{"id":"https://openalex.org/W2949985147","doi":"https://doi.org/10.1186/s40708-018-0091-0","title":"A structural equation model for imaging genetics using spatial transcriptomics","display_name":"A structural equation model for imaging genetics using spatial transcriptomics","publication_year":2018,"publication_date":"2018-11-02","ids":{"openalex":"https://openalex.org/W2949985147","doi":"https://doi.org/10.1186/s40708-018-0091-0","mag":"2949985147","pmid":"https://pubmed.ncbi.nlm.nih.gov/30390165"},"language":"en","primary_location":{"id":"doi:10.1186/s40708-018-0091-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40708-018-0091-0","pdf_url":"https://braininformatics.springeropen.com/track/pdf/10.1186/s40708-018-0091-0","source":{"id":"https://openalex.org/S2498492389","display_name":"Brain Informatics","issn_l":"2198-4018","issn":["2198-4018","2198-4026"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://braininformatics.springeropen.com/track/pdf/10.1186/s40708-018-0091-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"for the Alzheimer\u2019s Disease Neuroimaging Initiative","orcid":null},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"for the Alzheimer\u2019s Disease Neuroimaging Initiative","raw_affiliation_strings":["Leiden Computational Biology Center, Leiden University Medical Center, Leiden, the Netherlands","Delft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands"],"affiliations":[{"raw_affiliation_string":"Leiden Computational Biology Center, Leiden University Medical Center, Leiden, the Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Delft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054898871","display_name":"Sjoerd M. H. Huisman","orcid":"https://orcid.org/0000-0002-4322-8289"},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sjoerd M. H. Huisman","raw_affiliation_strings":["Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands","Leiden Computational Biology Center, Leiden University Medical Center, Leiden, The Netherlands","Leiden Computational Biology Center, Leiden University Medical Center, Leiden, the Netherlands","Delft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands"],"affiliations":[{"raw_affiliation_string":"Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]},{"raw_affiliation_string":"Leiden Computational Biology Center, Leiden University Medical Center, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Leiden Computational Biology Center, Leiden University Medical Center, Leiden, the Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Delft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006562407","display_name":"Ahmed Mahfouz","orcid":"https://orcid.org/0000-0001-8601-2149"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Ahmed Mahfouz","raw_affiliation_strings":["Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands","Leiden Computational Biology Center, Leiden University Medical Center, Leiden, The Netherlands","Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, USA"],"affiliations":[{"raw_affiliation_string":"Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]},{"raw_affiliation_string":"Leiden Computational Biology Center, Leiden University Medical Center, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031717623","display_name":"Kayhan Batmanghelich","orcid":"https://orcid.org/0000-0001-9893-9136"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Nematollah K. Batmanghelich","raw_affiliation_strings":["Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA","Leiden Computational Biology Center, Leiden University Medical Center, Leiden, The Netherlands","Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Leiden Computational Biology Center, Leiden University Medical Center, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019003563","display_name":"Boudewijn P. F. Lelieveldt","orcid":"https://orcid.org/0000-0001-8269-7603"},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Boudewijn P. F. Lelieveldt","raw_affiliation_strings":["Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands","Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands","Leiden Computational Biology Center, Leiden University Medical Center, Leiden, The Netherlands","Delft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands","Leiden Computational Biology Center, Leiden University Medical Center, Leiden, the Netherlands"],"affiliations":[{"raw_affiliation_string":"Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]},{"raw_affiliation_string":"Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Leiden Computational Biology Center, Leiden University Medical Center, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Delft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands","institution_ids":["https://openalex.org/I98358874"]},{"raw_affiliation_string":"Leiden Computational Biology Center, Leiden University Medical Center, Leiden, the Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052699801","display_name":"Marcel Reinders","orcid":"https://orcid.org/0000-0002-1148-1562"},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marcel J. T. Reinders","raw_affiliation_strings":["Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands. m.j.t.reinders@tudelft.nl","Leiden Computational Biology Center, Leiden University Medical Center, Leiden, The Netherlands. m.j.t.reinders@tudelft.nl"],"affiliations":[{"raw_affiliation_string":"Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands. m.j.t.reinders@tudelft.nl","institution_ids":["https://openalex.org/I98358874"]},{"raw_affiliation_string":"Leiden