{"id":"https://openalex.org/W17040122","doi":"https://doi.org/10.1371/journal.pcbi.0020135","title":"Leisure throughout the life cycle.","display_name":"Leisure throughout the life cycle.","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W17040122","doi":"https://doi.org/10.1371/journal.pcbi.0020135","mag":"17040122"},"language":"en","primary_location":{"id":"mag:17040122","is_oa":false,"landing_page_url":"https://www.cabdirect.org/abstracts/19951804166.html","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065907516","display_name":"J. Horna","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"J. Horna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065907516"],"corresponding_institution_ids":[],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00763002,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"10","first_page":"200","last_page":"221"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12783","display_name":"Migration, Aging, and Tourism Studies","score":0.5286999940872192,"subfield":{"id":"https://openalex.org/subfields/3317","display_name":"Demography"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T12783","display_name":"Migration, Aging, and Tourism Studies","score":0.5286999940872192,"subfield":{"id":"https://openalex.org/subfields/3317","display_name":"Demography"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/geography","display_name":"Geography","score":0.3454877734184265}],"concepts":[{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.3454877734184265}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:17040122","is_oa":false,"landing_page_url":"https://www.cabdirect.org/abstracts/19951804166.html","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.44999998807907104,"id":"https://metadata.un.org/sdg/2"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2472050353"],"related_works":["https://openalex.org/W306721866","https://openalex.org/W1035781938","https://openalex.org/W1493421623","https://openalex.org/W3045082553","https://openalex.org/W140535345","https://openalex.org/W2766050139","https://openalex.org/W1999097172","https://openalex.org/W3008754228","https://openalex.org/W2093253146","https://openalex.org/W2055190210","https://openalex.org/W839115339","https://openalex.org/W2063624654","https://openalex.org/W329375452","https://openalex.org/W2291954201","https://openalex.org/W230187907","https://openalex.org/W1510206108","https://openalex.org/W2502290307","https://openalex.org/W3010695846","https://openalex.org/W2396779820","https://openalex.org/W2511660214"],"abstract_inverted_index":{"Despite":[0],"many":[1],"years":[2],"of":[3,13,87,104,129,144,155,166,168,188,195,231,236,254,269,300,314],"potent":[4],"antiretroviral":[5,95],"therapy,":[6],"latently":[7,67,105,156],"infected":[8,68,106,157,170],"cells":[9,70,107,114,158,171],"and":[10,29,38,48,101,137,148,174,176,204,274,279,285,293,304],"low":[11],"levels":[12],"plasma":[14,216],"virus":[15],"have":[16,33],"been":[17,35],"found":[18],"to":[19,98,141,180,297],"persist":[20],"in":[21,164,228],"HIV-infected":[22],"patients.":[23],"The":[24,57,234],"factors":[25,295],"influencing":[26],"this":[27],"persistence":[28],"their":[30,315],"relative":[31],"contributions":[32,128],"not":[34],"fully":[36],"elucidated":[37],"remain":[39],"controversial.":[40],"Here,":[41],"we":[42,124],"address":[43],"these":[44],"issues":[45],"by":[46],"developing":[47],"employing":[49],"a":[50,283],"simple,":[51],"but":[52],"mechanistic":[53],"viral":[54,79,139,178,205,217,232,238,263,292],"dynamics":[55,179,299],"model.":[56],"model":[58,278],"has":[59],"two":[60],"novel":[61],"features.":[62],"First,":[63],"it":[64,82],"assumes":[65,83],"that":[66,84,115,183],"T":[69,130],"can":[71],"undergo":[72],"bystander":[73,132],"proliferation":[74,154],"without":[75,222],"transitioning":[76],"into":[77,310],"active":[78],"production.":[80],"Second,":[81],"the":[85,99,122,126,142,145,161,186,193,200,211,215,224,229,241,250,255,266,271,275,298,301,305,311],"rate":[86,213],"latent":[88,134,146,162,169,189,197,201,225,242,272,302],"cell":[89,131,135,190,198,202],"activation":[90,100,173,212,256],"decreases":[91],"with":[92],"time":[93],"on":[94,185,240],"therapy":[96],"due":[97],"subsequent":[102],"loss":[103,167],"specific":[108],"for":[109,246,259,288],"common":[110],"antigens,":[111],"leaving":[112],"behind":[113],"are":[116],"successively":[117],"less":[118],"frequently":[119],"activated.":[120],"Using":[121],"model,":[123],"examined":[125],"quantitative":[127,284],"proliferation,":[133],"activation,":[136,199],"ongoing":[138,237],"replication":[140,239,264],"stability":[143],"reservoir":[147,163,243,273,303],"persisting":[149],"low-level":[150],"viremia.":[151],"Not":[152],"surprisingly,":[153],"helped":[159],"maintain":[160],"spite":[165],"through":[172],"death,":[175],"affected":[177],"an":[181],"extent":[182],"depended":[184],"magnitude":[187],"activation.":[191],"In":[192],"limit":[194],"zero":[196],"pool":[203],"load":[206,218],"became":[207],"uncoupled.":[208],"However,":[209,258],"as":[210],"increased,":[214],"could":[219],"be":[220],"maintained":[221],"depleting":[223],"reservoir,":[226],"even":[227],"absence":[230],"replication.":[233],"influence":[235],"remained":[244],"insignificant":[245],"drug":[247,261],"efficacies":[248,262],"above":[249],"\"critical":[251],"efficacy\"":[252],"irrespective":[253],"rate.":[257],"lower":[260],"enabled":[265],"stable":[267],"maintenance":[268],"both":[270],"virus.":[276],"Our":[277],"analysis":[280],"methods":[281],"provide":[282],"qualitative":[286],"framework":[287],"probing":[289],"how":[290],"different":[291],"host":[294],"contribute":[296],"virus,":[306],"offering":[307],"new":[308],"insights":[309],"principal":[312],"determinants":[313],"persistence.":[316]},"counts_by_year":[],"updated_date":"2026-04-28T14:05:53.105641","created_date":"2016-06-24T00:00:00"}
