{"id":"https://openalex.org/W4415376259","doi":"https://doi.org/10.1186/s40537-025-01279-3","title":"Effects of hearing difficulty on stroke: retrospective cohort and mendelian randomization studies","display_name":"Effects of hearing difficulty on stroke: retrospective cohort and mendelian randomization studies","publication_year":2025,"publication_date":"2025-10-21","ids":{"openalex":"https://openalex.org/W4415376259","doi":"https://doi.org/10.1186/s40537-025-01279-3"},"language":"en","primary_location":{"id":"doi:10.1186/s40537-025-01279-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40537-025-01279-3","pdf_url":"https://journalofbigdata.springeropen.com/counter/pdf/10.1186/s40537-025-01279-3","source":{"id":"https://openalex.org/S2737955091","display_name":"Journal Of Big Data","issn_l":"2196-1115","issn":["2196-1115"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Big Data","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journalofbigdata.springeropen.com/counter/pdf/10.1186/s40537-025-01279-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002245645","display_name":"Dougho Park","orcid":"https://orcid.org/0000-0002-1288-470X"},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Dougho Park","raw_affiliation_strings":["Department of Rehabilitation Medicine, Pohang Stroke and Spine Hospital, Pohang, South Korea","Medical Science and Engineering, Graduate School of Convergence Science and Technology, Pohang University of Science and Technology, Pohang, South Korea"],"raw_orcid":"https://orcid.org/0000-0002-1288-470X","affiliations":[{"raw_affiliation_string":"Department of Rehabilitation Medicine, Pohang Stroke and Spine Hospital, Pohang, South Korea","institution_ids":[]},{"raw_affiliation_string":"Medical Science and Engineering, Graduate School of Convergence Science and Technology, Pohang University of Science and Technology, Pohang, South Korea","institution_ids":["https://openalex.org/I123900574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036490123","display_name":"Myeonghwan Bang","orcid":"https://orcid.org/0000-0002-5560-2397"},"institutions":[{"id":"https://openalex.org/I4210132713","display_name":"National Health Insurance Service Ilsan Hospital","ror":"https://ror.org/03c8k9q07","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210132713"]},{"id":"https://openalex.org/I4210156723","display_name":"National Health Insurance Service","ror":"https://ror.org/05efm5n07","country_code":"KR","type":"other","lineage":["https://openalex.org/I4210156723"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Myeonghwan Bang","raw_affiliation_strings":["Department of Physical Medicine and Rehabilitation, National Health Insurance Service Ilsan Hospital, Goyang, South Korea"],"raw_orcid":"https://orcid.org/0000-0002-5560-2397","affiliations":[{"raw_affiliation_string":"Department of Physical Medicine and Rehabilitation, National Health Insurance Service Ilsan Hospital, Goyang, South Korea","institution_ids":["https://openalex.org/I4210156723","https://openalex.org/I4210132713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048138131","display_name":"Seungsoo Kim","orcid":"https://orcid.org/0000-0002-6602-633X"},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seungsoo Kim","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-6602-633X","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079662741","display_name":"Yousin Suh","orcid":"https://orcid.org/0000-0002-9275-6192"},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yousin Suh","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-9275-6192","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101951405","display_name":"Hyoung Seop Kim","orcid":"https://orcid.org/0000-0002-5310-4802"},"institutions":[{"id":"https://openalex.org/I4210132713","display_name":"National Health Insurance Service Ilsan Hospital","ror":"https://ror.org/03c8k9q07","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210132713"]},{"id":"https://openalex.org/I4210156723","display_name":"National Health Insurance Service","ror":"https://ror.org/05efm5n07","country_code":"KR","type":"other","lineage":["https://openalex.org/I4210156723"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyoung Seop Kim","raw_affiliation_strings":["Department of Physical Medicine and Rehabilitation, National Health Insurance Service Ilsan Hospital, Goyang, South Korea","Department of Rehabilitation Medicine, Pohang Stroke and Spine Hospital, Pohang, South Korea"],"raw_orcid":"https://orcid.org/0000-0002-5310-4802","affiliations":[{"raw_affiliation_string":"Department of Physical Medicine and Rehabilitation, National Health Insurance Service Ilsan Hospital, Goyang, South Korea","institution_ids":["https://openalex.org/I4210156723","https://openalex.org/I4210132713"]},{"raw_affiliation_string":"Department of Rehabilitation Medicine, Pohang Stroke and Spine Hospital, Pohang, South Korea","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100434737","display_name":"Jong Hun Kim","orcid":"https://orcid.org/0000-0002-2594-1048"},"institutions":[{"id":"https://openalex.org/I3132035342","display_name":"Ansan University","ror":"https://ror.org/04zzths72","country_code":"KR","type":"education","lineage":["https://openalex.org/I3132035342"]},{"id":"https://openalex.org/I4210132713","display_name":"National