{"id":"https://openalex.org/W4391519949","doi":"https://doi.org/10.1186/s40537-024-00881-1","title":"Conventional dendritic cell 2 links the genetic causal association from allergic asthma to COVID-19: a Mendelian randomization and transcriptomic study","display_name":"Conventional dendritic cell 2 links the genetic causal association from allergic asthma to COVID-19: a Mendelian randomization and transcriptomic study","publication_year":2024,"publication_date":"2024-02-04","ids":{"openalex":"https://openalex.org/W4391519949","doi":"https://doi.org/10.1186/s40537-024-00881-1"},"language":"en","primary_location":{"id":"doi:10.1186/s40537-024-00881-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40537-024-00881-1","pdf_url":"https://journalofbigdata.springeropen.com/counter/pdf/10.1186/s40537-024-00881-1","source":{"id":"https://openalex.org/S2737955091","display_name":"Journal Of Big Data","issn_l":"2196-1115","issn":["2196-1115"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Big Data","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journalofbigdata.springeropen.com/counter/pdf/10.1186/s40537-024-00881-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111984000","display_name":"Hua Liu","orcid":"https://orcid.org/0000-0001-5427-8129"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua Liu","raw_affiliation_strings":["Department of Nuclear Medicine, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China"],"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China","institution_ids":["https://openalex.org/I4210159865","https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089749731","display_name":"Siting Huang","orcid":"https://orcid.org/0000-0002-4230-7735"},"institutions":[{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]},{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siting Huang","raw_affiliation_strings":["Hypothalamic Pituitary Research Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China"],"affiliations":[{"raw_affiliation_string":"Hypothalamic Pituitary Research Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China","institution_ids":["https://openalex.org/I4210159865","https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086950421","display_name":"Liting Yang","orcid":"https://orcid.org/0009-0001-2016-5975"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liting Yang","raw_affiliation_strings":["Department of Neurosurgery, Xiangya Hospital, Central South University, Jiangxi Hospital., Nanchang, No.266, Fenghe North Road, 330038, Jiangxi, China","Hypothalamic Pituitary Research Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China","National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, People\u2019s Republic of China"],"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Xiangya Hospital, Central South University, Jiangxi Hospital., Nanchang, No.266, Fenghe North Road, 330038, Jiangxi, China","institution_ids":["https://openalex.org/I4210159865","https://openalex.org/I139660479"]},{"raw_affiliation_string":"Hypothalamic Pituitary Research Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China","institution_ids":["https://openalex.org/I4210159865","https://openalex.org/I139660479"]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210159865","https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042935839","display_name":"Hongshu Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]},{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongshu Zhou","raw_affiliation_strings":["Department of Neurosurgery, Xiangya Hospital, Central South University, Jiangxi Hospital., Nanchang, No.266, Fenghe North Road, 330038, Jiangxi, China","Hypothalamic Pituitary Research Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China","National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, People\u2019s Republic of China"],"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Xiangya Hospital, Central South University, Jiangxi Hospital., Nanchang, No.266, Fenghe North Road, 330038, Jiangxi, China","institution_ids":["https://openalex.org/I4210159865","https://openalex.org/I139660479"]},{"raw_affiliation_string":"Hypothalamic Pituitary Research Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China","institution_ids":["https://openalex.org/I4210159865","https://openalex.org/I139660479"]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210159865","https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100427402","display_name":"Bo Chen","orcid":"https://orcid.org/0000-0003-0812-5775"},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]},{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]},{"id":"https://openalex.org/I2800810863","display_name":"Queen Mary Hospital","ror":"https://ror.org/02xkx3e48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2800810863"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Bo Chen","raw_affiliation_strings":["Department of Neurosurgery, Xiangya Hospital, Central South University, Jiangxi Hospital., Nanchang, No.266, Fenghe North Road, 330038, Jiangxi, China","Division of Neurosurgery, Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, People\u2019s Republic of China"],"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Xiangya Hospital, Central South University, Jiangxi Hospital., Nanchang, No.266, Fenghe North Road, 330038, Jiangxi, China","institution_ids":["https://openalex.org/I4210159865","https://openalex.org/I139660479"]},{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, People\u2019s Republic of China","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039351764","display_name":"Lisha Wu","orcid":"https://orcid.org/0000-0003-2847-1982"},"institutions":[{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]},{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lisha