{"id":"https://openalex.org/W2593050077","doi":"https://doi.org/10.1186/s13326-017-0121-5","title":"Therapeutic indications and other use-case-driven updates in the drug ontology: anti-malarials, anti-hypertensives, opioid analgesics, and a large term request","display_name":"Therapeutic indications and other use-case-driven updates in the drug ontology: anti-malarials, anti-hypertensives, opioid analgesics, and a large term request","publication_year":2017,"publication_date":"2017-03-03","ids":{"openalex":"https://openalex.org/W2593050077","doi":"https://doi.org/10.1186/s13326-017-0121-5","mag":"2593050077","pmid":"https://pubmed.ncbi.nlm.nih.gov/28253937"},"language":"en","primary_location":{"id":"doi:10.1186/s13326-017-0121-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13326-017-0121-5","pdf_url":"https://jbiomedsem.biomedcentral.com/track/pdf/10.1186/s13326-017-0121-5","source":{"id":"https://openalex.org/S172276550","display_name":"Journal of Biomedical Semantics","issn_l":"2041-1480","issn":["2041-1480"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Semantics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jbiomedsem.biomedcentral.com/track/pdf/10.1186/s13326-017-0121-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076610873","display_name":"William R. Hogan","orcid":"https://orcid.org/0000-0002-9881-1017"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William R. Hogan","raw_affiliation_strings":["Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA. hoganwr@ufl.edu","Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA. hoganwr@ufl.edu","institution_ids":[]},{"raw_affiliation_string":"Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007705764","display_name":"Josh Hanna","orcid":"https://orcid.org/0000-0002-4600-1258"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josh Hanna","raw_affiliation_strings":["Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109354722","display_name":"Amanda Hicks","orcid":null},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Hicks","raw_affiliation_strings":["Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022086891","display_name":"Samira Amirova","orcid":null},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samira Amirova","raw_affiliation_strings":["Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022864748","display_name":"Baxter Bramblett","orcid":null},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baxter Bramblett","raw_affiliation_strings":["Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030579890","display_name":"Matthew Diller","orcid":"https://orcid.org/0000-0001-6378-1703"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Diller","raw_affiliation_strings":["Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083806588","display_name":"Rodel Enderez","orcid":null},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rodel Enderez","raw_affiliation_strings":["Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000391076","display_name":"Timothy Modzelewski","orcid":null},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Modzelewski","raw_affiliation_strings":["Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047676858","display_name":"Mirela Vasconcelos","orcid":null},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mirela Vasconcelos","raw_affiliation_strings":["Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087903373","display_name":"Chris Delcher","orcid":"https://orcid.org/0000-0001-7214-0326"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris Delcher","raw_affiliation_strings":["Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5076610873"],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":{"value":1190,"currency":"GBP","value_usd":1459},"apc_paid":{"value":1190,"currency":"GBP","value_usd":1459},"fwci":1.1198,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.76712175,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"10","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.3725000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.3725000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.11469999700784683,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.09200000017881393,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.7566108703613281},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.490878164768219},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"Mechanism of action","score":0.48650163412094116},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.48253390192985535},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.44326573610305786},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.22106364369392395}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7566108703613281},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.490878164768219},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.48650163412094116},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48253390192985535},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44326573610305786},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22106364369392395},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064229","descriptor_name":"Biological Ontologies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064229","descriptor_name":"Biological Ontologies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064229","descriptor_name":"Biological Ontologies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064229","descriptor_name":"Biological Ontologies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s13326-017-0121-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13326-017-0121-5","pdf_url":"https://jbiomedsem.biomedcentral.com/track/pdf/10.1186/s13326-017-0121-5","source":{"id":"https://openalex.org/S172276550","display_name":"Journal of Biomedical Semantics","issn_l":"2041-1480","issn":["2041-1480"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Semantics","raw_type":"journal-article"},{"id":"pmid:28253937","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28253937","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical semantics","raw_type":null},{"id":"pmh:oai:UFDC:AA00054416_00001","is_oa":true,"landing_page_url":"http://ufdc.ufl.edu/AA00054416/00001","pdf_url":null,"source":{"id":"https://openalex.org/S4306400471","display_name":"University of Florida Digital Collections (University of Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I33213144","host_organization_name":"University of Florida","host_organization_lineage":["https://openalex.org/I33213144"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"mixed