{"id":"https://openalex.org/W1970586717","doi":"https://doi.org/10.1186/1471-2105-8-291","title":"Portraits of breast cancer progression","display_name":"Portraits of breast cancer progression","publication_year":2007,"publication_date":"2007-08-06","ids":{"openalex":"https://openalex.org/W1970586717","doi":"https://doi.org/10.1186/1471-2105-8-291","mag":"1970586717","pmid":"https://pubmed.ncbi.nlm.nih.gov/17683614"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-8-291","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-291","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-291","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-291","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067963394","display_name":"Gul S. Dalgin","orcid":null},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gul S Dalgin","raw_affiliation_strings":["Boston University, Boston, MA 02215, USA. sdalgin@bu.edu","Mol. Bio., Cell. Bio. and Biochem. Prog, Boston University, Boston, USA"],"affiliations":[{"raw_affiliation_string":"Boston University, Boston, MA 02215, USA. sdalgin@bu.edu","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Mol. Bio., Cell. Bio. and Biochem. Prog, Boston University, Boston, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037413866","display_name":"Gabriela Alexe","orcid":"https://orcid.org/0000-0002-5668-6297"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"funder","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I40036882","display_name":"Institute for Advanced Study","ror":"https://ror.org/00f809463","country_code":"US","type":"facility","lineage":["https://openalex.org/I40036882"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriela Alexe","raw_affiliation_strings":["The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, 02142, USA","The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ, 08540, USA","The Broad Institute of MIT and Harvard, Cambridge, USA","The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, USA"],"affiliations":[{"raw_affiliation_string":"The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, 02142, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ, 08540, USA","institution_ids":["https://openalex.org/I40036882","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"The Broad Institute of MIT and Harvard, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, USA","institution_ids":["https://openalex.org/I40036882","https://openalex.org/I4210155419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066476364","display_name":"Daniel Scanfeld","orcid":null},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"funder","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Scanfeld","raw_affiliation_strings":["The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, 02142, USA","The Broad Institute of MIT and Harvard, Cambridge, USA"],"affiliations":[{"raw_affiliation_string":"The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, 02142, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"The Broad Institute of MIT and Harvard, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017114712","display_name":"Pablo Tamayo","orcid":"https://orcid.org/0000-0002-9360-4668"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"funder","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pablo Tamayo","raw_affiliation_strings":["The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, 02142, USA","The Broad Institute of MIT and Harvard, Cambridge, USA"],"affiliations":[{"raw_affiliation_string":"The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, 02142, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"The Broad Institute of MIT and Harvard, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077622597","display_name":"Jill P. Mesirov","orcid":"https://orcid.org/0000-0002-9755-2818"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"funder","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jill P Mesirov","raw_affiliation_strings":["The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, 02142, USA","The Broad Institute of MIT and Harvard, Cambridge, USA"],"affiliations":[{"raw_affiliation_string":"The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, 02142, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"The Broad Institute of MIT and Harvard, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061989008","display_name":"Shridar Ganesan","orcid":"https://orcid.org/0000-0002-5404-3044"},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute of New Jersey","ror":"https://ror.org/0060x3y55","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]},{"id":"https://openalex.org/I4210154732","display_name":"Cancer Institute of Florida","ror":"https://ror.org/04my1rt02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210154732"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shridar Ganesan","raw_affiliation_strings":["Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ, 08903, USA","Cancer Institute of New Jersey, New Brunswick, USA"],"affiliations":[{"raw_affiliation_string":"Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ, 08903, USA","institution_ids":["https://openalex.org/I4210154732","https://openalex.org/I4390039325"]},{"raw_affiliation_string":"Cancer Institute of New Jersey, New Brunswick, USA","institution_ids":["https://openalex.org/I4210154732","https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027378666","display_name":"Charles DeLisi","orcid":"https://orcid.org/0000-0002-5847-1599"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210141612","display_name":"Advanced Genomic Technology (United States)","ror":"https://ror.org/03yk1a741","country_code":"US","type":"company","lineage":["https://openalex.org/I4210141612"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles DeLisi","raw_affiliation_strings":["Center for Advanced Genomic Technology, Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA","Center for Advanced Genomic Technology, Department of Biomedical Engineering, Boston University, Boston, USA"],"affiliations":[{"raw_affiliation_string":"Center for Advanced Genomic Technology, Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210141612"]},{"raw_affiliation_string":"Center for Advanced Genomic Technology, Department of Biomedical Engineering, Boston