{"id":"https://openalex.org/W2004445027","doi":"https://doi.org/10.1371/journal.pcbi.0020081","title":"From Functional Genomics to Functional Immunomics: New Challenges, Old Problems, Big Rewards","display_name":"From Functional Genomics to Functional Immunomics: New Challenges, Old Problems, Big Rewards","publication_year":2006,"publication_date":"2006-07-24","ids":{"openalex":"https://openalex.org/W2004445027","doi":"https://doi.org/10.1371/journal.pcbi.0020081","mag":"2004445027","pmid":"https://pubmed.ncbi.nlm.nih.gov/16863395"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.0020081","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0020081","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0020081&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0020081&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026990034","display_name":"Ulisses Braga-Neto","orcid":"https://orcid.org/0000-0002-1210-2173"},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Ulisses M Braga-Neto","raw_affiliation_strings":["Experimental Therapy Laboratory, Aggeu Magalh\u00e3es Research Center - CPqAM/FIOCRUZ, Recife, Brazil. ub@ieee.org","Experimental Therapy Laboratory, Aggeu Magalh\u00e3es Research Center - CPqAM/FIOCRUZ, Recife, Brazil"],"affiliations":[{"raw_affiliation_string":"Experimental Therapy Laboratory, Aggeu Magalh\u00e3es Research Center - CPqAM/FIOCRUZ, Recife, Brazil. ub@ieee.org","institution_ids":["https://openalex.org/I52325"]},{"raw_affiliation_string":"Experimental Therapy Laboratory, Aggeu Magalh\u00e3es Research Center - CPqAM/FIOCRUZ, Recife, Brazil","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027741209","display_name":"Ernesto T. A. Marques","orcid":"https://orcid.org/0000-0003-3826-9358"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ernesto T. A Marques","raw_affiliation_strings":["at the Virology and Experimental Therapy Laboratory, Aggeu Magalha es Research Center -CPqAM/FIOCRUZ, Recife, Brazil","at the Virology and Experimental Therapy Laboratory, Aggeu Magalha \u02dces Research Center -CPqAM/FIOCRUZ, Recife, Brazil"],"affiliations":[{"raw_affiliation_string":"at the Virology and Experimental Therapy Laboratory, Aggeu Magalha es Research Center -CPqAM/FIOCRUZ, Recife, Brazil","institution_ids":[]},{"raw_affiliation_string":"at the Virology and Experimental Therapy Laboratory, Aggeu Magalha \u02dces Research Center -CPqAM/FIOCRUZ, Recife, Brazil","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026990034"],"corresponding_institution_ids":["https://openalex.org/I52325"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.576,"has_fulltext":true,"cited_by_count":67,"citation_normalized_percentile":{"value":0.88909211,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"2","issue":"7","first_page":"e81","last_page":"e81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/functional-genomics","display_name":"Functional genomics","score":0.7255918383598328},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.6386532783508301},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5946816205978394},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5522416234016418},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4605838656425476},{"id":"https://openalex.org/keywords/biomedicine","display_name":"Biomedicine","score":0.42595311999320984},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.4123436510562897},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.32283779978752136},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.2803483009338379},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.26353442668914795},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16012334823608398},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.09250068664550781}],"concepts":[{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.7255918383598328},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.6386532783508301},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5946816205978394},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5522416234016418},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4605838656425476},{"id":"https://openalex.org/C66782513","wikidata":"https://www.wikidata.org/wiki/Q864601","display_name":"Biomedicine","level":2,"score":0.42595311999320984},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4123436510562897},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32283779978752136},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2803483009338379},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.26353442668914795},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16012334823608398},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09250068664550781},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018604","descriptor_name":"Epitope Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018604","descriptor_name":"Epitope Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018604","descriptor_name":"Epitope Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018604","descriptor_name":"Epitope