{"id":"https://openalex.org/W4410024327","doi":"https://doi.org/10.1186/s13040-025-00444-x","title":"Learning the therapeutic targets of acute myeloid leukemia through multiscale human interactome network and community analysis","display_name":"Learning the therapeutic targets of acute myeloid leukemia through multiscale human interactome network and community analysis","publication_year":2025,"publication_date":"2025-05-02","ids":{"openalex":"https://openalex.org/W4410024327","doi":"https://doi.org/10.1186/s13040-025-00444-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/40317082"},"language":"en","primary_location":{"id":"doi:10.1186/s13040-025-00444-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-025-00444-x","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/s13040-025-00444-x","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/s13040-025-00444-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106939896","display_name":"Suruthy Sivanathan","orcid":null},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Suruthy Sivanathan","raw_affiliation_strings":["School of Computing and the Department of Biomedical and Molecular Sciences, Queen's University, Goodwin Hall, Kingston, K7L 2N8, Ontario, Canada. 22ss59@queensu.ca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing and the Department of Biomedical and Molecular Sciences, Queen's University, Goodwin Hall, Kingston, K7L 2N8, Ontario, Canada. 22ss59@queensu.ca","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075046931","display_name":"Ting Hu","orcid":"https://orcid.org/0000-0001-6382-0602"},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ting Hu","raw_affiliation_strings":["School of Computing, Queen's University, Goodwin Hall, Kingston, K7L 2\u2009N8, Ontario, Canada","School of Computing, Queen's University, Goodwin Hall, Kingston, K7L 2\u2009N8K7L 2N8, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing, Queen's University, Goodwin Hall, Kingston, K7L 2\u2009N8, Ontario, Canada","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"School of Computing, Queen's University, Goodwin Hall, Kingston, K7L 2\u2009N8K7L 2N8, Ontario, Canada","institution_ids":["https://openalex.org/I204722609"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5106939896"],"corresponding_institution_ids":["https://openalex.org/I204722609"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":0.7477,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.7306719,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"18","issue":"1","first_page":"32","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9735000133514404,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interactome","display_name":"Interactome","score":0.869966983795166},{"id":"https://openalex.org/keywords/myeloid-leukemia","display_name":"Myeloid leukemia","score":0.7982650995254517},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5444435477256775},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.47610458731651306},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.38513368368148804},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3026390075683594},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.26227957010269165},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.1893180012702942},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12552714347839355},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.08803775906562805}],"concepts":[{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.869966983795166},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7982650995254517},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5444435477256775},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47610458731651306},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.38513368368148804},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3026390075683594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26227957010269165},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.1893180012702942},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12552714347839355},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08803775906562805}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s13040-025-00444-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-025-00444-x","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/s13040-025-00444-x","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},{"id":"pmid:40317082","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40317082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData mining","raw_type":null},{"id":"pmh:oai:doaj.org/article:290970ca41ef489f9d3de1573dcc80fb","is_oa":true,"landing_page_url":"https://doaj.org/article/290970ca41ef489f9d3de1573dcc80fb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Mining, Vol 18, Iss 1, Pp 1-27 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12049071","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12049071","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Min","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s13040-025-00444-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-025-00444-x","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/s13040-025-00444-x","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410024327.pdf","grobid_xml":"https://content.openalex.org/works/W4410024327.