{"id":"https://openalex.org/W4392237190","doi":"https://doi.org/10.1186/s13040-024-00358-0","title":"Interaction models matter: an efficient, flexible computational framework for model-specific investigation of epistasis","display_name":"Interaction models matter: an efficient, flexible computational framework for model-specific investigation of epistasis","publication_year":2024,"publication_date":"2024-02-28","ids":{"openalex":"https://openalex.org/W4392237190","doi":"https://doi.org/10.1186/s13040-024-00358-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/38419006"},"language":"en","primary_location":{"id":"doi:10.1186/s13040-024-00358-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-024-00358-0","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/s13040-024-00358-0","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/s13040-024-00358-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061407169","display_name":"Sandra Batista","orcid":"https://orcid.org/0000-0003-4605-9836"},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sandra Batista","raw_affiliation_strings":["Department of Computational Biomedicine, Cedars-Sinai Medical Center, 700 N San Vicente Blvd., Pacific Design Center, Guite G540, West Hollywood, CA, 90069, USA. sandraleeresearch@gmail.com","Department of Computational Biomedicine, Cedars-Sinai Medical Center, 700 N San Vicente Blvd., Pacific Design Center, Guite G540, West Hollywood, CA, 90069, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computational Biomedicine, Cedars-Sinai Medical Center, 700 N San Vicente Blvd., Pacific Design Center, Guite G540, West Hollywood, CA, 90069, USA. sandraleeresearch@gmail.com","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Computational Biomedicine, Cedars-Sinai Medical Center, 700 N San Vicente Blvd., Pacific Design Center, Guite G540, West Hollywood, CA, 90069, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070991337","display_name":"Vered Madar","orcid":"https://orcid.org/0000-0003-2743-6851"},"institutions":[{"id":"https://openalex.org/I4210090833","display_name":"Communities In Schools of Orange County","ror":"https://ror.org/00bzst557","country_code":"US","type":"education","lineage":["https://openalex.org/I4210090833"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vered\u00a0Senderovich Madar","raw_affiliation_strings":[", Chapel Hill, NC, USA","Chapel Hill, NC, USA"],"affiliations":[{"raw_affiliation_string":", Chapel Hill, NC, USA","institution_ids":[]},{"raw_affiliation_string":"Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I4210090833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049025538","display_name":"Philip J. Freda","orcid":"https://orcid.org/0000-0001-8658-9802"},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip\u00a0J. Freda","raw_affiliation_strings":["Department of Computational Biomedicine, Cedars-Sinai Medical Center, 700 N San Vicente Blvd., Pacific Design Center, Guite G540, West Hollywood, CA, 90069, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computational Biomedicine, Cedars-Sinai Medical Center, 700 N San Vicente Blvd., Pacific Design Center, Guite G540, West Hollywood, CA, 90069, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084570095","display_name":"Priyanka Bhandary","orcid":"https://orcid.org/0000-0002-6962-9638"},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priyanka Bhandary","raw_affiliation_strings":["Department of Computational Biomedicine, Cedars-Sinai Medical Center, 700 N San Vicente Blvd., Pacific Design Center, Guite G540, West Hollywood, CA, 90069, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computational Biomedicine, Cedars-Sinai Medical Center, 700 N San Vicente Blvd., Pacific Design Center, Guite G540, West Hollywood, CA, 90069, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025125590","display_name":"Attri Ghosh","orcid":null},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Attri Ghosh","raw_affiliation_strings":["Department of Computational Biomedicine, Cedars-Sinai Medical Center, 700 N San Vicente Blvd., Pacific Design Center, Guite G540, West Hollywood, CA, 90069, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computational Biomedicine, Cedars-Sinai Medical Center, 700 N San Vicente Blvd., Pacific Design Center, Guite G540, West Hollywood, CA, 90069, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054144186","display_name":"Nicholas Matsumoto","orcid":"https://orcid.org/0000-0002-3280-9678"},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Matsumoto","raw_affiliation_strings":["Department of Computational Biomedicine, Cedars-Sinai Medical Center, 700 N San Vicente Blvd., Pacific Design Center, Guite G540, West Hollywood, CA, 90069, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computational Biomedicine, Cedars-Sinai Medical Center, 700 N San Vicente Blvd., Pacific Design Center, Guite G540, West Hollywood, CA, 90069, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062171172","display_name":"Apurva S. Chitre","orcid":"https://orcid.org/0000-0003-1709-9214"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Apurva\u00a0S. Chitre","raw_affiliation_strings":["Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr., Mailcode: 0667, La Jolla, CA, 92093-0667, USA"],"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr., Mailcode: 0667, La Jolla, CA, 92093-0667, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031236440","display_name":"Abraham A. Palmer","orcid":"https://orcid.org/0000-0003-3634-0747"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abraham\u00a0A. Palmer","raw_affiliation_strings":["Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr., Mailcode: 0667, La Jolla, CA, 92093-0667, USA","Institute for Genomic