{"id":"https://openalex.org/W2083193004","doi":"https://doi.org/10.1371/journal.pcbi.0020044","title":"Spatial Regulation and the Rate of Signal Transduction Activation","display_name":"Spatial Regulation and the Rate of Signal Transduction Activation","publication_year":2006,"publication_date":"2006-05-08","ids":{"openalex":"https://openalex.org/W2083193004","doi":"https://doi.org/10.1371/journal.pcbi.0020044","mag":"2083193004","pmid":"https://pubmed.ncbi.nlm.nih.gov/16699596"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.0020044","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0020044","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0020044&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0020044&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018360930","display_name":"Nizar N. Batada","orcid":"https://orcid.org/0000-0002-8007-1487"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nizar N Batada","raw_affiliation_strings":["Program in Biophysics, Stanford University, Stanford, California, USA. nizar.batada@utoronto.ca","Program in Biophysics, Stanford University, Stanford, California, USA"],"affiliations":[{"raw_affiliation_string":"Program in Biophysics, Stanford University, Stanford, California, USA. nizar.batada@utoronto.ca","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Program in Biophysics, Stanford University, Stanford, California, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111774781","display_name":"L. A. Shepp","orcid":null},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry A Shepp","raw_affiliation_strings":["Department of Statistics, Rutgers University, Piscataway, New Jersey, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Statistics, Rutgers University, Piscataway, New Jersey, United States of America","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035091786","display_name":"David Siegmund","orcid":"https://orcid.org/0009-0009-2542-6124"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David O Siegmund","raw_affiliation_strings":["Department of Statistics, Stanford University, Stanford, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Statistics, Stanford University, Stanford, California, United States of America","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019080704","display_name":"Michael Levitt","orcid":"https://orcid.org/0000-0002-8414-7397"},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Levitt","raw_affiliation_strings":["Department of Structural Biology, Stanford School of Medicine, Stanford, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Structural Biology, Stanford School of Medicine, Stanford, California, United States of America","institution_ids":["https://openalex.org/I4210137306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5018360930"],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.5448,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.65145669,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"2","issue":"5","first_page":"e44","last_page":"e44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endocytosis","display_name":"Endocytosis","score":0.7293910384178162},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.7093259692192078},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6269879341125488},{"id":"https://openalex.org/keywords/exocytosis","display_name":"Exocytosis","score":0.591863751411438},{"id":"https://openalex.org/keywords/cell-surface-receptor","display_name":"Cell surface receptor","score":0.5470770597457886},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.5464524030685425},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.5182202458381653},{"id":"https://openalex.org/keywords/cell-membrane","display_name":"Cell membrane","score":0.5063492059707642},{"id":"https://openalex.org/keywords/cytoplasm","display_name":"Cytoplasm","score":0.470567911863327},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.46728000044822693},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4671461284160614},{"id":"https://openalex.org/keywords/transduction","display_name":"Transduction (biophysics)","score":0.42333394289016724},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3303874433040619},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.27803486585617065},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.17638269066810608}],"concepts":[{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.7293910384178162},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.7093259692192078},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6269879341125488},{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.591863751411438},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.5470770597457886},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5464524030685425},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5182202458381653},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.5063492059707642},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.470567911863327},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46728000044822693},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4671461284160614},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.42333394289016724},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3303874433040619},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.27803486585617065},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17638269066810608}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.0020044","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0020044","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0020044&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:16699596","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16699596","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:repository.upenn.edu:statistics_papers-1060","is_oa":false,"landing_page_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=1060&context=statistics_papers","pdf_url":null,"source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Statistics Papers","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.276.6823","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.6823","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/0a/ce/PLoS_Comput_Biol_2006_May_12_2(5)_e44.