{"id":"https://openalex.org/W4402275866","doi":"https://doi.org/10.1186/s13040-024-00386-w","title":"QIGTD: identifying critical genes in the evolution of lung adenocarcinoma with tensor decomposition","display_name":"QIGTD: identifying critical genes in the evolution of lung adenocarcinoma with tensor decomposition","publication_year":2024,"publication_date":"2024-09-04","ids":{"openalex":"https://openalex.org/W4402275866","doi":"https://doi.org/10.1186/s13040-024-00386-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/39232802"},"language":"en","primary_location":{"id":"doi:10.1186/s13040-024-00386-w","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s13040-024-00386-w","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13040-024-00386-w.pdf","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s13040-024-00386-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100748642","display_name":"Bolin Chen","orcid":"https://orcid.org/0000-0001-5507-2288"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bolin Chen","raw_affiliation_strings":["Key Laboratory of Big Data Storage and Management, Northwestern Polytechnical University, Ministry of Industry and Information Technology, Xi'an, 710012, China. blchen@nwpu.edu.cn","School of Computer Science, Northwestern Polytechnical University, Xi'an, 710012, China. blchen@nwpu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Big Data Storage and Management, Northwestern Polytechnical University, Ministry of Industry and Information Technology, Xi'an, 710012, China. blchen@nwpu.edu.cn","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"School of Computer Science, Northwestern Polytechnical University, Xi'an, 710012, China. blchen@nwpu.edu.cn","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072393490","display_name":"Jinlei Zhang","orcid":"https://orcid.org/0000-0003-0763-9344"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinlei Zhang","raw_affiliation_strings":["School of Computer Science, Northwestern Polytechnical University, Xi'an, 710012, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science, Northwestern Polytechnical University, Xi'an, 710012, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046387531","display_name":"Ci Shao","orcid":null},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ci Shao","raw_affiliation_strings":["School of Computer Science, Northwestern Polytechnical University, Xi'an, 710012, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science, Northwestern Polytechnical University, Xi'an, 710012, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103830458","display_name":"Jun Bian","orcid":null},"institutions":[{"id":"https://openalex.org/I4210142339","display_name":"Xi\u2019an Children\u2019s Hospital","ror":"https://ror.org/04595zj73","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142339"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Bian","raw_affiliation_strings":["Department of General Surgery, Xi'an Children's Hosptial, Xi'an Jiaotong University Affiliated Children's Hosptial, Xi'an, 710003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Xi'an Children's Hosptial, Xi'an Jiaotong University Affiliated Children's Hosptial, Xi'an, 710003, China","institution_ids":["https://openalex.org/I4210142339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111648126","display_name":"Ruiming Kang","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruiming Kang","raw_affiliation_strings":["Rewise (Hangzhou) Information Technology Co., LTD, Hangzhou, 310000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rewise (Hangzhou) Information Technology Co., LTD, Hangzhou, 310000, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109723363","display_name":"Xuequn Shang","orcid":null},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuequn Shang","raw_affiliation_strings":["Key Laboratory of Big Data Storage and Management, Northwestern Polytechnical University, Ministry of Industry and Information Technology, Xi'an, 710012, China","School of Computer Science, Northwestern Polytechnical University, Xi'an, 710012, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Big Data Storage and Management, Northwestern Polytechnical University, Ministry of Industry and Information Technology, Xi'an, 710012, China","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"School of Computer Science, Northwestern Polytechnical University, Xi'an, 710012, China","institution_ids":["https://openalex.org/I17145004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100748642"],"corresponding_institution_ids":["https://openalex.org/I17145004"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08331575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"1","first_page":"30","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.5468000173568726,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.5468000173568726,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12303","display_name":"Tensor