{"id":"https://openalex.org/W1907088627","doi":"https://doi.org/10.1186/s13637-015-0029-2","title":"Molecular network control through boolean canalization","display_name":"Molecular network control through boolean canalization","publication_year":2015,"publication_date":"2015-11-04","ids":{"openalex":"https://openalex.org/W1907088627","doi":"https://doi.org/10.1186/s13637-015-0029-2","mag":"1907088627","pmid":"https://pubmed.ncbi.nlm.nih.gov/26752585"},"language":"en","primary_location":{"id":"doi:10.1186/s13637-015-0029-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13637-015-0029-2","pdf_url":"https://bsb-eurasipjournals.springeropen.com/track/pdf/10.1186/s13637-015-0029-2","source":{"id":"https://openalex.org/S22696228","display_name":"EURASIP Journal on Bioinformatics and Systems Biology","issn_l":"1687-4145","issn":["1687-4145","1687-4153"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EURASIP Journal on Bioinformatics and Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://bsb-eurasipjournals.springeropen.com/track/pdf/10.1186/s13637-015-0029-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028197670","display_name":"David Murrugarra","orcid":"https://orcid.org/0000-0001-9710-5025"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"David Murrugarra","raw_affiliation_strings":["Department of Mathematics, University of Kentucky, Lexington, 40506-0027 KY USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Kentucky, Lexington, 40506-0027 KY USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040752756","display_name":"Elena Dimitrova","orcid":"https://orcid.org/0000-0001-7314-6367"},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena S. Dimitrova","raw_affiliation_strings":["Department of Mathematical Sciences, Clemson, 29634-0975 SC USA","Department of Mathematical Sciences, Clemson 29634-0975, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematical Sciences, Clemson, 29634-0975 SC USA","institution_ids":[]},{"raw_affiliation_string":"Department of Mathematical Sciences, Clemson 29634-0975, SC, USA","institution_ids":["https://openalex.org/I8078737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028197670"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2047,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.78303042,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"2015","issue":"1","first_page":"9","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.974399983882904,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/boolean-network","display_name":"Boolean network","score":0.8142893314361572},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7443227171897888},{"id":"https://openalex.org/keywords/boolean-function","display_name":"Boolean function","score":0.6693230271339417},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6111993193626404},{"id":"https://openalex.org/keywords/and-inverter-graph","display_name":"And-inverter graph","score":0.5338807106018066},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.4778846800327301},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.4564407765865326},{"id":"https://openalex.org/keywords/boolean-expression","display_name":"Boolean expression","score":0.449327290058136},{"id":"https://openalex.org/keywords/distributed-computing","display_name":"Distributed computing","score":0.32958725094795227},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3162352442741394},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.20365631580352783},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1339299976825714}],"concepts":[{"id":"https://openalex.org/C134444547","wikidata":"https://www.wikidata.org/wiki/Q585230","display_name":"Boolean network","level":3,"score":0.8142893314361572},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7443227171897888},{"id":"https://openalex.org/C187455244","wikidata":"https://www.wikidata.org/wiki/Q942353","display_name":"Boolean function","level":2,"score":0.6693230271339417},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6111993193626404},{"id":"https://openalex.org/C196836630","wikidata":"https://www.wikidata.org/wiki/Q4753279","display_name":"And-inverter graph","level":4,"score":0.5338807106018066},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.4778846800327301},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.4564407765865326},{"id":"https://openalex.org/C158465420","wikidata":"https://www.wikidata.org/wiki/Q1979515","display_name":"Boolean expression","level":3,"score":0.449327290058136},{"id":"https://openalex.org/C120314980","wikidata":"https://www.wikidata.org/wiki/Q180634","display_name":"Distributed computing","level":1,"score":0.32958725094795227},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3162352442741394},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.20365631580352783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1339299976825714},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1186/s13637-015-0029-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13637-015-0029-2","pdf_url":"https://bsb-eurasipjournals.springeropen.com/track/pdf/10.1186/s13637-015-0029-2","source":{"id":"https://openalex.org/S22696228","display_name":"EURASIP Journal on Bioinformatics and Systems Biology","issn_l":"1687-4145","issn":["1687-4145","1687-4153"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EURASIP Journal on Bioinformatics and Systems Biology","raw_type":"journal-article"},{"id":"pmid:26752585","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26752585","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EURASIP