{"id":"https://openalex.org/W4233227002","doi":"https://doi.org/10.12688/f1000research.9417.1","title":"Predicting Outcomes of Hormone and Chemotherapy in the Molecular\u00a0Taxonomy of\u00a0Breast Cancer\u00a0International\u00a0Consortium (METABRIC) Study by Biochemically-inspired Machine Learning","display_name":"Predicting Outcomes of Hormone and Chemotherapy in the Molecular\u00a0Taxonomy of\u00a0Breast Cancer\u00a0International\u00a0Consortium (METABRIC) Study by Biochemically-inspired Machine Learning","publication_year":2016,"publication_date":"2016-08-31","ids":{"openalex":"https://openalex.org/W4233227002","doi":"https://doi.org/10.12688/f1000research.9417.1"},"language":"en","primary_location":{"id":"doi:10.12688/f1000research.9417.1","is_oa":true,"landing_page_url":"https://doi.org/10.12688/f1000research.9417.1","pdf_url":null,"source":{"id":"https://openalex.org/S4210239046","display_name":"F1000Research","issn_l":"2046-1402","issn":["2046-1402"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320357","host_organization_name":"Faculty of 1000","host_organization_lineage":["https://openalex.org/P4310320357"],"host_organization_lineage_names":["Faculty of 1000"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"F1000Research","raw_type":"journal-article"},"type":"preprint","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.12688/f1000research.9417.1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032080063","display_name":"Iman Rezaeian","orcid":"https://orcid.org/0000-0002-6882-2911"},"institutions":[{"id":"https://openalex.org/I74413500","display_name":"University of Windsor","ror":"https://ror.org/01gw3d370","country_code":"CA","type":"education","lineage":["https://openalex.org/I74413500"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Iman Rezaeian","raw_affiliation_strings":["Department of Computer Science, University of Windsor, Windsor"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Windsor, Windsor","institution_ids":["https://openalex.org/I74413500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039487615","display_name":"Eliseos J. Mucaki","orcid":"https://orcid.org/0000-0002-6195-5535"},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Eliseos J. Mucaki","raw_affiliation_strings":["Department of Biochemistry, University of Western Ontario, London"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Western Ontario, London","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076519713","display_name":"Katherina Baranova","orcid":"https://orcid.org/0000-0003-4740-9789"},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Katherina Baranova","raw_affiliation_strings":["Department of Biochemistry, University of Western Ontario, London"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Western Ontario, London","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101459849","display_name":"Huy Quang Pham","orcid":"https://orcid.org/0000-0003-3495-3769"},"institutions":[{"id":"https://openalex.org/I74413500","display_name":"University of Windsor","ror":"https://ror.org/01gw3d370","country_code":"CA","type":"education","lineage":["https://openalex.org/I74413500"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Huy Q. Pham","raw_affiliation_strings":["Department of Computer Science, University of Windsor, Windsor"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Windsor, Windsor","institution_ids":["https://openalex.org/I74413500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012635715","display_name":"Dimo Angelov","orcid":null},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Dimo Angelov","raw_affiliation_strings":["Department of Computer Science, University of Western Ontario, London"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Western Ontario, London","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070302649","display_name":"Alioune Ngom","orcid":"https://orcid.org/0000-0003-2092-2494"},"institutions":[{"id":"https://openalex.org/I74413500","display_name":"University of Windsor","ror":"https://ror.org/01gw3d370","country_code":"CA","type":"education","lineage":["https://openalex.org/I74413500"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Alioune Ngom","raw_affiliation_strings":["Department of Computer Science, University of Windsor, Windsor"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Windsor, Windsor","institution_ids":["https://openalex.org/I74413500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040978295","display_name":"Luis Rueda","orcid":"https://orcid.org/0000-0001-7988-2058"},"institutions":[{"id":"https://openalex.org/I74413500","display_name":"University of Windsor","ror":"https://ror.org/01gw3d370","country_code":"CA","type":"education","lineage":["https://openalex.org/I74413500"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Luis Rueda","raw_affiliation_strings":["Department of Computer Science, University of Windsor, Windsor"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Windsor, Windsor","institution_ids":["https://openalex.org/I74413500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010680275","display_name":"Peter K. Rogan","orcid":"https://orcid.org/0000-0003-2070-5254"},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Peter K. Rogan","raw_affiliation_strings":["Department of Biochemistry, University of Western Ontario, London","Department of Computer Science, University of Western Ontario, London","CytoGnomix Inc, London"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Western Ontario, London","institution_ids":["https://openalex.org/I125749732"]},{"raw_affiliation_string":"Department of Computer Science, University of Western Ontario, London","institution_ids":["https://openalex.org/I125749732"]},{"raw_affiliation_string":"CytoGnomix