{"id":"https://openalex.org/W2344951652","doi":"https://doi.org/10.1186/s13321-016-0135-5","title":"Ligand cluster-based protein network and ePlatton, a multi-target ligand finder","display_name":"Ligand cluster-based protein network and ePlatton, a multi-target ligand finder","publication_year":2016,"publication_date":"2016-04-30","ids":{"openalex":"https://openalex.org/W2344951652","doi":"https://doi.org/10.1186/s13321-016-0135-5","mag":"2344951652","pmid":"https://pubmed.ncbi.nlm.nih.gov/27143991"},"language":"en","primary_location":{"id":"doi:10.1186/s13321-016-0135-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13321-016-0135-5","pdf_url":null,"source":{"id":"https://openalex.org/S180838163","display_name":"Journal of Cheminformatics","issn_l":"1758-2946","issn":["1758-2946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cheminformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s13321-016-0135-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011386500","display_name":"Yu Du","orcid":"https://orcid.org/0000-0002-4114-396X"},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yu Du","raw_affiliation_strings":["Center for Bioinformatics and Computational Biology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241 China","Center for Bioinformatics and Computational Biology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China"],"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics and Computational Biology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241 China","institution_ids":[]},{"raw_affiliation_string":"Center for Bioinformatics and Computational Biology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048591018","display_name":"Tieliu Shi","orcid":"https://orcid.org/0000-0001-5592-2836"},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tieliu Shi","raw_affiliation_strings":["Center for Bioinformatics and Computational Biology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241 China","Center for Bioinformatics and Computational Biology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China"],"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics and Computational Biology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241 China","institution_ids":[]},{"raw_affiliation_string":"Center for Bioinformatics and Computational Biology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China","institution_ids":["https://openalex.org/I66867065"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5011386500"],"corresponding_institution_ids":["https://openalex.org/I66867065"],"apc_list":{"value":1290,"currency":"GBP","value_usd":1582},"apc_paid":{"value":1290,"currency":"GBP","value_usd":1582},"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.02105065,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8","issue":"1","first_page":"23","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6797571182250977},{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.6391866207122803},{"id":"https://openalex.org/keywords/cluster","display_name":"Cluster (spacecraft)","score":0.6073465943336487},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4162350594997406},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3771131634712219},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2930254340171814},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.21641138195991516},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.12238824367523193},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11996710300445557}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6797571182250977},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.6391866207122803},{"id":"https://openalex.org/C164866538","wikidata":"https://www.wikidata.org/wiki/Q367351","display_name":"Cluster (spacecraft)","level":2,"score":0.6073465943336487},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4162350594997406},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3771131634712219},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2930254340171814},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.21641138195991516},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12238824367523193},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11996710300445557},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/s13321-016-0135-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13321-016-0135-5","pdf_url":null,"source":{"id":"https://openalex.org/S180838163","display_name":"Journal of Cheminformatics","issn_l":"1758-2946","issn":["1758-2946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cheminformatics","raw_type":"journal-article"},{"id":"pmid:27143991","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27143991","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cheminformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4853874","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4853874","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Cheminform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s13321-016-0135-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13321-016-0135-5","pdf_url":null,"source":{"id":"https://openalex.org/S180838163","display_name":"Journal of Cheminformatics","issn_l":"1758-2946","issn":["1758-2946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cheminformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4099999964237213,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322370","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67"},{"id":"https://openalex.org/F4320336024","display_name":"Specialized Research Fund for the Doctoral Program of Higher Education of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1487942432","https://openalex.org/W1544009106","https://openalex.org/W1974758710","https://openalex.org/W1986223165","https://openalex.org/W1994103352","https://openalex.org/W2026265322","https://openalex.org/W2067184525","https://openalex.org/W2081266727","https://openalex.org/W2096541451","https://openalex.org/W2099254366","https://openalex.org/W2101234009","https://openalex.org/W2104402742","https://openalex.org/W2108067237","https://openalex.org/W2113561798","https://openalex.org/W2119412782","https://openalex.org/W2119512897","https://openalex.org/W2121598284","https://openalex.org/W2123402141","https://openalex.org/W2124166542","https://openalex.org/W2127322768","https://openalex.org/W2142572836","https://openalex.org/W2146292423","https://openalex.org/W2148797284","https://openalex.org/W2159482845","https://openalex.org/W2159675211","https://openalex.org/W2162011385","https://openalex.org/W2164998314","https://openalex.org/W2165232124","https://openalex.org/W2166574880","https://openalex.org/W2169678694","https://openalex.org/W2177544602","https://openalex.org/W2319002234","https://openalex.org/W2503622251","https://openalex.org/W2582743722","https://openalex.org/W3140207494","https://openalex.org/W4241727697","https://openalex.org/W4253863064","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W2382290278","https://openalex.org/W2478288626","https://openalex.org/W2350741829","https://openalex.org/W2530322880","https://openalex.org/W1596801655"],"abstract_inverted_index":{"Although":[0],"there":[1],"were":[2,14,40],"some":[3],"disagreements":[4],"between":[5,81],"the":[6,16,33,44,64,67,78],"LCBN":[7,34],"and":[8,28,47,57,72,83,86,95,101,106],"SBN,":[9],"communities":[10],"in":[11,59,92,98],"both":[12],"networks":[13],"largely":[15],"same":[17],"with":[18],"normalized":[19],"mutual":[20],"information":[21,102],"at":[22],"0.9.":[23],"The":[24],"study":[25],"of":[26,66,70],"target":[27],"ligand":[29,38,68],"cluster":[30],"promiscuity":[31],"underlying":[32],"showed":[35],"that":[36,48],"light":[37],"clusters":[39],"more":[41],"promiscuous":[42],"than":[43],"heavy":[45],"one":[46],"highly":[49],"connected":[50],"nodes":[51],"tended":[52],"to":[53,76],"be":[54],"protein":[55],"kinases":[56],"involved":[58],"phosphorylation.":[60],"ePlatton":[61,89],"considerably":[62],"reduced":[63],"redundancy":[65],"set":[69],"targets":[71],"made":[73],"it":[74],"easy":[75],"deduce":[77],"possible":[79],"relationship":[80],"compounds":[82],"targets,":[84],"pathways":[85],"side":[87],"effects.":[88],"behaved":[90],"reliably":[91],"validation":[93],"experiments":[94],"also":[96],"fast":[97],"virtual":[99],"screening":[100],"retrieval.Graphical":[103],"abstractCluster":[104],"exemplars":[105],"ePlatton's":[107],"mechanism.":[108]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