Computational Biology Center, Leiden University Medical Center, Leiden, The Netherlands. m.j.t.reinders@tudelft.nl","institution_ids":["https://openalex.org/I2800006345"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2800006345","https://openalex.org/I98358874"],"apc_list":{"value":790,"currency":"GBP","value_usd":969},"apc_paid":{"value":790,"currency":"GBP","value_usd":969},"fwci":0.5433,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.74738739,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"5","issue":"2","first_page":"13","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10136","display_name":"Statistical Methods and Inference","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9764999747276306,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/imaging-genetics","display_name":"Imaging genetics","score":0.8590835928916931},{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.7780236005783081},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.655469536781311},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.6478909254074097},{"id":"https://openalex.org/keywords/structural-equation-modeling","display_name":"Structural equation modeling","score":0.5995973348617554},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.47811856865882874},{"id":"https://openalex.org/keywords/genetic-model","display_name":"Genetic model","score":0.4460839629173279},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4220293164253235},{"id":"https://openalex.org/keywords/dimensionality-reduction","display_name":"Dimensionality reduction","score":0.4218651056289673},{"id":"https://openalex.org/keywords/latent-variable","display_name":"Latent variable","score":0.41688984632492065},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4106854200363159},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4103364944458008},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.29847440123558044},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2901410460472107},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1639101505279541},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.1484612226486206}],"concepts":[{"id":"https://openalex.org/C18183760","wikidata":"https://www.wikidata.org/wiki/Q6002833","display_name":"Imaging genetics","level":3,"score":0.8590835928916931},{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.7780236005783081},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.655469536781311},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.6478909254074097},{"id":"https://openalex.org/C71104824","wikidata":"https://www.wikidata.org/wiki/Q1476639","display_name":"Structural equation modeling","level":2,"score":0.5995973348617554},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.47811856865882874},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.4460839629173279},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4220293164253235},{"id":"https://openalex.org/C70518039","wikidata":"https://www.wikidata.org/wiki/Q16000077","display_name":"Dimensionality reduction","level":2,"score":0.4218651056289673},{"id":"https://openalex.org/C51167844","wikidata":"https://www.wikidata.org/wiki/Q4422623","display_name":"Latent variable","level":2,"score":0.41688984632492065},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4106854200363159},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4103364944458008},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29847440123558044},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2901410460472107},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1639101505279541},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1484612226486206},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1186/s40708-018-0091-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40708-018-0091-0","pdf_url":"https://braininformatics.springeropen.com/track/pdf/10.1186/s40708-018-0091-0","source":{"id":"https://openalex.org/S2498492389","display_name":"Brain Informatics","issn_l":"2198-4018","issn":["2198-4018","2198-4026"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Informatics","raw_type":"journal-article"},{"id":"pmid:30390165","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30390165","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain informatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:f2b46be8d2cf404f90e914bee3a56a9c","is_oa":true,"landing_page_url":"https://doaj.org/article/f2b46be8d2cf404f90e914bee3a56a9c","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain Informatics, Vol 5, Iss 2, Pp 1-10 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5412295","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6429169","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_2972894","is_oa":false,"landing_page_url":"https://hdl.handle.net/1887/70357","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain Informatics","raw_type":"Article / Letter to editor"},{"id":"pmh:ul:oai:scholarlypublications.universiteitleiden.nl:item_2972894","is_oa":true,"landing_page_url":"http://hdl.handle.net/1887/70357","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain Informatics, 5, 13","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s40708-018-0091-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40708-018-0091-0","pdf_url":"https://braininformatics.springeropen.com/track/pdf/10.1186/s40708-018-0091-0","source":{"id":"https://openalex.org/S2498492389","display_name":"Brain