{"id":"https://openalex.org/W4282560006","doi":"https://doi.org/10.1186/s13321-022-00615-6","title":"KNIME workflow for retrieving causal drug and protein interactions, building networks, and performing topological enrichment analysis demonstrated by a DILI case study","display_name":"KNIME workflow for retrieving causal drug and protein interactions, building networks, and performing topological enrichment analysis demonstrated by a DILI case study","publication_year":2022,"publication_date":"2022-06-13","ids":{"openalex":"https://openalex.org/W4282560006","doi":"https://doi.org/10.1186/s13321-022-00615-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/35692045"},"language":"en","primary_location":{"id":"doi:10.1186/s13321-022-00615-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13321-022-00615-6","pdf_url":"https://jcheminf.biomedcentral.com/counter/pdf/10.1186/s13321-022-00615-6","source":{"id":"https://openalex.org/S180838163","display_name":"Journal of Cheminformatics","issn_l":"1758-2946","issn":["1758-2946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cheminformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jcheminf.biomedcentral.com/counter/pdf/10.1186/s13321-022-00615-6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044694431","display_name":"Barbara F\u00fczi","orcid":"https://orcid.org/0000-0001-5395-7920"},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Barbara F\u00fczi","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024795670","display_name":"Rahuman S. Malik\u2010Sheriff","orcid":"https://orcid.org/0000-0003-0705-9809"},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rahuman S. Malik-Sheriff","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, UK","institution_ids":["https://openalex.org/I1303153112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089264825","display_name":"Emma J. Manners","orcid":"https://orcid.org/0000-0001-7875-1259"},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Emma J. Manners","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, UK","institution_ids":["https://openalex.org/I1303153112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066783652","display_name":"Henning Hermjakob","orcid":"https://orcid.org/0000-0001-8479-0262"},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Henning Hermjakob","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, UK","institution_ids":["https://openalex.org/I1303153112"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014396881","display_name":"Gerhard F. Ecker","orcid":"https://orcid.org/0000-0003-4209-6883"},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Gerhard F. Ecker","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria. gerhard.f.ecker@univie.ac.at","Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria"],"raw_orcid":"https://orcid.org/0000-0003-4209-6883","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria. gerhard.f.ecker@univie.ac.at","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014396881"],"corresponding_institution_ids":["https://openalex.org/I129774422"],"apc_list":{"value":1290,"currency":"GBP","value_usd":1582},"apc_paid":{"value":2028,"currency":"EUR","value_usd":2187},"fwci":0.5306,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.66198535,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"14","issue":"1","first_page":"37","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/workflow","display_name":"Workflow","score":0.7842535376548767},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6843103766441345},{"id":"https://openalex.org/keywords/interactome","display_name":"Interactome","score":0.5345349311828613},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5105956196784973},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4943821430206299},{"id":"https://openalex.org/keywords/cheminformatics","display_name":"Cheminformatics","score":0.4783172905445099},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.438248872756958},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.43197938799858093},{"id":"https://openalex.org/keywords/virtual-screening","display_name":"Virtual screening","score":0.4150454103946686},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3923059105873108},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.34823572635650635},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.20122531056404114},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1854097843170166},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.13999295234680176},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.11524823307991028}],"concepts":[{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.7842535376548767},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6843103766441345},{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.5345349311828613},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5105956196784973},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4943821430206299},{"id":"https