{"id":"https://openalex.org/W2128117362","doi":"https://doi.org/10.1186/s13637-014-0018-x","title":"Discovering irregular pupil light responses to chromatic stimuli using waveform shapes of pupillograms","display_name":"Discovering irregular pupil light responses to chromatic stimuli using waveform shapes of pupillograms","publication_year":2014,"publication_date":"2014-10-06","ids":{"openalex":"https://openalex.org/W2128117362","doi":"https://doi.org/10.1186/s13637-014-0018-x","mag":"2128117362","pmid":"https://pubmed.ncbi.nlm.nih.gov/28194168"},"language":"en","primary_location":{"id":"doi:10.1186/s13637-014-0018-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13637-014-0018-x","pdf_url":"https://bsb-eurasipjournals.springeropen.com/counter/pdf/10.1186/s13637-014-0018-x","source":{"id":"https://openalex.org/S22696228","display_name":"EURASIP Journal on Bioinformatics and Systems Biology","issn_l":"1687-4145","issn":["1687-4145","1687-4153"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EURASIP Journal on Bioinformatics and Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://bsb-eurasipjournals.springeropen.com/counter/pdf/10.1186/s13637-014-0018-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070484773","display_name":"Minoru Nakayama","orcid":"https://orcid.org/0000-0001-5563-6901"},"institutions":[{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Minoru Nakayama","raw_affiliation_strings":["Department of Human System Science, Tokyo Institute of Technology, Ookayama, Meguro, Tokyo, 152-8552 Japan","Department of Human System Science, Tokyo Institute of Technology, Ookayama, Meguro, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human System Science, Tokyo Institute of Technology, Ookayama, Meguro, Tokyo, 152-8552 Japan","institution_ids":["https://openalex.org/I114531698"]},{"raw_affiliation_string":"Department of Human System Science, Tokyo Institute of Technology, Ookayama, Meguro, Tokyo, Japan","institution_ids":["https://openalex.org/I114531698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055446451","display_name":"Wioletta Nowak","orcid":"https://orcid.org/0000-0002-4135-2526"},"institutions":[{"id":"https://openalex.org/I11923345","display_name":"Wroc\u0142aw University of Science and Technology","ror":"https://ror.org/008fyn775","country_code":"PL","type":"education","lineage":["https://openalex.org/I11923345"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Wioletta Nowak","raw_affiliation_strings":["Institute of Biomedical Engineering and Instrumentation, Wroclaw University of Technology, Wroclaw, 50-370 Poland","Institute of Biomedical Engineering and Instrumentation, Wroclaw University of Technology, Wroclaw, Poland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering and Instrumentation, Wroclaw University of Technology, Wroclaw, 50-370 Poland","institution_ids":["https://openalex.org/I11923345"]},{"raw_affiliation_string":"Institute of Biomedical Engineering and Instrumentation, Wroclaw University of Technology, Wroclaw, Poland,","institution_ids":["https://openalex.org/I11923345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105696308","display_name":"Hitoshi Ishikawa","orcid":null},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitoshi Ishikawa","raw_affiliation_strings":["School of Allied Health Sciences, Kitasato University, Kitasato, Minami, Sagamihara, 252-0373 Japan","School of Allied Health Sciences, Kitasato University, Kitasato, Minami, Sagamihara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Allied Health Sciences, Kitasato University, Kitasato, Minami, Sagamihara, 252-0373 Japan","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"School of Allied Health Sciences, Kitasato University, Kitasato, Minami, Sagamihara, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065675332","display_name":"Ken Asakawa","orcid":"https://orcid.org/0000-0003-2382-2472"},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken Asakawa","raw_affiliation_strings":["School of Allied Health Sciences, Kitasato University, Kitasato, Minami, Sagamihara, 252-0373 Japan","School of Allied Health Sciences, Kitasato University, Kitasato, Minami, Sagamihara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Allied Health Sciences, Kitasato University, Kitasato, Minami, Sagamihara, 252-0373 Japan","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"School of Allied Health Sciences, Kitasato University, Kitasato, Minami, Sagamihara, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009293337","display_name":"Yoshiaki