Wu","raw_affiliation_strings":["Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China"],"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China","institution_ids":["https://openalex.org/I4210159865","https://openalex.org/I139660479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100412776","display_name":"Liyang Zhang","orcid":"https://orcid.org/0000-0002-4054-1667"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liyang Zhang","raw_affiliation_strings":["Department of Neurosurgery, Xiangya Hospital, Central South University, Jiangxi Hospital., Nanchang, No.266, Fenghe North Road, 330038, Jiangxi, China","Hypothalamic Pituitary Research Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China","National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, People\u2019s Republic of China"],"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Xiangya Hospital, Central South University, Jiangxi Hospital., Nanchang, No.266, Fenghe North Road, 330038, Jiangxi, China","institution_ids":["https://openalex.org/I4210159865","https://openalex.org/I139660479"]},{"raw_affiliation_string":"Hypothalamic Pituitary Research Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China","institution_ids":["https://openalex.org/I4210159865","https://openalex.org/I139660479"]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210159865","https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5039351764"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"],"apc_list":{"value":1060,"currency":"GBP","value_usd":1300},"apc_paid":{"value":1060,"currency":"GBP","value_usd":1300},"fwci":3.7231,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.93409554,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"11","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mendelian-randomization","display_name":"Mendelian randomization","score":0.8938343524932861},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.6569381356239319},{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.5604953169822693},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.5203573107719421},{"id":"https://openalex.org/keywords/2019-20-coronavirus-outbreak","display_name":"2019-20 coronavirus outbreak","score":0.4317830801010132},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.4125937223434448},{"id":"https://openalex.org/keywords/asthma","display_name":"Asthma","score":0.41096729040145874},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4008176326751709},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3662903904914856},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3428437113761902},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.31287437677383423},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.29955583810806274},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.25128257274627686},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.20385390520095825},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.1992734670639038},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.1879405975341797},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"Genetic variants","score":0.1576438546180725},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.15163961052894592},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.14385342597961426},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.12445172667503357},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.1130262017250061},{"id":"https://openalex.org/keywords/outbreak","display_name":"Outbreak","score":0.07407799363136292}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.8938343524932861},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.6569381356239319},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.5604953169822693},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5203573107719421},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.4317830801010132},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4125937223434448},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.41096729040145874},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4008176326751709},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3662903904914856},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3428437113761902},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31287437677383423},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29955583810806274},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.25128257274627686},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.20385390520095825},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1992734670639038},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.1879405975341797},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.1576438546180725},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.15163961052894592},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14385342597961426},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12445172667503357},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1130262017250061},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.07407799363136292},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/s40537-024-00881-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40537-024-00881-1","pdf_url":"https://journalofbigdata.springeropen.com/counter/pdf/10.1186/s40537-024-00881-1","source":{"id":"https://openalex.org/S2737955091","display_name":"Journal Of Big Data","issn_l":"2196-1115","issn":["2196-1115"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Big Data","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:2da64aed40484dc0b6fdfd6ad6f29cfd","is_oa":true,"landing_page_url":"https://doaj.org/article/2da64aed40484dc0b6fdfd6ad6f29cfd","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Big Data, Vol 11, Iss 1, Pp 1-18 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s40537-024-00881-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40537-024-00881-1","pdf_url":"https://journalofbigdata.springeropen.com/counter/pdf/10.1186/s40537-024-00881-1","source":{"id":"https://openalex.org/S2737955091","display_name":"Journal