Medicine, University of California, San Diego, 9500 Gilman Dr., Mailcode: 0667, La Jolla, CA, 92093-0667, USA"],"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr., Mailcode: 0667, La Jolla, CA, 92093-0667, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Institute for Genomic Medicine, University of California, San Diego, 9500 Gilman Dr., Mailcode: 0667, La Jolla, CA, 92093-0667, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032971510","display_name":"Jason H. Moore","orcid":"https://orcid.org/0000-0002-5015-1099"},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason\u00a0H. Moore","raw_affiliation_strings":["Department of Computational Biomedicine, Cedars-Sinai Medical Center, 700 N San Vicente Blvd., Pacific Design Center, Guite G540, West Hollywood, CA, 90069, USA. jason.moore@csmc.edu","Department of Computational Biomedicine, Cedars-Sinai Medical Center, 700 N San Vicente Blvd., Pacific Design Center, Guite G540, West Hollywood, CA, 90069, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computational Biomedicine, Cedars-Sinai Medical Center, 700 N San Vicente Blvd., Pacific Design Center, Guite G540, West Hollywood, CA, 90069, USA. jason.moore@csmc.edu","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Computational Biomedicine, Cedars-Sinai Medical Center, 700 N San Vicente Blvd., Pacific Design Center, Guite G540, West Hollywood, CA, 90069, USA","institution_ids":["https://openalex.org/I1282927834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5061407169"],"corresponding_institution_ids":["https://openalex.org/I1282927834"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.6951,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.89288649,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"17","issue":"1","first_page":"7","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epistasis","display_name":"Epistasis","score":0.9370859265327454},{"id":"https://openalex.org/keywords/pairwise-comparison","display_name":"Pairwise comparison","score":0.6478847861289978},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.561958909034729},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.47732171416282654},{"id":"https://openalex.org/keywords/multifactor-dimensionality-reduction","display_name":"Multifactor dimensionality reduction","score":0.4524983763694763},{"id":"https://openalex.org/keywords/multiplicative-function","display_name":"Multiplicative function","score":0.4489535391330719},{"id":"https://openalex.org/keywords/gene-interaction","display_name":"Gene interaction","score":0.42727139592170715},{"id":"https://openalex.org/keywords/permutation","display_name":"Permutation (music)","score":0.4133647680282593},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.35636836290359497},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.29377833008766174},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.23263365030288696},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2297290861606598},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19236966967582703},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10990041494369507},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.09600716829299927},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.0867270827293396}],"concepts":[{"id":"https://openalex.org/C61727976","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Epistasis","level":3,"score":0.9370859265327454},{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.6478847861289978},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.561958909034729},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.47732171416282654},{"id":"https://openalex.org/C25249476","wikidata":"https://www.wikidata.org/wiki/Q6934678","display_name":"Multifactor dimensionality reduction","level":5,"score":0.4524983763694763},{"id":"https://openalex.org/C42747912","wikidata":"https://www.wikidata.org/wiki/Q1048447","display_name":"Multiplicative function","level":2,"score":0.4489535391330719},{"id":"https://openalex.org/C2991772755","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Gene interaction","level":3,"score":0.42727139592170715},{"id":"https://openalex.org/C21308566","wikidata":"https://www.wikidata.org/wiki/Q7169365","display_name":"Permutation (music)","level":2,"score":0.4133647680282593},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.35636836290359497},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.29377833008766174},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.23263365030288696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2297290861606598},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19236966967582703},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10990041494369507},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.09600716829299927},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0867270827293396},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1186/s13040-024-00358-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-024-00358-0","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/s13040-024-00358-0","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},{"id":"pmid:38419006","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38419006","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData mining","raw_type":null},{"id":"pmh:oai:escholarship.org:ark:/13030/qt1mt422w0","is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/1mt422w0","pdf_url":"https://escholarship.org/content/qt1mt422w0/qt1mt422w0.pdf?t=sawasw","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Mining, vol 17, iss 1","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10900690","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10900690","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10900690/pdf/13040_2024_Article_358.