{"id":"https://openalex.org/W1984567848","doi":"https://doi.org/10.1371/journal.pcbi.0030025","title":"Specificity and Evolvability in Eukaryotic Protein Interaction Networks","display_name":"Specificity and Evolvability in Eukaryotic Protein Interaction Networks","publication_year":2007,"publication_date":"2007-02-14","ids":{"openalex":"https://openalex.org/W1984567848","doi":"https://doi.org/10.1371/journal.pcbi.0030025","mag":"1984567848","pmid":"https://pubmed.ncbi.nlm.nih.gov/17305419"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.0030025","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0030025","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0030025&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0030025&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050058340","display_name":"Pedro Beltr\u00e3o","orcid":"https://orcid.org/0000-0002-2724-7703"},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Pedro Beltrao","raw_affiliation_strings":["European Molecular Biology Laboratory, Structures and Computational Biology Program, Heidelberg, Germany. beltrao@embl.de","European Molecular Biology Laboratory, Structures and Computational Biology Program, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, Structures and Computational Biology Program, Heidelberg, Germany. beltrao@embl.de","institution_ids":["https://openalex.org/I4210153543","https://openalex.org/I4210138560"]},{"raw_affiliation_string":"European Molecular Biology Laboratory, Structures and Computational Biology Program, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210153543"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080707475","display_name":"Lu\u00eds Serrano","orcid":"https://orcid.org/0000-0002-5276-1392"},"institutions":[{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Luis Serrano","raw_affiliation_strings":["European Molecular Biology Laboratory, Structures and Computational Biology Program, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, Structures and Computational Biology Program, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210153543"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050058340"],"corresponding_institution_ids":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":5.1132,"has_fulltext":true,"cited_by_count":120,"citation_normalized_percentile":{"value":0.96285349,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"3","issue":"2","first_page":"e25","last_page":"e25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9732999801635742,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/evolvability","display_name":"Evolvability","score":0.8016645908355713},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.7162699699401855},{"id":"https://openalex.org/keywords/homo-sapiens","display_name":"Homo sapiens","score":0.6667290925979614},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.624293327331543},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.602341890335083},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.5680220127105713},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5540039539337158},{"id":"https://openalex.org/keywords/divergence","display_name":"Divergence (linguistics)","score":0.49513521790504456},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.4755555987358093},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.46004676818847656},{"id":"https://openalex.org/keywords/protein-interaction-networks","display_name":"Protein Interaction Networks","score":0.4462222754955292},{"id":"https://openalex.org/keywords/comparative-genomics","display_name":"Comparative genomics","score":0.4455392062664032},{"id":"https://openalex.org/keywords/negative-selection","display_name":"Negative selection","score":0.4319016933441162},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3056544065475464},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.24166151881217957},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.14643797278404236}],"concepts":[{"id":"https://openalex.org/C176147130","wikidata":"https://www.wikidata.org/wiki/Q909622","display_name":"Evolvability","level":2,"score":0.8016645908355713},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.7162699699401855},{"id":"https://openalex.org/C2777938546","wikidata":"https://www.wikidata.org/wiki/Q5","display_name":"Homo sapiens","level":2,"score":0.6667290925979614},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.624293327331543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.602341890335083},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5680220127105713},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5540039539337158},{"id":"https://openalex.org/C207390915","wikidata":"https://www.wikidata.org/wiki/Q1230525","display_name":"Divergence (linguistics)","level":2,"score":0.49513521790504456},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.4755555987358093},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.46004676818847656},{"id":"https://openalex.org/C2909613950","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Protein Interaction Networks","level":3,"score":0.4462222754955292},{"id":"https://openalex.org/C105176652","wikidata":"https://www.wikidata.org/wiki/Q1147112","display_name":"Comparative genomics","level":5,"score":0.4455392062664032},{"id":"https://openalex.org/C7386963","wikidata":"https://www.wikidata.org/wiki/Q3954859","display_name":"Negative selection","level":4,"score":0.4319016933441162},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3056544065475464},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.24166151881217957},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14643797278404236},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005057","descriptor_name":"Eukaryotic Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005057","descriptor_name":"Eukaryotic Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005057","descriptor_name":"Eukaryotic Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.0030025","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0030025","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0030025&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:17305419","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17305419","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:4246f71a5a12447ba4d062ebe6497d8e","is_oa":false,"landing_page_url":"https://doaj.org/article/4246f71a5a12447ba4d062ebe6497d8e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 