Informatics","issn_l":"2198-4018","issn":["2198-4018","2198-4026"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Informatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1095062678","display_name":null,"funder_award_id":"604102","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G1844275805","display_name":null,"funder_award_id":"12721","funder_id":"https://openalex.org/F4320334893","funder_display_name":"Stichting voor de Technische Wetenschappen"},{"id":"https://openalex.org/G2138066930","display_name":null,"funder_award_id":"STW Project 12721","funder_id":"https://openalex.org/F4320334893","funder_display_name":"Stichting voor de Technische Wetenschappen"},{"id":"https://openalex.org/G2692112574","display_name":null,"funder_award_id":"604102","funder_id":"https://openalex.org/F4320338370","funder_display_name":"FP7 Information and Communication Technologies"},{"id":"https://openalex.org/G2973790809","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3609240744","display_name":null,"funder_award_id":"1R01HL141813-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3829048491","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3981126665","display_name":null,"funder_award_id":"Seventh Framework Programme","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5593277320","display_name":null,"funder_award_id":"2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5702163051","display_name":null,"funder_award_id":"FP7/2007","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8051717526","display_name":null,"funder_award_id":"Grant","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8159361754","display_name":null,"funder_award_id":"Human Brain Project","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320794","display_name":"Canterbury Medical Research Foundation","ror":"https://ror.org/01kr2nz80"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334893","display_name":"Stichting voor de Technische Wetenschappen","ror":"https://ror.org/057tq3593"},{"id":"https://openalex.org/F4320338370","display_name":"FP7 Information and Communication Technologies","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2949985147.pdf","grobid_xml":"https://content.openalex.org/works/W2949985147.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1498123445","https://openalex.org/W1533942137","https://openalex.org/W1913957972","https://openalex.org/W1968258442","https://openalex.org/W1974565082","https://openalex.org/W1987653354","https://openalex.org/W1999530134","https://openalex.org/W2027662587","https://openalex.org/W2046847841","https://openalex.org/W2055655674","https://openalex.org/W2059334100","https://openalex.org/W2078059415","https://openalex.org/W2078524519","https://openalex.org/W2081984303","https://openalex.org/W2104048700","https://openalex.org/W2113506774","https://openalex.org/W2115779804","https://openalex.org/W2116668074","https://openalex.org/W2138821455","https://openalex.org/W2140054173","https://openalex.org/W2149916722","https://openalex.org/W2155513557","https://openalex.org/W2164201168","https://openalex.org/W2165314777","https://openalex.org/W2194391519","https://openalex.org/W2272246971","https://openalex.org/W2302574298","https://openalex.org/W2317350755","https://openalex.org/W2552372495","https://openalex.org/W2580386331","https://openalex.org/W2780645571","https://openalex.org/W4298091299"],"related_works":["https://openalex.org/W2905433371","https://openalex.org/W2888392564","https://openalex.org/W4310278675","https://openalex.org/W4388422664","https://openalex.org/W4390569940","https://openalex.org/W4361193272","https://openalex.org/W2963326959","https://openalex.org/W4388685194","https://openalex.org/W4396678544","https://openalex.org/W2156897583"],"abstract_inverted_index":{"Imaging":[0],"genetics":[1],"deals":[2],"with":[3,28],"relationships":[4,18],"between":[5,19],"genetic":[6,23,61,112],"variation":[7],"and":[8,22,33,66,105,137,148],"imaging":[9,67],"variables,":[10],"often":[11],"in":[12,101,108,144],"a":[13,57,73,102,145,151],"disease":[14,103],"context.":[15],"The":[16,140],"complex":[17],"brain":[20,98],"volumes":[21],"variants":[24],"have":[25],"been":[26],"explored":[27],"both":[29],"dimension":[30,85],"reduction":[31],"methods":[32],"model-based":[34],"approaches.":[35],"However,":[36],"these":[37],"models":[38,91],"usually":[39],"do":[40],"not":[41],"make":[42,115],"use":[43,88,116],"of":[44,48,52,84,117,154],"the":[45,49,78,82,124,131,155],"extensive":[46],"knowledge":[47],"spatio-anatomical":[50],"patterns":[51],"gene":[53],"activity.":[54],"We":[55,87,114],"present":[56],"method":[58],"for":[59],"integrating":[60],"markers":[62],"(single":[63],"nucleotide":[64],"polymorphisms)":[65],"features,":[68],"which":[69,106,134],"is":[70,142],"based":[71],"on":[72,150],"causal":[74],"model":[75,132,141],"and,":[76],"at":[77],"same":[79],"time,":[80],"uses":[81],"power":[83],"reduction.":[86],"structural":[89],"equation":[90],"to":[92,129],"find":[93],"latent":[94],"variables":[95],"that":[96],"explain":[97],"volume":[99],"changes":[100],"context,":[104],"are":[107],"turn":[109],"affected":[110],"by":[111],"variants.":[113],"publicly":[118],"available":[119],"spatial":[120],"transcriptome":[121],"data":[122],"from":[123],"Allen":[125],"Human":[126],"Brain":[127],"Atlas":[128],"specify":[130],"structure,":[133],"reduces":[135],"noise":[136],"improves":[138],"interpretability.":[139],"tested":[143],"simulation":[146],"setting":[147],"applied":[149],"case":[152],"study":[153],"Alzheimer's":[156],"Disease":[157],"Neuroimaging":[158],"Initiative.":[159]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}