{"id":"https://openalex.org/W1995404781","doi":"https://doi.org/10.1371/journal.pcbi.0020048","title":"Protein Family Expansions and Biological Complexity","display_name":"Protein Family Expansions and Biological Complexity","publication_year":2006,"publication_date":"2006-05-23","ids":{"openalex":"https://openalex.org/W1995404781","doi":"https://doi.org/10.1371/journal.pcbi.0020048","mag":"1995404781","pmid":"https://pubmed.ncbi.nlm.nih.gov/16733546"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.0020048","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0020048","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0020048&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0020048&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035122021","display_name":"Christine Vogel","orcid":"https://orcid.org/0000-0002-2856-3118"},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Christine Vogel","raw_affiliation_strings":["Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom. cvogel@mail.utexas.edu","Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom","Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom. cvogel@mail.utexas.edu","institution_ids":["https://openalex.org/I170203145","https://openalex.org/I90344618"]},{"raw_affiliation_string":"Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I170203145","https://openalex.org/I90344618"]},{"raw_affiliation_string":"Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105358652","display_name":"Cyrus Chothia","orcid":null},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Cyrus Chothia","raw_affiliation_strings":["Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I170203145","https://openalex.org/I90344618"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5035122021"],"corresponding_institution_ids":["https://openalex.org/I170203145","https://openalex.org/I86519309","https://openalex.org/I90344618"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":5.9981,"has_fulltext":true,"cited_by_count":230,"citation_normalized_percentile":{"value":0.97056714,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"2","issue":"5","first_page":"e48","last_page":"e48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10303","display_name":"Photosynthetic Processes and Mechanisms","score":0.9891999959945679,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10303","display_name":"Photosynthetic Processes and Mechanisms","score":0.9891999959945679,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9725000262260437,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9508000016212463,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7700698971748352},{"id":"https://openalex.org/keywords/multicellular-organism","display_name":"Multicellular organism","score":0.6940072774887085},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.5927368402481079},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"Gene duplication","score":0.5579527616500854},{"id":"https://openalex.org/keywords/taxonomic-rank","display_name":"Taxonomic rank","score":0.509505569934845},{"id":"https://openalex.org/keywords/most-recent-common-ancestor","display_name":"Most recent common ancestor","score":0.464080810546875},{"id":"https://openalex.org/keywords/protein-family","display_name":"Protein family","score":0.4494096338748932},{"id":"https://openalex.org/keywords/phylogenetics","display_name":"Phylogenetics","score":0.4432965815067291},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4223259389400482},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.38195550441741943},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3011600971221924},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.12503165006637573}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7700698971748352},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.6940072774887085},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5927368402481079},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.5579527616500854},{"id":"https://openalex.org/C189592816","wikidata":"https://www.wikidata.org/wiki/Q427626","display_name":"Taxonomic rank","level":3,"score":0.509505569934845},{"id":"https://openalex.org/C197583594","wikidata":"https://www.wikidata.org/wiki/Q1052390","display_name":"Most recent common ancestor","level":4,"score":0.464080810546875},{"id":"https://openalex.org/C171897839","wikidata":"https://www.wikidata.org/wiki/Q417841","display_name":"Protein family","level":3,"score":0.4494096338748932},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.4432965815067291},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4223259389400482},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38195550441741943},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3011600971221924},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.12503165006637573},{"id":"https://openalex.org/C71640776","wikidata":"https://www.wikidata.org/wiki/Q16521","display_name":"Taxon","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017343","descriptor_name":"Genes, Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017343","descriptor_name":"Genes, Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017343","descriptor_name":"Genes, Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017343","descriptor_name":"Genes, Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.0020048","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0020048","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0020048&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:16733546","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16733546","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:93555299f29b4d5da179e5ba88691265","is_oa":true,"landing_page_url":"https://doaj.org/article/93555299f29b4d5da179e5ba88691265","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 2, Iss 5, p e48 (2006)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/152929","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Protein_Family_Expansions_and_Biological_Complexity/152929","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:1464810","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1464810","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:repositories.lib.utexas.edu:2152/20543","is_oa":true,"landing_page_url":"http://hdl.handle.net/2152/20543","pdf_url":null,"source":{"id":"https://openalex.org/S4306400568","display_name":"Texas ScholarWorks (Texas Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210102904","host_organization_name":"Texas Digital Library","host_organization_lineage":["https://openalex.org/I4210102904"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.0020048","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0020048","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0020048&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320868","display_name":"Boehringer Ingelheim Fonds","ror":"https://ror.org/00dkye506"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1995404781.pdf","grobid_xml":"https://content.openalex.org/works/W1995404781.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1569553189","https://openalex.org/W1757909678","https://openalex.org/W1965941177","https://openalex.org/W1968031638","https://openalex.org/W1968316337","https://openalex.org/W1970279759","https://openalex.org/W1970995363","https://openalex.org/W1978088815","https://openalex.org/W1980051733","https://openalex.org/W1981045338","https://openalex.org/W1988714210","https://openalex.org/W1994949369","https://openalex.org/W2011235285","https://openalex.org/W2013340095","https://openalex.org/W2014666871","https://openalex.org/W2019670773","https://openalex.org/W2031209863","https://openalex.org/W2032244673","https://openalex.org/W2035278976","https://openalex.org/W2054049732","https://openalex.org/W2059890422","https://openalex.org/W2059922674","https://openalex.org/W2063753173","https://openalex.org/W2066718232","https://openalex.org/W2076502650","https://openalex.org/W2084214748","https://openalex.org/W2085277871","https://openalex.org/W2099946731","https://openalex.org/W2106013076","https://openalex.org/W2112792893","https://openalex.org/W2117681000","https://openalex.org/W2119195082","https://openalex.org/W2121190131","https://openalex.org/W2125725297","https://openalex.org/W2134484762","https://openalex.org/W2134966150","https://openalex.org/W2136280642","https://openalex.org/W2144724079","https://openalex.org/W2148950394","https://openalex.org/W2149138213","https://openalex.org/W2153458172","https://openalex.org/W2155606054","https://openalex.org/W2164435125","https://openalex.org/W2166647921","https://openalex.org/W2168909179","https://openalex.org/W4210580032","https://openalex.org/W4241088457"],"related_works":["https://openalex.org/W2963469014","https://openalex.org/W3129515806","https://openalex.org/W2136423986","https://openalex.org/W2802432105","https://openalex.org/W3015290071","https://openalex.org/W4317653917","https://openalex.org/W4388373831","https://openalex.org/W1547548607","https://openalex.org/W1979358876","https://openalex.org/W1505216348"],"abstract_inverted_index":{"During":[0],"the":[1,12,44,65,80,95,98,104,114,134,141,147,186,231,234,240],"course":[2,66],"of":[3,14,46,58,67,70,82,97,103,106,116,120,143,153,170,173,188,200,230,237,244],"evolution,":[4],"new":[5],"proteins":[6,26],"are":[7,91,123,129,137,157],"produced":[8],"very":[9],"largely":[10],"as":[11],"result":[13],"gene":[15],"duplication,":[16],"divergence":[17],"and,":[18],"in":[19,34,88,133,146,159,167,206,213,218],"many":[20],"cases,":[21],"combination.":[22],"This":[23],"means":[24],"that":[25],"or":[27,162],"protein":[28,224],"domains":[29],"belong":[30],"to":[31,94],"families":[32,225],"or,":[33],"cases":[35],"where":[36],"their":[37],"relationships":[38],"can":[39,60],"only":[40],"be":[41],"recognised":[42],"on":[43],"basis":[45],"structure,":[47],"superfamilies":[48,59,84,175,190],"whose":[49,85,131],"members":[50],"descended":[51],"from":[52],"a":[53,101],"common":[54],"ancestor.":[55],"The":[56],"size":[57],"vary":[61],"greatly.":[62],"Also,":[63],"during":[64],"evolution":[68],"organisms":[69,90,136],"increasing":[71],"complexity":[72,96,105,243],"have":[73,176],"arisen.":[74],"In":[75],"this":[76],"paper":[77],"we":[78,112],"determine":[79],"identity":[81],"those":[83],"relative":[86],"sizes":[87,132],"different":[89,117],"highly":[92],"correlated":[93,139,201],"organisms.":[99,148,246],"As":[100],"measure":[102],"38":[107,135],"uni-":[108],"and":[109,164,209,215,226,239],"multicellular":[110],"eukaryotes":[111],"took":[113],"number":[115,142,236],"cell":[118,144],"types":[119,145,169],"which":[121],"they":[122],"composed.":[124],"Of":[125],"1,219":[126],"superfamilies,":[127],"there":[128],"194":[130],"strongly":[138],"with":[140,180,192],"We":[149,182,195],"give":[150],"outline":[151],"descriptions":[152],"these":[154],"superfamilies.":[155],"Half":[156,172],"involved":[158],"extracellular":[160],"processes":[161],"regulation":[163],"smaller":[165],"proportions":[166],"other":[168],"activity.":[171],"all":[174],"no":[177],"significant":[178],"correlation":[179],"complexity.":[181],"also":[183],"determined":[184],"whether":[185],"expansions":[187,205],"large":[189,198],"correlate":[191],"each":[193],"other.":[194],"found":[196],"three":[197],"clusters":[199],"expansions:":[202],"one":[203,211,216,228],"involves":[204],"both":[207],"vertebrates":[208],"plants,":[210],"just":[212,217],"vertebrates,":[214],"plants.":[219],"Our":[220],"work":[221],"identifies":[222],"important":[223],"provides":[227],"explanation":[229],"discrepancy":[232],"between":[233],"total":[235],"genes":[238],"apparent":[241],"physiological":[242],"eukaryotic":[245]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":20}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}