{"id":"https://openalex.org/W2798950799","doi":"https://doi.org/10.1186/s13321-018-0275-x","title":"Finding the molecular scaffold of nuclear receptor inhibitors through high-throughput screening based on proteochemometric modelling","display_name":"Finding the molecular scaffold of nuclear receptor inhibitors through high-throughput screening based on proteochemometric modelling","publication_year":2018,"publication_date":"2018-04-12","ids":{"openalex":"https://openalex.org/W2798950799","doi":"https://doi.org/10.1186/s13321-018-0275-x","mag":"2798950799","pmid":"https://pubmed.ncbi.nlm.nih.gov/29651663"},"language":"en","primary_location":{"id":"doi:10.1186/s13321-018-0275-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13321-018-0275-x","pdf_url":"https://jcheminf.biomedcentral.com/track/pdf/10.1186/s13321-018-0275-x","source":{"id":"https://openalex.org/S180838163","display_name":"Journal of Cheminformatics","issn_l":"1758-2946","issn":["1758-2946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cheminformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jcheminf.biomedcentral.com/track/pdf/10.1186/s13321-018-0275-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029170473","display_name":"Tianyi Qiu","orcid":"https://orcid.org/0000-0003-2619-0298"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tianyi Qiu","raw_affiliation_strings":["School of Life Sciences and Technology, Shanghai 10th People's Hospital, Tongji University, No. 1239 SiPing Road, Shanghai, China","The Institute of Biomedical Sciences, Fudan University, No. 138 Medical College Road, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"School of Life Sciences and Technology, Shanghai 10th People's Hospital, Tongji University, No. 1239 SiPing Road, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]},{"raw_affiliation_string":"The Institute of Biomedical Sciences, Fudan University, No. 138 Medical College Road, Shanghai, China","institution_ids":["https://openalex.org/I133868755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022846353","display_name":"Dingfeng Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dingfeng Wu","raw_affiliation_strings":["School of Life Sciences and Technology, Shanghai 10th People's Hospital, Tongji University, No. 1239 SiPing Road, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"School of Life Sciences and Technology, Shanghai 10th People's Hospital, Tongji University, No. 1239 SiPing Road, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061840111","display_name":"Jingxuan Qiu","orcid":"https://orcid.org/0000-0001-8420-4593"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I148128674","display_name":"University of Shanghai for Science and Technology","ror":"https://ror.org/00ay9v204","country_code":"CN","type":"education","lineage":["https://openalex.org/I148128674"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingxuan Qiu","raw_affiliation_strings":["School of Life Sciences and Technology, Shanghai 10th People's Hospital, Tongji University, No. 1239 SiPing Road, Shanghai, China","School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, No. 516 JunGong Road, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"School of Life Sciences and Technology, Shanghai 10th People's Hospital, Tongji University, No. 1239 SiPing Road, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]},{"raw_affiliation_string":"School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, No. 516 JunGong Road, Shanghai, China","institution_ids":["https://openalex.org/I148128674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025886127","display_name":"Zhiwei Cao","orcid":"https://orcid.org/0000-0002-0341-8213"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiwei Cao","raw_affiliation_strings":["School of Life Sciences and Technology, Shanghai 10th People's Hospital, Tongji University, No. 1239 SiPing Road, Shanghai, China. zwcao@tongji.edu.cn","School of Life Sciences and Technology, Shanghai 10th People's Hospital, Tongji University, No. 1239 SiPing Road, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"School of Life Sciences and Technology, Shanghai 10th People's Hospital, Tongji University, No. 1239 SiPing Road, Shanghai, China. zwcao@tongji.edu.cn","institution_ids":["https://openalex.org/I116953780"]},{"raw_affiliation_string":"School of Life Sciences and Technology, Shanghai 10th People's Hospital, Tongji University, No. 1239 SiPing Road, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5029170473"],"corresponding_institution_ids":["https://openalex.org/I116953780","https://openalex.org/I133868755"],"apc_list":{"value":1290,"currency":"GBP","value_usd":1582},"apc_paid":{"value":1290,"currency":"GBP","value_usd":1582},"fwci":0.8549,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.75516467,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"10","issue":"1","first_page":"21","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9908000230789185,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.7888317108154297},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.612775444984436},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5987995862960815},{"id":"https://openalex.org/keywords/nuclear-receptor","display_name":"Nuclear receptor","score":0.5721403956413269},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"High-throughput screening","score":0.565334141254425},{"id":"https://openalex.org/keywords/drug-development","display_name":"Drug development","score":0.47052159905433655},{"id":"https://openalex.org/keywords/scaffold","display_name":"Scaffold","score":0.4636105000972748},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.44372352957725525},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4122299551963806},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.3053056001663208},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.30486059188842773},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.22644400596618652},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19984745979309082},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.19161760807037354},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.08055314421653748}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.7888317108154297},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.612775444984436},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5987995862960815},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.5721403956413269},{"id":"https://openalex.org/C51323132","wikidata":"https://www.wikidata.org/wiki/Q626251","display_name":"High-throughput