{"id":"https://openalex.org/W2912234274","doi":"https://doi.org/10.1186/s12918-018-0671-x","title":"Multi-omics integration reveals molecular networks and regulators of psoriasis","display_name":"Multi-omics integration reveals molecular networks and regulators of psoriasis","publication_year":2019,"publication_date":"2019-01-14","ids":{"openalex":"https://openalex.org/W2912234274","doi":"https://doi.org/10.1186/s12918-018-0671-x","mag":"2912234274","pmid":"https://pubmed.ncbi.nlm.nih.gov/30642337"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-018-0671-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0671-x","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0671-x","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0671-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101632904","display_name":"Yuqi Zhao","orcid":"https://orcid.org/0000-0003-0730-5854"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuqi Zhao","raw_affiliation_strings":["Department of Integrative Biology and Physiology, University of California, Los Angeles, 610 Charles E. Young Dr. East, Los Angeles, CA, 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Physiology, University of California, Los Angeles, 610 Charles E. Young Dr. East, Los Angeles, CA, 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085530690","display_name":"Deepali Jhamb","orcid":null},"institutions":[{"id":"https://openalex.org/I1320354487","display_name":"Target (United States)","ror":"https://ror.org/05mkyac79","country_code":"US","type":"company","lineage":["https://openalex.org/I1320354487"]},{"id":"https://openalex.org/I2802890147","display_name":"South College","ror":"https://ror.org/01fryje29","country_code":"US","type":"education","lineage":["https://openalex.org/I2802890147"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepali Jhamb","raw_affiliation_strings":["Target Sciences, Computational Biology (US) GSK, 1250 South Collegeville Road, Collegeville, PA, 19426, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Target Sciences, Computational Biology (US) GSK, 1250 South Collegeville Road, Collegeville, PA, 19426, USA","institution_ids":["https://openalex.org/I2802890147","https://openalex.org/I1320354487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013476326","display_name":"Le Shu","orcid":"https://orcid.org/0000-0001-5428-1969"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Le Shu","raw_affiliation_strings":["Department of Integrative Biology and Physiology, University of California, Los Angeles, 610 Charles E. Young Dr. East, Los Angeles, CA, 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Physiology, University of California, Los Angeles, 610 Charles E. Young Dr. East, Los Angeles, CA, 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057009272","display_name":"Douglas Arneson","orcid":"https://orcid.org/0000-0002-9464-2586"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas Arneson","raw_affiliation_strings":["Department of Integrative Biology and Physiology, University of California, Los Angeles, 610 Charles E. Young Dr. East, Los Angeles, CA, 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Physiology, University of California, Los Angeles, 610 Charles E. Young Dr. East, Los Angeles, CA, 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023136016","display_name":"Deepak K. Rajpal","orcid":"https://orcid.org/0000-0001-9289-6366"},"institutions":[{"id":"https://openalex.org/I2802890147","display_name":"South College","ror":"https://ror.org/01fryje29","country_code":"US","type":"education","lineage":["https://openalex.org/I2802890147"]},{"id":"https://openalex.org/I1320354487","display_name":"Target (United States)","ror":"https://ror.org/05mkyac79","country_code":"US","type":"company","lineage":["https://openalex.org/I1320354487"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepak K. Rajpal","raw_affiliation_strings":["Target Sciences, Computational Biology (US) GSK, 1250 South Collegeville Road, Collegeville, PA, 19426, USA. deepak.k.rajpal@gsk.com","Target Sciences, Computational Biology (US) GSK, 1250 South Collegeville Road, Collegeville, PA, 19426, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Target Sciences, Computational Biology (US) GSK, 1250 South Collegeville Road, Collegeville, PA, 19426, USA. deepak.k.rajpal@gsk.com","institution_ids":[]},{"raw_affiliation_string":"Target Sciences, Computational Biology (US) GSK, 1250 South Collegeville Road, Collegeville, PA, 19426, USA","institution_ids":["https://openalex.org/I2802890147","https://openalex.org/I1320354487"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088751229","display_name":"Xia Yang","orcid":"https://orcid.org/0000-0002-3971-038X"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xia Yang","raw_affiliation_strings":["Bioinformatics Interdepartmental Program, University of California, 10 Charles E. Young Dr. East, Los Angeles, CA, 90095, USA. xyang123@ucla.edu","Department of Integrative Biology and Physiology, University of California, Los Angeles, 610 Charles E. Young Dr. East, Los Angeles, CA, 90095, USA. xyang123@ucla.edu","Institute for Quantitative and Computational Biosciences, University of California , 610 Charles E. Young Dr. East, Los Angeles, CA, 90095, USA. xyang123@ucla.edu","Molecular Biology Institute, University of California, 610 Charles E. Young Dr. East, Los Angeles, CA, 