{"id":"https://openalex.org/W3134968392","doi":"https://doi.org/10.1186/s13321-021-00499-y","title":"Prediction of activity and selectivity profiles of human Carbonic Anhydrase inhibitors using machine learning classification models","display_name":"Prediction of activity and selectivity profiles of human Carbonic Anhydrase inhibitors using machine learning classification models","publication_year":2021,"publication_date":"2021-03-06","ids":{"openalex":"https://openalex.org/W3134968392","doi":"https://doi.org/10.1186/s13321-021-00499-y","mag":"3134968392","pmid":"https://pubmed.ncbi.nlm.nih.gov/33676550"},"language":"en","primary_location":{"id":"doi:10.1186/s13321-021-00499-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13321-021-00499-y","pdf_url":"https://jcheminf.biomedcentral.com/counter/pdf/10.1186/s13321-021-00499-y","source":{"id":"https://openalex.org/S180838163","display_name":"Journal of Cheminformatics","issn_l":"1758-2946","issn":["1758-2946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cheminformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jcheminf.biomedcentral.com/counter/pdf/10.1186/s13321-021-00499-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047242993","display_name":"Annachiara Tinivella","orcid":"https://orcid.org/0000-0003-2182-9267"},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Annachiara Tinivella","raw_affiliation_strings":["Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy","Department of Life Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi 103, 41125, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]},{"raw_affiliation_string":"Department of Life Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi 103, 41125, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014912634","display_name":"Luca Pinzi","orcid":"https://orcid.org/0000-0001-5572-2121"},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Pinzi","raw_affiliation_strings":["Department of Life Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi 103, 41125, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi 103, 41125, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066566738","display_name":"Giulio Rastelli","orcid":"https://orcid.org/0000-0002-2474-0607"},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulio Rastelli","raw_affiliation_strings":["Department of Life Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi 103, 41125, Modena, Italy. giulio.rastelli@unimore.it","Department of Life Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi 103, 41125, Modena, Italy"],"raw_orcid":"https://orcid.org/0000-0002-2474-0607","affiliations":[{"raw_affiliation_string":"Department of Life Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi 103, 41125, Modena, Italy. giulio.rastelli@unimore.it","institution_ids":["https://openalex.org/I122346577"]},{"raw_affiliation_string":"Department of Life Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi 103, 41125, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5047242993"],"corresponding_institution_ids":["https://openalex.org/I122346577"],"apc_list":{"value":1290,"currency":"GBP","value_usd":1582},"apc_paid":{"value":2055,"currency":"EUR","value_usd":2216},"fwci":1.4657,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.81768514,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"18","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12251","display_name":"Synthesis and Catalytic Reactions","score":0.9793000221252441,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chembl","display_name":"chEMBL","score":0.8712521195411682},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.710540235042572},{"id":"https://openalex.org/keywords/carbonic-anhydrase","display_name":"Carbonic anhydrase","score":0.6559619307518005},{"id":"https://openalex.org/keywords/gene-isoform","display_name":"Gene isoform","score":0.6412455439567566},{"id":"https://openalex.org/keywords/virtual-screening","display_name":"Virtual screening","score":0.578511655330658},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5480046272277832},{"id":"https://openalex.org/keywords/carbonic-anhydrase-ii","display_name":"Carbonic anhydrase II","score":0.5462626218795776},{"id":"https://openalex.org/keywords/selectivity","display_name":"Selectivity","score":0.5301291346549988},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5140265226364136},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.44571661949157715},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.41775041818618774},{"id":"https://openalex.org/keywords/a-priori-and-a-posteriori","display_name":"A priori and