{"id":"https://openalex.org/W3139341041","doi":"https://doi.org/10.1186/s13040-021-00264-9","title":"Evaluating risk detection methods to uncover ontogenic-mediated adverse drug effect mechanisms in children","display_name":"Evaluating risk detection methods to uncover ontogenic-mediated adverse drug effect mechanisms in children","publication_year":2021,"publication_date":"2021-07-22","ids":{"openalex":"https://openalex.org/W3139341041","doi":"https://doi.org/10.1186/s13040-021-00264-9","mag":"3139341041","pmid":"https://pubmed.ncbi.nlm.nih.gov/34294093"},"language":"en","primary_location":{"id":"doi:10.1186/s13040-021-00264-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-021-00264-9","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/s13040-021-00264-9","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/s13040-021-00264-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069041733","display_name":"Nicholas Giangreco","orcid":"https://orcid.org/0000-0001-8138-4947"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nicholas P. Giangreco","raw_affiliation_strings":["Departments of Systems Biology and Biomedical Informatics, Columbia University, 622 W. 168th Street, New York, NY, 10032, USA"],"raw_orcid":"https://orcid.org/0000-0001-8138-4947","affiliations":[{"raw_affiliation_string":"Departments of Systems Biology and Biomedical Informatics, Columbia University, 622 W. 168th Street, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086753691","display_name":"Nicholas P. Tatonetti","orcid":"https://orcid.org/0000-0002-2700-2597"},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas P. Tatonetti","raw_affiliation_strings":["Departments of Systems Biology and Biomedical Informatics, Columbia University, 622 W. 168th Street, New York, NY, 10032, USA. npt2105@cumc.columbia.edu","Departments of Systems Biology and Biomedical Informatics, Columbia University, 622 W. 168th Street, New York, NY, 10032, USA"],"raw_orcid":"https://orcid.org/0000-0002-2700-2597","affiliations":[{"raw_affiliation_string":"Departments of Systems Biology and Biomedical Informatics, Columbia University, 622 W. 168th Street, New York, NY, 10032, USA. npt2105@cumc.columbia.edu","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Departments of Systems Biology and Biomedical Informatics, Columbia University, 622 W. 168th Street, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5069041733"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.0389,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.77908511,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"14","issue":"1","first_page":"34","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.4223000109195709,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.4223000109195709,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.3154999911785126,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.03830000013113022,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leverage","display_name":"Leverage (statistics)","score":0.7188352346420288},{"id":"https://openalex.org/keywords/adverse-effect","display_name":"Adverse effect","score":0.5714501738548279},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.527559220790863},{"id":"https://openalex.org/keywords/event","display_name":"Event (particle physics)","score":0.47122064232826233},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.44537970423698425},{"id":"https://openalex.org/keywords/drug-development","display_name":"Drug development","score":0.43075430393218994},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"Pharmacodynamics","score":0.4183427393436432},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.41498565673828125},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3111075162887573},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.26004523038864136},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"Pharmacokinetics","score":0.19799962639808655},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.16546478867530823},{"id":"https://openalex.org/keywords/environmental-health","display_name":"Environmental health","score":0.14669761061668396}],"concepts":[{"id":"https://openalex.org/C153083717","wikidata":"https://www.wikidata.org/wiki/Q6535263","display_name":"Leverage (statistics)","level":2,"score":0.7188352346420288},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5714501738548279},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.527559220790863},{"id":"https://openalex.org/C2779662365","wikidata":"https://www.wikidata.org/wiki/Q5416694","display_name":"Event (particle physics)","level":2,"score":0.47122064232826233},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44537970423698425},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.43075430393218994},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.4183427393436432},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.41498565673828125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3111075162887573},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.26004523038864136},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.19799962639808655},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.16546478867530823},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.14669761061668396},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1186/s13040-021-00264-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-021-00264-9","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/s13040-021-00264-9","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},{"id":"pmid:34294093","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34294093","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData mining","raw_type":null},{"id":"pmh:oai:doaj.org/article:19859631776948fd94c9c1752e022dc6","is_oa":true,"landing_page_url":"https://doaj.org/article/19859631776948fd94c9c1752e022dc6","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Mining, Vol 