90095, USA. xyang123@ucla.edu","Institute for Quantitative and Computational Biosciences, University of California , 610 Charles E. Young Dr. East, Los Angeles, CA, 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Interdepartmental Program, University of California, 10 Charles E. Young Dr. East, Los Angeles, CA, 90095, USA. xyang123@ucla.edu","institution_ids":[]},{"raw_affiliation_string":"Department of Integrative Biology and Physiology, University of California, Los Angeles, 610 Charles E. Young Dr. East, Los Angeles, CA, 90095, USA. xyang123@ucla.edu","institution_ids":[]},{"raw_affiliation_string":"Institute for Quantitative and Computational Biosciences, University of California , 610 Charles E. Young Dr. East, Los Angeles, CA, 90095, USA. xyang123@ucla.edu","institution_ids":[]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, 610 Charles E. Young Dr. East, Los Angeles, CA, 90095, USA. xyang123@ucla.edu","institution_ids":[]},{"raw_affiliation_string":"Institute for Quantitative and Computational Biosciences, University of California , 610 Charles E. Young Dr. East, Los Angeles, CA, 90095, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5088751229"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4498,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.89747845,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"8","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.8021791577339172},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.6539546251296997},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6519302725791931},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6474179625511169},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.6120666861534119},{"id":"https://openalex.org/keywords/epigenome","display_name":"Epigenome","score":0.5606649518013},{"id":"https://openalex.org/keywords/psoriasis","display_name":"Psoriasis","score":0.5443503260612488},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5358824133872986},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.49064865708351135},{"id":"https://openalex.org/keywords/human-genetics","display_name":"Human genetics","score":0.4707867503166199},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.46306222677230835},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.4600851535797119},{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"Expression quantitative trait loci","score":0.42971354722976685},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.41203242540359497},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.38487061858177185},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.29814082384109497},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.2065751552581787},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.19696131348609924},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.16486507654190063},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.0605144202709198}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.8021791577339172},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.6539546251296997},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6519302725791931},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6474179625511169},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6120666861534119},{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.5606649518013},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.5443503260612488},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5358824133872986},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.49064865708351135},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.4707867503166199},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.46306222677230835},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.4600851535797119},{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.42971354722976685},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41203242540359497},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38487061858177185},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.29814082384109497},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.2065751552581787},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.19696131348609924},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.16486507654190063},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0605144202709198},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1186/s12918-018-0671-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0671-x","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0671-x","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:30642337","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30642337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:ark:/13030/qt5v98h78j","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:doaj.org/article:6b6a60da8a2c46db8aa3f61f82d441c8","is_oa":false,"landing_page_url":"https://doaj.org/article/6b6a60da8a2c46db8aa3f61f82d441c8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 13, Iss 1, Pp 1-14 (2019)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt5v98h78j","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/5v98h78j","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC systems biology, vol 13, iss 1","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5310019","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6332659","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6332659","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6332659","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12918-018-0671-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0671-x","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0671-x","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2912234274.pdf","grobid_xml":"https://content.openalex.org/works/W2912234274.