{"id":"https://openalex.org/W4408768884","doi":"https://doi.org/10.1186/s13040-025-00432-1","title":"High-dimensional mediation analysis reveals the mediating role of physical activity patterns in genetic pathways leading to AD-like brain atrophy","display_name":"High-dimensional mediation analysis reveals the mediating role of physical activity patterns in genetic pathways leading to AD-like brain atrophy","publication_year":2025,"publication_date":"2025-03-24","ids":{"openalex":"https://openalex.org/W4408768884","doi":"https://doi.org/10.1186/s13040-025-00432-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/40128806"},"language":"en","primary_location":{"id":"doi:10.1186/s13040-025-00432-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-025-00432-1","pdf_url":null,"source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s13040-025-00432-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114172324","display_name":"Hanxiang Xu","orcid":null},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanxiang Xu","raw_affiliation_strings":["Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA","Department of Family Medicine and Public Health, University of California, San Diego, CA, 92093, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Family Medicine and Public Health, University of California, San Diego, CA, 92093, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102681545","display_name":"Shizhuo Mu","orcid":null},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shizhuo Mu","raw_affiliation_strings":["Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114211529","display_name":"Jingxuan Bao","orcid":null},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingxuan Bao","raw_affiliation_strings":["Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034999945","display_name":"Christos Davatzikos","orcid":"https://orcid.org/0000-0002-1025-8561"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christos Davatzikos","raw_affiliation_strings":["Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA","Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057578473","display_name":"Haochang Shou","orcid":"https://orcid.org/0000-0002-3043-047X"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haochang Shou","raw_affiliation_strings":["Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. haochang.shou@pennmedicine.upenn.edu","Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. haochang.shou@pennmedicine.upenn.edu","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080198746","display_name":"Li Shen","orcid":"https://orcid.org/0000-0001-6520-1418"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Shen","raw_affiliation_strings":["Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. li.shen@pennmedicine.upenn.edu","Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. li.shen@pennmedicine.upenn.edu","Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA","Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. li.shen@pennmedicine.upenn.edu","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. li.shen@pennmedicine.upenn.edu","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04933216,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"1","first_page":"24","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.4702000021934509,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.4702000021934509,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.23250000178813934,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.09380000084638596,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrophy","display_name":"Atrophy","score":0.6209592819213867},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.501345157623291},{"id":"https://openalex.org/keywords/mediation","display_name":"Mediation","score":0.4772722125053406},{"id":"https://openalex.org/keywords/biobank","display_name":"Biobank","score":0.45272544026374817},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.44917601346969604},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.43229764699935913},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.4248621463775635},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.3801376223564148},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3386121392250061},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.33275365829467773},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2806699275970459},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.13175591826438904},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12106940150260925}],"concepts":[{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.6209592819213867},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.501345157623291},{"id":"https://openalex.org/C179420905","wikidata":"https://www.wikidata.org/wiki/Q223871","display_name":"Mediation","