Mapping","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D018604","descriptor_name":"Epitope Mapping","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D018604","descriptor_name":"Epitope Mapping","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.0020081","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0020081","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0020081&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:16863395","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16863395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:4b07155049624dac9a22c54bba07c551","is_oa":true,"landing_page_url":"https://doaj.org/article/4b07155049624dac9a22c54bba07c551","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 2, Iss 7, p e81 (2006)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1523295","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1523295","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.0020081","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0020081","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0020081&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6600000262260437}],"awards":[{"id":"https://openalex.org/G120275728","display_name":null,"funder_award_id":"Univer","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G1429890386","display_name":null,"funder_award_id":"(CNPq","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G1457133460","display_name":null,"funder_award_id":"U19 AI56541","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3601516360","display_name":null,"funder_award_id":"Brazil","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G5079005330","display_name":null,"funder_award_id":"support","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G5903061775","display_name":null,"funder_award_id":"NIAID","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320320984","display_name":"University of Queensland","ror":"https://ror.org/00rqy9422"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004445027.pdf","grobid_xml":"https://content.openalex.org/works/W2004445027.grobid-xml"},"referenced_works_count":124,"referenced_works":["https://openalex.org/W114846092","https://openalex.org/W170980853","https://openalex.org/W183241451","https://openalex.org/W204869595","https://openalex.org/W572161398","https://openalex.org/W1505550212","https://openalex.org/W1533966738","https://openalex.org/W1541464399","https://openalex.org/W1543109617","https://openalex.org/W1548280607","https://openalex.org/W1564947197","https://openalex.org/W1565242013","https://openalex.org/W1565693361","https://openalex.org/W1566544482","https://openalex.org/W1579290611","https://openalex.org/W1586182515","https://openalex.org/W1587920056","https://openalex.org/W1749101224","https://openalex.org/W1912585596","https://openalex.org/W1918211917","https://openalex.org/W1966095116","https://openalex.org/W1968955085","https://openalex.org/W1970089737","https://openalex.org/W1970156673","https://openalex.org/W1973006183","https://openalex.org/W1985557175","https://openalex.org/W1989040407","https://openalex.org/W1994990639","https://openalex.org/W1995656483","https://openalex.org/W1998696472","https://openalex.org/W2001707651","https://openalex.org/W2006631946","https://openalex.org/W2006877285","https://openalex.org/W2010248348","https://openalex.org/W2012385803","https://openalex.org/W2020858572","https://openalex.org/W2022680838","https://openalex.org/W2023732319","https://openalex.org/W2024293390","https://openalex.org/W2024563556","https://openalex.org/W2025729280","https://openalex.org/W2028891058","https://openalex.org/W2029555993","https://openalex.org/W2030994357","https://openalex.org/W2031473244","https://openalex.org/W2031639008","https://openalex.org/W2034861886","https://openalex.org/W2035909001","https://openalex.org/W2037401357","https://openalex.org/W2037849218","https://openalex.org/W2041468111","https://openalex.org/W2044215567","https://openalex.org/W2048848017","https://openalex.org/W2051295154","https://openalex.org/W2053351930","https://openalex.org/W2055285124","https://openalex.org/W2057848938","https://openalex.org/W2057933414","https://openalex.org/W2058221907","https://openalex.org/W2061455950","https://openalex.org/W2063266428","https://openalex.org/W2065006025","https://openalex.org/W2068945309","https://openalex.org/W2069231