{"id":"https://openalex.org/W4413309587","doi":"https://doi.org/10.1186/s13040-025-00472-7","title":"Exploring the common genetic basis of metabolic syndrome-related diseases and chronic kidney disease: insights from extensive genome-wide cross-trait analyses","display_name":"Exploring the common genetic basis of metabolic syndrome-related diseases and chronic kidney disease: insights from extensive genome-wide cross-trait analyses","publication_year":2025,"publication_date":"2025-08-17","ids":{"openalex":"https://openalex.org/W4413309587","doi":"https://doi.org/10.1186/s13040-025-00472-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/40820219"},"language":"en","primary_location":{"id":"doi:10.1186/s13040-025-00472-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-025-00472-7","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/s13040-025-00472-7","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/s13040-025-00472-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100837502","display_name":"Yu Yin","orcid":null},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yu Yin","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039782567","display_name":"Chenkai Zhao","orcid":"https://orcid.org/0000-0002-0962-2741"},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenkai Zhao","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109726998","display_name":"Yibo Hua","orcid":null},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yibo Hua","raw_affiliation_strings":["Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826","https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fei Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Yang","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040233161","display_name":"Dandan Qiu","orcid":"https://orcid.org/0000-0001-7910-8409"},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dandan Qiu","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030545452","display_name":"Jiasheng Yan","orcid":null},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiasheng Yan","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010846399","display_name":"Xiaodong Jin","orcid":null},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaodong Jin","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China. 20233003@zcmu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China. 20233003@zcmu.edu.cn","institution_ids":["https://openalex.org/I114539943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5100837502"],"corresponding_institution_ids":["https://openalex.org/I114539943"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.5128,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.84513842,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"18","issue":"1","first_page":"54","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.05730000138282776,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mendelian-randomization","display_name":"Mendelian randomization","score":0.7780619859695435},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.6962369680404663},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6372854709625244},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.5386566519737244},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5134121179580688},{"id":"https://openalex.org/keywords/pleiotropy","display_name":"Pleiotropy","score":0.4891400635242462},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.48324427008628845},{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"Expression quantitative trait loci","score":0.4557298421859741},{"id":"https://openalex.org/keywords/kidney-disease","display_name":"Kidney disease","score":0.4472987949848175},{"id":"https://openalex.org/keywords/candidate-gene","display_name":"Candidate gene","score":0.4367527365684509},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.42796093225479126},{"id":"https://openalex.org/keywords/quantitative-trait-locus","display_name":"Quantitative trait locus","score":0.4241364002227783},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"Metabolic syndrome","score":0.421726256608963},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.31708234548568726},{"id":"https://openalex.org/keywords/obesity","display_name":"Obesity","score":0.2766408920288086},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2664021849632263},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2625865638256073},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.24746578931808472},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2446151077747345},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.1523500680923462},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.1515096127986908},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"Genetic