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W2004621641","https://openalex.org/W2041678991","https://openalex.org/W2055255976","https://openalex.org/W2061733131","https://openalex.org/W2063909949","https://openalex.org/W2093606292","https://openalex.org/W2103485196","https://openalex.org/W2124283923","https://openalex.org/W2130402225","https://openalex.org/W2137252097","https://openalex.org/W2154313451","https://openalex.org/W2155505897","https://openalex.org/W2159675211","https://openalex.org/W2170146596","https://openalex.org/W2234045142","https://openalex.org/W2328841379","https://openalex.org/W2506307224","https://openalex.org/W2581164166","https://openalex.org/W2747905863","https://openalex.org/W2769876973","https://openalex.org/W2778849455","https://openalex.org/W2913106281","https://openalex.org/W2921577938","https://openalex.org/W2928912053","https://openalex.org/W2949873777","https://openalex.org/W3001536458","https://openalex.org/W3004076595","https://openalex.org/W3006643887","https://openalex.org/W3016229308","https://openalex.org/W3034861032","https://openalex.org/W3090514538","https://openalex.org/W3094559596","https://openalex.org/W3095757021","https://openalex.org/W3101928875","https://openalex.org/W3120246130","https://openalex.org/W3137864305","https://openalex.org/W3159397045","https://openalex.org/W3162913615","https://openalex.org/W3163284023","https://openalex.org/W3164477864","https://openalex.org/W3183776936","https://openalex.org/W4200337903","https://openalex.org/W4214704287","https://openalex.org/W4238908247","https://openalex.org/W4281765458","https://openalex.org/W4283822588","https://openalex.org/W4283834156","https://openalex.org/W4294613032","https://openalex.org/W4308197761","https://openalex.org/W4309362469","https://openalex.org/W4310038910","https://openalex.org/W4389003190","https://openalex.org/W4393947775","https://openalex.org/W6678774816"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4292634579","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W2056125010","https://openalex.org/W3005984791","https://openalex.org/W2169777166","https://openalex.org/W2007507741"],"abstract_inverted_index":{"Acute":[0],"myeloid":[1,10],"leukemia":[2],"(AML)":[3],"is":[4,24,35,48,74],"caused":[5],"by":[6,31,84],"proliferation":[7],"of":[8,40,44,87,189],"mutated":[9],"progenitor":[11],"cells.":[12],"The":[13,70,110],"standard":[14],"chemotherapy":[15],"regimen":[16],"does":[17],"not":[18],"efficiently":[19],"cause":[20],"remission":[21],"as":[22,154],"there":[23,47],"a":[25,64,75,155,194],"high":[26],"relapse":[27],"rate.":[28],"Resistance":[29],"acquired":[30],"leukemic":[32],"stem":[33],"cells":[34],"suggested":[36],"to":[37,51,164],"be":[38,95,152],"one":[39],"the":[41,88,102,107,136,146,175],"root":[42],"causes":[43],"relapse.":[45],"Therefore,":[46],"an":[49,184],"urgency":[50],"develop":[52],"new":[53],"drugs":[54,59],"for":[55,60,130,157,183,192],"therapy.":[56],"Repurposing":[57],"approved":[58],"AML":[61,131],"can":[62,79],"provide":[63],"cost-friendly,":[65],"time-efficient,":[66],"and":[67,90,117,132,138,169,177,186],"affordable":[68],"alternative.":[69],"multiscale":[71,103],"interactome":[72,104],"network":[73,105],"computational":[76],"tool":[77],"that":[78,93,142,149,171],"identify":[80,127],"potential":[81,190],"therapeutic":[82,128,147],"candidates":[83,129,191],"comparing":[85],"mechanisms":[86,134,170],"drug":[89],"disease.":[91,197],"Communities":[92],"could":[94,150],"potentially":[96,151],"experimentally":[97],"validated":[98],"are":[99,112,143,172],"detected":[100],"in":[101,145],"using":[106],"algorithm":[108],"CRank.":[109],"results":[111],"evaluated":[113],"through":[114],"literature":[115],"search":[116],"Gene":[118],"Ontology":[119],"(GO)":[120],"enrichment":[121],"analysis.":[122],"In":[123],"this":[124],"research,":[125],"we":[126],"their":[133],"from":[135],"interactome,":[137],"isolate":[139],"prioritized":[140],"communities":[141],"dominant":[144],"mechanism":[148],"used":[153],"prompt":[156],"pre-clinical/translational":[158],"research":[159],"(e.g.":[160],"bioinformatics,":[161],"laboratory":[162],"research)":[163],"focus":[165],"on":[166],"biological":[167],"functions":[168],"associated":[173],"with":[174],"disease":[176],"drug.":[178],"This":[179],"method":[180],"may":[181],"allow":[182],"efficient":[185],"accelerated":[187],"discovery":[188],"AML,":[193],"rapidly":[195],"progressing":[196]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-07-29T09:40:50.615796","created_date":"2025-10-10T00:00:00"}
