{"id":"https://openalex.org/W4393951247","doi":"https://doi.org/10.1186/s12859-024-05731-8","title":"Multiple phenotype association tests based on sliced inverse regression","display_name":"Multiple phenotype association tests based on sliced inverse regression","publication_year":2024,"publication_date":"2024-04-04","ids":{"openalex":"https://openalex.org/W4393951247","doi":"https://doi.org/10.1186/s12859-024-05731-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/38575890"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-024-05731-8","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s12859-024-05731-8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-024-05731-8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-024-05731-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100550421","display_name":"Wenyuan Sun","orcid":null},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]},{"id":"https://openalex.org/I1793135","display_name":"Yanbian University","ror":"https://ror.org/039xnh269","country_code":"CN","type":"education","lineage":["https://openalex.org/I1793135"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenyuan Sun","raw_affiliation_strings":["Department of Mathematics, College of Science, Yanbian University, Yanji, 133002, Jilin, China","Key Laboratory for Applied Statistics of MOE, School of Mathematics and Statistics, Northeast Normal University, Changchun, 130024, Jilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, College of Science, Yanbian University, Yanji, 133002, Jilin, China","institution_ids":["https://openalex.org/I1793135"]},{"raw_affiliation_string":"Key Laboratory for Applied Statistics of MOE, School of Mathematics and Statistics, Northeast Normal University, Changchun, 130024, Jilin, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031308789","display_name":"Kyongson Jon","orcid":"https://orcid.org/0000-0002-1209-9808"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kyongson Jon","raw_affiliation_strings":["Faculty of Mathematics, Kim Il Sung University, Pyongyan , 999093, Democratic People's Republic of Korea","Key Laboratory for Applied Statistics of MOE, School of Mathematics and Statistics, Northeast Normal University, Changchun, 130024, Jilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Mathematics, Kim Il Sung University, Pyongyan , 999093, Democratic People's Republic of Korea","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory for Applied Statistics of MOE, School of Mathematics and Statistics, Northeast Normal University, Changchun, 130024, Jilin, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069804888","display_name":"W. J. Zhu","orcid":"https://orcid.org/0000-0002-0156-3222"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wensheng Zhu","raw_affiliation_strings":["Key Laboratory for Applied Statistics of MOE, School of Mathematics and Statistics, Northeast Normal University, Changchun, 130024, Jilin, China. wszhu@nenu.edu.cn","School of Mathematical Sciences, Harbin Normal University, Harbin, 150025, Heilongjiang, China. wszhu@nenu.edu.cn","Key Laboratory for Applied Statistics of MOE, School of Mathematics and Statistics, Northeast Normal University, Changchun, 130024, Jilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Applied Statistics of MOE, School of Mathematics and Statistics, Northeast Normal University, Changchun, 130024, Jilin, China. wszhu@nenu.edu.cn","institution_ids":[]},{"raw_affiliation_string":"School of Mathematical Sciences, Harbin Normal University, Harbin, 150025, Heilongjiang, China. wszhu@nenu.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory for Applied Statistics of MOE, School of Mathematics and Statistics, Northeast Normal University, Changchun, 130024, Jilin, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"last","author":{"id":null,"display_name":"the\u00a0Alzheimer\u2019s\u00a0Disease\u00a0Neuroimaging\u00a0Initiative","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"the\u00a0Alzheimer\u2019s\u00a0Disease\u00a0Neuroimaging\u00a0Initiative","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100550421"],"corresponding_institution_ids":["https://openalex.org/I1793135","https://openalex.org/I184983240"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05419187,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"1","first_page":"144","last_page":"144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9498999714851379,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9498999714851379,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10136","display_name":"Statistical Methods and Inference","score":0.024900000542402267,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.6383979320526123},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5523687601089478},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.5321463942527771},{"id":"https://openalex.org/keywords/curse-of-dimensionality","display_name":"Curse of dimensionality","score":0.49069440364837646},{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.485825777053833},{"id":"https://openalex.org/keywords/regression","display_name":"Regression","score":0.4362521171569824},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4173102378845215},{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.4102945029735565},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.33897727727890015},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3304709792137146},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.29318132996559143},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.29043814539909363},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2658484876155853},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24674299359321594},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.21544033288955688},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1998620629310608},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.0910581648349762}],"concepts":[{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.6383979320526123},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5523687601089478},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5321463942527771},{"id":"https://openalex.org/C111030470","wikidata":"https://www.wikidata.org/wiki/Q1430460","display_name":"Curse