variants","score":0.09716889262199402}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.7780619859695435},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.6962369680404663},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6372854709625244},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5386566519737244},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5134121179580688},{"id":"https://openalex.org/C26207810","wikidata":"https://www.wikidata.org/wiki/Q1134884","display_name":"Pleiotropy","level":4,"score":0.4891400635242462},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.48324427008628845},{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.4557298421859741},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.4472987949848175},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.4367527365684509},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.42796093225479126},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.4241364002227783},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.421726256608963},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.31708234548568726},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.2766408920288086},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2664021849632263},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2625865638256073},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.24746578931808472},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2446151077747345},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1523500680923462},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.1515096127986908},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.09716889262199402}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s13040-025-00472-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-025-00472-7","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/s13040-025-00472-7","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},{"id":"pmid:40820219","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40820219","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData mining","raw_type":null},{"id":"pmh:oai:doaj.org/article:b776069c72284e5ea3ad403b75b3be63","is_oa":true,"landing_page_url":"https://doaj.org/article/b776069c72284e5ea3ad403b75b3be63","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Mining, Vol 18, Iss 1, Pp 1-20 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12359972","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12359972","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Min","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s13040-025-00472-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-025-00472-7","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/s13040-025-00472-7","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7699999809265137,"display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322929","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413309587.pdf","grobid_xml":"https://content.openalex.org/works/W4413309587.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W1968366673","https://openalex.org/W1972296124","https://openalex.org/W1976307656","https://openalex.org/W1978228542","https://openalex.org/W1978569216","https://openalex.org/W1979959797","https://openalex.org/W2027991336","https://openalex.org/W2037389395","https://openalex.org/W2051314902","https://openalex.org/W2051882044","https://openalex.org/W2090313348","https://openalex.org/W2105987065","https://openalex.org/W2110230544","https://openalex.org/W2115944543","https://openalex.org/W2130410032","https://openalex.org/W2132452462","https://openalex.org/W2141618557","https://openalex.org/W2144434696","https://openalex.org/W2145601431","https://openalex.org/W2153860431","https://openalex.org/W2162078360","https://openalex.org/W2171777347","https://openalex.org/W2255811523","https://openalex.org/W2287859856","https://openalex.org/W2559913810","https://openalex.org/W2604218568","https://openalex.org/W2754289264","https://openalex.org/W2757656649","https://openalex.org/W2770092353","https://openalex.org/W2787269887","https://openalex.org/W2799535074","https://openalex.org/W2802953148","https://openalex.org/W2923773844","https://openalex.org/W2923787619","https://openalex.org/W2937232328","https://openalex.org/W2947278243","https://openalex.org/W2964375803","https://openalex.org/W2969604259","https://openalex.org/W2983306749","https://openalex.org/W2997273572","https://openalex.org/W2997939171","https://openalex.org/W3005627128","https://openalex.org/W3005957464","https://openalex.org/W3034611697","https://openalex.org/W3037588075","https://openalex.org/W3042936392","https://openalex.org/W3083581581","https://openalex.org/W3090563015","https://openalex.org/W3107928135","https://openalex.org/W3112344733","https://openalex.org/W3123801992","https://openalex.org/W3126704164","https://openalex.org/W3132811225","https://openalex.org/W3133859624","https://openalex.org/W3141294941","https