journal on bioinformatics & systems biology","raw_type":null},{"id":"pmh:oai:arXiv.org:1508.03026","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1508.03026","pdf_url":"https://arxiv.org/pdf/1508.03026","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:uknowledge.uky.edu:math_facpub-1012","is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/math_facpub/12","pdf_url":null,"source":{"id":"https://openalex.org/S4306402622","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mathematics Faculty Publications","raw_type":"text"},{"id":"pmh:oai:europepmc.org:3681678","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4699631","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s13637-015-0029-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13637-015-0029-2","pdf_url":"https://bsb-eurasipjournals.springeropen.com/track/pdf/10.1186/s13637-015-0029-2","source":{"id":"https://openalex.org/S22696228","display_name":"EURASIP Journal on Bioinformatics and Systems Biology","issn_l":"1687-4145","issn":["1687-4145","1687-4153"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EURASIP Journal on Bioinformatics and Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4599784514","display_name":"Collaborative research: Data selection for unique model identification","funder_award_id":"1419038","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6622104527","display_name":null,"funder_award_id":"1419038","funder_id":"https://openalex.org/F4320332172","funder_display_name":"Directorate for Mathematical and Physical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332172","display_name":"Directorate for Mathematical and Physical Sciences","ror":"https://ror.org/029b7h395"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1907088627.pdf","grobid_xml":"https://content.openalex.org/works/W1907088627.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W51833465","https://openalex.org/W1971224531","https://openalex.org/W1971548199","https://openalex.org/W1991980854","https://openalex.org/W1994094326","https://openalex.org/W1998639983","https://openalex.org/W2004114069","https://openalex.org/W2009437679","https://openalex.org/W2010949918","https://openalex.org/W2030683290","https://openalex.org/W2042431901","https://openalex.org/W2044013267","https://openalex.org/W2049480816","https://openalex.org/W2053961182","https://openalex.org/W2081466838","https://openalex.org/W2083851229","https://openalex.org/W2088259098","https://openalex.org/W2094902224","https://openalex.org/W2097263107","https://openalex.org/W2101803083","https://openalex.org/W2111123076","https://openalex.org/W2114518254","https://openalex.org/W2115782725","https://openalex.org/W2123183032","https://openalex.org/W2132935366","https://openalex.org/W2133191229","https://openalex.org/W2134978629","https://openalex.org/W2136559804","https://openalex.org/W2151852639","https://openalex.org/W2160196028","https://openalex.org/W2165284694","https://openalex.org/W2213101934","https://openalex.org/W2605192879","https://openalex.org/W2963731580","https://openalex.org/W2963855685","https://openalex.org/W3105108438","https://openalex.org/W4242024146","https://openalex.org/W6873097010"],"related_works":["https://openalex.org/W2109998394","https://openalex.org/W3141532631","https://openalex.org/W2131164334","https://openalex.org/W2105128170","https://openalex.org/W1991822629","https://openalex.org/W2246807618","https://openalex.org/W2995277268","https://openalex.org/W2106622045","https://openalex.org/W2061512596","https://openalex.org/W2011175857"],"abstract_inverted_index":{"Boolean":[0,13,25,88],"networks":[1],"are":[2],"an":[3,161],"important":[4],"class":[5],"of":[6,17,20,23,34,40,45,50,64,82,87,106,137,147,154,160,173],"computational":[7],"models":[8],"for":[9,61,69,95,109,143],"molecular":[10,89],"interaction":[11],"networks.":[12,90],"canalization,":[14],"a":[15,24,43,93,107,141,158,179,185],"type":[16],"hierarchical":[18],"clustering":[19],"the":[21,32,48,51,62,80,85,97,103,131,134,138,145,151,155,165],"inputs":[22],"function,":[26],"has":[27],"been":[28,59],"extensively":[29],"studied":[30],"in":[31,47,84,102,133,150,164],"context":[33],"network":[35,55,108],"modeling":[36],"where":[37],"each":[38],"layer":[39],"canalization":[41,83],"adds":[42],"degree":[44],"stability":[46],"dynamics":[49],"network.":[52,139],"Recently,":[53],"dynamic":[54],"control":[56,86,101,171,191],"approaches":[57],"have":[58],"used":[60],"design":[63],"new":[65],"therapeutic":[66],"interventions":[67],"and":[68,183],"other":[70],"applications":[71],"such":[72],"as":[73,157],"stem":[74],"cell":[75],"reprogramming.":[76],"This":[77],"work":[78],"studies":[79],"role":[81],"It":[91],"provides":[92],"method":[94,115,142],"identifying":[96,119],"potential":[98,190],"edges":[99,132],"to":[100,178,184,188],"wiring":[104,135,166],"diagram":[105,136,167],"avoiding":[110],"undesirable":[111,124],"state":[112,152],"transitions.":[113],"The":[114,170],"is":[116,168],"based":[117],"on":[118,123],"appropriate":[120],"input-output":[121],"combinations":[122],"transitions":[125,149],"that":[126],"can":[127],"be":[128],"modified":[129],"using":[130],"Moreover,":[140],"estimating":[144],"number":[146],"changed":[148],"space":[153],"system":[156],"result":[159],"edge":[162],"deletion":[163],"presented.":[169],"methods":[172],"this":[174],"paper":[175],"were":[176],"applied":[177],"mutated":[180],"cell-cycle":[181],"model":[182,187],"p53-mdm2":[186],"identify":[189],"targets.":[192]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-05-16T08:24:45.110214","created_date":"2025-10-10T00:00:00"}