3, Iss 2, p e25 (2007)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2622235","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC1797819","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/152386","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Specificity_and_Evolvability_in_Eukaryotic_Protein_Interaction_Networks/152386","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:1797819","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1797819","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/531894","is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/531894","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 3 (2)","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"doi:10.3929/ethz-b-000531894","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-b-000531894","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.0030025","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0030025","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0030025&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5299999713897705,"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1984567848.pdf","grobid_xml":"https://content.openalex.org/works/W1984567848.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W613417511","https://openalex.org/W1964881184","https://openalex.org/W1965479796","https://openalex.org/W1984164188","https://openalex.org/W1987378985","https://openalex.org/W1987749411","https://openalex.org/W1994803330","https://openalex.org/W1997088865","https://openalex.org/W1999027354","https://openalex.org/W2008620264","https://openalex.org/W2017455573","https://openalex.org/W2019591778","https://openalex.org/W2029158589","https://openalex.org/W2037036397","https://openalex.org/W2040892797","https://openalex.org/W2054624670","https://openalex.org/W2054755820","https://openalex.org/W2065304353","https://openalex.org/W2065769502","https://openalex.org/W2071469133","https://openalex.org/W2072159031","https://openalex.org/W2079818352","https://openalex.org/W2081306806","https://openalex.org/W2081933515","https://openalex.org/W2084619201","https://openalex.org/W2098045561","https://openalex.org/W2101181377","https://openalex.org/W2101330776","https://openalex.org/W2101671848","https://openalex.org/W2102101495","https://openalex.org/W2103017472","https://openalex.org/W2104106326","https://openalex.org/W2104315543","https://openalex.org/W2115806022","https://openalex.org/W2116905253","https://openalex.org/W2117526623","https://openalex.org/W2117790117","https://openalex.org/W2118025286","https://openalex.org/W2119195082","https://openalex.org/W2124463526","https://openalex.org/W2128969076","https://openalex.org/W2130790725","https://openalex.org/W2134672568","https://openalex.org/W2134711219","https://openalex.org/W2135021437","https://openalex.org/W2136316164","https://openalex.org/W2137441463","https://openalex.org/W2137464714","https://openalex.org/W2150910849","https://openalex.org/W2152653671","https://openalex.org/W2164813401","https://openalex.org/W2167222948","https://openalex.org/W2167680767","https://openalex.org/W2167869241","https://openalex.org/W2171081680","https://openalex.org/W2486658609","https://openalex.org/W3103071483","https://openalex.org/W4256527490"],"related_works":["https://openalex.org/W3005393963","https://openalex.org/W3083701422","https://openalex.org/W2003938058","https://openalex.org/W2057065397","https://openalex.org/W4229728790","https://openalex.org/W2113782798","https://openalex.org/W2180749449","https://openalex.org/W2075963387","https://openalex.org/W4311275500","https://openalex.org/W2049735364"],"abstract_inverted_index":{"Progress":[0],"in":[1,115,160],"uncovering":[2],"the":[3,28,36,91,97,149,155,169],"protein":[4,31,68,161,176],"interaction":[5,32,98,162],"networks":[6,163],"of":[7,14,30,62,73,93,121,125,130,139,175],"several":[8],"species":[9,53],"has":[10],"led":[11],"to":[12,26,80,145],"questions":[13],"what":[15],"underlying":[16],"principles":[17],"might":[18],"govern":[19],"their":[20,56],"organization.":[21],"Few":[22],"studies":[23],"have":[24,54],"tried":[25],"determine":[27],"impact":[29],"network":[33,150],"evolution":[34],"on":[35],"observed":[37,159],"physiological":[38],"differences":[39],"between":[40],"species.":[41],"Using":[42],"comparative":[43],"genomics":[44],"and":[45,100,119],"structural":[46],"information,":[47],"we":[48,88],"show":[49,105,123],"here":[50],"that":[51,90,101,135,154],"eukaryotic":[52],"rewired":[55],"interactomes":[57],"at":[58,148],"a":[59,136],"fast":[60],"rate":[61],"approximately":[63],"10(-5)":[64],"interactions":[65,82],"changed":[66,83],"per":[67,70,84],"pair,":[69],"million":[71,85],"years":[72],"divergence.":[74],"For":[75],"Homo":[76],"sapiens":[77],"this":[78],"corresponds":[79],"10(3)":[81],"years.":[86],"Additionally":[87],"find":[89],"specificity":[92],"binding":[94,177],"strongly":[95],"determines":[96],"turnover":[99],"different":[102,107,173],"biological":[103],"processes":[104],"significantly":[106],"link":[108],"dynamics.":[109],"In":[110],"particular,":[111],"human":[112],"proteins":[113],"involved":[114],"immune":[116],"response,":[117],"transport,":[118],"establishment":[120],"localization":[122],"signs":[124],"positive":[126],"selection":[127],"for":[128,172],"change":[129],"interactions.":[131],"Our":[132],"analysis":[133],"suggests":[134],"small":[137],"degree":[138],"molecular":[140],"divergence":[141],"can":[142],"give":[143],"rise":[144],"important":[146],"changes":[147],"level.":[151],"We":[152],"propose":[153],"power":[156],"law":[157],"distribution":[158],"could":[164],"be":[165],"partly":[166],"explained":[167],"by":[168],"cell's":[170],"requirement":[171],"degrees":[174],"specificity.":[178]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":20}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}