830","https://openalex.org/W2076639605","https://openalex.org/W2077521424","https://openalex.org/W2079129173","https://openalex.org/W2079542677","https://openalex.org/W2080401629","https://openalex.org/W2081400647","https://openalex.org/W2081955017","https://openalex.org/W2082437572","https://openalex.org/W2082796552","https://openalex.org/W2083683580","https://openalex.org/W2090110765","https://openalex.org/W2090528816","https://openalex.org/W2090553035","https://openalex.org/W2091226872","https://openalex.org/W2094157366","https://openalex.org/W2094706980","https://openalex.org/W2095501561","https://openalex.org/W2095586611","https://openalex.org/W2099427184","https://openalex.org/W2101772322","https://openalex.org/W2103498243","https://openalex.org/W2103990111","https://openalex.org/W2104738901","https://openalex.org/W2106022504","https://openalex.org/W2108020239","https://openalex.org/W2114033596","https://openalex.org/W2114781040","https://openalex.org/W2118577784","https://openalex.org/W2118854505","https://openalex.org/W2123341019","https://openalex.org/W2124181672","https://openalex.org/W2125732073","https://openalex.org/W2127432084","https://openalex.org/W2127618177","https://openalex.org/W2130494035","https://openalex.org/W2134978629","https://openalex.org/W2142831360","https://openalex.org/W2149970341","https://openalex.org/W2153616989","https://openalex.org/W2155081037","https://openalex.org/W2155402817","https://openalex.org/W2158096909","https://openalex.org/W2159394343","https://openalex.org/W2160887077","https://openalex.org/W2164360179","https://openalex.org/W2165224041","https://openalex.org/W2166357323","https://openalex.org/W2168909179","https://openalex.org/W2169590681","https://openalex.org/W2217326163","https://openalex.org/W2277419039","https://openalex.org/W2387522997","https://openalex.org/W2406976459","https://openalex.org/W2439454780","https://openalex.org/W3214380909","https://openalex.org/W4233622718","https://openalex.org/W4246395620","https://openalex.org/W4247420482","https://openalex.org/W4319053986","https://openalex.org/W4388252848"],"related_works":["https://openalex.org/W2360935227","https://openalex.org/W2364993072","https://openalex.org/W2115576822","https://openalex.org/W2356429006","https://openalex.org/W2155595079","https://openalex.org/W2380568150","https://openalex.org/W2385787406","https://openalex.org/W2411510900","https://openalex.org/W2263355832","https://openalex.org/W284518807"],"abstract_inverted_index":{"The":[0],"development":[1,30],"of":[2,13,18,31,41,47,102,143,154,165,171],"DNA":[3],"microarray":[4,33,124],"technology":[5,38,125],"a":[6,99,158],"decade":[7],"ago":[8],"led":[9],"to":[10,55,70,91,97,135],"the":[11,19,28,140,152],"establishment":[12],"functional":[14,48,62,136],"genomics":[15],"as":[16,82,120,157],"one":[17],"most":[20],"active":[21],"and":[22,89,107,126,129,131],"successful":[23],"scientific":[24,105],"disciplines":[25],"today.":[26],"With":[27],"ongoing":[29],"immunomic":[32,123,155,172],"technology-a":[34],"spatially":[35],"addressable,":[36],"large-scale":[37],"for":[39,160],"measurement":[40],"specific":[42],"immunological":[43],"response-the":[44],"new":[45],"challenge":[46],"immunomics":[49],"is":[50,57],"emerging,":[51],"which":[52],"bears":[53],"similarities":[54],"but":[56],"also":[58],"significantly":[59],"different":[60],"from":[61],"genomics.":[63],"Immunonic":[64],"data":[65],"has":[66],"been":[67],"successfully":[68],"used":[69],"identify":[71],"biological":[72],"markers":[73],"involved":[74],"in":[75,146,162],"autoimmune":[76],"diseases,":[77],"allergies,":[78],"viral":[79],"infections":[80],"such":[81,119],"human":[83],"immunodeficiency":[84],"virus":[85],"(HIV),":[86],"influenza,":[87],"diabetes,":[88],"responses":[90],"cancer":[92],"vaccines.":[93],"This":[94],"review":[95],"intends":[96],"provide":[98],"coherent":[100],"vision":[101],"this":[103],"nascent":[104],"field,":[106],"speculate":[108],"on":[109,139],"future":[110],"research":[111],"directions.":[112],"We":[113],"discuss":[114],"at":[115],"some":[116],"length":[117],"issues":[118],"epitope":[121],"prediction,":[122],"its":[127],"applications,":[128],"computation":[130],"statistical":[132],"challenges":[133],"related":[134],"immunomics.":[137],"Based":[138],"recent":[141],"discovery":[142],"regulation":[144],"mechanisms":[145],"T":[147],"cell":[148],"responses,":[149,168],"we":[150],"envision":[151],"use":[153],"microarrays":[156],"tool":[159],"advances":[161],"systems":[163],"biology":[164],"cellular":[166],"immune":[167],"by":[169],"means":[170],"regulatory":[173],"network":[174],"models.":[175]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-03-16T09:10:04.655348","created_date":"2025-10-10T00:00:00"}