Ichibe","orcid":null},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiaki Ichibe","raw_affiliation_strings":["School of Medicine, Kitasato University, Kitasato, Minami, Sagamihara, 252-0373 Japan","School of Medicine, Kitasato University, Kitasato, Minami, Sagamihara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Kitasato University, Kitasato, Minami, Sagamihara, 252-0373 Japan","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"School of Medicine, Kitasato University, Kitasato, Minami, Sagamihara, Japan","institution_ids":["https://openalex.org/I64189623"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0785,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.78251351,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"2014","issue":"1","first_page":"18","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10381","display_name":"Ophthalmology and Visual Impairment Studies","score":0.18129999935626984,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10381","display_name":"Ophthalmology and Visual Impairment Studies","score":0.18129999935626984,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.11940000206232071,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.09539999812841415,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/waveform","display_name":"Waveform","score":0.8009743094444275},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.6577771902084351},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6476443409919739},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5497931241989136},{"id":"https://openalex.org/keywords/pupil","display_name":"Pupil","score":0.49188876152038574},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.4500083923339844},{"id":"https://openalex.org/keywords/amplitude","display_name":"Amplitude","score":0.44360771775245667},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.09787243604660034}],"concepts":[{"id":"https://openalex.org/C197424946","wikidata":"https://www.wikidata.org/wiki/Q1165717","display_name":"Waveform","level":3,"score":0.8009743094444275},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.6577771902084351},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6476443409919739},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5497931241989136},{"id":"https://openalex.org/C2777394604","wikidata":"https://www.wikidata.org/wiki/Q173318","display_name":"Pupil","level":2,"score":0.49188876152038574},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.4500083923339844},{"id":"https://openalex.org/C180205008","wikidata":"https://www.wikidata.org/wiki/Q159190","display_name":"Amplitude","level":2,"score":0.44360771775245667},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.09787243604660034},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C554190296","wikidata":"https://www.wikidata.org/wiki/Q47528","display_name":"Radar","level":2,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/s13637-014-0018-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13637-014-0018-x","pdf_url":"https://bsb-eurasipjournals.springeropen.com/counter/pdf/10.1186/s13637-014-0018-x","source":{"id":"https://openalex.org/S22696228","display_name":"EURASIP Journal on Bioinformatics and Systems Biology","issn_l":"1687-4145","issn":["1687-4145","1687-4153"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EURASIP Journal on Bioinformatics and Systems Biology","raw_type":"journal-article"},{"id":"pmid:28194168","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28194168","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EURASIP journal on bioinformatics & systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:5270378","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5270378","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EURASIP J Bioinform Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s13637-014-0018-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13637-014-0018-x","pdf_url":"https://bsb-eurasipjournals.springeropen.com/counter/pdf/10.1186/s13637-014-0018-x","source":{"id":"https://openalex.org/S22696228","display_name":"EURASIP Journal on Bioinformatics and Systems Biology","issn_l":"1687-4145","issn":["1687-4145","1687-4153"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EURASIP Journal on Bioinformatics and Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","score":0.41999998688697815,"id":"https://metadata.un.org/sdg/15"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2128117362.pdf","grobid_xml":"https://content.openalex.org/works/W2128117362.