{"id":"https://openalex.org/W3176330383","doi":"https://doi.org/10.1186/s40708-021-00137-1","title":"Exploring highly reliable substructures in auto-reconstructions of a neuron","display_name":"Exploring highly reliable substructures in auto-reconstructions of a neuron","publication_year":2021,"publication_date":"2021-08-24","ids":{"openalex":"https://openalex.org/W3176330383","doi":"https://doi.org/10.1186/s40708-021-00137-1","mag":"3176330383","pmid":"https://pubmed.ncbi.nlm.nih.gov/34431008"},"language":"en","primary_location":{"id":"doi:10.1186/s40708-021-00137-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40708-021-00137-1","pdf_url":"https://braininformatics.springeropen.com/track/pdf/10.1186/s40708-021-00137-1","source":{"id":"https://openalex.org/S2498492389","display_name":"Brain Informatics","issn_l":"2198-4018","issn":["2198-4018","2198-4026"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://braininformatics.springeropen.com/track/pdf/10.1186/s40708-021-00137-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018461433","display_name":"Yishan He","orcid":"https://orcid.org/0000-0002-1771-6027"},"institutions":[{"id":"https://openalex.org/I37796252","display_name":"Beijing University of Technology","ror":"https://ror.org/037b1pp87","country_code":"CN","type":"education","lineage":["https://openalex.org/I37796252"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yishan He","raw_affiliation_strings":["Beijing International Collaboration Base On Brain Informatics and Wisdom Services, 100 Pingleyuan, Chaoyang District, Beijing, 100124, China","Faculty of Information Technology, Beijing University of Technology, 100 Pingleyuan, Chaoyang District, Beijing, 100124, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing International Collaboration Base On Brain Informatics and Wisdom Services, 100 Pingleyuan, Chaoyang District, Beijing, 100124, China","institution_ids":[]},{"raw_affiliation_string":"Faculty of Information Technology, Beijing University of Technology, 100 Pingleyuan, Chaoyang District, Beijing, 100124, China","institution_ids":["https://openalex.org/I37796252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079270412","display_name":"Jiajin Huang","orcid":"https://orcid.org/0000-0002-7495-3440"},"institutions":[{"id":"https://openalex.org/I37796252","display_name":"Beijing University of Technology","ror":"https://ror.org/037b1pp87","country_code":"CN","type":"education","lineage":["https://openalex.org/I37796252"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajin Huang","raw_affiliation_strings":["Beijing International Collaboration Base On Brain Informatics and Wisdom Services, 100 Pingleyuan, Chaoyang District, Beijing, 100124, China","Faculty of Information Technology, Beijing University of Technology, 100 Pingleyuan, Chaoyang District, Beijing, 100124, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing International Collaboration Base On Brain Informatics and Wisdom Services, 100 Pingleyuan, Chaoyang District, Beijing, 100124, China","institution_ids":[]},{"raw_affiliation_string":"Faculty of Information Technology, Beijing University of Technology, 100 Pingleyuan, Chaoyang District, Beijing, 100124, China","institution_ids":["https://openalex.org/I37796252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103637441","display_name":"Gaowei Wu","orcid":"https://orcid.org/0000-0003-2104-972X"},"institutions":[{"id":"https://openalex.org/I4210094879","display_name":"Shandong Institute of Automation","ror":"https://ror.org/00qdtba35","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210094879","https://openalex.org/I4210142748"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gaowei Wu","raw_affiliation_strings":["Institute of Automation, Chinese Academy of Sciences, Haidian District, 95 Zhongguancun East Road, Beijing, 100190, China","School of Artificial Intelligence, University of Chinese Academy of Sciences, 19(A) Yuquan Road, Shijingshan District, Beijing, 100049, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Automation, Chinese Academy of Sciences, Haidian District, 95 Zhongguancun East Road, Beijing, 100190, China","institution_ids":["https://openalex.org/I4210094879"]},{"raw_affiliation_string":"School of Artificial Intelligence, University of Chinese Academy of Sciences, 19(A) Yuquan Road, Shijingshan District, Beijing, 100049, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101507281","display_name":"Jian Yang","orcid":"https://orcid.org/0000-0002-8922-7687"},"institutions":[{"id":"https://openalex.org/I37796252","display_name":"Beijing University of Technology","ror":"https://ror.org/037b1pp87","country_code":"CN","type":"education","lineage":["https://openalex.org/I37796252"]},{"id":"https://openalex.org/I4210100255","display_name":"Beijing Academy of Artificial Intelligence","ror":"https://ror.org/016a74861","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210100255"]},{"id":"https://openalex.org/I4210164898","display_name":"Beijing Chaoyang Emergency