{"id":"https://openalex.org/W4411237205","doi":"https://doi.org/10.1186/s13040-025-00455-8","title":"DBSCAN and DBCV application to open medical records heterogeneous data for identifying clinically significant clusters of patients with neuroblastoma","display_name":"DBSCAN and DBCV application to open medical records heterogeneous data for identifying clinically significant clusters of patients with neuroblastoma","publication_year":2025,"publication_date":"2025-06-12","ids":{"openalex":"https://openalex.org/W4411237205","doi":"https://doi.org/10.1186/s13040-025-00455-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/40506780"},"language":"en","primary_location":{"id":"doi:10.1186/s13040-025-00455-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-025-00455-8","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/s13040-025-00455-8","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/s13040-025-00455-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011556172","display_name":"Davide Chicco","orcid":"https://orcid.org/0000-0001-9655-7142"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["CA","IT"],"is_corresponding":true,"raw_author_name":"Davide Chicco","raw_affiliation_strings":["University of Toronto, Toronto, Ontario, Canada. davidechicco@davidechicco.it","Universit\u00e0 di Milano-Bicocca, Milan, Italy. davidechicco@davidechicco.it","Universit\u00e0 di Milano-Bicocca, Milan, Italy","University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0001-9655-7142","affiliations":[{"raw_affiliation_string":"University of Toronto, Toronto, Ontario, Canada. davidechicco@davidechicco.it","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Universit\u00e0 di Milano-Bicocca, Milan, Italy. davidechicco@davidechicco.it","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"Universit\u00e0 di Milano-Bicocca, Milan, Italy","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045802198","display_name":"Luca Oneto","orcid":"https://orcid.org/0000-0002-8445-395X"},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Oneto","raw_affiliation_strings":["Universit\u00e0 di Genova, Genoa, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8445-395X","affiliations":[{"raw_affiliation_string":"Universit\u00e0 di Genova, Genoa, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079494146","display_name":"Davide Cangelosi","orcid":"https://orcid.org/0000-0002-6010-5619"},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Davide Cangelosi","raw_affiliation_strings":["IRCCS Istituto Giannina Gaslini, Genoa, Italy"],"raw_orcid":"https://orcid.org/0000-0002-6010-5619","affiliations":[{"raw_affiliation_string":"IRCCS Istituto Giannina Gaslini, Genoa, Italy","institution_ids":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011556172"],"corresponding_institution_ids":["https://openalex.org/I185261750","https://openalex.org/I66752286"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":4.3041,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.94210706,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"18","issue":"1","first_page":"40","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9900000095367432,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9900000095367432,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9736999869346619,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9358999729156494,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7059313654899597},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.5405951142311096},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"Neuroblastoma","score":0.4282355010509491},{"id":"https://openalex.org/keywords/medical-record","display_name":"Medical record","score":0.4230748414993286},{"id":"https://openalex.org/keywords/dbscan","display_name":"DBSCAN","score":0.42181649804115295},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.35499584674835205},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.34984830021858215},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.3104356825351715},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2548683285713196},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.23419755697250366},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.19399920105934143},{"id":"https://openalex.org/keywords/fuzzy-clustering","display_name":"Fuzzy clustering","score":0.07685711979866028}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7059313654899597},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5405951142311096},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.4282355010509491},{"id":"https://openalex.org/C195910791","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Medical record","level":2,"score":0.4230748414993286},{"id":"https://openalex.org/C46576248","wikidata":"https://www.wikidata.org/wiki/Q1114630","display_name":"DBSCAN","level":5,"score":0.42181649804115295},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.35499584674835205},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.34984830021858215},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.3104356825351715},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2548683285713196},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23419755697250366},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.19399920105934143},{"id":"https://openalex.org/C17212007","wikidata":"https://www.wikidata.org/wiki/Q5511111","display_name":"Fuzzy clustering","level":3,"score":0.07685711979866028},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.0},{"id":"https://openalex.org/C104047586","wikidata":"https://www.wikidata.org/wiki/Q5033439","display_name":"Canopy clustering algorithm","level":4,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1186/s13040-025-00455-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-025-00455-8","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/s13040-025-00455-8","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},{"id":"pmid:40506780","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40506780","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData mining","raw_type":null},{"id":"pmh:oai:boa.unimib.it:10281/562203","is_oa":true,"landing_page_url":"https://hdl.handle.net/10281/562203","pdf_url":null,"source":{"id":"https://openalex.org/S4306401259","display_name":"BOA (University of Milano-Bicocca)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:d2ca0fbb442e4b50ad438cbe56de8167","is_oa":true,"landing_page_url":"https://doaj.org/article/d2ca0fbb442e4b50ad438cbe56de8167","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Mining, Vol 