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Min","raw_type":"Text"},{"id":"pmh:ark:/13030/qt1mt422w0","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:doaj.org/article:1366e57e410d486ebca558fd373f3588","is_oa":true,"landing_page_url":"https://doaj.org/article/1366e57e410d486ebca558fd373f3588","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Mining, Vol 17, Iss 1, Pp 1-37 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13040-024-00358-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-024-00358-0","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/s13040-024-00358-0","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2866775907","display_name":null,"funder_award_id":"AG066833","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G350679715","display_name":null,"funder_award_id":"U01 AG066833","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4706438170","display_name":null,"funder_award_id":"R01 LM010098","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6682602594","display_name":null,"funder_award_id":"LM010098","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320308668","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4392237190.pdf"},"referenced_works_count":99,"referenced_works":["https://openalex.org/W69501525","https://openalex.org/W1483804921","https://openalex.org/W1570272764","https://openalex.org/W1822695366","https://openalex.org/W1868492295","https://openalex.org/W1965635919","https://openalex.org/W1966360257","https://openalex.org/W1967997195","https://openalex.org/W1968783143","https://openalex.org/W1970149620","https://openalex.org/W1973094248","https://openalex.org/W1973316176","https://openalex.org/W1973455222","https://openalex.org/W1974835328","https://openalex.org/W1976806178","https://openalex.org/W1981723690","https://openalex.org/W1987081490","https://openalex.org/W1994633217","https://openalex.org/W1996226986","https://openalex.org/W1997744129","https://openalex.org/W2003095660","https://openalex.org/W2005452204","https://openalex.org/W2007076214","https://openalex.org/W2007669896","https://openalex.org/W2009969871","https://openalex.org/W2028393082","https://openalex.org/W2032667971","https://openalex.org/W2033151532","https://openalex.org/W2035300844","https://openalex.org/W2035618305","https://openalex.org/W2046355391","https://openalex.org/W2050477554","https://openalex.org/W2061232867","https://openalex.org/W2066511429","https://openalex.org/W2076011171","https://openalex.org/W2077744980","https://openalex.org/W2085812964","https://openalex.org/W2088486634","https://openalex.org/W2090144206","https://openalex.org/W2091239497","https://openalex.org/W2094902224","https://openalex.org/W2106601849","https://openalex.org/W2108352360","https://openalex.org/W2114549333","https://openalex.org/W2130856032","https://openalex.org/W2140099276","https://openalex.org/W2150449617","https://openalex.org/W2153153786","https://openalex.org/W2153685804","https://openalex.org/W2154572047","https://openalex.org/W2155078868","https://openalex.org/W2161633633","https://openalex.org/W2161653752","https://openalex.org/W2162683818","https://openalex.org/W2166924189","https://openalex.org/W2171373235","https://openalex.org/W2173689381","https://openalex.org/W2181523240","https://openalex.org/W2228687373","https://openalex.org/W2292418975","https://openalex.org/W2325325200","https://openalex.org/W2335429725","https://openalex.org/W2339765445","https://openalex.org/W2414852797","https://openalex.org/W2416023135","https://openalex.org/W2534605303","https://openalex.org/W2548120468","https://openalex.org/W2792910619","https://openalex.org/W2949922395","https://openalex.org/W2952431387","https://openalex.org/W2952893067","https://openalex.org/W2975208972","https://openalex.org/W2985386410","https://openalex.org/W2998634487","https://openalex.org/W3003257820","https://openalex.org/W3047927732","https://openalex.org/W3082963240","https://openalex.org/W3093042356","https://openalex.org/W3103145119","https://openalex.org/W3104824402","https://openalex.org/W3125573404","https://openalex.org/W3128984844","https://openalex.org/W3157337552","https://openalex.org/W3175752499","https://openalex.org/W3187545772","https://openalex.org/W3191903009","https://openalex.org/W3196691939","https://openalex.org/W3200477862","https://openalex.org/W3217536345","https://openalex.org/W4213196016","https://openalex.org/W4220930003","https://openalex.org/W4225935513","https://openalex.org/W4252782584","https://openalex.org/W4280597994","https://openalex.org/W4283165920","https://openalex.org/W4322619263","https://openalex.org/W4363673433","https://openalex.org/W4385409023","https://openalex.org/W4390705046"],"related_works":["https://openalex.org/W1998101959","https://openalex.org/W2092969276","https://openalex.org/W2975208972","https://openalex.org/W4280530339","https://openalex.org/W2779655343","https://openalex.org/W4206544128","https://openalex.org/W4288060525","https://openalex.org/W2321864844","https://openalex.org/W4207039569","https://openalex.org/W1966360257"],"abstract_inverted_index":{"Our":[0],"results":[1],"in":[2,38],"both":[3],"species":[4],"show":[5],"that":[6,25,36],"many":[7],"biologically":[8],"relevant":[9],"epistatic":[10,34],"relationships":[11],"would":[12],"have":[13],"been":[14],"undetected":[15],"if":[16],"only":[17],"one":[18],"interaction":[19,27],"model":[20],"was":[21],"applied,":[22],"providing":[23],"evidence":[24],"varied":[26],"models":[28],"should":[29],"be":[30],"implemented":[31],"to":[32],"explore":[33],"interactions":[35],"occur":[37],"living":[39],"systems.":[40]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}