{"id":"https://openalex.org/W4399439417","doi":"https://doi.org/10.1186/s40537-024-00945-2","title":"Hypoxia within tumor microenvironment characterizes distinct genomic patterns and aids molecular subtyping for guiding individualized immunotherapy","display_name":"Hypoxia within tumor microenvironment characterizes distinct genomic patterns and aids molecular subtyping for guiding individualized immunotherapy","publication_year":2024,"publication_date":"2024-06-07","ids":{"openalex":"https://openalex.org/W4399439417","doi":"https://doi.org/10.1186/s40537-024-00945-2"},"language":"en","primary_location":{"id":"doi:10.1186/s40537-024-00945-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40537-024-00945-2","pdf_url":"https://journalofbigdata.springeropen.com/counter/pdf/10.1186/s40537-024-00945-2","source":{"id":"https://openalex.org/S2737955091","display_name":"Journal Of Big Data","issn_l":"2196-1115","issn":["2196-1115"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Big Data","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journalofbigdata.springeropen.com/counter/pdf/10.1186/s40537-024-00945-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115592829","display_name":"Run Shi","orcid":null},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Run Shi","raw_affiliation_strings":["Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826","https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101538099","display_name":"Jing Sun","orcid":"https://orcid.org/0000-0003-3642-051X"},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]},{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Sun","raw_affiliation_strings":["Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China","The First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China","institution_ids":["https://openalex.org/I131434179","https://openalex.org/I4210152119"]},{"raw_affiliation_string":"The First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110949727","display_name":"Hanyu Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hanyu Zhou","raw_affiliation_strings":["Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826","https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112108015","display_name":"Tong Hu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tong Hu","raw_affiliation_strings":["Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826","https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018314178","display_name":"Zhaojia Gao","orcid":"https://orcid.org/0000-0002-8400-5145"},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaojia Gao","raw_affiliation_strings":["Department of Thoracic Surgery, The Affiliated Changzhou No. 2 People\u2019s Hospital of Nanjing Medical University, Changzhou, China","Department of Thoracic Surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, The Affiliated Changzhou No. 2 People\u2019s Hospital of Nanjing Medical University, Changzhou, China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Thoracic Surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067036774","display_name":"Xin Wang","orcid":"https://orcid.org/0000-0003-1456-335X"},"institutions":[{"id":"https://openalex.org/I4210128482","display_name":"Jiangsu Cancer Hospital","ror":"https://ror.org/03108sf43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128482"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Wang","raw_affiliation_strings":["Department of Oncology, Jiangsu Cancer Hospital, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Institute of Cancer Research, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Jiangsu Cancer Hospital, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Institute of Cancer Research, Nanjing, China","institution_ids":["https://openalex.org/I4210128482","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102784850","display_name":"Minglun Li","orcid":"https://orcid.org/0000-0002-7312-8350"},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I4210117663","display_name":"Klinikum L\u00fcneburg","ror":"https://ror.org/02k57ty04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210117663"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Minglun Li","raw_affiliation_strings":["Department of Radiation Oncology, LMU University Hospital, LMU Munich, Munich, Germany","Department of Radiation Oncology, Lueneburg Municipal Hospital, Lueneburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, LMU University Hospital, LMU Munich, Munich, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"raw_affiliation_string":"Department of Radiation Oncology, Lueneburg Municipal Hospital, Lueneburg, Germany","institution_ids":["https://openalex.org/I4210117663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051283231","display_name":"Zhaokai Zhou","orcid":"https://orcid.org/0000-0001-6628-3750"},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaokai Zhou","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074904959","display_name":"Yongqian Shu","orcid":"https://orcid.org/0000-0003-2103-0877"},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongqian Shu","raw_affiliation_strings":["Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826","https://openalex.org/I4210152119"]},{"raw_affiliation_string":"Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5074904959"],"corresponding_institution_ids":["https://openalex.org/I4210152119","https://openalex.org/I83519826"],"apc_list":{"value":1060,"currency":"GBP","value_usd":1300},"apc_paid":{"value":1060,"currency":"GBP","value_usd":1300},"fwci":0.8441,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.71811067,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"11","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"Tumor microenvironment","score":0.8137561082839966},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.8135937452316284},{"id":"https://openalex.org/keywords/subtyping","display_name":"Subtyping","score":0.5809910893440247},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"Cancer immunotherapy","score":0.540009617805481},{"id":"https://openalex.org/keywords/hypoxia","display_name":"Hypoxia (environmental)","score":0.504128098487854},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.4939478039741516},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"Personalized