University, Boston, USA","institution_ids":["https://openalex.org/I4210141612","https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018308750","display_name":"Gyan Bhanot","orcid":"https://orcid.org/0000-0001-7822-5259"},"institutions":[{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4210109165","display_name":"Environmental and Occupational Health Sciences Institute","ror":"https://ror.org/01vta4r13","country_code":"US","type":"education","lineage":["https://openalex.org/I4210109165"]},{"id":"https://openalex.org/I4210154732","display_name":"Cancer Institute of Florida","ror":"https://ror.org/04my1rt02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210154732"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute of New Jersey","ror":"https://ror.org/0060x3y55","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]},{"id":"https://openalex.org/I40036882","display_name":"Institute for Advanced Study","ror":"https://ror.org/00f809463","country_code":"US","type":"facility","lineage":["https://openalex.org/I40036882"]},{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210141612","display_name":"Advanced Genomic Technology (United States)","ror":"https://ror.org/03yk1a741","country_code":"US","type":"company","lineage":["https://openalex.org/I4210141612"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gyan Bhanot","raw_affiliation_strings":["BioMaPS Institute and Department of Biomedical Engineering, Rutgers University, Piscataway, NJ, 08854, USA","Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ, 08903, USA","Center for Advanced Genomic Technology, Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA","The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ, 08540, USA","The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, USA","Center for Advanced Genomic Technology, Department of Biomedical Engineering, Boston University, Boston, USA","BioMaPS Institute and Department of Biomedical Engineering, Rutgers University, Piscataway, USA","Cancer Institute of New Jersey, New Brunswick, USA"],"affiliations":[{"raw_affiliation_string":"BioMaPS Institute and Department of Biomedical Engineering, Rutgers University, Piscataway, NJ, 08854, USA","institution_ids":["https://openalex.org/I4210109165"]},{"raw_affiliation_string":"Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ, 08903, USA","institution_ids":["https://openalex.org/I4210154732","https://openalex.org/I4390039325"]},{"raw_affiliation_string":"Center for Advanced Genomic Technology, Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210141612"]},{"raw_affiliation_string":"The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ, 08540, USA","institution_ids":["https://openalex.org/I40036882","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, USA","institution_ids":["https://openalex.org/I40036882","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Center for Advanced Genomic Technology, Department of Biomedical Engineering, Boston University, Boston, USA","institution_ids":["https://openalex.org/I4210141612","https://openalex.org/I111088046"]},{"raw_affiliation_string":"BioMaPS Institute and Department of Biomedical Engineering, Rutgers University, Piscataway, USA","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Cancer Institute of New Jersey, New Brunswick, USA","institution_ids":["https://openalex.org/I4210154732","https://openalex.org/I4390039325"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5018308750"],"corresponding_institution_ids":["https://openalex.org/I102322142","https://openalex.org/I111088046","https://openalex.org/I40036882","https://openalex.org/I4210109165","https://openalex.org/I4210141612","https://openalex.org/I4210154732","https://openalex.org/I4210155419","https://openalex.org/I4390039325"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.6794,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.89837828,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"8","issue":"1","first_page":"291","last_page":"291"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.7074787020683289},{"id":"https://openalex.org/keywords/ductal-carcinoma","display_name":"Ductal carcinoma","score":0.673782467842102},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5909788608551025},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5089666843414307},{"id":"https://openalex.org/keywords/genetic-heterogeneity","display_name":"Genetic heterogeneity","score":0.4452112913131714},{"id":"https://openalex.org/keywords/pathological","display_name":"Pathological","score":0.4280877113342285},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4248572587966919},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.42427128553390503},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.41749900579452515},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.3836171627044678},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.38181477785110474},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3666471242904663},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3264397978782654},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.30872201919555664},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2297290861606598},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.07867643237113953}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7074787020683289},{"id":"https://openalex.org/C2780862961","wikidata":"https://www.wikidata.org/wiki/Q5311598","display_name":"Ductal carcinoma","level":4,"score":0.673782467842102},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5909788608551025},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5089666843414307},{"id":"https://openalex.org/C64618202","wikidata":"https://www.wikidata.org/wiki/Q3733697","display_name":"Genetic