://openalex.org/C68762167","wikidata":"https://www.wikidata.org/wiki/Q910164","display_name":"Cheminformatics","level":2,"score":0.4783172905445099},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.438248872756958},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.43197938799858093},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.4150454103946686},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3923059105873108},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.34823572635650635},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20122531056404114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1854097843170166},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.13999295234680176},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11524823307991028},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s13321-022-00615-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13321-022-00615-6","pdf_url":"https://jcheminf.biomedcentral.com/counter/pdf/10.1186/s13321-022-00615-6","source":{"id":"https://openalex.org/S180838163","display_name":"Journal of Cheminformatics","issn_l":"1758-2946","issn":["1758-2946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cheminformatics","raw_type":"journal-article"},{"id":"pmid:35692045","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35692045","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cheminformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:0616fa70d451455780445ea32b406b6a","is_oa":false,"landing_page_url":"https://doaj.org/article/0616fa70d451455780445ea32b406b6a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Cheminformatics, Vol 14, Iss 1, Pp 1-10 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9188852","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9188852","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Cheminform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s13321-022-00615-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13321-022-00615-6","pdf_url":"https://jcheminf.biomedcentral.com/counter/pdf/10.1186/s13321-022-00615-6","source":{"id":"https://openalex.org/S180838163","display_name":"Journal of Cheminformatics","issn_l":"1758-2946","issn":["1758-2946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cheminformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6200000047683716}],"awards":[{"id":"https://openalex.org/G1499650114","display_name":"The ChEMBL Database An Open Resource for Drug Discovery","funder_award_id":"104104","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2116550614","display_name":null,"funder_award_id":"218244/Z/19/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G302012681","display_name":null,"funder_award_id":"116030","funder_id":"https://openalex.org/F4320314178","funder_display_name":"European Federation of Pharmaceutical Industries and Associations"},{"id":"https://openalex.org/G3616335944","display_name":null,"funder_award_id":"104104/A/14/Z and 218244/Z/19/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3771206209","display_name":null,"funder_award_id":"104104/A/14/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4607779693","display_name":null,"funder_award_id":"218244/Z/19/Z","funder_id":"https://openalex.org/F4320307874","funder_display_name":"Wellcome"},{"id":"https://openalex.org/G5053374963","display_name":"Molecular Drug Targets","funder_award_id":"W1232","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G5145803756","display_name":null,"funder_award_id":"104104/A/14/Z","funder_id":"https://openalex.org/F4320307874","funder_display_name":"Wellcome"},{"id":"https://openalex.org/G5278229474","display_name":null,"funder_award_id":"116030","funder_id":"https://openalex.org/F4320326631","funder_display_name":"Innovative Medicines Initiative"},{"id":"https://openalex.org/G5426256440","display_name":"The ChEMBL database","funder_award_id":"218244","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G7842005466","display_name":null,"funder_award_id":"Horizon 2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8435999542","display_name":"Translational quantitative systems toxicology to improve the understanding of the safety of medicines - Sofia: 116030","funder_award_id":"116030","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320307874","display_name":"Wellcome","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320314023","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39"},{"id":"https://openalex.org/F4320314178","display_name":"European Federation of Pharmaceutical Industries and Associations","ror":"https://ror.org/00g1x4v36"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321181","display_name":"Austrian Science Fund","ror":"https://ror.org/013tf3c58"},{"id":"https://openalex.org/F4320326631","display_name":"Innovative Medicines Initiative","ror":"https://ror.org/019af4n30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4282560006.pdf","grobid_xml":"https://content.openalex.org/works/W4282560006.