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:7e25a361efeb4f9bbfa1b86fbb8aecd5","is_oa":true,"landing_page_url":"https://doaj.org/article/7e25a361efeb4f9bbfa1b86fbb8aecd5","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 2, Iss 5, p e44 (2006)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2622030","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC1458967","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/152999","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Spatial_Regulation_and_the_Rate_of_Signal_Transduction_Activation/152999","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:1458967","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1458967","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.0020044","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0020044","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0020044&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3600092148","display_name":"Statisical Methods in Fast Functional MRI","funder_award_id":"0203086","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4515207065","display_name":null,"funder_award_id":"Grant","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G5795459225","display_name":"Detection, Estimation and Optimization Problems in Stochastic Systems, Genetics and Economics","funder_award_id":"0072523","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2083193004.pdf","grobid_xml":"https://content.openalex.org/works/W2083193004.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W35546089","https://openalex.org/W322962242","https://openalex.org/W590142342","https://openalex.org/W1492513278","https://openalex.org/W1523866988","https://openalex.org/W1564861448","https://openalex.org/W1574498833","https://openalex.org/W1591710988","https://openalex.org/W1595449036","https://openalex.org/W1597994956","https://openalex.org/W1603900493","https://openalex.org/W1963654595","https://openalex.org/W1967816643","https://openalex.org/W1972859350","https://openalex.org/W1988812517","https://openalex.org/W1991655565","https://openalex.org/W1992139451","https://openalex.org/W1993180174","https://openalex.org/W2002478108","https://openalex.org/W2008940139","https://openalex.org/W2009956378","https://openalex.org/W2017615656","https://openalex.org/W2024444576","https://openalex.org/W2024828365","https://openalex.org/W2029705670","https://openalex.org/W2046320783","https://openalex.org/W2055862760","https://openalex.org/W2055864348","https://openalex.org/W2057809752","https://openalex.org/W2058160393","https://openalex.org/W2064844308","https://openalex.org/W2073369580","https://openalex.org/W2082706608","https://openalex.org/W2083163414","https://openalex.org/W2115150990","https://openalex.org/W2118265926","https://openalex.org/W2119737153","https://openalex.org/W2120062331","https://openalex.org/W2122882997","https://openalex.org/W2134344512","https://openalex.org/W2136716105","https://openalex.org/W2141166576","https://openalex.org/W2141367941","https://openalex.org/W2147688960","https://openalex.org/W2147845309","https://openalex.org/W2154827556","https://openalex.org/W2161281789","https://openalex.org/W2169364318","https://openalex.org/W2279626446","https://openalex.org/W4254294289"],"related_works":["https://openalex.org/W2607082573","https://openalex.org/W2041890090","https://openalex.org/W2028888912","https://openalex.org/W1949005472","https://openalex.org/W2058833411","https://openalex.org/W3216596429","https://openalex.org/W2013262011","https://openalex.org/W2072572820","https://openalex.org/W2609244189","https://openalex.org/W2053550995"],"abstract_inverted_index":{"Of":[0],"the":[1,10,30,47,103,119,129,185,197],"many":[2],"important":[3],"signaling":[4,171],"events":[5,172],"that":[6,35,53,83,127,196,204],"take":[7,175],"place":[8],"on":[9,113],"surface":[11,25,37,108,136,192],"of":[12,17,23,29,90,121,131,159,169,190,199,205],"a":[13,114,151,156,160,166,180],"mammalian":[14,153],"cell,":[15],"activation":[16,74,187],"signal":[18,72],"transduction":[19,73],"pathways":[20,82],"via":[21,188],"interactions":[22],"cell":[24,36,107,135,154,191],"receptors":[26],"is":[27,59,62,94,140,201],"one":[28],"most":[31,202],"important.":[32],"Evidence":[33],"suggests":[34],"proteins":[38,110],"are":[39],"not":[40],"as":[41,44],"freely":[42],"diffusible":[43],"implied":[45],"by":[46],"classic":[48],"fluid":[49],"mosaic":[50],"model":[51,117],"and":[52,123],"their":[54],"confinement":[55],"to":[56,70,77,144,174],"membrane":[57,109],"domains":[58],"regulated.":[60],"It":[61],"unknown":[63],"whether":[64],"these":[65,91],"dynamic":[66],"localization":[67],"mechanisms":[68],"function":[69],"enhance":[71],"rate":[75,104,139,148,183],"or":[76],"minimize":[78],"cross":[79],"talk":[80],"among":[81],"share":[84],"common":[85],"intermediates.":[86],"To":[87],"determine":[88],"which":[89,106],"two":[92,162],"possibilities":[93],"more":[95],"likely,":[96],"we":[97,194],"derive":[98],"an":[99],"explicit":[100],"equation":[101],"for":[102],"at":[105,179],"interact":[111],"based":[112],"Brownian":[115],"motion":[116],"in":[118,128,150],"presence":[120],"endocytosis":[122],"exocytosis.":[124],"We":[125],"find":[126],"absence":[130],"any":[132],"diffusion":[133],"constraints,":[134],"protein":[137,146],"interaction":[138,147],"extremely":[141],"high":[142],"relative":[143],"cytoplasmic":[145],"even":[149],"large":[152],"with":[155],"receptor":[157],"abundance":[158],"mere":[161],"hundred":[163],"molecules.":[164],"Since":[165],"larger":[167],"number":[168],"downstream":[170],"needs":[173],"place,":[176],"each":[177],"occurring":[178],"much":[181],"slower":[182],"than":[184,209],"initial":[186],"association":[189],"proteins,":[193],"conclude":[195],"role":[198],"co-localization":[200],"likely":[203],"cross-talk":[206],"reduction":[207],"rather":[208],"coupling":[210],"efficiency":[211],"enhancement.":[212]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}