level":2,"score":0.4772722125053406},{"id":"https://openalex.org/C116567970","wikidata":"https://www.wikidata.org/wiki/Q864217","display_name":"Biobank","level":2,"score":0.45272544026374817},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44917601346969604},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.43229764699935913},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.4248621463775635},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3801376223564148},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3386121392250061},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.33275365829467773},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2806699275970459},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.13175591826438904},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12106940150260925},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1186/s13040-025-00432-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-025-00432-1","pdf_url":null,"source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},{"id":"pmid:40128806","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40128806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData mining","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt01c7r613","is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/01c7r613","pdf_url":"https://escholarship.org/content/qt01c7r613/qt01c7r613.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Mining, vol 18, iss 1","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11931790","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11931790","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Min","raw_type":"Text"},{"id":"pmh:ark:/13030/qt01c7r613","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:doaj.org/article:8e994c141b374649b99bb15c7695f347","is_oa":true,"landing_page_url":"https://doaj.org/article/8e994c141b374649b99bb15c7695f347","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Mining, Vol 18, Iss 1, Pp 1-18 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13040-025-00432-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-025-00432-1","pdf_url":null,"source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.41999998688697815,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G2446501125","display_name":"Artificial Intelligence Strategies for Alzheimer's Disease Research","funder_award_id":"3u01ag066833-04s1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3183472389","display_name":"Machine Learning and Large-scale Imaging analytics for dimensional representations of brain trajectories in aging and preclinical Alzheimer's Disease: The brain aging chart and the iSTAGING consortium","funder_award_id":"3rf1ag054409-02s1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6258998","display_name":"Biomedical Image Computing and Informatics Cluster","funder_award_id":"1s10od023495-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G921880143","display_name":"Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease Biobanks","funder_award_id":"5u01ag068057-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W37092016","https://openalex.org/W1908991493","https://openalex.org/W2009110843","https://openalex.org/W2010143351","https://openalex.org/W2032582137","https://openalex.org/W2037584836","https://openalex.org/W2056621649","https://openalex.org/W2070330801","https://openalex.org/W2081221323","https://openalex.org/W2097522066","https://openalex.org/W2132575282","https://openalex.org/W2152723280","https://openalex.org/W2196038229","https://openalex.org/W2216742501","https://openalex.org/W2285799064","https://openalex.org/W2609563494","https://openalex.org/W2790240746","https://openalex.org/W2807749226","https://openalex.org/W2895486342","https://openalex.org/W2905504149","https://openalex.org/W2914694758","https://openalex.org/W2916891806","https://openalex.org/W2946436162","https://openalex.org/W2947686928","https://openalex.org/W2982417329","https://openalex.org/W2986860507","https://openalex.org/W2990439639","https://openalex.org/W3005680437","https://openalex.org/W3023804329","https://openalex.org/W3024208464","https://openalex.org/W3081437647","https://openalex.org/W3081528139","https://openalex.org/W3084546953","https://openalex.org/W3091619687","https://openalex.org/W3116286537","https://openalex.org/W3120950357","https://openalex.org/W3138447915","https://openalex.org/W3158105701","https://openalex.org/W3165645117","https://openalex.org/W3200841751","https://openalex.org/W3210373320","https://openalex.org/W4205463106","https://openalex.org/W4220722125","https://openalex.org/W4224999681","https://openalex.org/W4281563332","https://openalex.org/W4283836372","https://openalex.org/W4285305860","https://openalex.org/W4287973405","https://openalex.org/W4296691503","https://openalex.org/W4