screening","level":2,"score":0.565334141254425},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.47052159905433655},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.4636105000972748},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.44372352957725525},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4122299551963806},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3053056001663208},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.30486059188842773},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22644400596618652},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19984745979309082},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19161760807037354},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.08055314421653748},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1186/s13321-018-0275-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13321-018-0275-x","pdf_url":"https://jcheminf.biomedcentral.com/track/pdf/10.1186/s13321-018-0275-x","source":{"id":"https://openalex.org/S180838163","display_name":"Journal of Cheminformatics","issn_l":"1758-2946","issn":["1758-2946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cheminformatics","raw_type":"journal-article"},{"id":"pmid:29651663","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29651663","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cheminformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:b67d0f8b54024fc98e22b6817ac167c4","is_oa":true,"landing_page_url":"https://doaj.org/article/b67d0f8b54024fc98e22b6817ac167c4","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Cheminformatics, Vol 10, Iss 1, Pp 1-9 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4831240","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5897275","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5897275","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5897275","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Cheminform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s13321-018-0275-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13321-018-0275-x","pdf_url":"https://jcheminf.biomedcentral.com/track/pdf/10.1186/s13321-018-0275-x","source":{"id":"https://openalex.org/S180838163","display_name":"Journal of Cheminformatics","issn_l":"1758-2946","issn":["1758-2946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cheminformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7300000190734863}],"awards":[{"id":"https://openalex.org/G2376276132","display_name":null,"funder_award_id":"China","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G5372691491","display_name":null,"funder_award_id":"1350219165","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G5612697103","display_name":null,"funder_award_id":"2017M","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G8472655864","display_name":null,"funder_award_id":"BX201600033","funder_id":"https://openalex.org/F4320335768","funder_display_name":"National Postdoctoral Program for Innovative Talents"}],"funders":[{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320335768","display_name":"National Postdoctoral Program for Innovative Talents","ror":null},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2798950799.pdf","grobid_xml":"https://content.openalex.org/works/W2798950799.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1964124955","https://openalex.org/W1965633919","https://openalex.org/W1968682237","https://openalex.org/W1969120945","https://openalex.org/W1971849220","https://openalex.org/W1975420361","https://openalex.org/W1982131304","https://openalex.org/W1995530068","https://openalex.org/W1996630442","https://openalex.org/W2002757138","https://openalex.org/W2029973510","https://openalex.org/W2031082559","https://openalex.org/W2031906658","https://openalex.org/W2042290675","https://openalex.org/W2047544230","https://openalex.org/W2050847085","https://openalex.org/W2060531713","https://openalex.org/W2068819452","https://openalex.org/W2071472412","https://openalex.org/W2085124463","https://openalex.org/W2087064593","https://openalex.org/W2104916446","https://openalex.org/W2106440817","https://openalex.org/W2106591444","https://openalex.org/W2127905857","https://openalex.org/W2128606159","https://openalex.org/W2134815007","https://openalex.org/W2144377773","https://openalex.org/W2156515964","https://openalex.org/W2191378904","https://openalex.org/W2199485679","https://openalex.org/W2268071782","https://openalex.org/W2298885479","https://openalex.org/W2323299231","https://openalex.org/W2346278979","https://openalex.org/W2418981864","https://openalex.org/W2516867065","https://openalex.org/W2519454444","https://openalex.org/W2523362814","https://openalex.org/W2528065586","https://openalex.org/W2550812444","https://openalex.org/W2580499567","https://openalex.org/W2591705589","https://openalex.org/W2610362409","https://openalex.org/W2611425558"],"related_works":["https://openalex.org/W3129816939","https://openalex.org/W2912862995","https://openalex.org/W2985427592","https://openalex.org/W2101501829","https://openalex.org/W2400569965","https://openalex.org/W2060263731","https://openalex.org/W2003194288","https://openalex.org/W391093122","https://openalex.org/W4407713039","https://openalex.org/W1521239975"],"abstract_inverted_index":{"Nuclear":[0],"receptors":[1],"(NR)":[2],"are":[3,9],"a":[4,122],"class":[5],"of":[6,32,53,87,124,143,168],"proteins":[7],"that":[8,22],"responsible":[10],"for":[11,55,63,91,131],"sensing":[12],"steroid":[13],"and":[14,17,35,80,103,121,150,155],"thyroid":[15],"hormones":[16],"certain":[18],"other":[19],"molecules.":[20],"In":[21,66],"case,":[23],"NR":[24,57,81,134,145],"have":[25],"the":[26,30,50,75,85,153,166,177],"ability":[27,52,86],"to":[28,73,118,175],"regulate":[29],"expression":[31],"specific":[33],"genes":[34],"associated":[36],"with":[37],"various":[38],"diseases,":[39],"which":[40,47],"make":[41],"it":[42],"essential":[43,140],"drug":[44,64,180],"targets.":[45,82,135],"Approaches":[46],"can":[48,128,147,162],"predict":[49],"inhibition":[51],"compounds":[54,79,114],"different":[56,144],"target":[58,146],"should":[59],"be":[60,129,148],"particularly":[61],"helpful":[62],"development.":[65],"this":[67,160],"study,":[68],"proteochemometric":[69],"modelling":[70],"was":[71],"introduced":[72],"analysis":[74],"bioactivity":[76],"between":[77],"chemical":[78],"Results":[83],"illustrated":[84],"our":[88],"PCM":[89],"model":[90],"high-throughput":[92],"NR-inhibitor":[93],"screening":[94,167],"after":[95],"evaluated":[96],"on":[97],"both":[98],"internal":[99],"(AUC":[100,105],">":[101,106],"0.870)":[102],"external":[104],"0.746)":[107],"validation":[108],"set.":[109],"Moreover,":[110],"in-silico":[111],"predicted":[112],"bioactive":[113,141],"were":[115],"clustered":[116],"according":[117],"structure":[119],"similarity":[120],"series":[123],"representative":[125],"molecular":[126,156],"scaffolds":[127,137,142,157],"derived":[130],"five":[132],"major":[133],"Through":[136],"analysis,":[138],"those":[139],"detected":[149],"compared.":[151],"Generally,":[152],"methods":[154],"proposed":[158],"in":[159],"article":[161],"not":[163],"only":[164],"help":[165],"potential":[169],"therapeutic":[170],"NR-inhibitors":[171],"but":[172],"also":[173],"able":[174],"guide":[176],"future":[178],"NR-related":[179],"discovery.":[181]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":4}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