Health Insurance Service Ilsan Hospital","ror":"https://ror.org/03c8k9q07","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210132713"]},{"id":"https://openalex.org/I4210156723","display_name":"National Health Insurance Service","ror":"https://ror.org/05efm5n07","country_code":"KR","type":"other","lineage":["https://openalex.org/I4210156723"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong Hun Kim","raw_affiliation_strings":["Department of Neurology, Korea University Ansan Hospital, 123, Jeokgeum-ro, Ansan, 15355, Republic of Korea","Department of Neurology, National Health Insurance Service Ilsan Hospital, Goyang, South Korea"],"raw_orcid":"https://orcid.org/0000-0002-2594-1048","affiliations":[{"raw_affiliation_string":"Department of Neurology, Korea University Ansan Hospital, 123, Jeokgeum-ro, Ansan, 15355, Republic of Korea","institution_ids":["https://openalex.org/I3132035342"]},{"raw_affiliation_string":"Department of Neurology, National Health Insurance Service Ilsan Hospital, Goyang, South Korea","institution_ids":["https://openalex.org/I4210156723","https://openalex.org/I4210132713"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5002245645"],"corresponding_institution_ids":["https://openalex.org/I123900574"],"apc_list":{"value":1060,"currency":"GBP","value_usd":1300},"apc_paid":{"value":1060,"currency":"GBP","value_usd":1300},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30721532,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9944000244140625,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9944000244140625,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9793000221252441,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.9473999738693237,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mendelian-randomization","display_name":"Mendelian randomization","score":0.8686000108718872},{"id":"https://openalex.org/keywords/propensity-score-matching","display_name":"Propensity score matching","score":0.7516000270843506},{"id":"https://openalex.org/keywords/confounding","display_name":"Confounding","score":0.7203999757766724},{"id":"https://openalex.org/keywords/hazard-ratio","display_name":"Hazard ratio","score":0.691100001335144},{"id":"https://openalex.org/keywords/retrospective-cohort-study","display_name":"Retrospective cohort study","score":0.6741999983787537},{"id":"https://openalex.org/keywords/stroke","display_name":"Stroke (engine)","score":0.5794000029563904},{"id":"https://openalex.org/keywords/observational-study","display_name":"Observational study","score":0.5580999851226807},{"id":"https://openalex.org/keywords/biobank","display_name":"Biobank","score":0.5428000092506409},{"id":"https://openalex.org/keywords/proportional-hazards-model","display_name":"Proportional hazards model","score":0.5424000024795532}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.8686000108718872},{"id":"https://openalex.org/C17923572","wikidata":"https://www.wikidata.org/wiki/Q7250160","display_name":"Propensity score matching","level":2,"score":0.7516000270843506},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7249000072479248},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.7203999757766724},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.691100001335144},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.6741999983787537},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5794000029563904},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5580999851226807},{"id":"https://openalex.org/C116567970","wikidata":"https://www.wikidata.org/wiki/Q864217","display_name":"Biobank","level":2,"score":0.5428000092506409},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5424000024795532},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.49050000309944153},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.48739999532699585},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.41769999265670776},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3456999957561493},{"id":"https://openalex.org/C2779668873","wikidata":"https://www.wikidata.org/wiki/Q6693756","display_name":"Lower risk","level":3,"score":0.34459999203681946},{"id":"https://openalex.org/C165064840","wikidata":"https://www.wikidata.org/wiki/Q1321061","display_name":"Matching (statistics)","level":2,"score":0.3050000071525574},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.30090001225471497},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.2759000062942505},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.2734000086784363},{"id":"https://openalex.org/C2779318504","wikidata":"https://www.wikidata.org/wiki/Q1438035","display_name":"Research design","level":2,"score":0.2696000039577484},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.26840001344680786},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.262800008058548},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.25949999690055847},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.257099986076355}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/s40537-025-01279-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40537-025-01279-3","pdf_url":"https://journalofbigdata.springeropen.com/counter/pdf/10.1186/s40537-025-01279-3","source":{"id":"https://openalex.org/S2737955091","display_name":"Journal