{"id":"https://openalex.org/W2018740767","doi":"https://doi.org/10.1371/journal.pcbi.0030016","title":"Automatic Extraction of Protein Point Mutations Using a Graph Bigram Association","display_name":"Automatic Extraction of Protein Point Mutations Using a Graph Bigram Association","publication_year":2007,"publication_date":"2007-02-02","ids":{"openalex":"https://openalex.org/W2018740767","doi":"https://doi.org/10.1371/journal.pcbi.0030016","mag":"2018740767","pmid":"https://pubmed.ncbi.nlm.nih.gov/17274683"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.0030016","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0030016","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0030016&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0030016&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058371349","display_name":"Lawrence C Lee","orcid":null},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence C Lee","raw_affiliation_strings":["Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, United States of America","Biomedical Informatics, University of California San Francisco, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Biomedical Informatics, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006528437","display_name":"Florence Horn","orcid":null},"institutions":[{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Florence Horn","raw_affiliation_strings":["Laboratoire de Biologie, Informatique et Math\u00e9matiques, Commissariat \u00e0 l'Energie Atomique, Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biologie, Informatique et Math\u00e9matiques, Commissariat \u00e0 l'Energie Atomique, Grenoble, France","institution_ids":["https://openalex.org/I2738703131"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113714363","display_name":"Fred E. Cohen","orcid":null},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fred E Cohen","raw_affiliation_strings":["","Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America","Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113714363"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.7681,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.90599598,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"3","issue":"2","first_page":"e16","last_page":"e16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bigram","display_name":"Bigram","score":0.9109541177749634},{"id":"https://openalex.org/keywords/point-mutation","display_name":"Point mutation","score":0.718058168888092},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5559520721435547},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.466951459646225},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.45826369524002075},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.424377977848053},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.37127554416656494},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3604879379272461},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.30175796151161194},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.29526287317276},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1843838393688202},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.1796175241470337}],"concepts":[{"id":"https://openalex.org/C108757681","wikidata":"https://www.wikidata.org/wiki/Q2773912","display_name":"Bigram","level":3,"score":0.9109541177749634},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.718058168888092},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5559520721435547},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.466951459646225},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.45826369524002075},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.424377977848053},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.37127554416656494},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3604879379272461},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.30175796151161194},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29526287317276},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1843838393688202},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.1796175241470337},{"id":"https://openalex.org/C137546455","wikidata":"https://www.wikidata.org/wiki/Q3213474","display_name":"Trigram","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.0030016","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0030016","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0030016&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:17274683","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17274683","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:europepmc.org:2622224","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC1794323","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1794323","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1794323","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:HAL:cea-00162086v1","is_oa":true,"landing_page_url":"https://cea.hal.science/cea-00162086","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2007, 3 (2), pp.e16. ⟨10.1371/journal.pcbi.0030016⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:73e84d7ff9be4287848c5567d2d704e2","is_oa":true,"landing_page_url":"https://doaj.org/article/73e84d7ff9be4287848c5567d2d704e2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 3, Iss 2, p e16 (2007)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/152385","is_oa":true,"landing_page_url":"https://figshare.com/articles/Automatic_Extraction_of_Protein_Point_Mutations_Using_a_Graph_Bigram_Association/152385","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.0030016","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0030016","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0030016&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Quality Education","score":0.5400000214576721,"id":"https://metadata.un.org/sdg/4"}],"awards":[{"id":"https://openalex.org/G6097749317","display_name":null,"funder_award_id":"GM039900-15","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7408061991","display_name":null,"funder_award_id":"F37 LM008883","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G8290890446","display_name":null,"funder_award_id":"LM008883-01","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018740767.pdf","grobid_xml":"https://content.openalex.org/works/W2018740767.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W13703775","https://openalex.org/W1577527925","https://openalex.org/W2013313106","https://openalex.org/W2015954361","https://openalex.org/W2018874418","https://openalex.org/W2040734632","https://openalex.org/W2044602212","https://openalex.org/W2048501271","https://openalex.org/W2059044388","https://openalex.org/W2061166439","https://openalex.org/W2093723065","https://openalex.org/W2104768328","https://openalex.org/W2106015945","https://openalex.org/W2107580398","https://openalex.org/W2117243442","https://openalex.org/W2117479478","https://openalex.org/W2119412782","https://openalex.org/W2122732537","https://openalex.org/W2123758939","https://openalex.org/W2126276057","https://openalex.org/W2127479124","https://openalex.org/W2133876293","https://openalex.org/W2141869602","https://openalex.org/W2144001613","https://openalex.org/W2148853951","https://openalex.org/W2152698860","https://openalex.org/W2158505321","https://openalex.org/W2162629891","https://openalex.org/W4213060373","https://openalex.org/W4248234957"],"related_works":["https://openalex.org/W2550943714","https://openalex.org/W3212350425","https://openalex.org/W2388007221","https://openalex.org/W2511508046","https://openalex.org/W1974452506","https://openalex.org/W2363458739","https://openalex.org/W2385244308","https://openalex.org/W2028961943","https://openalex.org/W2375287167","https://openalex.org/W1994083192"],"abstract_inverted_index":{"Protein":[0],"point":[1,26,31,60,69,76,118,138,149,232,273],"mutations":[2,32,61,150],"are":[3,40],"an":[4,49,133],"essential":[5],"component":[6],"of":[7,13,37,68,84,129,179,245,254,286],"the":[8,34,38,43,75,100,137,152,192,201,238,249,258,284],"evolutionary":[9],"and":[10,16,33,58,82,98,126,159,212,234,276],"experimental":[11],"analysis":[12],"protein":[14,81,102,162,186,206,226],"structure":[15],"function.":[17],"While":[18],"many":[19],"manually":[20],"curated":[21],"databases":[22],"attempt":[23],"to":[24,73,93,104,135,230,263,277,280],"index":[25],"mutations,":[27],"most":[28],"experimentally":[29],"generated":[30],"biological":[35],"impacts":[36],"changes":[39],"described":[41],"in":[42,121,132,182,220],"peer-reviewed":[44],"published":[45],"literature.":[46,64],"We":[47,164,256],"describe":[48],"application,":[50],"Mutation":[51],"GraB":[52],"(Graph":[53],"Bigram),":[54],"that":[55,122,191],"identifies,":[56],"extracts,":[57],"verifies":[59],"from":[62,114,151],"biomedical":[63],"The":[65,108],"principal":[66],"problem":[67],"mutation":[70,77,119,233,274],"extraction":[71,120,275],"is":[72,112,236],"link":[74],"with":[78,248],"its":[79],"associated":[80],"organism":[83],"origin.":[85],"Our":[86,141,188],"algorithm":[87],"uses":[88],"a":[89,171,197,231,243,265],"graph-based":[90],"bigram":[91,110,168,194,240,260],"traversal":[92],"identify":[94],"these":[95,183],"relevant":[96],"associations":[97],"exploits":[99],"Swiss-Prot":[101],"database":[103],"verify":[105],"this":[106],"information.":[107],"graph":[109,167,193,239,259],"method":[111,142],"different":[113,185],"other":[115],"models":[116],"for":[117,174,200,272],"it":[123],"incorporates":[124],"frequency":[125],"positional":[127],"data":[128],"all":[130],"terms":[131],"article":[134],"drive":[136],"mutation-protein":[139],"association.":[140],"was":[143],"tested":[144],"on":[145,177],"589":[146],"articles":[147],"describing":[148],"G":[153],"protein-coupled":[154],"receptor":[155],"(GPCR),":[156],"tyrosine":[157,207],"kinase,":[158],"ion":[160,213],"channel":[161,214],"families.":[163,187],"evaluated":[165],"our":[166],"metric":[169,173,195,241,252,262],"against":[170],"word-proximity":[172],"term":[175],"association":[176,285],"datasets":[178],"full-text":[180],"literature":[181],"three":[184],"testing":[189],"shows":[190],"achieves":[196,242],"higher":[198],"F-measure":[199],"GPCRs":[202],"(0.79":[203],"versus":[204,210,217],"0.76),":[205],"kinases":[208],"(0.72":[209],"0.69),":[211],"transporters":[215],"(0.76":[216],"0.74).":[218],"Importantly,":[219],"situations":[221],"where":[222],"more":[223],"than":[224],"one":[225],"can":[227],"be":[228,264,278],"assigned":[229],"disambiguation":[235],"required,":[237],"precision":[244,253],"0.84":[246],"compared":[247],"word":[250],"distance":[251],"0.73.":[255],"believe":[257],"search":[261,270],"significant":[266],"improvement":[267],"over":[268],"previous":[269],"metrics":[271],"applicable":[279],"text-mining":[281],"application":[282],"requiring":[283],"words.":[287]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}