material"},{"id":"pmh:oai:pubmedcentral.nih.gov:5335794","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5335794","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Biomed Semantics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s13326-017-0121-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13326-017-0121-5","pdf_url":"https://jbiomedsem.biomedcentral.com/track/pdf/10.1186/s13326-017-0121-5","source":{"id":"https://openalex.org/S172276550","display_name":"Journal of Biomedical Semantics","issn_l":"2041-1480","issn":["2041-1480"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Semantics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8600000143051147,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1421834292","display_name":null,"funder_award_id":"UL1 TR000064","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1765904267","display_name":null,"funder_award_id":"UL1 TR001427","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2707742091","display_name":null,"funder_award_id":"UL1 TR000064","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G3035549695","display_name":null,"funder_award_id":"CDRN-1501-26692","funder_id":"https://openalex.org/F4320308927","funder_display_name":"Patient-Centered Outcomes Research Institute"},{"id":"https://openalex.org/G4317685444","display_name":null,"funder_award_id":"UL1TR000064","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G4818037007","display_name":null,"funder_award_id":"TR001427","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5500374692","display_name":null,"funder_award_id":"TR000064","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G6138076438","display_name":null,"funder_award_id":"CDRN-1501-26692","funder_id":"https://openalex.org/F4320310009","funder_display_name":"University of Florida"},{"id":"https://openalex.org/G6665007911","display_name":null,"funder_award_id":"UL1 TR001427","funder_id":"https://openalex.org/F4320310009","funder_display_name":"University of Florida"},{"id":"https://openalex.org/G7410578442","display_name":null,"funder_award_id":"UL1 TR000064","funder_id":"https://openalex.org/F4320310009","funder_display_name":"University of Florida"},{"id":"https://openalex.org/G7612683197","display_name":null,"funder_award_id":"UL1 TR001427","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G7711884891","display_name":null,"funder_award_id":"TR000064","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320308927","display_name":"Patient-Centered Outcomes Research Institute","ror":"https://ror.org/014q65q44"},{"id":"https://openalex.org/F4320310009","display_name":"University of Florida","ror":"https://ror.org/02y3ad647"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2593050077.pdf","grobid_xml":"https://content.openalex.org/works/W2593050077.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1126991912","https://openalex.org/W1490161904","https://openalex.org/W1593611264","https://openalex.org/W1802346448","https://openalex.org/W1863753810","https://openalex.org/W1934602670","https://openalex.org/W2106830745","https://openalex.org/W2113142309","https://openalex.org/W2141201603","https://openalex.org/W2151868700","https://openalex.org/W2163827272","https://openalex.org/W2168091868","https://openalex.org/W2337023886","https://openalex.org/W2468014659","https://openalex.org/W2567583209","https://openalex.org/W2593050077","https://openalex.org/W2603968081","https://openalex.org/W2750826707"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,161],"Drug":[2,43],"Ontology":[3],"(DrOn)":[4],"is":[5,164,196,269,279],"an":[6],"OWL2-based":[7],"representation":[8],"of":[9,16,39,55,90,127,155,168,180,186,192,206,239,256,258],"drug":[10,49,137,194,207,218,240],"products":[11,138,241],"and":[12,19,57,119,132,153,182,237],"their":[13,243],"ingredients,":[14],"mechanisms":[15,126,185,257],"action,":[17,56,91,259],"strengths,":[18],"dose":[20],"forms.":[21],"We":[22,123],"originally":[23],"created":[24],"DrOn":[25,68,98,268],"for":[26,111,129,149,215,230,253],"use":[27,114],"cases":[28],"in":[29,61,97,139,157,202],"comparative":[30],"effectiveness":[31],"research,":[32],"primarily":[33],"to":[34,72,141,171],"identify":[35],"historically":[36],"complete":[37],"sets":[38],"United":[40],"States":[41],"National":[42],"Codes":[44],"(NDCs)":[45],"that":[46,77,85,174],"represent":[47],"packaged":[48],"products,":[50,208],"by":[51],"the":[52,70,147,217],"ingredient(s),":[53],"mechanism(s)":[54],"so":[58],"on":[59],"contained":[60],"those":[62,75,83],"products.":[63],"Although":[64],"we":[65,92,107],"had":[66,93],"designed":[67,222],"from":[69,82,146],"outset":[71],"carefully":[73],"distinguish":[74],"entities":[76,84],"have":[78,86],"a":[79,87,142,165,193,199,228],"therapeutic":[80,101,109,178,190,200,213,233],"indication":[81,191],"molecular":[88],"mechanism":[89],"not":[94,221],"previously":[95],"represented":[96,197],"any":[99],"particular":[100],"indication.":[102],"RESULTS:":[103],"In":[104],"this":[105],"work,":[106],"add":[108],"indications":[110],"three":[112,176],"research":[113],"cases:":[115],"resistant":[116],"hypertension,":[117],"malaria,":[118],"opioid":[120,130],"abuse":[121],"research.":[122],"also":[124,247],"added":[125,133],"action":[128],"analgesics":[131],"108":[134],"classes":[135,179],"representing":[136,231],"response":[140],"large":[143],"term":[144],"request":[145],"Program":[148],"Resistance,":[150],"Immunology,":[151],"Surveillance":[152],"Modeling":[154],"Malaria":[156],"Uganda":[158],"(PRISM)":[159],"project.":[160],"net":[162],"result":[163],"new":[166,184],"version":[167,276],"DrOn,":[169],"current":[170],"May":[172],"2016,":[173],"represents":[175],"major":[177],"drugs":[181],"six":[183],"action.":[187],"CONCLUSIONS:":[188],"A":[189,274],"product":[195,219],"as":[198,209,211],"function":[201],"DrOn.":[203],"Adverse":[204],"effects":[205,261],"well":[210],"other":[212],"uses":[214,238],"which":[216],"was":[220],"are":[223],"dispositions.":[224],"Our":[225,245],"work":[226,246],"provides":[227],"framework":[229],"additional":[232],"indications,":[234],"adverse":[235],"effects,":[236],"beyond":[242],"design.":[244],"validated":[248],"our":[249],"past":[250],"modeling":[251],"decisions":[252],"specific":[254],"types":[255],"namely":[260],"mediated":[262],"via":[263],"receptor":[264],"and/or":[265],"enzyme":[266],"binding.":[267],"available":[270,280],"at:":[271,281],"http://purl.obolibrary.org/obo/dron.owl":[272],".":[273],"smaller":[275],"without":[277],"NDCs":[278],"http://purl.obolibrary.org/obo/dron/dron-lite.owl.":[282]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2017,"cited_by_count":2}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}