decomposition and applications","score":0.24169999361038208,"subfield":{"id":"https://openalex.org/subfields/2605","display_name":"Computational Mathematics"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11273","display_name":"Advanced Graph Neural Networks","score":0.016499999910593033,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/decomposition","display_name":"Decomposition","score":0.5778923034667969},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.544772744178772},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5110834836959839},{"id":"https://openalex.org/keywords/tensor","display_name":"Tensor (intrinsic definition)","score":0.5078063607215881},{"id":"https://openalex.org/keywords/adenocarcinoma","display_name":"Adenocarcinoma","score":0.47372308373451233},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.33431220054626465},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.25027990341186523},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.14414742588996887},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.10636153817176819},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.09223344922065735}],"concepts":[{"id":"https://openalex.org/C124681953","wikidata":"https://www.wikidata.org/wiki/Q339062","display_name":"Decomposition","level":2,"score":0.5778923034667969},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.544772744178772},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5110834836959839},{"id":"https://openalex.org/C155281189","wikidata":"https://www.wikidata.org/wiki/Q3518150","display_name":"Tensor (intrinsic definition)","level":2,"score":0.5078063607215881},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.47372308373451233},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33431220054626465},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25027990341186523},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.14414742588996887},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.10636153817176819},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.09223344922065735},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s13040-024-00386-w","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s13040-024-00386-w","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13040-024-00386-w.pdf","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},{"id":"pmid:39232802","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39232802","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData mining","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11376055","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11376055","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11376055/pdf/13040_2024_Article_386.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Min","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a60df1c17ec14d468080967b8cf4b45a","is_oa":true,"landing_page_url":"https://doaj.org/article/a60df1c17ec14d468080967b8cf4b45a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Mining, Vol 17, Iss 1, Pp 1-14 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13040-024-00386-w","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s13040-024-00386-w","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13040-024-00386-w.pdf","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5799999833106995,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"awards":[{"id":"https://openalex.org/G1962516004","display_name":null,"funder_award_id":"2021YFA1000402","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G2809053749","display_name":null,"funder_award_id":"22YXYJ0057","funder_id":"https://openalex.org/F4320325079","funder_display_name":"Xi'an Municipal Bureau of Science and Technology"},{"id":"https://openalex.org/G6058077316","display_name":"\u764c\u75c7\u52a8\u6001\u6f14\u5316\u673a\u5236\u53ca\u5176\u9a71\u52a8\u56e0\u5b50\u8bc6\u522b\u7814\u7a76","funder_award_id":"61972320","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320325079","display_name":"Xi'an Municipal Bureau of Science and Technology","ror":"https://ror.org/02rn5dn49"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402275866.pdf","grobid_xml":"https://content.openalex.org/works/W4402275866.