://openalex.org/W3159877673","https://openalex.org/W3214522116","https://openalex.org/W4205484184","https://openalex.org/W4211210745","https://openalex.org/W4226412099","https://openalex.org/W4233878203","https://openalex.org/W4285600790","https://openalex.org/W4285731597","https://openalex.org/W4313236580","https://openalex.org/W4319461015","https://openalex.org/W4378952591","https://openalex.org/W4384155766","https://openalex.org/W4387091686","https://openalex.org/W4394795138","https://openalex.org/W4396636742","https://openalex.org/W4396748579","https://openalex.org/W4402844941","https://openalex.org/W4403317574","https://openalex.org/W4403896496","https://openalex.org/W4405646778","https://openalex.org/W6676171730","https://openalex.org/W6676457750","https://openalex.org/W6730216708","https://openalex.org/W6748242114","https://openalex.org/W6750964467","https://openalex.org/W6761105826","https://openalex.org/W6807538478","https://openalex.org/W7002187497"],"related_works":["https://openalex.org/W2784614321","https://openalex.org/W4396219410","https://openalex.org/W2945740433","https://openalex.org/W3041584880","https://openalex.org/W2508244144","https://openalex.org/W4400475119","https://openalex.org/W3105571484","https://openalex.org/W4298354422","https://openalex.org/W2951961863","https://openalex.org/W3092497798"],"abstract_inverted_index":{"BACKGROUND:":[0],"Chronic":[1],"kidney":[2],"disease":[3],"(CKD)":[4],"is":[5,35],"a":[6,36,77,253],"globally":[7],"prevalent":[8],"chronic":[9],"condition":[10],"characterized":[11,28],"by":[12,29],"progressive":[13],"renal":[14],"function":[15],"decline,":[16],"imposing":[17],"significant":[18,37,195],"economic":[19],"and":[20,33,49,60,70,89,101,105,116,153,189,211,228,245,260,272,279],"psychological":[21],"burdens":[22],"on":[23,63],"patients.":[24],"Metabolic":[25,216],"syndrome":[26],"(MetS),":[27],"obesity,":[30],"hypertension,":[31],"hyperglycemia,":[32],"dyslipidemia,":[34],"risk":[38,66,164],"factor":[39],"for":[40,139,285],"CKD.":[41,261],"A":[42],"strong":[43],"epidemiological":[44],"association":[45,141],"exists":[46],"between":[47,57,114,150,270],"CKD":[48,90,115,271],"MetS.":[50,117],"This":[51,263],"study":[52,145,264],"explores":[53],"the":[54,93,126,194,198,226,239,266],"genetic":[55,72,148,268,277],"connections":[56],"MetS-related":[58,87,258,273],"diseases":[59,88,259],"CKD,":[61],"focusing":[62],"identifying":[64,275],"shared":[65,98,147,276],"loci,":[67],"key":[68],"tissues,":[69],"underlying":[71],"mechanisms.":[73],"METHODS:":[74],"We":[75],"performed":[76],"cross-trait":[78],"pleiotropy":[79],"analysis":[80,179,192,251],"using":[81],"summary-level":[82],"GWAS":[83],"data":[84],"from":[85,92],"ten":[86],"obtained":[91],"IEU":[94],"database":[95],"to":[96,110,124],"detect":[97],"pleiotropic":[99,157,183,233],"loci":[100,158,166,171,278],"genes.":[102],"Functional":[103],"annotation":[104],"tissue-specific":[106],"analyses":[107,224],"were":[108,167],"conducted":[109],"reveal":[111],"potential":[112],"associations":[113],"Additionally,":[118],"we":[119],"used":[120],"metabolite":[121,249],"colocalization":[122,175,250],"methods":[123],"explore":[125],"metabolic":[127,254],"perspective":[128],"of":[129,197,200,205,214],"these":[130,220],"diseases'":[131],"associations.":[132],"Finally,":[133],"Mendelian":[134],"randomization":[135],"(MR)":[136],"was":[137],"employed":[138],"further":[140],"analysis.":[142,176],"RESULTS:":[143],"The":[144],"identified":[146,180,193],"mechanisms":[149,234],"mental":[151],"disorders":[152],"prostatitis,":[154],"revealing":[155],"1,437":[156],"at":[159,225],"genome-wide":[160],"significance.":[161],"Forty-four":[162],"dominant":[163],"SNP":[165,227],"annotated,":[168],"with":[169],"11":[170],"confirmed":[172],"through":[173],"causal":[174],"Further":[177],"gene-level":[178],"eight":[181],"unique":[182],"genes,":[184],"including":[185],"APOC1,":[186],"APOE,":[187],"BICC1,":[188],"PDILT.":[190],"Pathway":[191],"involvement":[196],"Metabolism":[199],"Fat-Soluble":[201],"Vitamins,":[202],"Positive":[203,212],"Regulation":[204,213],"Plasma":[206],"Membrane-Bounded":[207],"Cell":[208],"Projection":[209],"Assembly,":[210],"RNA":[215],"Process":[217],"pathways":[218],"in":[219,238],"diseases.":[221],"Tissue":[222],"enrichment":[223],"gene":[229],"levels":[230],"indicated":[231],"that":[232],"play":[235],"crucial":[236],"roles":[237],"Adipose":[240],"Visceral":[241],"Omentum,":[242],"Brain":[243],"Cerebellum,":[244],"Testis.":[246],"Ultimately,":[247],"phenotypic-level":[248],"revealed":[252],"intermediary":[255],"mechanism":[256],"linking":[257],"CONCLUSION:":[262],"uncovers":[265],"complex":[267],"interactions":[269],"diseases,":[274],"biological":[280],"pathways,":[281],"providing":[282],"novel":[283],"insights":[284],"future":[286],"therapeutic":[287],"strategies.":[288]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}