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W26154758","https://openalex.org/W1782747004","https://openalex.org/W1815404375","https://openalex.org/W1832327890","https://openalex.org/W1968410101","https://openalex.org/W1969476474","https://openalex.org/W1971708477","https://openalex.org/W1976306345","https://openalex.org/W1977535059","https://openalex.org/W1981409633","https://openalex.org/W1987287073","https://openalex.org/W1989223663","https://openalex.org/W2002364623","https://openalex.org/W2018733922","https://openalex.org/W2031950862","https://openalex.org/W2032830223","https://openalex.org/W2032840557","https://openalex.org/W2033105784","https://openalex.org/W2045113343","https://openalex.org/W2056007075","https://openalex.org/W2072103747","https://openalex.org/W2072926000","https://openalex.org/W2076541689","https://openalex.org/W2079139407","https://openalex.org/W2100239923","https://openalex.org/W2100667488","https://openalex.org/W2101347991","https://openalex.org/W2102889851","https://openalex.org/W2103017472","https://openalex.org/W2106608030","https://openalex.org/W2108510600","https://openalex.org/W2112485391","https://openalex.org/W2113443914","https://openalex.org/W2117446594","https://openalex.org/W2124999415","https://openalex.org/W2130410032","https://openalex.org/W2138848739","https://openalex.org/W2139294174","https://openalex.org/W2146512944","https://openalex.org/W2147714160","https://openalex.org/W2152183952","https://openalex.org/W2159482845","https://openalex.org/W2160516174","https://openalex.org/W2161406854","https://openalex.org/W2169785917","https://openalex.org/W2200388872","https://openalex.org/W2248670303","https://openalex.org/W2250812993","https://openalex.org/W2273075340","https://openalex.org/W2294302252","https://openalex.org/W2374847037","https://openalex.org/W2408811052","https://openalex.org/W2548971621","https://openalex.org/W2560075599","https://openalex.org/W2582679467","https://openalex.org/W2584297375","https://openalex.org/W2618122943","https://openalex.org/W2625652723","https://openalex.org/W2759319697","https://openalex.org/W2784764983","https://openalex.org/W6925357637"],"related_works":["https://openalex.org/W2158714033","https://openalex.org/W3012307849","https://openalex.org/W4386628104","https://openalex.org/W78967844","https://openalex.org/W2020355323","https://openalex.org/W3213185671","https://openalex.org/W4206945140","https://openalex.org/W2130939068","https://openalex.org/W3163717165","https://openalex.org/W2114466827"],"abstract_inverted_index":{"BACKGROUND:":[0],"Psoriasis":[1],"is":[2],"a":[3,50,58,157],"complex":[4],"multi-factorial":[5],"disease,":[6],"involving":[7],"both":[8,103,110],"genetic":[9,29],"susceptibilities":[10],"and":[11,18,30,77,86,91,112,114,128,131,154,160,173,180],"environmental":[12],"triggers.":[13],"Genome-wide":[14],"association":[15,20],"studies":[16,21],"(GWAS)":[17],"epigenome-wide":[19],"(EWAS)":[22],"have":[23],"been":[24],"carried":[25],"out":[26],"to":[27,80],"identify":[28,81],"epigenetic":[31],"variants":[32],"that":[33,88],"are":[34,89],"associated":[35,93,187],"with":[36,94,188],"psoriasis.":[37,138],"However,":[38],"these":[39],"loci":[40,73],"cannot":[41],"fully":[42],"explain":[43],"the":[44,82,106,119,129,148,151,167,184],"disease":[45],"pathogenesis.":[46],"METHODS:":[47],"To":[48],"achieve":[49],"comprehensive":[51,181],"mechanistic":[52],"understanding":[53],"of":[54,175],"psoriasis,":[55],"we":[56,146],"conducted":[57],"systems":[59],"biology":[60],"study,":[61],"integrating":[62],"multi-omics":[63,176],"datasets":[64],"including":[65],"GWAS,":[66],"EWAS,":[67],"tissue-specific":[68,142,158],"transcriptome,":[69],"expression":[70],"quantitative":[71],"trait":[72],"(eQTLs),":[74],"gene":[75,143],"networks,":[76,145],"biological":[78,116,185],"pathways":[79,155],"key":[83,163],"genes,":[84],"processes,":[85],"networks":[87],"genetically":[90],"epigenetically":[92],"psoriasis":[95,168,189],"risk.":[96],"RESULTS:":[97],"This":[98],"integrative":[99],"genomics":[100],"study":[101],"identified":[102],"well-characterized":[104],"(e.g.,":[105,118],"IL17":[107],"pathway":[108,133],"in":[109,126,134,137,156,166],"GWAS":[111,127],"EWAS)":[113,135],"novel":[115],"processes":[117],"branched":[120],"chain":[121],"amino":[122],"acid":[123],"catabolism":[124],"process":[125],"platelet":[130],"coagulation":[132],"involved":[136],"Finally,":[139],"by":[140],"utilizing":[141],"regulatory":[144,164],"unraveled":[147],"interactions":[149],"among":[150],"psoriasis-associated":[152],"genes":[153,165],"manner":[159],"detected":[161],"potential":[162],"networks.":[169],"CONCLUSIONS:":[170],"The":[171],"integration":[172],"convergence":[174],"signals":[177],"provide":[178],"deeper":[179],"insights":[182],"into":[183],"mechanisms":[186],"susceptibility.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":6}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}