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1505810610","https://openalex.org/W1536060130","https://openalex.org/W1931400479","https://openalex.org/W1964343149","https://openalex.org/W1970913835","https://openalex.org/W1971937094","https://openalex.org/W2026622593","https://openalex.org/W2056944867","https://openalex.org/W2060611411","https://openalex.org/W2061425021","https://openalex.org/W2070143715","https://openalex.org/W2096328440","https://openalex.org/W2098005762","https://openalex.org/W2106474670","https://openalex.org/W2113553645","https://openalex.org/W2127888717","https://openalex.org/W2139322472","https://openalex.org/W2139682891","https://openalex.org/W2145859809","https://openalex.org/W2167777772","https://openalex.org/W2193871446","https://openalex.org/W2327974553","https://openalex.org/W2470757901","https://openalex.org/W2609428401","https://openalex.org/W2884813961","https://openalex.org/W2914622179","https://openalex.org/W2942747511","https://openalex.org/W2954025126","https://openalex.org/W2970031095","https://openalex.org/W2991655993","https://openalex.org/W3011054405","https://openalex.org/W3012944668","https://openalex.org/W3025097460","https://openalex.org/W3103589660","https://openalex.org/W3103657871","https://openalex.org/W3135342929","https://openalex.org/W3136076221","https://openalex.org/W4206188361","https://openalex.org/W4317425578","https://openalex.org/W4398254946","https://openalex.org/W6888842805"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W1971568933"],"abstract_inverted_index":{"BACKGROUND:":[0],"Identifying":[1],"critical":[2,57,60,284],"genes":[3,58],"is":[4,59,119,158],"important":[5,28],"for":[6,61,291],"understanding":[7,62,302],"the":[8,17,39,63,97,114,123,141,149,154,214,224,240,276,303],"pathogenesis":[9],"of":[10,19,67,76,125,144,153,175,180,213,216,223,306],"complex":[11],"diseases.":[12,68],"Traditional":[13],"studies":[14],"typically":[15],"comparing":[16],"change":[18],"biomecules":[20],"between":[21,44,107],"normal":[22],"and":[23,55,65,99,130,148,162,189,195,219,243,265,282,298],"disease":[24,46],"samples":[25],"or":[26],"detecting":[27],"vertices":[29],"from":[30],"a":[31,90,131,160,172,288],"single":[32],"static":[33],"biomolecular":[34,53],"network,":[35,129],"which":[36,104],"often":[37],"overlook":[38],"dynamic":[40],"changes":[41,51,278],"that":[42,165,206],"occur":[43],"different":[45],"stages.":[47],"However,":[48],"investigating":[49],"temporal":[50,101,277,293],"in":[52,84,211,248,279,295,301],"networks":[54,108,281,297],"identifying":[56],"occurrence":[64],"development":[66],"METHODS:":[69],"A":[70,117],"novel":[71],"method":[72,135,164],"called":[73],"Quantifying":[74],"Importance":[75],"Genes":[77],"with":[78,171],"Tensor":[79],"Decomposition":[80],"(QIGTD)":[81],"was":[82,136,182],"proposed":[83,137],"this":[85,126],"study.":[86],"It":[87,286],"first":[88],"constructs":[89],"time":[91,127,150],"series":[92,128,151],"network":[93,102,146],"by":[94],"integrating":[95],"both":[96,140,217],"intra":[98],"inter":[100],"information,":[103],"preserving":[105],"connections":[106,124],"at":[109],"adjacent":[110],"stages":[111],"according":[112,238],"to":[113,121,138,169,232,236,239],"local":[115],"similarities.":[116],"tensor":[118,133],"employed":[120,198],"describe":[122],"3-order":[132],"decomposition":[134],"capture":[139],"topological":[142],"information":[143],"each":[145],"snapshot":[147],"characteristics":[152],"whole":[155],"network.":[156],"QIGTD":[157,181,207,273],"also":[159],"learning-free":[161],"efficient":[163],"can":[166,299],"be":[167,233],"applied":[168],"datasets":[170,188],"small":[173],"number":[174],"samples.":[176],"RESULTS:":[177],"The":[178],"effectiveness":[179],"evaluated":[183],"using":[184],"lung":[185],"adenocarcinoma":[186],"(LUAD)":[187],"three":[190],"state-of-the-art":[191],"methods:":[192],"T-degree,":[193],"T-closeness,":[194],"T-betweenness":[196],"were":[197],"as":[199,309],"benchmark":[200],"methods.":[201],"Numerical":[202],"experimental":[203],"results":[204],"demonstrate":[205],"outperforms":[208],"these":[209],"methods":[210],"terms":[212],"indices":[215],"precision":[218],"mAP.":[220],"Notably,":[221],"out":[222],"top":[225],"50":[226],"genes,":[227],"29":[228],"have":[229],"been":[230],"verified":[231],"highly":[234],"related":[235,250],"LUAD":[237,249],"DisGeNET":[241],"Database,":[242],"36":[244],"are":[245],"significantly":[246],"enriched":[247],"Gene":[251],"Ontology":[252],"(GO)":[253],"terms,":[254],"including":[255],"nuclear":[256,259],"division,":[257,260],"mitotic":[258,266],"chromosome":[261],"segregation,":[262],"organelle":[263],"fission,":[264],"sister":[267],"chromatid":[268],"segregation.":[269],"CONCLUSION:":[270],"In":[271],"conclusion,":[272],"effectively":[274],"captures":[275],"gene":[280],"identifies":[283],"genes.":[285],"provides":[287],"valuable":[289],"tool":[290],"studying":[292],"dynamics":[294],"biological":[296],"aid":[300],"underlying":[304],"mechanisms":[305],"diseases":[307],"such":[308],"LUAD.":[310]},"counts_by_year":[],"updated_date":"2026-08-28T12:50:07.497085","created_date":"2025-10-10T00:00:00"}