medicine","score":0.475912868976593},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.46901172399520874},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.4344688057899475},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.41270074248313904},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.40571361780166626},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3937883675098419},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.3927077353000641},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3561999499797821},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.21234813332557678},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.20893338322639465},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.1471574902534485},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.08066257834434509},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.07560113072395325}],"concepts":[{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.8137561082839966},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.8135937452316284},{"id":"https://openalex.org/C83852419","wikidata":"https://www.wikidata.org/wiki/Q2713292","display_name":"Subtyping","level":2,"score":0.5809910893440247},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.540009617805481},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.504128098487854},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4939478039741516},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.475912868976593},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46901172399520874},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.4344688057899475},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.41270074248313904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40571361780166626},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3937883675098419},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3927077353000641},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3561999499797821},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21234813332557678},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.20893338322639465},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1471574902534485},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.08066257834434509},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07560113072395325},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/s40537-024-00945-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40537-024-00945-2","pdf_url":"https://journalofbigdata.springeropen.com/counter/pdf/10.1186/s40537-024-00945-2","source":{"id":"https://openalex.org/S2737955091","display_name":"Journal Of Big Data","issn_l":"2196-1115","issn":["2196-1115"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Big Data","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:690fd745a68745e3a0cb4e7409f1ff13","is_oa":true,"landing_page_url":"https://doaj.org/article/690fd745a68745e3a0cb4e7409f1ff13","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Big Data, Vol 11, Iss 1, Pp 1-21 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s40537-024-00945-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40537-024-00945-2","pdf_url":"https://journalofbigdata.springeropen.com/counter/pdf/10.1186/s40537-024-00945-2","source":{"id":"https://openalex.org/S2737955091","display_name":"Journal Of Big Data","issn_l":"2196-1115","issn":["2196-1115"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Big Data","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7699999809265137,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G4265600258","display_name":null,"funder_award_id":"BK20220732","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"}],"funders":[{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399439417.pdf"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1493048246","https://openalex.org/W1966327575","https://openalex.org/W1985987855","https://openalex.org/W2024903578","https://openalex.org/W2028433016","https://openalex.org/W2033278321","https://openalex.org/W2060469376","https://openalex.org/W2075294566","https://openalex.org/W2107429737","https://openalex.org/W2118655588","https://openalex.org/W2124496728","https://openalex.org/W2130430382","https://openalex.org/W2132719707","https://openalex.org/W2152883907","https://openalex.org/W2299181842","https://openalex.org/W2323751645","https://openalex.org/W2761575992","https://openalex.org/W2796207838","https://openalex.org/W2801309958","https://openalex.org/W2884397450","https://openalex.org/W2908755714","https://openalex.org/W2912137016","https://openalex.org/W2921460161","https://openalex.org/W2949273159","https://openalex.org/W2949453788","https://openalex.org/W3134916687","https://openalex.org/W3137102918","https://openalex.org/W3158928451","https://openalex.org/W3183142599","https://openalex.org/W3188491639","https://openalex.org/W4210910593","https://openalex.org/W4221120384","https://openalex.org/W4226536377","https://openalex.org/W4285173671","https://openalex.org/W4309514267"],"related_works":["https://openalex.org/W3082935376","https://openalex.org/W4386960999","https://openalex.org/W2899657781","https://openalex.org/W4322484660","https://openalex.org/W3193951088","https://openalex.org/W4388011470","https://openalex.org/W4230423494","https://openalex.org/W4298001029","https://openalex.org/W4393252403","https://openalex.org/W4383105306"],"abstract_inverted_index":{"Abstract":[0],"Assessing":[1],"the":[2,6,86,105,151],"hypoxic":[3,33],"status":[4],"within":[5],"tumor":[7,46,134,167],"microenvironment":[8],"(TME)":[9],"is":[10],"crucial":[11],"for":[12,116,162,173],"its":[13],"significant":[14],"clinical":[15],"relevance":[16],"in":[17],"evaluating":[18],"drug":[19,112],"resistance":[20],"and":[21,42,62,71,82,137,169],"tailoring":[22],"individualized":[23],"strategies.":[24],"In":[25,140],"this":[26],"study,":[27],"we":[28,92],"proposed":[29],"a":[30,100,130],"robust":[31],"pan-cancer":[32,125],"quantification":[34],"method":[35],"utilizing":[36],"multiple":[37,94],"public":[38],"databases,":[39],"diverse":[40],"bioinformatics,":[41],"statistical":[43],"methods.":[44],"All":[45],"samples":[47],"were":[48],"classified":[49],"into":[50,166],"four":[51,87],"subtypes:":[52],"non-hypoxic/TME":[53,59],"high":[54,57],"(C1),":[55],"hypoxic/TME":[56,63],"(C2),":[58],"low":[60,64],"(C3),":[61],"(C4).":[65],"We":[66],"systematically":[67],"analyzed":[68],"multi-omics":[69],"data":[70,75],"single-cell":[72],"RNA-sequencing":[73],"(scRNA-seq)":[74],"to":[76,98,103,122,153],"reveal":[77],"distinct":[78],"immune":[79],"landscape":[80],"patterns":[81],"genomic":[83],"characteristics":[84],"among":[85],"subtypes":[88],"across":[89],"pan-cancer.":[90],"Furthermore,":[91],"employed":[93],"machine":[95],"learning":[96],"approaches":[97],"construct":[99],"hypoxic-TME":[101,164],"model":[102],"enhance":[104],"predictive":[106],"accuracy":[107],"of":[108],"immunotherapy":[109,138],"response.":[110],"Additionally,":[111],"repositioning":[113],"was":[114],"implemented":[115],"cancer":[117,174],"patients":[118],"predicted":[119],"as":[120,129],"non-responders":[121],"immunotherapy.":[123,154],"A":[124],"analysis":[126],"identified":[127],"PDK1":[128,148],"hub":[131],"gene":[132],"linking":[133],"hypoxia,":[135],"glycolysis,":[136],"resistance.":[139],"vivo":[141],"experimental":[142],"validation":[143],"further":[144],"confirmed":[145],"that":[146],"targeting":[147],"could":[149],"improve":[150],"response":[152],"Overall,":[155],"our":[156],"study":[157],"may":[158],"offer":[159],"valuable":[160],"insights":[161],"integrating":[163],"classification":[165],"staging":[168],"providing":[170],"personalized":[171],"strategies":[172],"patients.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
