{"id":"https://openalex.org/W3120388949","doi":"https://doi.org/10.1186/s13040-021-00243-0","title":"A comparison of methods for interpreting random forest models of genetic association in the presence of non-additive interactions","display_name":"A comparison of methods for interpreting random forest models of genetic association in the presence of non-additive interactions","publication_year":2021,"publication_date":"2021-01-29","ids":{"openalex":"https://openalex.org/W3120388949","doi":"https://doi.org/10.1186/s13040-021-00243-0","mag":"3120388949","pmid":"https://pubmed.ncbi.nlm.nih.gov/33514397"},"language":"en","primary_location":{"id":"doi:10.1186/s13040-021-00243-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-021-00243-0","pdf_url":"https://biodatamining.biomedcentral.com/track/pdf/10.1186/s13040-021-00243-0","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://biodatamining.biomedcentral.com/track/pdf/10.1186/s13040-021-00243-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039313073","display_name":"Alena Orlenko","orcid":"https://orcid.org/0000-0003-1757-293X"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alena Orlenko","raw_affiliation_strings":["Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA, USA"],"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032971510","display_name":"Jason H. Moore","orcid":"https://orcid.org/0000-0002-5015-1099"},"institutions":[{"id":"https://openalex.org/I1333153716","display_name":"University City Science Center","ror":"https://ror.org/00s5a4h94","country_code":"US","type":"facility","lineage":["https://openalex.org/I1333153716"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason H. Moore","raw_affiliation_strings":["Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA, USA. jhmoore@upenn.edu","Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA, USA"],"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA, USA. jhmoore@upenn.edu","institution_ids":["https://openalex.org/I1333153716"]},{"raw_affiliation_string":"Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039313073"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":8.4839,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.98122716,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"14","issue":"1","first_page":"9","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/random-forest","display_name":"Random forest","score":0.9193540215492249},{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.8847184777259827},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.7169106602668762},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.7029350996017456},{"id":"https://openalex.org/keywords/metric","display_name":"Metric (unit)","score":0.6358755826950073},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5829112529754639},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5382127165794373},{"id":"https://openalex.org/keywords/permutation","display_name":"Permutation (music)","score":0.5309369564056396},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.493913471698761},{"id":"https://openalex.org/keywords/additive-model","display_name":"Additive model","score":0.4349082112312317},{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.41586968302726746},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.36839884519577026}],"concepts":[{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.9193540215492249},{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.8847184777259827},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.7169106602668762},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.7029350996017456},{"id":"https://openalex.org/C176217482","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Metric (unit)","level":2,"score":0.6358755826950073},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5829112529754639},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5382127165794373},{"id":"https://openalex.org/C21308566","wikidata":"https://www.wikidata.org/wiki/Q7169365","display_name":"Permutation (music)","level":2,"score":0.5309369564056396},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.493913471698761},{"id":"https://openalex.org/C203223496","wikidata":"https://www.wikidata.org/wiki/Q4681344","display_name":"Additive model","level":2,"score":0.4349082112312317},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.41586968302726746},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.36839884519577026},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s13040-021-00243-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-021-00243-0","pdf_url":"https://biodatamining.biomedcentral.com/track/pdf/10.1186/s13040-021-00243-0","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},{"id":"pmid:33514397","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33514397","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData mining","raw_type":null},{"id":"pmh:oai:doaj.org/article:186ed527250c4044bad3cf4c7a894fe2","is_oa":true,"landing_page_url":"https://doaj.org/article/186ed527250c4044bad3cf4c7a894fe2","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Mining, Vol 14, Iss 1, Pp 1-17 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7847145","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7847145","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Min","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s13040-021-00243-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-021-00243-0","pdf_url":"https://biodatamining.biomedcentral.com/track/pdf/10.1186/s13040-021-00243-0","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.4099999964237213,"display_name":"Life in Land"}],"awards":[{"id":"https://openalex.org/G6634558516","display_name":null,"funder_award_id":"AI116794","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6682602594","display_name":null,"funder_award_id":"LM010098","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3120388949.pdf","grobid_xml":"https://content.openalex.org/works/W3120388949.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W307744830","https://openalex.org/W1134579862","https://openalex.org/W1542772707","https://openalex.org/W1597994084","https://openalex.org/W1868492295","https://openalex.org/W1875061881","https://openalex.org/W1966360257","https://openalex.org/W2007669896","https://openalex.org/W2017406452","https://openalex.org/W2024860192","https://openalex.org/W2036362108","https://openalex.org/W2044863747","https://openalex.org/W2067328319","https://openalex.org/W2076220518","https://openalex.org/W2089797399","https://openalex.org/W2094189284","https://openalex.org/W2095243453","https://openalex.org/W2097508746","https://openalex.org/W2101350555","https://openalex.org/W2102636708","https://openalex.org/W2106525823","https://openalex.org/W2118215201","https://openalex.org/W2125847307","https://openalex.org/W2129338678","https://openalex.org/W2137503082","https://openalex.org/W2152905639","https://openalex.org/W2154337852","https://openalex.org/W2160331326","https://openalex.org/W2168391930","https://openalex.org/W2237837248","https://openalex.org/W2263825730","https://openalex.org/W2282821441","https://openalex.org/W2319197375","https://openalex.org/W2322754609","https://openalex.org/W2582281256","https://openalex.org/W2593649365","https://openalex.org/W2618572535","https://openalex.org/W2618851150","https://openalex.org/W2768115058","https://openalex.org/W2770371658","https://openalex.org/W2787894218","https://openalex.org/W2802643674","https://openalex.org/W2911964244","https://openalex.org/W2926714285","https://openalex.org/W3182129999","https://openalex.org/W6695661434"],"related_works":["https://openalex.org/W4361806667","https://openalex.org/W4388745254","https://openalex.org/W2980082554","https://openalex.org/W1517228774","https://openalex.org/W2767419625","https://openalex.org/W2389704471","https://openalex.org/W4386977970","https://openalex.org/W2946956129","https://openalex.org/W2897047917","https://openalex.org/W2952159951"],"abstract_inverted_index":{"By":[0],"analyzing":[1],"both":[2],"real":[3],"and":[4],"simulated":[5],"data,":[6],"we":[7],"established":[8],"that":[9],"the":[10,23],"permutation":[11],"feature":[12,18],"importance":[13,19],"metric":[14],"provides":[15],"more":[16],"precise":[17],"rank":[20],"estimation":[21],"in":[22],"presence":[24],"of":[25],"non-additive":[26],"interactions.":[27]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}