Of Big Data","issn_l":"2196-1115","issn":["2196-1115"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Big Data","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.699999988079071,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391519949.pdf"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1985987855","https://openalex.org/W2010832475","https://openalex.org/W2113594480","https://openalex.org/W2125435699","https://openalex.org/W2160311441","https://openalex.org/W2268049636","https://openalex.org/W2337357336","https://openalex.org/W2533508881","https://openalex.org/W2549714683","https://openalex.org/W2581245397","https://openalex.org/W2614566443","https://openalex.org/W2770598799","https://openalex.org/W2781617771","https://openalex.org/W2801645040","https://openalex.org/W2916020270","https://openalex.org/W2949177718","https://openalex.org/W2952001873","https://openalex.org/W2971741532","https://openalex.org/W2984472267","https://openalex.org/W2998849120","https://openalex.org/W3002770500","https://openalex.org/W3005396812","https://openalex.org/W3024643080","https://openalex.org/W3048439737","https://openalex.org/W3095481968","https://openalex.org/W3109493435","https://openalex.org/W3132661792","https://openalex.org/W3134481070","https://openalex.org/W3134802527","https://openalex.org/W3135675767","https://openalex.org/W3136606829","https://openalex.org/W3155169207","https://openalex.org/W3177041693","https://openalex.org/W3189119826","https://openalex.org/W3193609746","https://openalex.org/W3204794681","https://openalex.org/W3210570897","https://openalex.org/W3211083157","https://openalex.org/W3213348312","https://openalex.org/W3217273511","https://openalex.org/W4206105705","https://openalex.org/W4213341894","https://openalex.org/W4214925106","https://openalex.org/W4220810597","https://openalex.org/W4229026561","https://openalex.org/W4280554493","https://openalex.org/W4282922600","https://openalex.org/W4282927405","https://openalex.org/W4285494962","https://openalex.org/W4291291938","https://openalex.org/W4293367462","https://openalex.org/W4293770081","https://openalex.org/W4304097724","https://openalex.org/W4307839727","https://openalex.org/W4308973104","https://openalex.org/W4309436704","https://openalex.org/W4310054371","https://openalex.org/W4321605018","https://openalex.org/W4324020269","https://openalex.org/W4353016868","https://openalex.org/W4372337416","https://openalex.org/W4377294245","https://openalex.org/W4380265301","https://openalex.org/W4381309309"],"related_works":["https://openalex.org/W2901309888","https://openalex.org/W2169283889","https://openalex.org/W4210703904","https://openalex.org/W2052821216","https://openalex.org/W1136751063","https://openalex.org/W3111647380","https://openalex.org/W4294125588","https://openalex.org/W2416849719","https://openalex.org/W2036527494","https://openalex.org/W1604069670"],"abstract_inverted_index":{"Abstract":[0,220],"Recent":[1],"evidence":[2],"suggests":[3],"that":[4,53],"allergic":[5],"asthma":[6],"(AA)":[7],"decreases":[8],"the":[9,17,50,98,193],"risk":[10],"of":[11,168],"Coronavirus":[12],"Disease":[13],"2019":[14],"(COVID-19).":[15],"However,":[16],"reasons":[18],"remain":[19],"unclear.":[20],"Here,":[21],"we":[22],"systematically":[23],"explored":[24],"data":[25],"from":[26,68,196],"GWAS":[27],"(18":[28],"cohorts":[29,36,44],"with":[30,37,45,216],"11,071,744":[31],"samples),":[32,39],"bulk":[33],"transcriptomes":[34,42],"(3":[35],"601":[38],"and":[40,56,104,121,133,135,147,160,172,183,206,214],"single-cell":[41],"(2":[43],"29":[46],"samples)":[47],"to":[48,70,198,212],"reveal":[49],"immune":[51],"mechanisms":[52],"connect":[54],"AA":[55,69,103,151,197,213],"COVID-19.":[57,105,165,199],"Two-sample":[58],"Mendelian":[59],"randomization":[60],"(MR)":[61],"analysis":[62],"identified":[63,93],"a":[64],"negative":[65],"causal":[66],"correlation":[67,83],"COVID-19":[71,203],"hospitalization":[72],"(OR":[73],"=":[74,80],"0.968,":[75],"95%":[76],"CI":[77],"0.940\u20130.997,":[78],"P":[79],"0.031).":[81],"This":[82],"was":[84],"bridged":[85],"through":[86,179],"white":[87],"cell":[88,113],"count.":[89],"Furthermore,":[90],"machine":[91],"learning":[92],"dendritic":[94,112],"cells":[95],"(DCs)":[96],"as":[97],"most":[99],"discriminative":[100],"immunocytes":[101],"in":[102,150,163,187],"Among":[106],"five":[107],"DC":[108],"subtypes,":[109],"only":[110],"conventional":[111],"2":[114],"(cDC2)":[115],"exhibited":[116,142],"differential":[117],"expression":[118],"between":[119],"AA/COVID-19":[120],"controls":[122],"(P":[123],"&lt;":[124],"0.05).":[125],"Subsequently,":[126],"energy":[127],"metabolism,":[128],"intercellular":[129],"communication,":[130],"cellular":[131],"stemness":[132],"differentiation,":[134,144,157],"molecular":[136],"docking":[137],"analyses":[138],"were":[139],"performed.":[140],"cDC2s":[141],"more":[143],"increased":[145],"numbers,":[146],"enhanced":[148,161,178],"activation":[149,162],"exacerbation,":[152],"while":[153],"they":[154],"showed":[155],"less":[156],"reduced":[158],"number,":[159],"severe":[164],"The":[166],"capacity":[167],"cDC2":[169,191],"for":[170,202],"differentiation":[171],"SARS-CoV-2":[173],"antigen":[174],"presentation":[175],"may":[176],"be":[177,209],"ZBTB46,":[180],"EXOC4,":[181],"TLR1,":[182],"TNFSF4":[184],"gene":[185],"mutations":[186],"AA.":[188],"Taken":[189],"together,":[190],"links":[192],"genetic":[194],"causality":[195],"Future":[200],"strategies":[201],"prevention,":[204],"intervention,":[205],"treatment":[207],"could":[208],"stratified":[210],"according":[211],"guided":[215],"DC-based":[217],"therapies.":[218],"Graphical":[219]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":12}],"updated_date":"2026-03-17T17:19:04.345684","created_date":"2025-10-10T00:00:00"}
