{"id":"https://openalex.org/W2075622473","doi":"https://doi.org/10.1371/journal.pcbi.0020145","title":"Identification of the Proliferation/Differentiation Switch in the Cellular Network of Multicellular Organisms","display_name":"Identification of the Proliferation/Differentiation Switch in the Cellular Network of Multicellular Organisms","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2075622473","doi":"https://doi.org/10.1371/journal.pcbi.0020145","mag":"2075622473","pmid":"https://pubmed.ncbi.nlm.nih.gov/17166053"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.0020145","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0020145","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0020145&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0020145&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025528570","display_name":"Kai Xia","orcid":"https://orcid.org/0000-0003-1326-0891"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Xia","raw_affiliation_strings":["The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China"],"affiliations":[{"raw_affiliation_string":"The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I4210124606","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013423070","display_name":"Huiling Xue","orcid":"https://orcid.org/0000-0001-8616-5815"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiling Xue","raw_affiliation_strings":["The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China"],"affiliations":[{"raw_affiliation_string":"The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I4210124606","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318629","display_name":"Dong Dong","orcid":"https://orcid.org/0000-0002-8087-7763"},"institutions":[{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Dong","raw_affiliation_strings":["The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China"],"affiliations":[{"raw_affiliation_string":"The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I4210124606","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035471284","display_name":"Shanshan Zhu","orcid":"https://orcid.org/0000-0002-4039-3350"},"institutions":[{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanshan Zhu","raw_affiliation_strings":["The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China"],"affiliations":[{"raw_affiliation_string":"The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I4210124606","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047964053","display_name":"Jiamu Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiamu Wang","raw_affiliation_strings":["The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China"],"affiliations":[{"raw_affiliation_string":"The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I4210124606","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052391290","display_name":"Qingpeng Zhang","orcid":"https://orcid.org/0000-0002-6819-0686"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingpeng Zhang","raw_affiliation_strings":["The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China"],"affiliations":[{"raw_affiliation_string":"The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I4210124606","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073868540","display_name":"Lei Hou","orcid":"https://orcid.org/0000-0002-5636-4028"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Hou","raw_affiliation_strings":["The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China"],"affiliations":[{"raw_affiliation_string":"The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I4210124606","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100380230","display_name":"Hua Chen","orcid":"https://orcid.org/0000-0002-9829-6561"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua Chen","raw_affiliation_strings":["The State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, People's Republic of China"],"affiliations":[{"raw_affiliation_string":"The State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087325326","display_name":"Ran Tao","orcid":"https://orcid.org/0000-0002-1106-2923"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ran Tao","raw_affiliation_strings":["The State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, People's Republic of China"],"affiliations":[{"raw_affiliation_string":"The State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101898692","display_name":"Zheng Huang","orcid":"https://orcid.org/0000-0001-5143-5192"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng Huang","raw_affiliation_strings":["The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China"],"affiliations":[{"raw_affiliation_string":"The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I4210124606","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003529918","display_name":"Zheng Fu","orcid":"https://orcid.org/0000-0001-7627-8824"},"institutions":[{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng Fu","raw_affiliation_strings":["The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China"],"affiliations":[{"raw_affiliation_string":"The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I4210124606","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031295186","display_name":"Ye\u2010Guang Chen","orcid":"https://orcid.org/0000-0002-6701-0065"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ye-Guang Chen","raw_affiliation_strings":["The State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, People's Republic of China"],"affiliations":[{"raw_affiliation_string":"The State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103171811","display_name":"Jing\u2010Dong J. Han","orcid":"https://orcid.org/0000-0002-9270-7139"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing-Dong J. Han","raw_affiliation_strings":["The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China"],"affiliations":[{"raw_affiliation_string":"The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I4210124606","https://openalex.org/I19820366"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5103171811"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210124606"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.8981,"has_fulltext":true,"cited_by_count":100,"citation_normalized_percentile":{"value":0.84499636,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"2","issue":"11","first_page":"e145","last_page":"e145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9850000143051147,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multicellular-organism","display_name":"Multicellular organism","score":0.9577597975730896},{"id":"https://openalex.org/keywords/interactome","display_name":"Interactome","score":0.9335653781890869},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7215043306350708},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.6624316573143005},{"id":"https://openalex.org/keywords/cellular-differentiation","display_name":"Cellular