{"id":"https://openalex.org/W4386845728","doi":"https://doi.org/10.1186/s13321-023-00742-8","title":"Integrating synthetic accessibility with AI-based generative drug design","display_name":"Integrating synthetic accessibility with AI-based generative drug design","publication_year":2023,"publication_date":"2023-09-19","ids":{"openalex":"https://openalex.org/W4386845728","doi":"https://doi.org/10.1186/s13321-023-00742-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/37726842"},"language":"en","primary_location":{"id":"doi:10.1186/s13321-023-00742-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13321-023-00742-8","pdf_url":"https://jcheminf.biomedcentral.com/counter/pdf/10.1186/s13321-023-00742-8","source":{"id":"https://openalex.org/S180838163","display_name":"Journal of Cheminformatics","issn_l":"1758-2946","issn":["1758-2946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cheminformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jcheminf.biomedcentral.com/counter/pdf/10.1186/s13321-023-00742-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085460012","display_name":"Maud Parrot","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maud Parrot","raw_affiliation_strings":["Iktos, 65 rue de Prony, 75017, Paris, France","Iktos, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iktos, 65 rue de Prony, 75017, Paris, France","institution_ids":[]},{"raw_affiliation_string":"Iktos, Paris, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076358635","display_name":"Hamza Tajmouati","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hamza Tajmouati","raw_affiliation_strings":["Iktos, 65 rue de Prony, 75017, Paris, France","Iktos, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iktos, 65 rue de Prony, 75017, Paris, France","institution_ids":[]},{"raw_affiliation_string":"Iktos, Paris, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007620254","display_name":"Vin\u00edcius Barros Ribeiro da Silva","orcid":"https://orcid.org/0000-0001-9712-6985"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vinicius Barros Ribeiro da Silva","raw_affiliation_strings":["Iktos, 65 rue de Prony, 75017, Paris, France","Iktos, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iktos, 65 rue de Prony, 75017, Paris, France","institution_ids":[]},{"raw_affiliation_string":"Iktos, Paris, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048123648","display_name":"Brian Ross Atwood","orcid":"https://orcid.org/0000-0002-4332-3630"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Ross Atwood","raw_affiliation_strings":["Iktos, 65 rue de Prony, 75017, Paris, France","Iktos, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iktos, 65 rue de Prony, 75017, Paris, France","institution_ids":[]},{"raw_affiliation_string":"Iktos, Paris, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014109357","display_name":"Robin Fourcade","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robin Fourcade","raw_affiliation_strings":["Iktos, 65 rue de Prony, 75017, Paris, France","Iktos, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iktos, 65 rue de Prony, 75017, Paris, France","institution_ids":[]},{"raw_affiliation_string":"Iktos, Paris, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017284775","display_name":"Yann Gaston\u2010Math\u00e9","orcid":"https://orcid.org/0000-0002-9635-7324"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yann Gaston-Math\u00e9","raw_affiliation_strings":["Iktos, 65 rue de Prony, 75017, Paris, France","Iktos, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iktos, 65 rue de Prony, 75017, Paris, France","institution_ids":[]},{"raw_affiliation_string":"Iktos, Paris, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032278965","display_name":"Nicolas Do Huu","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicolas Do Huu","raw_affiliation_strings":["Iktos, 65 rue de Prony, 75017, Paris, France","Iktos, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iktos, 65 rue de Prony, 75017, Paris, France","institution_ids":[]},{"raw_affiliation_string":"Iktos, Paris, France","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019498465","display_name":"Quentin Perron","orcid":null},"institutions":[{"id":"https://openalex.org/I4210113255","display_name":"Chronos (France)","ror":"https://ror.org/026c6z776","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210113255"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Quentin Perron","raw_affiliation_strings":["Iktos, 65 rue de Prony, 75017, Paris, France. quentin.perron@iktos.com","Iktos, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iktos, 65 rue de Prony, 75017, Paris, France. quentin.perron@iktos.com","institution_ids":["https://openalex.org/I4210113255"]},{"raw_affiliation_string":"Iktos, Paris, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5019498465"],"corresponding_institution_ids":["https://openalex.org/I4210113255"],"apc_list":{"value":1290,"currency":"GBP","value_usd":1582},"apc_paid":{"value":1290,"currency":"GBP","value_usd":1582},"fwci":10.0759,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.98619225,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"15","issue":"1","first_page":"83","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11948","display_name":"Machine