of dimensionality","level":2,"score":0.49069440364837646},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.485825777053833},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.4362521171569824},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4173102378845215},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.4102945029735565},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.33897727727890015},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3304709792137146},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.29318132996559143},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.29043814539909363},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2658484876155853},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24674299359321594},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.21544033288955688},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1998620629310608},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0910581648349762},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-024-05731-8","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s12859-024-05731-8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-024-05731-8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38575890","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38575890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10996256","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10996256","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10996256/pdf/12859_2024_Article_5731.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3142c9768ee44101b434dffee2fcf688","is_oa":true,"landing_page_url":"https://doaj.org/article/3142c9768ee44101b434dffee2fcf688","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 25, Iss 1, Pp 1-21 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12859-024-05731-8","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s12859-024-05731-8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-024-05731-8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1425076074","display_name":null,"funder_award_id":"12171077","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G165509557","display_name":null,"funder_award_id":"2022YFA1003701","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1828120343","display_name":null,"funder_award_id":"2022YFA1003701","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G4558216502","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7854119329","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4393951247.pdf","grobid_xml":"https://content.openalex.org/works/W4393951247.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1526540789","https://openalex.org/W1534058232","https://openalex.org/W1558143922","https://openalex.org/W1926182559","https://openalex.org/W1972467611","https://openalex.org/W1976587387","https://openalex.org/W2004844001","https://openalex.org/W2053225089","https://openalex.org/W2065397672","https://openalex.org/W2086014844","https://openalex.org/W2107199945","https://openalex.org/W2113697014","https://openalex.org/W2124204548","https://openalex.org/W2152304413","https://openalex.org/W2154777493","https://openalex.org/W2158739914","https://openalex.org/W2163490846","https://openalex.org/W2166774283","https://openalex.org/W2210351761","https://openalex.org/W2230292985","https://openalex.org/W2292058622","https://openalex.org/W2560382769","https://openalex.org/W2562266836","https://openalex.org/W2593636852","https://openalex.org/W2734233718","https://openalex.org/W2963607751","https://openalex.org/W3038676492","https://openalex.org/W4213170682","https://openalex.org/W4293780034"],"related_works":["https://openalex.org/W2594299395","https://openalex.org/W2066467839","https://openalex.org/W2111842731","https://openalex.org/W2170506381","https://openalex.org/W2765794416","https://openalex.org/W2039666944","https://openalex.org/W1531630856","https://openalex.org/W1486217206","https://openalex.org/W1992310781","https://openalex.org/W2794350630"],"abstract_inverted_index":{"BACKGROUND:":[0],"Joint":[1],"analysis":[2,141],"of":[3,8,31,45,52,99,107,131],"multiple":[4,80,83],"phenotypes":[5],"in":[6,33,41,75,90],"studies":[7,89,137],"biological":[9],"systems":[10],"such":[11],"as":[12],"Genome-Wide":[13],"Association":[14],"Studies":[15],"is":[16,71,148],"critical":[17],"to":[18,126],"revealing":[19],"the":[20,42,50,56,77,104,113,117,127,135,144],"functional":[21],"interactions":[22],"between":[23,79],"various":[24,97],"traits":[25],"and":[26,73,82,93,102,138,150],"genetic":[27,128],"variants,":[28],"but":[29],"growth":[30],"data":[32,140],"dimensionality":[34],"has":[35],"become":[36],"a":[37,65,152],"very":[38],"challenging":[39],"problem":[40],"widespread":[43],"use":[44],"joint":[46],"analysis.":[47],"To":[48],"handle":[49],"excessiveness":[51],"variables,":[53],"we":[54,63],"consider":[55,103],"sliced":[57],"inverse":[58],"regression":[59],"(SIR)":[60],"method.":[61],"Specifically,":[62],"propose":[64],"novel":[66],"SIR-based":[67,145],"association":[68,78,129,146],"test":[69,147],"that":[70,112,143],"robust":[72],"powerful":[74],"testing":[76],"predictors":[81],"outcomes.":[84],"RESULTS:":[85],"We":[86,120],"conduct":[87],"simulation":[88,136],"both":[91],"low-":[92],"high-dimensional":[94],"settings":[95],"with":[96,156],"numbers":[98],"Single-Nucleotide":[100],"Polymorphisms":[101],"correlation":[105],"structure":[106],"traits.":[108],"Simulation":[109],"results":[110],"show":[111,142],"proposed":[114],"method":[115,125],"outperforms":[116],"existing":[118],"methods.":[119],"also":[121],"successfully":[122],"apply":[123],"our":[124],"study":[130],"ADNI":[132],"dataset.":[133],"Both":[134],"real":[139],"valid":[149],"achieves":[151],"higher":[153],"efficiency":[154],"compared":[155],"its":[157],"competitors.":[158],"CONCLUSION:":[159],".":[160]},"counts_by_year":[],"updated_date":"2026-05-11T08:15:01.531666","created_date":"2025-10-10T00:00:00"}