Medical Center","ror":"https://ror.org/05anb7a53","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164898"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Yang","raw_affiliation_strings":["Beijing International Collaboration Base On Brain Informatics and Wisdom Services, 100 Pingleyuan, Chaoyang District, Beijing, 100124, China. jianyang@bjut.edu.cn","Faculty of Information Technology, Beijing University of Technology, 100 Pingleyuan, Chaoyang District, Beijing, 100124, China. jianyang@bjut.edu.cn","School of Artificial Intelligence, University of Chinese Academy of Sciences, 19(A) Yuquan Road, Shijingshan District, Beijing, 100049, China. jianyang@bjut.edu.cn","Beijing International Collaboration Base On Brain Informatics and Wisdom Services, 100 Pingleyuan, Chaoyang District, Beijing, 100124, China","Faculty of Information Technology, Beijing University of Technology, 100 Pingleyuan, Chaoyang District, Beijing, 100124, China","School of Artificial Intelligence, University of Chinese Academy of Sciences, 19(A) Yuquan Road, Shijingshan District, Beijing, 100049, China"],"raw_orcid":"https://orcid.org/0000-0002-8922-7687","affiliations":[{"raw_affiliation_string":"Beijing International Collaboration Base On Brain Informatics and Wisdom Services, 100 Pingleyuan, Chaoyang District, Beijing, 100124, China. jianyang@bjut.edu.cn","institution_ids":["https://openalex.org/I4210164898"]},{"raw_affiliation_string":"Faculty of Information Technology, Beijing University of Technology, 100 Pingleyuan, Chaoyang District, Beijing, 100124, China. jianyang@bjut.edu.cn","institution_ids":["https://openalex.org/I37796252","https://openalex.org/I4210164898"]},{"raw_affiliation_string":"School of Artificial Intelligence, University of Chinese Academy of Sciences, 19(A) Yuquan Road, Shijingshan District, Beijing, 100049, China. jianyang@bjut.edu.cn","institution_ids":["https://openalex.org/I4210100255","https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Beijing International Collaboration Base On Brain Informatics and Wisdom Services, 100 Pingleyuan, Chaoyang District, Beijing, 100124, China","institution_ids":[]},{"raw_affiliation_string":"Faculty of Information Technology, Beijing University of Technology, 100 Pingleyuan, Chaoyang District, Beijing, 100124, China","institution_ids":["https://openalex.org/I37796252"]},{"raw_affiliation_string":"School of Artificial Intelligence, University of Chinese Academy of Sciences, 19(A) Yuquan Road, Shijingshan District, Beijing, 100049, China","institution_ids":["https://openalex.org/I4210165038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5018461433"],"corresponding_institution_ids":["https://openalex.org/I37796252"],"apc_list":{"value":790,"currency":"GBP","value_usd":969},"apc_paid":{"value":790,"currency":"GBP","value_usd":969},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04376544,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"1","first_page":"17","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9775999784469604,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6794553995132446},{"id":"https://openalex.org/keywords/tracing","display_name":"Tracing","score":0.6560176610946655},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5557575821876526},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5270445942878723},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4660326838493347},{"id":"https://openalex.org/keywords/3d-reconstruction","display_name":"3D reconstruction","score":0.45585545897483826},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.3303258419036865}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6794553995132446},{"id":"https://openalex.org/C138673069","wikidata":"https://www.wikidata.org/wiki/Q322229","display_name":"Tracing","level":2,"score":0.6560176610946655},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5557575821876526},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5270445942878723},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4660326838493347},{"id":"https://openalex.org/C109950114","wikidata":"https://www.wikidata.org/wiki/Q4464732","display_name":"3D reconstruction","level":2,"score":0.45585545897483826},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.3303258419036865},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s40708-021-00137-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40708-021-00137-1","pdf_url":"https://braininformatics.springeropen.com/track/pdf/10.1186/s40708-021-00137-1","source":{"id":"https://openalex.org/S2498492389","display_name":"Brain Informatics","issn_l":"2198-4018","issn":["2198-4018","2198-4026"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Informatics","raw_type":"journal-article"},{"id":"pmid:34431008","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34431008","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain informatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:c38b324b3579440cbbf4c61d8a0f4348","is_oa":true,"landing_page_url":"https://doaj.org/article/c38b324b3579440cbbf4c61d8a0f4348","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain Informatics, Vol 8, Iss 1, Pp 1-10 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8384950","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8384950","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain Inform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s40708-021-00137-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40708-021-00137-1","pdf_url":"https://braininformatics.springeropen.com/track/pdf/10.1186/s40708-021-00137-1","source":{"id":"https://openalex.org/S2498492389","display_name":"Brain Informatics","issn_l":"2198-4018","issn":["2198-4018","2198-4026"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Informatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Sustainable cities and communities","id":"https://metadata.un.org/sdg/11","score":0.550000011920929}],"awards":[],"funders":[{"id":"https://openalex.org/F4320333617","display_name":"Beijing Advanced Innovation Center for Imaging Technology","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3176330383.pdf","grobid_xml":"https://content.openalex.org/works/W3176330383.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1508135620","https://openalex.org/W1814698663","https://openalex.org/W1885626623","https://openalex.org/W1969963182","https://openalex.org/W1989396876","https://openalex.org/W2000018820","https://openalex.org/W2011650974","https://openalex.org/W2014252132","https://openalex.org/W2018227909","https://openalex.org/W2019305522","https://openalex.org/W2036901575","https://openalex.org/W2047951563","https://openalex.org/W2071646331","https://openalex.org/W2088687438","https://openalex.org/W2092859932","https://openalex.org/W2106091890","https://openalex.org/W2124257654","https://openalex.org/W2138342944","https://openalex.org/W2153965609","https://openalex.org/W2156114286","https://openalex.org/W2178605380","https://openalex.org/W2256981962","https://openalex.org/W2404192493","https://openalex.org/W2548266803","https://openalex.org/W2560171554","https://openalex.org/W2587001086","https://openalex.org/W2602766962","https://openalex.org/W2884739365","https://openalex.org/W2952846208","https://openalex.org/W3013692235","https://openalex.org/W3094232608","https://openalex.org/W3156926590"],"related_works":["https://openalex.org/W2051487156","https://openalex.org/W2073681303","https://openalex.org/W2888673113","https://openalex.org/W2056065966","https://openalex.org/W2352602608","https://openalex.org/W2062641654","https://openalex.org/W2212288070","https://openalex.org/W3149975758","https://openalex.org/W1517786189","https://openalex.org/W3165233182"],"abstract_inverted_index":{"The":[0,124],"digital":[1],"reconstruction":[2,36,42,107,170,203,210],"of":[3,87,131,212],"a":[4,35,41,46,75,88,104,202],"neuron":[5,19],"is":[6,30,43,127,171],"the":[7,92,121],"most":[8],"direct":[9],"and":[10,66,108,112,157,192],"effective":[11],"way":[12],"to":[13,32,80,98,116,196],"investigate":[14],"its":[15,176],"morphology.":[16],"Many":[17],"automatic":[18,52,85,209],"tracing":[20,53,142],"methods":[21,54],"have":[22,158,179],"been":[23],"proposed,":[24],"but":[25],"without":[26],"manual":[27],"check":[28],"it":[29],"difficult":[31],"know":[33],"whether":[34],"or":[37,58,204],"which":[38,136],"substructure":[39],"in":[40,84,96,189],"accurate.":[44],"For":[45],"neuron's":[47],"reconstructions":[48,86,130,156,165,207],"generated":[49,138],"by":[50,139],"multiple":[51,109,133,190],"with":[55],"different":[56,213],"principles":[57],"models,":[59],"their":[60],"common":[61,186],"substructures":[62,188,200],"are":[63,137,150],"highly":[64],"reliable":[65],"named":[67],"individual":[68,82,118,148,177],"motifs.":[69],"In":[70],"this":[71],"work,":[72],"we":[73],"propose":[74],"Vaa3D-based":[76],"method":[77],"called":[78],"Lamotif":[79,90,126],"explore":[81],"motifs":[83,119,149,178,184],"neuron.":[89],"utilizes":[91],"local":[93,100],"alignment":[94,101],"algorithm":[95],"BlastNeuron":[97],"extract":[99],"pairs":[102,115],"between":[103],"specified":[105],"objective":[106,122,164,169],"reference":[110],"reconstructions,":[111,191],"combines":[113],"these":[114],"generate":[117],"on":[120,129,152],"reconstruction.":[123],"proposed":[125],"evaluated":[128],"163":[132],"species":[134],"neurons,":[135],"four":[140],"state-of-the-art":[141],"methods.":[143],"Experimental":[144],"results":[145],"show":[146],"that":[147],"almost":[151],"corresponding":[153],"gold":[154],"standard":[155],"much":[159],"higher":[160],"precision":[161],"rate":[162],"than":[163],"themselves.":[166],"Furthermore,":[167],"an":[168],"mostly":[172],"quite":[173],"accurate":[174,199,206],"if":[175],"high":[180],"recall":[181],"rate.":[182],"Individual":[183],"contain":[185],"geometry":[187],"can":[193],"be":[194],"used":[195],"select":[197],"some":[198,205],"from":[201,208],"dataset":[211],"neurons.":[214]},"counts_by_year":[],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}