18, Iss 1, Pp 1-17 (2025)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:10975507","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12164137","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:iris.unige.it:11567/1261822","is_oa":false,"landing_page_url":"https://hdl.handle.net/11567/1261822","pdf_url":null,"source":{"id":"https://openalex.org/S4377196291","display_name":"CINECA IRIS Institutial Research Information System (University of Genoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I83816512","host_organization_name":"University of Genoa","host_organization_lineage":["https://openalex.org/I83816512"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s13040-025-00455-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-025-00455-8","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/s13040-025-00455-8","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411237205.pdf","grobid_xml":"https://content.openalex.org/works/W4411237205.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1594527429","https://openalex.org/W1987971958","https://openalex.org/W1990643970","https://openalex.org/W1991154291","https://openalex.org/W1995875735","https://openalex.org/W2022686119","https://openalex.org/W2029064186","https://openalex.org/W2037591813","https://openalex.org/W2046386156","https://openalex.org/W2049017883","https://openalex.org/W2051224630","https://openalex.org/W2071949631","https://openalex.org/W2085487226","https://openalex.org/W2103909453","https://openalex.org/W2129688634","https://openalex.org/W2135964318","https://openalex.org/W2152420890","https://openalex.org/W2152842394","https://openalex.org/W2160197181","https://openalex.org/W2171180835","https://openalex.org/W2262188337","https://openalex.org/W2278186831","https://openalex.org/W2302501749","https://openalex.org/W2408186052","https://openalex.org/W2529944135","https://openalex.org/W2552031156","https://openalex.org/W2594975452","https://openalex.org/W2620294703","https://openalex.org/W2740924709","https://openalex.org/W2787846247","https://openalex.org/W2801926025","https://openalex.org/W2889989836","https://openalex.org/W2892587974","https://openalex.org/W2892933709","https://openalex.org/W2969802495","https://openalex.org/W2975612929","https://openalex.org/W2996984981","https://openalex.org/W3076622137","https://openalex.org/W3108015338","https://openalex.org/W3122815434","https://openalex.org/W3129803974","https://openalex.org/W3170373966","https://openalex.org/W3206046727","https://openalex.org/W4220712627","https://openalex.org/W4231029117","https://openalex.org/W4245031745","https://openalex.org/W4282014924","https://openalex.org/W4301396488","https://openalex.org/W4303055841","https://openalex.org/W4323050290","https://openalex.org/W4386003022","https://openalex.org/W4386496483","https://openalex.org/W4386888280","https://openalex.org/W4388263324","https://openalex.org/W4390670611","https://openalex.org/W4405108053"],"related_works":["https://openalex.org/W3163639875","https://openalex.org/W1974317126","https://openalex.org/W2331058431","https://openalex.org/W2021744816","https://openalex.org/W2943556186","https://openalex.org/W3176449234","https://openalex.org/W2767235736","https://openalex.org/W2045002201","https://openalex.org/W4225278791","https://openalex.org/W4322502698"],"abstract_inverted_index":{"Neuroblastoma":[0,140],"is":[1,25,103],"a":[2,148,235,253],"common":[3,267],"pediatric":[4],"cancer":[5],"that":[6,54,189,214,223],"affects":[7],"thousands":[8],"of":[9,17,29,33,44,79,181,198,250,252],"infants":[10],"worldwide,":[11],"especially":[12],"children":[13],"under":[14],"five":[15],"years":[16],"age.":[18],"Although":[19],"recovery":[20],"for":[21,90,112],"patients":[22,45,53,92,127,218,251],"with":[23,35,46,129,167,183],"neuroblastoma":[24,39,229],"possible":[26],"in":[27,72,204,227],"80%":[28],"cases,":[30],"only":[31,187],"40%":[32],"those":[34],"high-risk":[36],"stage":[37],"four":[38],"survive.":[40],"Electronic":[41,141],"health":[42,239],"records":[43],"this":[47,117],"disease":[48,255],"contain":[49],"valuable":[50],"data":[51,125,249],"on":[52,238],"can":[55,74,82,233,256],"be":[56],"analyzed":[57,156],"using":[58,159],"computational":[59,243],"intelligence":[60],"and":[61,134,147,163,208,261,272],"statistical":[62],"software":[63],"by":[64,202],"biomedical":[65],"informatics":[66],"researchers.":[67],"Unsupervised":[68],"machine":[69],"learning":[70],"methods,":[71],"particular,":[73],"identify":[75],"clinically":[76],"significant":[77,236],"subgroups":[78],"patients,":[80],"which":[81],"lead":[83],"to":[84,94,100,109,246,258],"new":[85],"therapies":[86],"or":[87],"medical":[88],"treatments":[89],"future":[91],"belonging":[93],"the":[95,131,135,139,151,165,168,186,195,205,217,220,228],"same":[96],"subgroups.":[97],"However,":[98],"access":[99],"these":[101,157,175],"datasets":[102,123,158,207],"often":[104],"restricted,":[105],"making":[106],"it":[107],"difficult":[108],"obtain":[110],"them":[111],"independent":[113],"research":[114],"projects.":[115],"In":[116],"study,":[118],"we":[119],"retrieved":[120],"three":[121,206],"open":[122],"containing":[124],"from":[126,138,150],"diagnosed":[128],"neuroblastoma:":[130],"Genoa":[132],"dataset":[133,137,149],"Shanghai":[136],"Health":[142],"Records":[143],"Open":[144],"Data":[145],"Repository,":[146],"TARGET-NBL":[152],"renowned":[153],"program.":[154],"We":[155,193],"several":[160,210],"clustering":[161],"techniques":[162],"measured":[164],"results":[166,232],"DBCV":[169,262],"(Density-Based":[170,178],"Clustering":[171,180],"Validation)":[172],"index.":[173],"Among":[174],"algorithms,":[176],"DBSCAN":[177,203,260],"Spatial":[179],"Applications":[182],"Noise)":[184],"was":[185],"one":[188],"produced":[190],"meaningful":[191],"results.":[192],"scrutinized":[194],"two":[196,221],"clusters":[197,222],"patients'":[199],"profiles":[200],"identified":[201],"recognized":[209],"relevant":[211],"clinical":[212,225],"variables":[213],"clearly":[215],"partitioned":[216],"into":[219],"have":[224,234],"meaning":[226],"literature.":[230],"Our":[231],"impact":[237],"informatics,":[240],"because":[241],"any":[242],"analyst":[244],"wishing":[245],"cluster":[247],"small":[248],"rare":[254],"choose":[257],"use":[259],"rather":[263],"than":[264],"utilizing":[265],"more":[266],"methods":[268],"such":[269],"as":[270],"k-Means":[271],"Silhouette":[273],"coefficient.":[274]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}