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W136559104","https://openalex.org/W1544009106","https://openalex.org/W1975875968","https://openalex.org/W1979900513","https://openalex.org/W1980737710","https://openalex.org/W1988452823","https://openalex.org/W2031595392","https://openalex.org/W2061132293","https://openalex.org/W2062533676","https://openalex.org/W2099768941","https://openalex.org/W2127587566","https://openalex.org/W2128900650","https://openalex.org/W2155330008","https://openalex.org/W2156899846","https://openalex.org/W2289901683","https://openalex.org/W2598630627","https://openalex.org/W2620149199","https://openalex.org/W2749320391","https://openalex.org/W2767891136","https://openalex.org/W2771328536","https://openalex.org/W2900090807","https://openalex.org/W2900596913","https://openalex.org/W2982368177","https://openalex.org/W2982659388","https://openalex.org/W2984996233","https://openalex.org/W3032892710","https://openalex.org/W3107527779","https://openalex.org/W3116354484","https://openalex.org/W3132273599","https://openalex.org/W3205272684","https://openalex.org/W3211402536","https://openalex.org/W4206496183"],"related_works":["https://openalex.org/W4362464865","https://openalex.org/W2098840560","https://openalex.org/W4302604134","https://openalex.org/W2768880727","https://openalex.org/W2113146994","https://openalex.org/W2073081213","https://openalex.org/W2009405916","https://openalex.org/W2063905494","https://openalex.org/W2101998831","https://openalex.org/W2048384644"],"abstract_inverted_index":{"As":[0,113],"an":[1],"alternative":[2],"to":[3,53,60,97,153,164,179,271,277],"one":[4],"drug-one":[5],"target":[6,55,58,273,287],"approaches,":[7],"systems":[8,27],"biology":[9],"methods":[10,33],"can":[11,30,70,303,308],"provide":[12],"a":[13,45,86,114,186],"deeper":[14],"insight":[15],"into":[16],"the":[17,66,77,83,98,124,132,147,158,170,180,234,239,301],"holistic":[18],"effects":[19],"of":[20,26,82,118,141,172,189,242,254,281,290,300],"drugs.":[21],"Network-based":[22],"approaches":[23,276],"are":[24,136,150,161,295],"tools":[25],"biology,":[28],"that":[29,149,160],"represent":[31],"valuable":[32],"for":[34,73,90,127],"visualizing":[35,74],"and":[36,39,57,75,94,109,157,175,202,207,227,257,259,274,284,292],"analysing":[37],"drug-protein":[38],"protein-protein":[40],"interactions.":[41],"In":[42],"this":[43,215],"study,":[44,116],"KNIME":[46,267],"workflow":[47,84,102,218],"is":[48,103,123],"presented":[49],"which":[50],"connects":[51],"drugs":[52,148],"causal":[54,62,203],"proteins":[56,59,177,220],"their":[61,110,139,262,286],"protein":[63],"interactors.":[64],"With":[65],"collected":[67],"data,":[68],"networks":[69],"be":[71,304,309],"constructed":[72,206],"interpreting":[76],"connections.":[78],"The":[79,101,144,193,217,244,266,298],"last":[80],"part":[81],"provides":[85],"topological":[87,208,245],"enrichment":[88,210],"test":[89],"identifying":[91],"relevant":[92],"pathways":[93,250],"processes":[95,293],"connected":[96,178],"submitted":[99],"data.":[100],"based":[104],"on":[105],"openly":[106],"available":[107],"databases":[108],"web":[111],"services.":[112],"case":[115],"compounds":[117,135,171],"DILIRank":[119,122],"were":[120,183,205],"analysed.":[121],"benchmark":[125],"dataset":[126],"Drug-Induced":[128],"Liver":[129],"Injury":[130],"by":[131,138],"FDA,":[133],"where":[134],"categorized":[137],"likeliness":[140],"causing":[142],"DILI.":[143,265],"study":[145],"includes":[146],"most":[151],"likely":[152,163],"cause":[154,165],"DILI":[155,166],"(\"mostDILI\")":[156],"ones":[159],"not":[162],"(\"noDILI\").":[167],"After":[168],"selecting":[169],"interest,":[173],"down-":[174],"upregulated":[176],"mostDILI":[181],"group":[182],"identified;":[184],"furthermore,":[185],"liver-specific":[187],"subset":[188],"those":[190],"was":[191,212,269],"created.":[192],"downregulated":[194],"sub-list":[195],"had":[196],"considerably":[197],"more":[198],"entries,":[199],"therefore,":[200],"network":[201,246],"interactome":[204],"pathway":[209],"analysis":[211,247],"performed":[213],"with":[214],"list.":[216],"identified":[219],"such":[221,251],"as":[222,230,252,311],"Prostaglandin":[223],"G7H":[224],"synthase":[225],"1":[226],"UDP-glucuronosyltransferase":[228],"1A9":[229],"key":[231],"participants":[232],"in":[233,249,264],"potential":[235],"toxic":[236],"events":[237],"disclosing":[238],"possible":[240],"mode":[241,289],"action.":[243],"resulted":[248],"recycling":[253],"bile":[255],"acids":[256],"salts":[258],"glucuronidation,":[260],"indicating":[261],"involvement":[263],"pipeline":[268,302],"built":[270],"support":[272],"network-based":[275],"analyse":[278],"any":[279],"sets":[280],"drug":[282],"data":[283],"identify":[285],"proteins,":[288],"actions":[291],"they":[294],"involved":[296],"in.":[297],"fragments":[299],"used":[305],"separately":[306],"or":[307],"combined":[310],"required.":[312]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-07-18T07:39:51.176621","created_date":"2025-10-10T00:00:00"}