Learning in Materials Science","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9736999869346619,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7733348608016968},{"id":"https://openalex.org/keywords/retrosynthetic-analysis","display_name":"Retrosynthetic analysis","score":0.6554185152053833},{"id":"https://openalex.org/keywords/python","display_name":"Python (programming language)","score":0.49924445152282715},{"id":"https://openalex.org/keywords/cheminformatics","display_name":"Cheminformatics","score":0.4744497239589691},{"id":"https://openalex.org/keywords/generator","display_name":"Generator (circuit theory)","score":0.4611935615539551},{"id":"https://openalex.org/keywords/approved-drug","display_name":"Approved drug","score":0.43809768557548523},{"id":"https://openalex.org/keywords/program-synthesis","display_name":"Program synthesis","score":0.4315507411956787},{"id":"https://openalex.org/keywords/generative-grammar","display_name":"Generative grammar","score":0.4275386333465576},{"id":"https://openalex.org/keywords/generative-model","display_name":"Generative model","score":0.420198529958725},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3879706561565399},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.3864520490169525},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3807830214500427},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.354022741317749},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.1470576822757721},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.11782878637313843},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.09852242469787598}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7733348608016968},{"id":"https://openalex.org/C42437451","wikidata":"https://www.wikidata.org/wiki/Q902227","display_name":"Retrosynthetic analysis","level":3,"score":0.6554185152053833},{"id":"https://openalex.org/C519991488","wikidata":"https://www.wikidata.org/wiki/Q28865","display_name":"Python (programming language)","level":2,"score":0.49924445152282715},{"id":"https://openalex.org/C68762167","wikidata":"https://www.wikidata.org/wiki/Q910164","display_name":"Cheminformatics","level":2,"score":0.4744497239589691},{"id":"https://openalex.org/C2780992000","wikidata":"https://www.wikidata.org/wiki/Q17016113","display_name":"Generator (circuit theory)","level":3,"score":0.4611935615539551},{"id":"https://openalex.org/C2777494893","wikidata":"https://www.wikidata.org/wiki/Q4781752","display_name":"Approved drug","level":3,"score":0.43809768557548523},{"id":"https://openalex.org/C2776937632","wikidata":"https://www.wikidata.org/wiki/Q4117718","display_name":"Program synthesis","level":2,"score":0.4315507411956787},{"id":"https://openalex.org/C39890363","wikidata":"https://www.wikidata.org/wiki/Q36108","display_name":"Generative grammar","level":2,"score":0.4275386333465576},{"id":"https://openalex.org/C167966045","wikidata":"https://www.wikidata.org/wiki/Q5532625","display_name":"Generative model","level":3,"score":0.420198529958725},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3879706561565399},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.3864520490169525},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3807830214500427},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.354022741317749},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.1470576822757721},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.11782878637313843},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.09852242469787598},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C35753019","wikidata":"https://www.wikidata.org/wiki/Q644785","display_name":"Total synthesis","level":2,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s13321-023-00742-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13321-023-00742-8","pdf_url":"https://jcheminf.biomedcentral.com/counter/pdf/10.1186/s13321-023-00742-8","source":{"id":"https://openalex.org/S180838163","display_name":"Journal of Cheminformatics","issn_l":"1758-2946","issn":["1758-2946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cheminformatics","raw_type":"journal-article"},{"id":"pmid:37726842","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37726842","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cheminformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10507964","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10507964","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10507964/pdf/13321_2023_Article_742.