a posteriori","score":0.41225701570510864},{"id":"https://openalex.org/keywords/drug-target","display_name":"Drug target","score":0.41090449690818787},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3883298635482788},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.36814412474632263},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.24714255332946777},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.24260756373405457},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1361691653728485},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10022029280662537}],"concepts":[{"id":"https://openalex.org/C63222358","wikidata":"https://www.wikidata.org/wiki/Q6120337","display_name":"chEMBL","level":3,"score":0.8712521195411682},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.710540235042572},{"id":"https://openalex.org/C2775914622","wikidata":"https://www.wikidata.org/wiki/Q284089","display_name":"Carbonic anhydrase","level":3,"score":0.6559619307518005},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.6412455439567566},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.578511655330658},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5480046272277832},{"id":"https://openalex.org/C2780416268","wikidata":"https://www.wikidata.org/wiki/Q18021049","display_name":"Carbonic anhydrase II","level":4,"score":0.5462626218795776},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.5301291346549988},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5140265226364136},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.44571661949157715},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41775041818618774},{"id":"https://openalex.org/C75553542","wikidata":"https://www.wikidata.org/wiki/Q178161","display_name":"A priori and a posteriori","level":2,"score":0.41225701570510864},{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.41090449690818787},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3883298635482788},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.36814412474632263},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24714255332946777},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.24260756373405457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1361691653728485},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10022029280662537},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1186/s13321-021-00499-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13321-021-00499-y","pdf_url":"https://jcheminf.biomedcentral.com/counter/pdf/10.1186/s13321-021-00499-y","source":{"id":"https://openalex.org/S180838163","display_name":"Journal of Cheminformatics","issn_l":"1758-2946","issn":["1758-2946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cheminformatics","raw_type":"journal-article"},{"id":"pmid:33676550","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33676550","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cheminformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:a8f783afe9d04978a1995322e1fb4ec0","is_oa":true,"landing_page_url":"https://doaj.org/article/a8f783afe9d04978a1995322e1fb4ec0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Cheminformatics, Vol 13, Iss 1, Pp 1-15 (2021)","raw_type":"article"},{"id":"pmh:oai:iris.unimore.it:11380/1238545","is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/1238545","pdf_url":null,"source":{"id":"https://openalex.org/S4377196326","display_name":"Iris Unimore (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7937250","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7937250","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Cheminform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s13321-021-00499-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13321-021-00499-y","pdf_url":"https://jcheminf.biomedcentral.com/counter/pdf/10.1186/s13321-021-00499-y","source":{"id":"https://openalex.org/S180838163","display_name":"Journal of Cheminformatics","issn_l":"1758-2946","issn":["1758-2946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cheminformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Clean water and sanitation","score":0.4300000071525574,"id":"https://metadata.un.org/sdg/6"}],"awards":[{"id":"https://openalex.org/G7216254361","display_name":null,"funder_award_id":"FAR2019, DR496/2019","funder_id":"https://openalex.org/F4320311022","funder_display_name":"Universit\u00e0 Degli Studi di Modena e Reggio Emila"},{"id":"https://openalex.org/G7478102334","display_name":null,"funder_award_id":"FAR 2019","funder_id":"https://openalex.org/F4320311022","funder_display_name":"Universit\u00e0 Degli Studi di Modena e Reggio Emila"}],"funders":[{"id":"https://openalex.org/F4320311022","display_name":"Universit\u00e0 Degli Studi di Modena e Reggio Emila","ror":"https://ror.org/02d4c4y02"},{"id":"https://openalex.org/F4320326075","display_name":"Regione Emilia-Romagna","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3134968392.pdf","grobid_xml":"https://content.openalex.org/works/W3134968392.