{"id":"https://openalex.org/W7140622296","doi":"https://doi.org/10.1186/s13040-026-00549-x","title":"DBSCAN applied to EHRs data from patients with glioblastoma clusters patients based on cytosolic Hsp70 protein, sex, and brain subventricular zone","display_name":"DBSCAN applied to EHRs data from patients with glioblastoma clusters patients based on cytosolic Hsp70 protein, sex, and brain subventricular zone","publication_year":2026,"publication_date":"2026-03-27","ids":{"openalex":"https://openalex.org/W7140622296","doi":"https://doi.org/10.1186/s13040-026-00549-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/41888940"},"language":"en","primary_location":{"id":"doi:10.1186/s13040-026-00549-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-026-00549-x","pdf_url":null,"source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s13040-026-00549-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011556172","display_name":"Davide Chicco","orcid":"https://orcid.org/0000-0001-9655-7142"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["CA","IT"],"is_corresponding":true,"raw_author_name":"Davide Chicco","raw_affiliation_strings":["University of Toronto, Toronto, ON, Canada. davide.chicco@unimib.it","Universit\u00e0 di Milano-Bicocca, Milan, Italy. davide.chicco@unimib.it"],"raw_orcid":"https://orcid.org/0000-0001-9655-7142","affiliations":[{"raw_affiliation_string":"University of Toronto, Toronto, ON, Canada. davide.chicco@unimib.it","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Universit\u00e0 di Milano-Bicocca, Milan, Italy. davide.chicco@unimib.it","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130710103","display_name":"Srinjoy Dora","orcid":null},"institutions":[{"id":"https://openalex.org/I7848551","display_name":"Tbilisi State Medical University","ror":"https://ror.org/020jbrt22","country_code":"GE","type":"education","lineage":["https://openalex.org/I7848551"]}],"countries":["GE"],"is_corresponding":false,"raw_author_name":"Srinjoy Dora","raw_affiliation_strings":["Tbilisi State Medical University, Tbilisi, Georgia"],"raw_orcid":"https://orcid.org/0009-0008-0806-9842","affiliations":[{"raw_affiliation_string":"Tbilisi State Medical University, Tbilisi, Georgia","institution_ids":["https://openalex.org/I7848551"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5130695155","display_name":"Luca Oneto","orcid":null},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Oneto","raw_affiliation_strings":["Universit\u00e1 di Genova, Genoa, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8445-395X","affiliations":[{"raw_affiliation_string":"Universit\u00e1 di Genova, Genoa, Italy","institution_ids":["https://openalex.org/I83816512"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011556172"],"corresponding_institution_ids":["https://openalex.org/I185261750","https://openalex.org/I66752286"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.40148479,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.8615999817848206,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.8615999817848206,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14364","display_name":"Clusterin in disease pathology","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"Glioblastoma","score":0.7631999850273132},{"id":"https://openalex.org/keywords/subventricular-zone","display_name":"Subventricular zone","score":0.7314000129699707},{"id":"https://openalex.org/keywords/cytosol","display_name":"Cytosol","score":0.6079000234603882},{"id":"https://openalex.org/keywords/dbscan","display_name":"DBSCAN","score":0.510200023651123},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.3549000024795532},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.34599998593330383}],"concepts":[{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.7631999850273132},{"id":"https://openalex.org/C2777542384","wikidata":"https://www.wikidata.org/wiki/Q937403","display_name":"Subventricular zone","level":4,"score":0.7314000129699707},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.6079000234603882},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5666000247001648},{"id":"https://openalex.org/C46576248","wikidata":"https://www.wikidata.org/wiki/Q1114630","display_name":"DBSCAN","level":5,"score":0.510200023651123},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44670000672340393},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.35670000314712524},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.3549000024795532},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3513999879360199},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.34599998593330383},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32019999623298645},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.3075999915599823},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.2971999943256378},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.2937999963760376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2847000062465668},{"id":"https://openalex.org/C71472368","wikidata":"https://www.wikidata.org/wiki/Q676880","display_name":"Text mining","level":2,"score":0.2671000063419342},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2612000107765198},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.2508000135421753}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s13040-026-00549-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-026-00549-x","pdf_url":null,"source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},{"id":"pmid:41888940","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41888940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData