversification":[298],"function":[300]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-04-07T14:57:38.498316","created_date":"2025-10-10T00:00:00"}