heterogeneity","level":4,"score":0.4452112913131714},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4280877113342285},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4248572587966919},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.42427128553390503},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.41749900579452515},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3836171627044678},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38181477785110474},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3666471242904663},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3264397978782654},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30872201919555664},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2297290861606598},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.07867643237113953}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044584","descriptor_name":"Carcinoma, Ductal","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D044584","descriptor_name":"Carcinoma, Ductal","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D044584","descriptor_name":"Carcinoma, Ductal","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D044584","descriptor_name":"Carcinoma, Ductal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044584","descriptor_name":"Carcinoma, Ductal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044584","descriptor_name":"Carcinoma, Ductal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1186/1471-2105-8-291","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-291","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-291","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17683614","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17683614","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:dspace.mit.edu:1721.1/59307","is_oa":true,"landing_page_url":"http://hdl.handle.net/1721.1/59307","pdf_url":"http://hdl.handle.net/1721.1/59307","source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioMed Central Ltd","raw_type":"http://purl.org/eprint/type/JournalArticle"},{"id":"pmh:oai:dash.harvard.edu:1/11213333","is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:11213333","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:alma.01RUT_INST:11664888050004646","is_oa":false,"landing_page_url":"https://scholarship.libraries.rutgers.edu/esploro/outputs/journalArticle/Portraits-of-breast-cancer-progression/991031665333704646","pdf_url":null,"source":{"id":"https://openalex.org/S4210197018","display_name":"View","issn_l":"2688-268X","issn":["2688-268X","2688-3988"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:1ea5e6914c074eb199e0cb31e195f639","is_oa":true,"landing_page_url":"https://doaj.org/article/1ea5e6914c074eb199e0cb31e195f639","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 8, Iss 1, p 291 (2007)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt79k0x87f","is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/79k0x87f","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, vol 8, iss 1","raw_type":"article"},{"id":"pmh:oai:open.bu.edu:2144/3001","is_oa":true,"landing_page_url":"https://hdl.handle.net/2144/3001","pdf_url":null,"source":{"id":"https://openalex.org/S4306402183","display_name":"OpenBU/Boston University Institutional Repository (Boston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I111088046","host_organization_name":"Boston University","host_organization_lineage":["https://openalex.org/I111088046"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1978212","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1978212","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-8-291","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-291","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-291","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.800000011920929,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1970586717.pdf","grobid_xml":"https://content.openalex.org/works/W1970586717.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W109201752","https://openalex.org/W1493047032","https://openalex.org/W1493454437","https://openalex.org/W1548779692","https://openalex.org/W1970580356","https://openalex.org/W1974570521","https://openalex.org/W1985804036","https://openalex.org/W1997062019","https://openalex.org/W2002277805","https://openalex.org/W2007220571","https://openalex.org/W2033590067","https://openalex.org/W2034269086","https://openalex.org/W2036987424","https://openalex.org/W2042035594","https://openalex.org/W2044514479","https://openalex.org/W2044702943","https://openalex.org/W2047928920","https://openalex.org/W2049633694","https://openalex.org/W2071949631","https://openalex.org/W2094909687","https://openalex.org/W2097255042","https://openalex.org/W2103543394","https://openalex.org/W2109363337","https://openalex.org/W2110065044","https://openalex.org/W2122683221","https://openalex.org/W2143033696","https://openalex.org/W2146578910","https://openalex.org/W2148115950","https://openalex.org/W2161770015","https://openalex.org/W2163563958","https://openalex.org/W2170798597","https://openalex.org/W2259802687","https://openalex.org/W2488701045","https://openalex.org/W2911934539","https://openalex.org/W2913066018","https://openalex.org/W2913254968","https://openalex.org/W2999729612","https://openalex.org/W3099514962","https://openalex.org/W3148116038","https://openalex.org/W4233876876","https://openalex.org/W4245024447","https://openalex.org/W4246664177","https://openalex.org/W4249273120","https://openalex.org/W4250857377","https://openalex.org/W4252521233"],"related_works":["https://openalex.org/W2365243064","https://openalex.org/W2386699790","https://openalex.org/W2116142739","https://openalex.org/W2063918854","https://openalex.org/W2373252393","https://openalex.org/W2352462806","https://openalex.org/W2143131037","https://openalex.org/W1969552685","https://openalex.org/W3153837127","https://openalex.org/W4311009748"],"abstract_inverted_index":{"We":[0,30],"confirm":[1],"that":[2,51,71],"the":[3,13,23,45,52,61,64,72],"cancer":[4],"phenotype":[5],"can":[6],"be":[7],"identified":[8],"in":[9,16,44,75],"early":[10],"stage":[11,18],"because":[12],"genes":[14],"altered":[15],"this":[17],"progressively":[19],"alter":[20],"further":[21],"as":[22],"disease":[24,35,55,65],"progresses":[25],"through":[26],"DCIS":[27],"into":[28],"IDC.":[29],"identify":[31],"six":[32],"subtypes":[33,57,73],"of":[34,54,63],"which":[36],"have":[37],"distinct":[38,77],"genetic":[39],"signatures":[40],"and":[41],"remain":[42],"separated":[43],"clustering":[46],"hierarchy.":[47],"Our":[48],"findings":[49],"suggest":[50],"heterogeneity":[53,62],"across":[56],"is":[58],"higher":[59],"than":[60],"progression":[66],"within":[67],"a":[68],"subtype,":[69],"indicating":[70],"are":[74],"fact":[76],"diseases.":[78]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}