Inc, London","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5032080063"],"corresponding_institution_ids":["https://openalex.org/I74413500"],"apc_list":{"value":1350,"currency":"USD","value_usd":1350},"apc_paid":{"value":1350,"currency":"USD","value_usd":1350},"fwci":0.788,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.77096351,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"5","issue":null,"first_page":"2124","last_page":"2124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5088613033294678},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.5076371431350708},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.45858311653137207},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.41734546422958374},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.38020461797714233},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3004226088523865}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5088613033294678},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5076371431350708},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.45858311653137207},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41734546422958374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38020461797714233},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3004226088523865}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.12688/f1000research.9417.1","is_oa":true,"landing_page_url":"https://doi.org/10.12688/f1000research.9417.1","pdf_url":null,"source":{"id":"https://openalex.org/S4210239046","display_name":"F1000Research","issn_l":"2046-1402","issn":["2046-1402"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320357","host_organization_name":"Faculty of 1000","host_organization_lineage":["https://openalex.org/P4310320357"],"host_organization_lineage_names":["Faculty of 1000"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"F1000Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.12688/f1000research.9417.1","is_oa":true,"landing_page_url":"https://doi.org/10.12688/f1000research.9417.1","pdf_url":null,"source":{"id":"https://openalex.org/S4210239046","display_name":"F1000Research","issn_l":"2046-1402","issn":["2046-1402"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320357","host_organization_name":"Faculty of 1000","host_organization_lineage":["https://openalex.org/P4310320357"],"host_organization_lineage_names":["Faculty of 1000"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"F1000Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.41999998688697815,"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1670192389","https://openalex.org/W2005895632","https://openalex.org/W2076706358","https://openalex.org/W2087312216","https://openalex.org/W2131987814","https://openalex.org/W2133990480","https://openalex.org/W2140593657","https://openalex.org/W2158501247","https://openalex.org/W2908757591"],"related_works":["https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W2151865869","https://openalex.org/W2892677547"],"abstract_inverted_index":{"<ns4:p>":[0],"Genomic":[1],"aberrations":[2],"and":[3,18,67,83,89,152,200],"gene":[4,26,77,95,216,247,265],"expression-defined":[5],"subtypes":[6],"in":[7,40,47,62,70,92,145,163,205,240,252],"the":[8,98,102,121],"large":[9],"METABRIC":[10,41],"patient":[11],"cohort":[12],"have":[13],"been":[14],"used":[15,24,74,91],"to":[16,33,75],"stratify":[17],"predict":[19,34],"survival.":[20],"The":[21,167],"present":[22],"study":[23],"normalized":[25],"expression":[27,194,266],"signatures":[28,78,96,267],"of":[29,79,117,169,187,195],"paclitaxel":[30,118],"drug":[31,280],"response":[32,119],"outcome":[35],"for":[36,276],"different":[37,178],"survival":[38,107,155,179,236,278],"times":[39],"patients":[42,147,254],"receiving":[43],"hormone":[44],"(HT)":[45],"and,":[46],"some":[48],"cases,":[49],"chemotherapy":[50],"(CT)":[51],"agents.":[52],"This":[53],"machine":[54,114,171,270],"learning":[55,172,271],"method,":[56],"which":[57],"distinguishes":[58],"sensitivity":[59],"vs.":[60],"resistance":[61],"breast":[63],"cancer":[64],"cell":[65],"lines":[66],"validates":[68],"predictions":[69],"patients,":[71],"was":[72,142,160,202],"also":[73,105,175],"derive":[76],"other":[80,103,170],"HT":[81,151,242],"(tamoxifen)":[82],"CT":[84,153,207,257],"agents":[85,104],"(methotrexate,":[86],"epirubicin,":[87],"doxorubicin,":[88],"5-fluorouracil)":[90],"METABRIC.":[93],"Paclitaxel":[94],"exhibited":[97],"best":[99],"performance,":[100],"however":[101],"predicted":[106,233],"with":[108,149,237,256],"acceptable":[109],"accuracies.":[110],"A":[111,209,244],"support":[112],"vector":[113],"(SVM)":[115],"model":[116],"containing":[120],"<ns4:italic>ABCB1,":[122],"ABCB11,":[123],"ABCC1,":[124,197,220],"ABCC10,":[125],"BAD,":[126,198,221],"BBC3,":[127],"BCL2,":[128,222],"BCL2L1,":[129],"BMF,":[130],"CYP2C8,":[131,223],"CYP3A4,":[132,224],"MAP2,":[133],"MAP4,":[134,225],"MAPT,":[135,226],"NR1I2,":[136,227],"SLCO1B3,":[137],"TUBB1,":[138,228],"TUBB4A,":[139],"TUBB4B</ns4:italic>":[140],"genes":[141],"78.6%":[143],"accurate":[144,204],"84":[146],"treated":[148,255],"both":[150],"(median":[154],"\u2265":[156],"4.4":[157],"yr).":[158],"Accuracy":[159],"lower":[161],"(73.4%)":[162],"304":[164],"untreated":[165],"patients.":[166,208,243],"performance":[168],"approaches":[173],"were":[174],"evaluated":[176],"at":[177],"thresholds.":[180],"Minimum":[181],"redundancy":[182],"maximum":[183],"relevance":[184],"feature":[185],"selection":[186],"a":[188,215],"paclitaxel-based":[189],"SVM":[190],"classifier":[191,213],"based":[192],"on":[193],"<ns4:italic>ABCB11,":[196,219],"BBC3":[199],"BCL2L1</ns4:italic>":[201],"79%":[203],"53":[206],"random":[210],"forest":[211],"(RF)":[212],"produced":[214],"signature":[217,248],"(":[218],"GBP1,":[229],"OPRK1</ns4:italic>":[230],")":[231],"that":[232,263],"&gt;3":[234],"year":[235],"82.4%":[238],"accuracy":[239,251],"420":[241],"similar":[245],"RF":[246],"showed":[249],"79.6%":[250],"504":[253],"and/or":[258],"HT.":[259],"These":[260],"results":[261],"suggest":[262],"tumor":[264],"refined":[268],"by":[269],"techniques":[272],"can":[273],"be":[274],"useful":[275],"predicting":[277],"after":[279],"therapies.":[281],"</ns4:p>":[282]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-03-27T14:29:43.386196","created_date":"2025-10-10T00:00:00"}