differentiation","score":0.6134719848632812},{"id":"https://openalex.org/keywords/organism","display_name":"Organism","score":0.562064528465271},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5439252257347107},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.49048492312431335},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4749032258987427},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3566761612892151},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.25091642141342163},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.21162965893745422},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.1047368049621582}],"concepts":[{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.9577597975730896},{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.9335653781890869},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7215043306350708},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6624316573143005},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.6134719848632812},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.562064528465271},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5439252257347107},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.49048492312431335},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4749032258987427},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3566761612892151},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25091642141342163},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.21162965893745422},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.1047368049621582}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001695","descriptor_name":"Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001695","descriptor_name":"Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001695","descriptor_name":"Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001695","descriptor_name":"Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.0020145","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0020145","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0020145&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:17166053","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17166053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:7b3dc5a02e28451e96c64fbb1e3db46c","is_oa":true,"landing_page_url":"https://doaj.org/article/7b3dc5a02e28451e96c64fbb1e3db46c","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 2, Iss 11, p e145 (2006)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:392000","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1664705","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/152711","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Identification_of_the_Proliferation_Differentiation_Switch_in_the_Cellular_Network_of_Multicellular_Organisms/152711","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:1664705","is_oa":true,"landing_page_url":"http://doi.org/10.1371/journal.pcbi.0020145","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.0020145","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0020145","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0020145&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.49000000953674316}],"awards":[{"id":"https://openalex.org/G848032724","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2075622473.pdf","grobid_xml":"https://content.openalex.org/works/W2075622473.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1541484034","https://openalex.org/W1976842438","https://openalex.org/W1979369962","https://openalex.org/W1986903527","https://openalex.org/W1994803330","https://openalex.org/W1998639983","https://openalex.org/W2012852001","https://openalex.org/W2017738723","https://openalex.org/W2036799174","https://openalex.org/W2037433020","https://openalex.org/W2053959638","https://openalex.org/W2056780622","https://openalex.org/W2061439657","https://openalex.org/W2083752219","https://openalex.org/W2084488354","https://openalex.org/W2094902224","https://openalex.org/W2100268885","https://openalex.org/W2100831836","https://openalex.org/W2101181377","https://openalex.org/W2103017472","https://openalex.org/W2104315543","https://openalex.org/W2110065044","https://openalex.org/W2111892023","https://openalex.org/W2122840995","https://openalex.org/W2133548874","https://openalex.org/W2134672568","https://openalex.org/W2134759932","https://openalex.org/W2138973161","https://openalex.org/W2142072523","https://openalex.org/W2150926065","https://openalex.org/W2153562609","https://openalex.org/W2153624566","https://openalex.org/W2159675211","https://openalex.org/W2159686118","https://openalex.org/W2167190345"],"related_works":["https://openalex.org/W4254238697","https://openalex.org/W2505404359","https://openalex.org/W93506351","https://openalex.org/W1995226864","https://openalex.org/W2768690359","https://openalex.org/W2475096012","https://openalex.org/W2280157287","https://openalex.org/W2163903195","https://openalex.org/W3025873693","https://openalex.org/W2035423850"],"abstract_inverted_index":{"The":[0,63,74],"protein-protein":[1],"interaction":[2],"networks,":[3,6],"or":[4],"interactome":[5,36,56],"have":[7,11],"been":[8],"shown":[9],"to":[10,33,88,141],"dynamic":[12],"modular":[13],"structures,":[14],"yet":[15],"the":[16,22,35,38,83,102,105,113,130,146,165,168,178],"functional":[17],"connections":[18],"between":[19,170],"and":[20,37,61,71,96,121,132,136,149],"among":[21,79],"modules":[23,65,138,172],"are":[24,66],"less":[25],"well":[26],"understood.":[27],"Here,":[28],"using":[29],"a":[30,42,119,152,157],"new":[31],"pipeline":[32],"integrate":[34],"transcriptome,":[39],"we":[40],"identified":[41],"pair":[43],"of":[44,50,52,93,104,145],"transcriptionally":[45],"anticorrelated":[46],"modules,":[47],"each":[48],"consisting":[49],"hundreds":[51],"genes":[53],"in":[54,118,156],"multicellular":[55,89,158],"networks":[57],"across":[58],"different":[59,100],"individuals":[60],"populations.":[62],"two":[64,142],"associated":[67],"with":[68],"cellular":[69],"proliferation":[70,75,106,135],"differentiation,":[72],"respectively.":[73],"module":[76,85,107,115],"is":[77,86,108,116],"conserved":[78],"eukaryotic":[80],"organisms,":[81,101],"whereas":[82],"differentiation":[84,92,114,137],"specific":[87],"organisms.":[90],"Upon":[91],"various":[94],"tissues":[95],"cell":[97],"lines":[98],"from":[99],"expression":[103],"more":[109],"uniformly":[110],"suppressed,":[111],"while":[112],"upregulated":[117],"tissue-":[120],"species-specific":[122],"manner.":[123],"Our":[124,160],"results":[125],"indicate":[126],"that":[127,164],"even":[128],"at":[129,177],"tissue":[131],"organism":[133],"levels,":[134],"may":[139,150,173],"correspond":[140],"alternative":[143],"states":[144],"molecular":[147],"network":[148],"reflect":[151],"universal":[153],"symbiotic":[154],"relationship":[155],"organism.":[159],"analyses":[161],"further":[162],"predict":[163],"proteins":[166],"mediating":[167],"interactions":[169],"these":[171],"serve":[174],"as":[175],"modulators":[176],"proliferation/differentiation":[179],"switch.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":13}],"updated_date":"2026-03-15T09:29:46.208133","created_date":"2025-10-10T00:00:00"}