{"id":"https://openalex.org/W1997184616","doi":"https://doi.org/10.13053/cys-18-4-1920","title":"Estudio de la din\u00e1mica global para un modelo de Evasi\u00f3n-Inmune de un tumor cancer\u00edgeno","display_name":"Estudio de la din\u00e1mica global para un modelo de Evasi\u00f3n-Inmune de un tumor cancer\u00edgeno","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W1997184616","doi":"https://doi.org/10.13053/cys-18-4-1920","mag":"1997184616"},"language":"es","primary_location":{"id":"doi:10.13053/cys-18-4-1920","is_oa":false,"landing_page_url":"https://doi.org/10.13053/cys-18-4-1920","pdf_url":null,"source":{"id":"https://openalex.org/S61446325","display_name":"Computaci\u00f3n y Sistemas","issn_l":"1405-5546","issn":["1405-5546","2007-9737"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319599","host_organization_name":"National Polytechnic Institute","host_organization_lineage":["https://openalex.org/P4310319599"],"host_organization_lineage_names":["National Polytechnic Institute"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computaci\u00f3n y Sistemas","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033678658","display_name":"Paul A. Valle","orcid":"https://orcid.org/0000-0001-6567-1065"},"institutions":[{"id":"https://openalex.org/I59361560","display_name":"Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/059sp8j34","country_code":"MX","type":"education","lineage":["https://openalex.org/I59361560"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Paul Antonio Valle Trujillo","raw_affiliation_strings":["Instituto Polit\u00e9cnico Nacional, M\u00e9xico, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Polit\u00e9cnico Nacional, M\u00e9xico, M\u00e9xico","institution_ids":["https://openalex.org/I59361560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025113450","display_name":"Luis N. Coria","orcid":"https://orcid.org/0000-0002-1219-0433"},"institutions":[{"id":"https://openalex.org/I4210118730","display_name":"Instituto Tecnol\u00f3gico de Tijuana","ror":"https://ror.org/03dga7879","country_code":"MX","type":"education","lineage":["https://openalex.org/I4210118730"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Luis Nestor Coria de los Rios","raw_affiliation_strings":["Instituto Tecnol\u00f3gico de Tijuana, Tijuana, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Tecnol\u00f3gico de Tijuana, Tijuana, M\u00e9xico","institution_ids":["https://openalex.org/I4210118730"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044105745","display_name":"Konstantin E. Starkov","orcid":"https://orcid.org/0000-0001-8267-2318"},"institutions":[{"id":"https://openalex.org/I59361560","display_name":"Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/059sp8j34","country_code":"MX","type":"education","lineage":["https://openalex.org/I59361560"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Konstantin Starkov","raw_affiliation_strings":["Instituto Polit\u00e9cnico Nacional, Mexico, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Polit\u00e9cnico Nacional, Mexico, Mexico","institution_ids":["https://openalex.org/I59361560"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2471,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.59945365,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"18","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9797999858856201,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/humanities","display_name":"Humanities","score":0.6788617372512817},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.375440776348114},{"id":"https://openalex.org/keywords/philosophy","display_name":"Philosophy","score":0.26477640867233276}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.6788617372512817},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.375440776348114},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.26477640867233276}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.13053/cys-18-4-1920","is_oa":false,"landing_page_url":"https://doi.org/10.13053/cys-18-4-1920","pdf_url":null,"source":{"id":"https://openalex.org/S61446325","display_name":"Computaci\u00f3n y Sistemas","issn_l":"1405-5546","issn":["1405-5546","2007-9737"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319599","host_organization_name":"National Polytechnic Institute","host_organization_lineage":["https://openalex.org/P4310319599"],"host_organization_lineage_names":["National Polytechnic Institute"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computaci\u00f3n y Sistemas","raw_type":"journal-article"},{"id":"pmh:oai:ipn.redalyc.org:61532985012","is_oa":false,"landing_page_url":"http://www.redalyc.org/articulo.oa?id=61532985012","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instname:Instituto