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Cheminform","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:c00070d8eba741aeb536bbb3910125d4","is_oa":true,"landing_page_url":"https://doaj.org/article/c00070d8eba741aeb536bbb3910125d4","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Cheminformatics, Vol 15, Iss 1, Pp 1-17 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13321-023-00742-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13321-023-00742-8","pdf_url":"https://jcheminf.biomedcentral.com/counter/pdf/10.1186/s13321-023-00742-8","source":{"id":"https://openalex.org/S180838163","display_name":"Journal of Cheminformatics","issn_l":"1758-2946","issn":["1758-2946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cheminformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386845728.pdf"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1977267072","https://openalex.org/W1981711832","https://openalex.org/W1992699251","https://openalex.org/W2020859943","https://openalex.org/W2034549041","https://openalex.org/W2054137409","https://openalex.org/W2060531713","https://openalex.org/W2160592148","https://openalex.org/W2529996553","https://openalex.org/W2578240541","https://openalex.org/W2610148085","https://openalex.org/W2783658781","https://openalex.org/W2900090807","https://openalex.org/W2900694120","https://openalex.org/W2915175970","https://openalex.org/W2951548154","https://openalex.org/W2953128081","https://openalex.org/W2956961449","https://openalex.org/W3014154196","https://openalex.org/W3043969542","https://openalex.org/W3094553402","https://openalex.org/W3098269892","https://openalex.org/W3101155908","https://openalex.org/W3110229430","https://openalex.org/W3121207609","https://openalex.org/W3123775255","https://openalex.org/W4214567217","https://openalex.org/W4239091587","https://openalex.org/W4287550254","https://openalex.org/W6679338098"],"related_works":["https://openalex.org/W2040103915","https://openalex.org/W2792880831","https://openalex.org/W4389523661","https://openalex.org/W4389599499","https://openalex.org/W3003333974","https://openalex.org/W3120165387","https://openalex.org/W4220747243","https://openalex.org/W4200214421","https://openalex.org/W4200620983","https://openalex.org/W2963521731"],"abstract_inverted_index":{"Generative":[0],"models":[1],"are":[2],"frequently":[3],"used":[4],"for":[5,51],"de":[6],"novo":[7],"design":[8],"in":[9,57],"drug":[10],"discovery":[11],"projects":[12],"to":[13,42,54,63,125,159,172,206,229],"propose":[14],"new":[15,208],"molecules.":[16],"However,":[17],"the":[18,24,44,87,146,195,215,243,246],"question":[19],"of":[20,96,137,166,188],"whether":[21,75],"or":[22,76,217],"not":[23,31,77],"generated":[25,45,138],"molecules":[26,46,97,161],"can":[27,197,248],"be":[28,55,198,249],"synthesized":[29],"is":[30,47,71,80,148],"systematically":[32],"taken":[33],"into":[34],"account":[35],"during":[36,222],"generation,":[37],"even":[38],"though":[39],"being":[40,170],"able":[41],"synthesize":[43],"a":[48,78,92,100,126,135,141,149,157,164,186,201,207,220],"fundamental":[49],"requirement":[50],"such":[52],"methods":[53],"useful":[56],"practice.":[58],"Methods":[59],"have":[60],"been":[61],"developed":[62],"estimate":[64],"molecule":[65,79],"\"synthesizability\",":[66],"but,":[67],"so":[68],"far,":[69],"there":[70],"no":[72],"consensus":[73],"on":[74,134,251],"synthesizable.":[81],"In":[82],"this":[83,176],"paper":[84],"we":[85],"introduce":[86],"Retro-Score":[88],"(RScore),":[89],"which":[90,204],"computes":[91],"synthetic":[93,107,122,151],"accessibility":[94,123,152],"score":[95],"by":[98,119,132,178,200],"performing":[99,179],"full":[101],"retrosynthetic":[102],"analysis":[103],"through":[104],"our":[105,226],"data-driven":[106],"planning":[108],"software":[109],"Spaya,":[110],"and":[111,190,245],"its":[112],"dedicated":[113],"API:":[114],"Spaya-API":[115],"(https://spaya.ai).":[116],"We":[117,154,174,192,211],"start":[118],"comparing":[120,181],"several":[121],"scores":[124,244],"binary":[127],"\"chemist":[128],"score\"":[129],"as":[130,140,219],"estimated":[131],"chemists":[133],"bench":[136],"molecules,":[139],"first":[142],"experimental":[143],"validation":[144],"that":[145,162,194,213],"RScore":[147,196,216],"reliable":[150],"score.":[153],"then":[155],"describe":[156],"pipeline":[158],"generate":[160],"validate":[163],"list":[165],"targets":[167],"while":[168],"still":[169],"easy":[171],"synthesize.":[173],"further":[175],"idea":[177],"experiments":[180,247],"molecular":[182,223,227],"generator":[183],"outputs":[184],"across":[185],"range":[187],"constraints":[189],"conditions.":[191],"show":[193],"learned":[199],"Neural":[202],"Network,":[203],"leads":[205],"score:":[209],"RSPred.":[210],"demonstrate":[212],"using":[214],"RSPred":[218],"constraint":[221],"generation":[224],"enables":[225],"generators":[228],"produce":[230],"more":[231],"synthesizable":[232],"solutions,":[233],"with":[234],"higher":[235],"diversity.":[236],"The":[237],"open-source":[238],"Python":[239],"code":[240],"containing":[241],"all":[242],"found":[250],"(":[252],"https://github.com/iktos/generation-under-synthetic-constraint":[253],").":[254]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":29},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-04-25T08:17:42.794288","created_date":"2025-10-10T00:00:00"}