Of Big Data","issn_l":"2196-1115","issn":["2196-1115"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Big Data","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:60c67d43e5b54d77968142ea37c364a1","is_oa":true,"landing_page_url":"https://doaj.org/article/60c67d43e5b54d77968142ea37c364a1","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Big Data, Vol 12, Iss 1, Pp 1-13 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s40537-025-01279-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40537-025-01279-3","pdf_url":"https://journalofbigdata.springeropen.com/counter/pdf/10.1186/s40537-025-01279-3","source":{"id":"https://openalex.org/S2737955091","display_name":"Journal Of Big Data","issn_l":"2196-1115","issn":["2196-1115"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Big Data","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4415376259.pdf"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W2139265416","https://openalex.org/W2143943302","https://openalex.org/W2490528887","https://openalex.org/W2757321799","https://openalex.org/W2779763511","https://openalex.org/W2779914462","https://openalex.org/W2791863121","https://openalex.org/W2805983714","https://openalex.org/W2818417770","https://openalex.org/W2894620986","https://openalex.org/W2895486342","https://openalex.org/W2897181378","https://openalex.org/W2915948485","https://openalex.org/W2923153702","https://openalex.org/W3119800676","https://openalex.org/W3120603588","https://openalex.org/W3135774079","https://openalex.org/W3157971051","https://openalex.org/W3165032494","https://openalex.org/W3200162158","https://openalex.org/W3210682982","https://openalex.org/W4211103501","https://openalex.org/W4220966186","https://openalex.org/W4317390883","https://openalex.org/W4380576400","https://openalex.org/W4385577954","https://openalex.org/W4390953346","https://openalex.org/W4392734974","https://openalex.org/W4394620038","https://openalex.org/W4402242712","https://openalex.org/W4403202152","https://openalex.org/W4405443499"],"related_works":[],"abstract_inverted_index":{"Despite":[0],"observational":[1,203,271],"studies":[2,204,276],"associating":[3],"hearing":[4],"difficulty":[5],"(HD)":[6],"with":[7,99,270],"an":[8],"increased":[9,209],"risk":[10,97,211],"of":[11,70,212],"stroke,":[12,263,290],"biases,":[13],"such":[14],"as":[15],"confounding":[16],"and":[17,31,39,60,80,88,113,165,233,262,299],"reverse":[18],"causation,":[19],"remain.":[20],"This":[21,62,248],"study":[22,249],"aimed":[23],"to":[24,94,127,145,177,195,228,242,260,295],"elucidate":[25],"the":[26,56,71,210,216,281],"causal":[27,109,161,255],"relationship":[28],"between":[29,111,163,257],"HD":[30,112,164,207,261,286],"stroke":[32,96,114,166,213],"more":[33],"definitively":[34],"using":[35,51],"Mendelian":[36,48],"randomization":[37,49],"(MR)":[38],"retrospective":[40,67,272],"cohort":[41,68,273],"studies.":[42,274],"We":[43],"employed":[44],"a":[45,107,159,254,266],"multifaceted,":[46],"two-sample":[47],"approach":[50,63],"large-scale":[52],"GWAS":[53],"data":[54],"from":[55],"UK":[57,81,234],"Biobank,":[58],"FinnGen,":[59],"MEGASTROKE.":[61],"was":[64,265],"complemented":[65],"by":[66],"analyses":[69],"Korean":[72,217],"National":[73],"Health":[74,77],"Insurance":[75],"Service":[76],"Screening":[78],"(NHIS-HEALS)":[79],"Biobank":[82,235],"databases,":[83],"applying":[84],"propensity":[85],"score":[86],"matching":[87],"time-dependent":[89],"Cox":[90],"proportional":[91],"hazards":[92],"models":[93],"evaluate":[95],"associated":[98],"HD.":[100],"The":[101,153],"inverse":[102],"variance":[103],"weighted":[104],"analysis":[105],"demonstrated":[106],"negative":[108,160],"association":[110,162,256],"(FinnGen:":[115,167],"\u03b2":[116,136,168,186],"=":[117,124,131,137,142,149,169,174,181,187,192,199,223,237],"\u2212":[118,125,128,138,143,146,170,175,178,188,193,196],"1.71;":[119],"95%":[120,140,172,190,225,239],"confidence":[121],"interval":[122],"[CI]":[123],"2.43":[126],"1.00;":[129],"p":[130,148,180,198,230,244],"2.38":[132],"\u00d7":[133,151,183],"10\u20136;":[134],"MEGASTROKE:":[135,185],"0.92;":[139],"CI":[141,173,191],"1.53":[144,241],"0.31;":[147],"3.29":[150],"10\u20133).":[152],"weight":[154],"median":[155],"method":[156],"similarly":[157],"supported":[158],"1.28;":[171],"2.31":[176],"0.24;":[179],"1.56":[182],"10\u20132;":[184],"0.81;":[189],"1.59":[194],"0.04;":[197],"0.039).":[200],"In":[201],"contrast,":[202],"revealed":[205],"that":[206,287],"significantly":[208],"in":[214,285],"both":[215],"NHIS-HEALS":[218],"(adjusted":[219],"hazard":[220],"ratio":[221],"[aHR]":[222],"1.83;":[224,238],"CI,":[226,240],"1.69":[227],"1.98;":[229],"<":[231,245],"0.001)":[232,246],"(aHR":[236],"1.19;":[243],"databases.":[247],"provided":[250],"robust":[251],"evidence":[252],"for":[253,302],"genetic":[258],"predisposition":[259],"which":[264,291],"conflicting":[267],"result":[268],"compared":[269],"Future":[275],"should":[277],"focus":[278],"on":[279],"elucidating":[280],"biological":[282],"pathways":[283],"involved":[284],"may":[288],"influence":[289],"can":[292],"potentially":[293],"lead":[294],"novel":[296],"preventive":[297],"strategies":[298],"therapeutic":[300],"interventions":[301],"stroke.":[303]},"counts_by_year":[],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-21T00:00:00"}