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W47069713","https://openalex.org/W343767102","https://openalex.org/W1480679871","https://openalex.org/W1582127415","https://openalex.org/W1601975653","https://openalex.org/W1820840969","https://openalex.org/W1974216069","https://openalex.org/W1977598216","https://openalex.org/W1992514305","https://openalex.org/W2000714496","https://openalex.org/W2006130774","https://openalex.org/W2008986591","https://openalex.org/W2029570806","https://openalex.org/W2030366252","https://openalex.org/W2035853180","https://openalex.org/W2044141700","https://openalex.org/W2053277628","https://openalex.org/W2055125906","https://openalex.org/W2062242288","https://openalex.org/W2077830514","https://openalex.org/W2077888073","https://openalex.org/W2085158154","https://openalex.org/W2087148598","https://openalex.org/W2088437108","https://openalex.org/W2090549741","https://openalex.org/W2091741662","https://openalex.org/W2092510003","https://openalex.org/W2114469359","https://openalex.org/W2116532233","https://openalex.org/W2122827492","https://openalex.org/W2123311935","https://openalex.org/W2146672416","https://openalex.org/W2159168803","https://openalex.org/W2160214073","https://openalex.org/W2169065610","https://openalex.org/W2767344291","https://openalex.org/W2799061466","https://openalex.org/W4230305234","https://openalex.org/W4300890579"],"related_works":["https://openalex.org/W2176409448","https://openalex.org/W2085612832","https://openalex.org/W2024093099","https://openalex.org/W2906950246","https://openalex.org/W2052573907","https://openalex.org/W4205322683","https://openalex.org/W2621052390","https://openalex.org/W2320210125","https://openalex.org/W2074869632","https://openalex.org/W2007425567"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,61,105,176,243,269],"waveforms":[2,206],"of":[3,71,75,108,131,139,171,194,200,205,236,271,273],"the":[4,69,88,111,114,125,140,160,172,180,192,195,212,234,247,259,267],"pupillary":[5],"light":[6],"reflex":[7],"(PLR)":[8],"can":[9],"be":[10,279],"analyzed":[11],"in":[12,144,282],"a":[13,52,119,129,198],"diagnostic":[14,54],"test":[15],"that":[16,179,246],"allows":[17],"for":[18,58,183,197,215,227,250],"differentiation":[19],"between":[20],"disorders":[21,25],"affecting":[22,26],"photoreceptors":[23],"and":[24,44,77,94,102,113,156,164,186,203,240,253],"retinal":[27],"ganglion":[28],"cells,":[29],"using":[30,87,110,159,169,233],"various":[31],"signal":[32],"processing":[33],"techniques.":[34],"This":[35],"procedure":[36,55,226],"has":[37,230],"been":[38,231],"used":[39,66,98,264],"on":[40],"both":[41],"healthy":[42,157,184,251],"subjects":[43],"patients":[45,83,216,229,274],"with":[46,217,275],"age-related":[47],"macular":[48],"degeneration":[49],"(AMD),":[50],"as":[51,209],"simple":[53],"is":[56,65],"required":[57],"diagnosis.":[59],"RESULTS:":[60],"Fourier":[62],"descriptor":[63],"technique":[64,116],"to":[67,99,136,265,284],"extract":[68],"features":[70,112,133,204,235],"PLR":[72,141,201,237],"waveform":[73,142,238],"shapes":[74,143,239],"pupillograms":[76],"their":[78,241],"amplitudes.":[79,242],"To":[80,123],"detect":[81],"those":[82],"affected":[84],"by":[85],"AMD":[86,109,228,254],"extracted":[89],"features,":[90],"multidimensional":[91],"scaling":[92],"(MDS)":[93],"clustering":[95],"techniques":[96],"were":[97,167,189,256],"emphasize":[100],"stimuli":[101],"subject":[103],"differences.":[104],"detection":[106,126],"performance":[107,127,147],"MDS":[115],"shows":[117],"only":[118],"qualitative":[120],"tendency,":[121],"however.":[122],"evaluate":[124,137],"quantitatively,":[128],"set":[130],"combined":[132],"was":[134,148,207,220,263],"created":[135],"characteristics":[138],"detail.":[145],"Classification":[146],"compared":[149],"across":[150],"three":[151],"categories":[152],"(AMD":[153],"patients,":[154],"aged,":[155],"subjects)":[158],"Random":[161,260],"Forest":[162,261],"method,":[163],"weighted":[165],"values":[166],"optimized":[168,208],"variations":[170],"classification":[173,225,270],"error":[174,181,213,248],"rates.":[175],"results":[177,244],"show":[178,245],"rates":[182,214,249],"pupils":[185,188,272],"AMD-affected":[187],"low":[190,257],"when":[191,258],"value":[193],"coefficient":[196],"combination":[199],"amplitudes":[202],"1.5.":[210],"However,":[211],"age-affected":[218,276],"eyes":[219,277],"not":[221],"low.":[222],"CONCLUSIONS:":[223],"A":[224],"developed":[232],"PLRs":[252,255],"method":[262],"produce":[266,285],"classification.":[268],"should":[278],"carefully":[280],"considered":[281],"order":[283],"optimum":[286],"results.":[287]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}