{"id":"https://openalex.org/W2122410503","doi":"https://doi.org/10.1371/journal.pcbi.0020041","title":"Inferring Loss-of-Heterozygosity from Unpaired Tumors Using High-Density Oligonucleotide SNP Arrays","display_name":"Inferring Loss-of-Heterozygosity from Unpaired Tumors Using High-Density Oligonucleotide SNP Arrays","publication_year":2006,"publication_date":"2006-05-08","ids":{"openalex":"https://openalex.org/W2122410503","doi":"https://doi.org/10.1371/journal.pcbi.0020041","mag":"2122410503","pmid":"https://pubmed.ncbi.nlm.nih.gov/16699594"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.0020041","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0020041","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0020041&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0020041&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041980697","display_name":"Rameen Beroukhim","orcid":"https://orcid.org/0000-0001-6303-3609"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rameen Beroukhim","raw_affiliation_strings":["Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA","Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America","Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America","Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111877797","display_name":"Ming Gang Lin","orcid":null},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Lin","raw_affiliation_strings":["Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America,","Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America,","Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America","Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America,","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103234596","display_name":"Yuhyun Park","orcid":"https://orcid.org/0009-0007-7617-6546"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuhyun Park","raw_affiliation_strings":["Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America,","Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America,","Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America","Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America,","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101437034","display_name":"Ke Hao","orcid":"https://orcid.org/0000-0001-9537-2023"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ke Hao","raw_affiliation_strings":["Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America,","Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100629102","display_name":"Xiaojun Zhao","orcid":"https://orcid.org/0000-0002-9229-2949"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaojun Zhao","raw_affiliation_strings":["Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America,","Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America,","Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America,","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055048393","display_name":"Levi A. Garraway","orcid":"https://orcid.org/0000-0003-3739-0471"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Levi A Garraway","raw_affiliation_strings":["Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America","Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106083058","display_name":"Edward A. Fox","orcid":null},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward A Fox","raw_affiliation_strings":["Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America,","Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America,","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035186913","display_name":"Ephraim P. Hochberg","orcid":"https://orcid.org/0000-0001-9050-7208"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ephraim P Hochberg","raw_affiliation_strings":["Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America","Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America","Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020324479","display_name":"Ingo K. Mellinghoff","orcid":"https://orcid.org/0000-0002-4347-8149"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210096972","display_name":"Los Angeles Medical Center","ror":"https://ror.org/00spys463","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210096972"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ingo K Mellinghoff","raw_affiliation_strings":["Departments of Medicine and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America,","Departments of Medicine and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America,","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210096972"]},{"raw_affiliation_string":"Departments of Medicine and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101887913","display_name":"Matthias D. Hofer","orcid":"https://orcid.org/0000-0001-8393-2468"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthias D Hofer","raw_affiliation_strings":["Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America,","Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America,","Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America","Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America,","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033163047","display_name":"A. Descazeaud","orcid":null},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aurelien Descazeaud","raw_affiliation_strings":["Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America,","Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America,","Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America","Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America,","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035068594","display_name":"Mark A. Rubin","orcid":"https://orcid.org/0000-0002-8321-9950"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A