Polit\u00e9cnico Nacional","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:redalyc.org:61532985012","is_oa":false,"landing_page_url":"https://www.redalyc.org/articulo.oa?id=61532985012","pdf_url":null,"source":{"id":"https://openalex.org/S4377196100","display_name":"Redalyc (Universidad Aut\u00f3noma del Estado de M\u00e9xico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I179647637","host_organization_name":"Universidad Aut\u00f3noma del Estado de M\u00e9xico","host_organization_lineage":["https://openalex.org/I179647637"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instname:Instituto Polit\u00e9cnico Nacional","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.75,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W615572238","https://openalex.org/W1565731923","https://openalex.org/W1978104987","https://openalex.org/W1991008614","https://openalex.org/W2008947068","https://openalex.org/W2014133785","https://openalex.org/W2029159090","https://openalex.org/W2035674671","https://openalex.org/W2040837794","https://openalex.org/W2046674108","https://openalex.org/W2047902191","https://openalex.org/W2049724218","https://openalex.org/W2056708573","https://openalex.org/W2057727894","https://openalex.org/W2073679760","https://openalex.org/W2080617120","https://openalex.org/W2094560928","https://openalex.org/W2106474849","https://openalex.org/W2107760337","https://openalex.org/W2145926562","https://openalex.org/W2147977282","https://openalex.org/W2158112175","https://openalex.org/W4292994524","https://openalex.org/W6633940225","https://openalex.org/W6647839290","https://openalex.org/W6662196496","https://openalex.org/W6662412761","https://openalex.org/W6668808910","https://openalex.org/W6676175011","https://openalex.org/W6857736828"],"related_works":["https://openalex.org/W2935759653","https://openalex.org/W3105167352","https://openalex.org/W54078636","https://openalex.org/W2954470139","https://openalex.org/W1501425562","https://openalex.org/W2902782467","https://openalex.org/W3084825885","https://openalex.org/W2298861036","https://openalex.org/W3148032049","https://openalex.org/W2271181815"],"abstract_inverted_index":{"En":[0],"este":[1],"documento":[2],"se":[3,66,77,127,148,176,181],"estudia":[4],"la":[5,22,101,151],"din\u00e1mica":[6],"global":[7],"del":[8,38,103,139,171],"modelo":[9,85],"de":[10,49,60,62,74,86,90,112,121,124,136,146,153,185,190],"Evasi\u00f3n-Inmune":[11],"presentado":[12],"por":[13,133],"Arciero,":[14],"Jackson":[15],"y":[16,29,33,53,107,119,126,180],"Kirschner":[17],",":[18],"el":[19,36,58,72,84],"cual":[20],"describe":[21],"interacci\u00f3n":[23],"entre":[24],"c\u00e9lulas":[25,27],"efectoras,":[26],"cancer\u00edgenas":[28],"las":[30,80,122,169,186],"citocinas":[31],"IL-2":[32],"TGF-\u03b2":[34],"en":[35,71,105],"sitio":[37],"tumor.":[39],"El":[40],"sistema":[41,172],"modela":[42],"distintos":[43],"comportamientos,":[44],"como":[45],"lo":[46,160],"son:":[47],"puntos":[48],"equilibrio,":[50],"\u00f3rbitas":[51],"peri\u00f3dicas":[52],"ciclos":[54],"l\u00edmite":[55],"estables.":[56],"Utilizando":[57],"m\u00e9todo":[59],"Localizaci\u00f3n":[61],"Conjuntos":[63],"Compactos":[64],"Invariantes":[65],"logra":[67],"definir":[68],"un":[69,156,183],"dominio":[70,92,114,157],"espacio":[73],"estados":[75],"donde":[76],"localizan":[78],"todas":[79],"din\u00e1micas":[81],"que":[82,97,150,161,164],"exhibe":[83],"Evasi\u00f3n-inmune.":[87],"La":[88],"localizaci\u00f3n":[89,154],"dicho":[91],"es":[93,155],"importante":[94],"debido":[95],"a":[96],"proporciona":[98],"informaci\u00f3n":[99],"sobre":[100],"salud":[102],"individuo":[104],"corto":[106],"largo":[108],"plazo.":[109],"Los":[110],"l\u00edmites":[111],"tal":[113],"representan":[115],"los":[116,137,191],"valores":[117],"m\u00ednimos":[118],"m\u00e1ximos":[120],"variables":[123],"estado":[125],"expresan":[128],"mediante":[129,142],"desigualdades":[130],"algebraicas":[131],"dadas":[132],"una":[134,143],"combinaci\u00f3n":[135],"par\u00e1metros":[138],"sistema.":[140],"Adicionalmente,":[141],"funci\u00f3n":[144],"candidata":[145],"Lyapunov,":[147],"demuestra":[149],"regi\u00f3n":[152],"positivamente":[158],"invariante,":[159],"permite":[162],"asegurar":[163],"dada":[165],"cualquier":[166],"condici\u00f3n":[167],"inicial,":[168],"trayectorias":[170],"no":[173],"divergen.":[174],"Finalmente,":[175],"presentan":[177],"simulaciones":[178],"num\u00e9ricas":[179],"realiza":[182],"an\u00e1lisis":[184],"posibles":[187],"implicaciones":[188],"biol\u00f3gicas":[189],"resultados":[192],"obtenidos.":[193]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}