mining","raw_type":null},{"id":"pmh:oai:doaj.org/article:da148100eafe462483fb4e6f22fa6ab3","is_oa":true,"landing_page_url":"https://doaj.org/article/da148100eafe462483fb4e6f22fa6ab3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Mining, Vol 19, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13147812","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13147812/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Min","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s13040-026-00549-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-026-00549-x","pdf_url":null,"source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1597559145","https://openalex.org/W1987971958","https://openalex.org/W1991800725","https://openalex.org/W2022401242","https://openalex.org/W2022686119","https://openalex.org/W2025183726","https://openalex.org/W2036318837","https://openalex.org/W2051526030","https://openalex.org/W2080418553","https://openalex.org/W2152842394","https://openalex.org/W2159355549","https://openalex.org/W2160197181","https://openalex.org/W2160642098","https://openalex.org/W2171180835","https://openalex.org/W2302501749","https://openalex.org/W2408186052","https://openalex.org/W2601243251","https://openalex.org/W2620951925","https://openalex.org/W2740924709","https://openalex.org/W2747758441","https://openalex.org/W2761714660","https://openalex.org/W2792172681","https://openalex.org/W2914296406","https://openalex.org/W2945976633","https://openalex.org/W2945986701","https://openalex.org/W2969672910","https://openalex.org/W2971538598","https://openalex.org/W2977098467","https://openalex.org/W2979896911","https://openalex.org/W2981809923","https://openalex.org/W3003257820","https://openalex.org/W3025355824","https://openalex.org/W3035965352","https://openalex.org/W3043555620","https://openalex.org/W3094480217","https://openalex.org/W3118434586","https://openalex.org/W3129990808","https://openalex.org/W3133831696","https://openalex.org/W3161321578","https://openalex.org/W4221086781","https://openalex.org/W4231029117","https://openalex.org/W4285388295","https://openalex.org/W4321480571","https://openalex.org/W4365452787","https://openalex.org/W4366753617","https://openalex.org/W4382344675","https://openalex.org/W4383558681","https://openalex.org/W4386888280","https://openalex.org/W4389440438","https://openalex.org/W4392884296","https://openalex.org/W4393356824","https://openalex.org/W4396217733","https://openalex.org/W4398145571","https://openalex.org/W4408105981","https://openalex.org/W4411237205","https://openalex.org/W4411610434","https://openalex.org/W4412177632","https://openalex.org/W4413834052","https://openalex.org/W4414404079","https://openalex.org/W4415081083"],"related_works":[],"abstract_inverted_index":{"Glioblastoma":[0],"is":[1,64],"an":[2,55,65,72],"aggressive":[3],"brain":[4,205],"cancer":[5],"that":[6,89,191],"kills":[7],"approximately":[8],"one":[9],"hundred":[10],"thousand":[11],"people":[12],"worldwide":[13],"every":[14],"year.":[15],"Unfortunately,":[16],"treatment":[17],"and":[18,27,51,87,110,121,155,189,204],"therapy":[19],"for":[20,60],"patients":[21,125],"with":[22,127,138,167],"this":[23,97],"disease":[24],"are":[25],"complicated":[26],"have":[28],"limited":[29],"efficacy":[30],"in":[31,195,200,208],"improving":[32],"individuals\u2019":[33],"chances":[34],"of":[35,58,67,124,150,165,183],"survival.":[36],"Electronic":[37],"health":[38,115],"records":[39],"(EHRs)":[40],"contain":[41],"patient":[42],"information":[43],"collected":[44],"routinely":[45],"at":[46],"hospitals":[47],"through":[48],"medical":[49],"visits":[50],"laboratory":[52],"tests,":[53],"providing":[54],"interesting":[56],"source":[57],"data":[59,75],"computational":[61],"analyses.":[62],"Clustering":[63,141,164],"area":[66],"unsupervised":[68],"machine":[69],"learning":[70],"where":[71],"algorithm":[73],"partitions":[74],"according":[76],"to":[77,94,104,214],"certain":[78],"statistical":[79],"properties":[80],"or":[81],"rules,":[82],"thereby":[83],"identifying":[84],"hidden":[85],"patterns":[86],"correlations":[88],"would":[90],"otherwise":[91],"be":[92],"difficult":[93],"notice.":[95],"In":[96],"study,":[98],"we":[99],"applied":[100],"several":[101],"clustering":[102,136],"techniques":[103],"three":[105,176],"open":[106],"datasets":[107],"(Munich2019,":[108],"Tainan2020,":[109],"Utrecht2019)":[111],"derived":[112],"from":[113],"electronic":[114],"records,":[116],"which":[117],"included":[118],"clinical,":[119],"genetic,":[120],"administrative":[122],"features":[123,182],"diagnosed":[126],"glioblastoma,":[128],"considering":[129],"two":[130,217],"possible":[131],"clusters.":[132,157,218],"We":[133,178],"evaluated":[134],"our":[135],"results":[137,173],"the":[139,159,171,181,184,196,201,209,216],"Density-Based":[140],"Validation":[142],"(DBCV)":[143],"index,":[144],"a":[145],"relatively":[146],"new":[147],"score":[148],"capable":[149,213],"accurately":[151],"assessing":[152],"both":[153],"convex-shaped":[154],"concave-shaped":[156],"Among":[158],"methods":[160],"tested,":[161],"Density-based":[162],"Spatial":[163],"Applications":[166],"Noise":[168],"(DBSCAN)":[169],"yielded":[170],"best":[172],"across":[174],"all":[175],"datasets.":[177],"then":[179],"analyzed":[180],"clusters":[185],"identified":[186],"by":[187],"DBSCAN":[188],"found":[190],"cytosolic":[192],"Hsp70":[193],"protein":[194],"Munich2019":[197],"dataset,":[198,203],"sex":[199],"Tainan2020":[202],"subventricular":[206],"zone":[207],"Utrecht2019":[210],"resulted":[211],"significantly":[212],"distinguish":[215]},"counts_by_year":[],"updated_date":"2026-06-17T08:01:34.144755","created_date":"2026-03-27T00:00:00"}