Rubin","raw_affiliation_strings":["Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America,","Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America,","Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America","Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America,","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056373767","display_name":"Matthew Meyerson","orcid":"https://orcid.org/0000-0002-9133-8108"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Meyerson","raw_affiliation_strings":["Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America","Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015401462","display_name":"Wing Hung Wong","orcid":"https://orcid.org/0000-0001-7466-2339"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wing Hung Wong","raw_affiliation_strings":["Department of Statistics, Stanford University, Stanford, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Statistics, Stanford University, Stanford, California, United States of America","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057346782","display_name":"William R. Sellers","orcid":"https://orcid.org/0000-0002-3539-9803"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William R Sellers","raw_affiliation_strings":["Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America","Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America","Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Pathology, and Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100354298","display_name":"Cheng Li","orcid":"https://orcid.org/0000-0003-4366-6139"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cheng Li","raw_affiliation_strings":["Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America,","Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America,","Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America","Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America,","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Departments of Biostatistics and Computational Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":16,"corresponding_author_ids":["https://openalex.org/A5057346782","https://openalex.org/A5100354298"],"corresponding_institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210117453"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":9.6717,"has_fulltext":true,"cited_by_count":159,"citation_normalized_percentile":{"value":0.98835455,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"2","issue":"5","first_page":"e41","last_page":"e41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"Loss of heterozygosity","score":0.9104676842689514},{"id":"https://openalex.org/keywords/genotyping","display_name":"Genotyping","score":0.76289963722229},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7369563579559326},{"id":"https://openalex.org/keywords/snp-genotyping","display_name":"SNP genotyping","score":0.6479800939559937},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.6316460371017456},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.6245051026344299},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.5244852900505066},{"id":"https://openalex.org/keywords/snp-array","display_name":"SNP array","score":0.5114001631736755},{"id":"https://openalex.org/keywords/molecular-inversion-probe","display_name":"Molecular Inversion Probe","score":0.4414916932582855},{"id":"https://openalex.org/keywords/allele","display_name":"Allele","score":0.4097500443458557},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.40892457962036133},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.32290059328079224},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.13701540231704712}],"concepts":[{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.9104676842689514},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.76289963722229},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7369563579559326},{"id":"https://openalex.org/C163691529","wikidata":"https://www.wikidata.org/wiki/Q7391886","display_name":"SNP genotyping","level":5,"score":0.6479800939559937},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6316460371017456},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.6245051026344299},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5244852900505066},{"id":"https://openalex.org/C122060243","wikidata":"https://www.wikidata.org/wiki/Q7391885","display_name":"SNP array","level":5,"score":0.5114001631736755},{"id":"https://openalex.org/C59701697","wikidata":"https://www.wikidata.org/wiki/Q6895959","display_name":"Molecular Inversion Probe","level":5,"score":0.4414916932582855},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4097500443458557},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40892457962036133},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.32290059328079224},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13701540231704712}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019656","descriptor_name":"Loss of Heterozygosity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019656","descriptor_name":"Loss of Heterozygosity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019656","descriptor_name":"Loss of Heterozygosity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D041322","descriptor_name":"Chromosomes, Human, Y","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D041322","descriptor_name":"Chromosomes, Human, Y","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D041322","descriptor_name":"Chromosomes, Human, Y","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.0020041","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0020041","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0020041&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:16699594","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16699594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:dash.harvard.edu:1/5129838","is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:5129838","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:plo:pcbi00:0020041","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.0020041","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:ce4f67892b384292819d1424c67e2ab9","is_oa":true,"landing_page_url":"https://doaj.org/article/ce4f67892b384292819d1424c67e2ab9","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 