14, Iss 1, Pp 1-17 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8296590","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8296590","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Min","raw_type":"Text"},{"id":"doi:10.7916/08z8-kz64","is_oa":true,"landing_page_url":"https://doi.org/10.7916/08z8-kz64","pdf_url":null,"source":{"id":"https://openalex.org/S4306402601","display_name":"Columbia Academic Commons (Columbia University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I78577930","host_organization_name":"Columbia University","host_organization_lineage":["https://openalex.org/I78577930"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/s13040-021-00264-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-021-00264-9","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/s13040-021-00264-9","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5299999713897705}],"awards":[{"id":"https://openalex.org/G5278842409","display_name":null,"funder_award_id":"R35GM131905","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3139341041.pdf","grobid_xml":"https://content.openalex.org/works/W3139341041.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1487139063","https://openalex.org/W1556631438","https://openalex.org/W1568717401","https://openalex.org/W1887737698","https://openalex.org/W1965064543","https://openalex.org/W1965853078","https://openalex.org/W1988100739","https://openalex.org/W2005546854","https://openalex.org/W2021542813","https://openalex.org/W2022144328","https://openalex.org/W2055017324","https://openalex.org/W2060298585","https://openalex.org/W2064115956","https://openalex.org/W2075643141","https://openalex.org/W2088630631","https://openalex.org/W2091265741","https://openalex.org/W2092478321","https://openalex.org/W2098418526","https://openalex.org/W2101134226","https://openalex.org/W2107533226","https://openalex.org/W2108342895","https://openalex.org/W2122189144","https://openalex.org/W2143742989","https://openalex.org/W2150199104","https://openalex.org/W2152006872","https://openalex.org/W2157355630","https://openalex.org/W2161669645","https://openalex.org/W2171131253","https://openalex.org/W2193153316","https://openalex.org/W2195155186","https://openalex.org/W2233660390","https://openalex.org/W2402097658","https://openalex.org/W2415208045","https://openalex.org/W2415850696","https://openalex.org/W2418123132","https://openalex.org/W2559646245","https://openalex.org/W2565795639","https://openalex.org/W2590419105","https://openalex.org/W2741336923","https://openalex.org/W2761755831","https://openalex.org/W2787894218","https://openalex.org/W2892507705","https://openalex.org/W2901731184","https://openalex.org/W2913075488","https://openalex.org/W2913374613","https://openalex.org/W2927322282","https://openalex.org/W2946106600","https://openalex.org/W2995904755","https://openalex.org/W3111480315","https://openalex.org/W3112717819"],"related_works":["https://openalex.org/W2386091134","https://openalex.org/W2352270727","https://openalex.org/W2365521366","https://openalex.org/W2024172875","https://openalex.org/W2128612529","https://openalex.org/W2044949422","https://openalex.org/W2386079082","https://openalex.org/W2357941502","https://openalex.org/W4245706755","https://openalex.org/W2787993192"],"abstract_inverted_index":{"BACKGROUND:":[0],"Identifying":[1],"adverse":[2,68,86,105],"drugs":[3],"effects":[4,106],"(ADEs)":[5],"in":[6,52,157],"children,":[7],"overall":[8],"and":[9,19,39,46,62,124,137,145,172],"within":[10,80],"pediatric":[11,53],"age":[12],"groups,":[13],"is":[14,30,72,94],"essential":[15],"for":[16,83,194,211],"preventing":[17],"disability":[18],"death":[20],"from":[21],"marketed":[22],"drugs.":[23],"At":[24],"the":[25,155,192],"same":[26],"time,":[27],"however,":[28],"detection":[29,209],"challenging":[31],"due":[32],"to":[33,59,75,95,135],"dynamic":[34,159],"biological":[35],"processes":[36],"during":[37],"growth":[38],"maturation,":[40],"called":[41],"ontogeny,":[42],"that":[43,99,149],"alter":[44],"pharmacokinetics":[45],"pharmacodynamics.":[47],"As":[48],"a":[49,114,125],"result,":[50],"methodologies":[51],"drug":[54,77,160,201],"safety":[55],"have":[56,63],"been":[57],"limited":[58],"event":[60,69,78,87,161,202],"surveillance":[61],"not":[64],"focused":[65],"on":[66],"investigating":[67],"mechanisms.":[70,88,214],"There":[71],"an":[73],"opportunity":[74,193],"identify":[76,101,136],"patterns":[79],"observational":[81],"databases":[82],"evaluating":[84,212],"ontogenic-mediated":[85],"The":[89],"first":[90],"step":[91],"of":[92,104],"which":[93,199],"establish":[96],"statistical":[97],"models":[98],"can":[100],"temporal":[102],"trends":[103],"across":[107,163,184,204],"childhood.":[108],"RESULTS:":[109],"Using":[110],"simulation,":[111],"we":[112],"evaluated":[113],"population":[115,126,196],"stratification":[116],"method":[117,128],"(the":[118,129],"proportional":[119],"reporting":[120,143,162,203],"ratio":[121],"or":[122,133],"PRR)":[123],"modeling":[127,197],"generalized":[130],"additive":[131],"model":[132],"GAM)":[134],"quantify":[138],"ADE":[139,174],"risk":[140,175],"at":[141,177],"varying":[142],"rates":[144],"dynamics.":[146],"We":[147],"found":[148],"GAMs":[150,168],"showed":[151],"improved":[152],"performance":[153],"over":[154],"PRR":[156],"detecting":[158],"child":[164,185],"development":[165,179,186,205],"stages.":[166,187],"Moreover,":[167],"exhibited":[169],"normally":[170],"distributed":[171],"robust":[173],"estimation":[176],"all":[178],"stages":[180],"by":[181],"sharing":[182],"information":[183],"CONCLUSIONS:":[188],"Our":[189],"study":[190],"underscores":[191],"using":[195],"techniques,":[198],"leverage":[200],"stages,":[206],"as":[207],"biologically-inspired":[208],"methods":[210],"ontogenic":[213]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}