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1642443113","https://openalex.org/W1979900513","https://openalex.org/W1999798000","https://openalex.org/W2021748110","https://openalex.org/W2051349300","https://openalex.org/W2052943632","https://openalex.org/W2053717624","https://openalex.org/W2078530460","https://openalex.org/W2081062244","https://openalex.org/W2082283100","https://openalex.org/W2083957993","https://openalex.org/W2096541451","https://openalex.org/W2096729078","https://openalex.org/W2098685167","https://openalex.org/W2101234009","https://openalex.org/W2109553965","https://openalex.org/W2159425682","https://openalex.org/W2162964640","https://openalex.org/W2212089270","https://openalex.org/W2288366709","https://openalex.org/W2290847742","https://openalex.org/W2419105462","https://openalex.org/W2472085920","https://openalex.org/W2561904149","https://openalex.org/W2565684601","https://openalex.org/W2567231876","https://openalex.org/W2753588101","https://openalex.org/W2801991413","https://openalex.org/W2809661273","https://openalex.org/W2950354128","https://openalex.org/W2971801381","https://openalex.org/W2995728553","https://openalex.org/W3100157108","https://openalex.org/W3100743833","https://openalex.org/W3143749224","https://openalex.org/W4211118618"],"related_works":["https://openalex.org/W4200070360","https://openalex.org/W2072444571","https://openalex.org/W2172288068","https://openalex.org/W3178245966","https://openalex.org/W1969599525","https://openalex.org/W3047084383","https://openalex.org/W3132064566","https://openalex.org/W2901750118","https://openalex.org/W4200262289","https://openalex.org/W2588869820"],"abstract_inverted_index":{"The":[0,123,194],"development":[1,63],"of":[2,5,32,38,64,80,91,112,134,187,197],"selective":[3,36],"inhibitors":[4],"the":[6,35,46,62,71,76,107,168,184,216,222],"clinically":[7],"relevant":[8],"human":[9,115],"Carbonic":[10,116],"Anhydrase":[11,117],"(hCA)":[12],"isoforms":[13,118],"IX":[14,120],"and":[15,73,109,121,142,149,210,218],"XII":[16],"has":[17],"become":[18],"a":[19,89,129,190,208],"major":[20],"topic":[21],"in":[22,29,65,207],"drug":[23],"research,":[24],"due":[25],"to":[26,45,53,69,105,138,152,158,174,204,214],"their":[27],"deregulation":[28],"several":[30],"types":[31],"cancer.":[33],"Indeed,":[34],"inhibition":[37],"these":[39],"two":[40],"isoforms,":[41],"especially":[42],"with":[43,57,128,164,183],"respect":[44],"homeostatic":[47],"isoform":[48],"II,":[49,119],"holds":[50],"great":[51],"promise":[52],"develop":[54],"anticancer":[55],"drugs":[56],"limited":[58],"side":[59],"effects.":[60],"Therefore,":[61],"silico":[66],"models":[67,156,181,200],"able":[68,104,157],"predict":[70,106,215],"activity":[72,108,155,192,217],"selectivity":[74,110,219],"against":[75,221],"desired":[77],"isoform(s)":[78],"is":[79],"central":[81],"interest.":[82],"In":[83],"this":[84],"work,":[85],"we":[86],"have":[87],"developed":[88],"series":[90],"machine":[92],"learning":[93],"classification":[94],"models,":[95],"trained":[96],"on":[97],"high":[98],"confidence":[99],"data":[100],"extracted":[101],"from":[102],"ChEMBL,":[103],"profiles":[111,220],"ligands":[113],"for":[114],"XII.":[122],"training":[124],"datasets":[125],"were":[126],"built":[127,182],"procedure":[130],"that":[131],"made":[132],"use":[133],"flexible":[135],"bioactivity":[136],"thresholds":[137],"obtain":[139],"well-balanced":[140],"active":[141,160],"inactive":[143,162],"classes.":[144],"We":[145],"used":[146],"multiple":[147],"algorithms":[148],"sampling":[150],"sizes":[151],"finally":[153],"select":[154],"classify":[159],"or":[161],"molecules":[163],"excellent":[165],"performances.":[166],"Remarkably,":[167],"results":[169],"herein":[170],"reported":[171],"turned":[172],"out":[173],"be":[175,205],"better":[176],"than":[177],"those":[178],"obtained":[179],"by":[180],"classic":[185],"approach":[186],"selecting":[188],"an":[189],"priori":[191],"threshold.":[193],"sequential":[195],"application":[196],"such":[198],"validated":[199],"enables":[201],"virtual":[202],"screening":[203],"performed":[206],"fast":[209],"more":[211],"reliable":[212],"way":[213],"investigated":[223],"isoforms.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}