2, Iss 5, p e41 (2006)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2622027","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC1458964","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/152937","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Inferring_Loss_of_Heterozygosity_from_Unpaired_Tumors_Using_High_Density_Oligonucleotide_SNP_Arrays/152937","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:1458964","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1458964","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.0020041","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.0020041","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0020041&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G346488890","display_name":null,"funder_award_id":"CA96470","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320308625","display_name":"Flight Attendant Medical Research Institute","ror":"https://ror.org/00ybhm522"},{"id":"https://openalex.org/F4320310151","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2122410503.pdf","grobid_xml":"https://content.openalex.org/works/W2122410503.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1512173429","https://openalex.org/W1835750525","https://openalex.org/W1970761420","https://openalex.org/W1971912858","https://openalex.org/W1994678797","https://openalex.org/W1998158007","https://openalex.org/W2009570821","https://openalex.org/W2009978569","https://openalex.org/W2033041275","https://openalex.org/W2043138639","https://openalex.org/W2066721762","https://openalex.org/W2077858999","https://openalex.org/W2082458448","https://openalex.org/W2096769034","https://openalex.org/W2096916467","https://openalex.org/W2097331522","https://openalex.org/W2101813098","https://openalex.org/W2102058141","https://openalex.org/W2104241530","https://openalex.org/W2105241306","https://openalex.org/W2107966042","https://openalex.org/W2110227850","https://openalex.org/W2120793026","https://openalex.org/W2123444907","https://openalex.org/W2125255775","https://openalex.org/W2143316734","https://openalex.org/W2143362349","https://openalex.org/W2156357008","https://openalex.org/W2166187656","https://openalex.org/W2217809488","https://openalex.org/W4234467048"],"related_works":["https://openalex.org/W2414446413","https://openalex.org/W1504890006","https://openalex.org/W3139651602","https://openalex.org/W2936024166","https://openalex.org/W2097166530","https://openalex.org/W2783076127","https://openalex.org/W2412475779","https://openalex.org/W2034657403","https://openalex.org/W2135364516","https://openalex.org/W2026621123"],"abstract_inverted_index":{"Loss":[0],"of":[1,4,17,23,66,73,90,96,132,152,165,168,172,196,204,213,231,233],"heterozygosity":[2,126],"(LOH)":[3],"chromosomal":[5],"regions":[6,25,37,167,173,212,232],"bearing":[7],"tumor":[8,30,117],"suppressors":[9],"is":[10],"a":[11,107,202,219],"key":[12],"event":[13],"in":[14,41,47,237],"the":[15,42,48,64,94,129,133,139,166,184,240],"evolution":[16],"epithelial":[18],"and":[19,31,35,56,128,235],"mesenchymal":[20],"tumors.":[21],"Identification":[22],"these":[24],"usually":[26],"relies":[27],"on":[28,144],"genotyping":[29,78],"counterpart":[32],"normal":[33,43,52,102,244],"DNA":[34,44],"noting":[36],"where":[38],"heterozygous":[39,97],"alleles":[40],"become":[45],"homozygous":[46],"tumor.":[49],"However,":[50],"paired":[51,208,243],"samples":[53,206],"for":[54,221,242],"tumors":[55,238],"cell":[57],"lines":[58],"are":[59],"often":[60],"not":[61],"available.":[62],"With":[63],"advent":[65],"oligonucleotide":[67,224],"arrays":[68],"that":[69],"simultaneously":[70],"assay":[71],"thousands":[72],"single-nucleotide":[74],"polymorphism":[75],"(SNP)":[76],"markers,":[77],"can":[79],"now":[80],"be":[81],"done":[82],"at":[83],"high":[84],"enough":[85],"resolution":[86],"to":[87,101,112,141,189,199,228],"allow":[88],"identification":[89],"LOH":[91,114,191,234],"events":[92],"by":[93],"absence":[95],"loci,":[98],"without":[99,207,239],"comparison":[100],"controls.":[103],"Here":[104],"we":[105,137,148,186],"describe":[106],"hidden":[108],"Markov":[109],"model-based":[110],"method":[111,140,198,220],"identify":[113,230],"from":[115,192,201],"unpaired":[116],"samples,":[118],"taking":[119],"into":[120,183],"account":[121],"SNP":[122,153,225],"intermarker":[123],"distances,":[124],"SNP-specific":[125],"rates,":[127],"haplotype":[130],"structure":[131],"human":[134],"genome.":[135],"When":[136],"applied":[138],"data":[142,200,227],"genotyped":[143],"100":[145],"K":[146],"arrays,":[147],"correctly":[149,162],"identified":[150,163,210],"99%":[151],"markers":[154],"as":[155],"either":[156],"retention":[157,236],"or":[158],"loss.":[159],"We":[160,216],"also":[161],"81%":[164],"LOH,":[169],"including":[170],"98%":[171],"greater":[174],"than":[175],"3":[176],"megabases.":[177],"By":[178],"integrating":[179],"copy":[180],"number":[181],"analysis":[182],"method,":[185],"were":[187],"able":[188],"distinguish":[190],"allelic":[193],"imbalance.":[194],"Application":[195],"this":[197],"set":[203],"prostate":[205],"normals":[209],"known":[211],"prevalent":[214],"LOH.":[215],"have":[217],"developed":[218],"analyzing":[222],"high-density":[223],"array":[226],"accurately":[229],"need":[241],"samples.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":12}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}