300960604","https://openalex.org/W4318762032","https://openalex.org/W4323350075","https://openalex.org/W4324309277","https://openalex.org/W4378953128","https://openalex.org/W4381661837","https://openalex.org/W4386154475","https://openalex.org/W4386246977","https://openalex.org/W4386484883","https://openalex.org/W4387331502","https://openalex.org/W4387494261","https://openalex.org/W4389440153","https://openalex.org/W4390015097","https://openalex.org/W4393279563","https://openalex.org/W4399317247"],"related_works":["https://openalex.org/W4285087457","https://openalex.org/W3113746618","https://openalex.org/W4226051228","https://openalex.org/W3017691140","https://openalex.org/W4384208482","https://openalex.org/W4244742767","https://openalex.org/W2470939431","https://openalex.org/W2024651825","https://openalex.org/W4401623684","https://openalex.org/W4395677717"],"abstract_inverted_index":{"BACKGROUND:":[0],"Alzheimer's":[1],"disease":[2],"(AD)":[3],"is":[4],"a":[5,145,212,245,252,317],"complex":[6,125],"disorder":[7],"that":[8,159,180],"affects":[9],"multiple":[10],"biological":[11],"systems":[12],"including":[13],"cognition,":[14],"behavior":[15,131],"and":[16,29,52,68,73,95,113,132,140,194,231,311],"physical":[17,49,267,306],"health.":[18],"Unfortunately,":[19],"the":[20,30,37,43,89,124,136,241,271,282,321,330,333,340],"pathogenic":[21,322],"mechanisms":[22,67,323,341],"behind":[23],"AD":[24,157,170],"are":[25,33,181],"not":[26],"yet":[27],"clear":[28],"treatment":[31],"options":[32],"still":[34],"limited.":[35],"Despite":[36],"increasing":[38],"number":[39],"of":[40,61,70,103,138,151,155,202,248,254,284,297,305,320,324,332,342],"studies":[41],"examining":[42],"pairwise":[44],"relationships":[45,90],"between":[46,226,308],"genetic":[47,92,128,260,309],"factors,":[48,93,130],"activity":[50,307],"(PA),":[51],"AD,":[53],"few":[54],"have":[55],"successfully":[56],"integrated":[57],"all":[58],"three":[59],"domains":[60],"data,":[62,299],"which":[63],"may":[64],"help":[65],"reveal":[66],"impact":[69],"these":[71,208],"genomic":[72],"phenomic":[74],"factors":[75,310],"on":[76],"AD.":[77,141,325],"We":[78,107,189,250],"use":[79],"high-dimensional":[80,213,285,334],"mediation":[81,214,256,278,286,291,303,335],"analysis":[82,198,215,287,296,336],"as":[83,164,186,204],"an":[84,165],"integrative":[85,295],"framework":[86],"to":[87,122,168,199,221,239,316],"study":[88],"among":[91,127],"PA":[94,112,203,229],"AD-like":[96,161],"brain":[97,104,133,162],"atrophy":[98],"quantified":[99],"by":[100,265],"spatial":[101],"patterns":[102,201],"atrophy.":[105],"RESULTS:":[106],"integrate":[108],"data":[109],"from":[110,117,244],"genetics,":[111],"neuroimaging":[114],"measures":[115],"collected":[116],"13,425":[118],"UK":[119],"Biobank":[120],"samples":[121],"unveil":[123],"relationship":[126],"risk":[129],"signatures":[134,230],"in":[135,338],"contexts":[137],"aging":[139],"Specifically,":[142],"we":[143,174,210,280,300],"used":[144],"composite":[146],"imaging":[147],"marker,":[148],"Spatial":[149],"Pattern":[150],"Abnormality":[152],"for":[153],"Recognition":[154],"Early":[156],"(SPARE-AD)":[158],"characterizes":[160],"atrophy,":[163],"outcome":[166],"variable":[167],"represent":[169],"risk.":[171],"Through":[172,294],"GWAS,":[173],"identified":[175,251,301],"single":[176],"nucleotide":[177],"polymorphisms":[178],"(SNPs)":[179],"significantly":[182],"associated":[183],"with":[184,273],"SPARE-AD":[185,264],"exposure":[187],"variables.":[188],"employed":[190],"conventional":[191],"summary":[192],"statistics":[193],"functional":[195],"principal":[196],"component":[197],"extract":[200],"mediators.":[205],"After":[206],"constructing":[207],"variables,":[209],"utilized":[211],"method,":[216],"Bayesian":[217,235],"Mediation":[218],"Analysis":[219],"(BAMA),":[220],"estimate":[222],"potential":[223,331],"mediating":[224],"pathways":[225,304],"SNPs,":[227],"multivariate":[228],"SPARE-AD.":[232,312],"BAMA":[233],"incorporates":[234],"continuous":[236],"shrinkage":[237],"prior":[238],"select":[240],"active":[242],"mediators":[243],"large":[246],"pool":[247],"candidates.":[249],"total":[253],"22":[255],"pathways,":[257],"indicating":[258],"how":[259],"variants":[261],"can":[262],"influence":[263],"altering":[266],"activity.":[268],"By":[269],"comparing":[270],"results":[272],"those":[274],"obtained":[275],"using":[276],"univariate":[277,290],"analysis,":[279],"demonstrate":[281],"advantages":[283],"methods":[288],"over":[289],"analysis.":[292],"CONCLUSION:":[293],"multi-omics":[298],"several":[302],"These":[313],"findings":[314],"contribute":[315],"better":[318],"understanding":[319],"Moreover,":[326],"our":[327],"research":[328],"demonstrates":[329],"method":[337],"revealing":[339],"disease.":[343]},"counts_by_year":[],"updated_date":"2026-09-02T07:38:04.252551","created_date":"2025-10-10T00:00:00"}