{"id":"https://openalex.org/W3093259931","doi":"https://doi.org/10.1186/s13040-020-00227-6","title":"Examining the effector mechanisms of Xuebijing injection on COVID-19 based on network pharmacology","display_name":"Examining the effector mechanisms of Xuebijing injection on COVID-19 based on network pharmacology","publication_year":2020,"publication_date":"2020-10-16","ids":{"openalex":"https://openalex.org/W3093259931","doi":"https://doi.org/10.1186/s13040-020-00227-6","mag":"3093259931","pmid":"https://pubmed.ncbi.nlm.nih.gov/33082858"},"language":"en","primary_location":{"id":"doi:10.1186/s13040-020-00227-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-020-00227-6","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/s13040-020-00227-6","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/s13040-020-00227-6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020894539","display_name":"Wenjiang Zheng","orcid":"https://orcid.org/0000-0001-5234-0339"},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen-jiang Zheng","raw_affiliation_strings":["The First Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou, China","institution_ids":["https://openalex.org/I117532281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100758971","display_name":"Qian Yan","orcid":"https://orcid.org/0000-0002-2892-7145"},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Yan","raw_affiliation_strings":["The First Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou, China","institution_ids":["https://openalex.org/I117532281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040977033","display_name":"Yongshi Ni","orcid":null},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong-shi Ni","raw_affiliation_strings":["The Second Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou, China","institution_ids":["https://openalex.org/I117532281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045842763","display_name":"Shaofeng Zhan","orcid":"https://orcid.org/0000-0002-7978-1318"},"institutions":[{"id":"https://openalex.org/I4210105832","display_name":"First Affiliated Hospital of Guangzhou University of Chinese Medicine","ror":"https://ror.org/01mxpdw03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105832"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shao-feng Zhan","raw_affiliation_strings":["The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China","institution_ids":["https://openalex.org/I4210105832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103165680","display_name":"Liuliu Yang","orcid":"https://orcid.org/0000-0001-9656-5062"},"institutions":[{"id":"https://openalex.org/I4210105832","display_name":"First Affiliated Hospital of Guangzhou University of Chinese Medicine","ror":"https://ror.org/01mxpdw03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105832"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liu-liu Yang","raw_affiliation_strings":["The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China","institution_ids":["https://openalex.org/I4210105832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014249983","display_name":"Hongfa Zhuang","orcid":"https://orcid.org/0000-0002-1369-1969"},"institutions":[{"id":"https://openalex.org/I4210105832","display_name":"First Affiliated Hospital of Guangzhou University of Chinese Medicine","ror":"https://ror.org/01mxpdw03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105832"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-fa Zhuang","raw_affiliation_strings":["The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China","institution_ids":["https://openalex.org/I4210105832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100321212","display_name":"Xiaohong Liu","orcid":"https://orcid.org/0000-0003-4795-3039"},"institutions":[{"id":"https://openalex.org/I4210105832","display_name":"First Affiliated Hospital of Guangzhou University of Chinese Medicine","ror":"https://ror.org/01mxpdw03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105832"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiao-hong Liu","raw_affiliation_strings":["The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China","institution_ids":["https://openalex.org/I4210105832"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066071426","display_name":"Yong Jiang","orcid":"https://orcid.org/0000-0002-3609-2280"},"institutions":[{"id":"https://openalex.org/I4210160314","display_name":"Shenzhen Pingle Orthopedic Hospital","ror":"https://ror.org/04ppv2c95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160314"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yong Jiang","raw_affiliation_strings":["Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, China"],"raw_orcid":"https://orcid.org/0000-0002-3609-2280","affiliations":[{"raw_affiliation_string":"Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, China","institution_ids":["https://openalex.org/I4210160314"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5066071426","https://openalex.org/A5100321212"],"corresponding_institution_ids":["https://openalex.org/I4210105832","https://openalex.org/I4210160314"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":4.0562,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.94971074,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"17","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.18379999697208405,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.18379999697208405,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11889","display_name":"Ginseng Biological Effects and Applications","score":0.06530000269412994,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12817","display_name":"Pharmacological Effects of Natural Compounds","score":0.062199998646974564,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.8217760324478149},{"id":"https://openalex.org/keywords/effector","display_name":"Effector","score":0.7264530658721924},{"id":"https://openalex.org/keywords/severe-acute-respiratory-syndrome-coronavirus-2","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","score":0.5601562857627869},{"id":"https://openalex.org/keywords/2019-20-coronavirus-outbreak","display_name":"2019-20 coronavirus outbreak","score":0.5541427135467529},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4847230911254883},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.36017340421676636},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2660960853099823},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.2645449936389923},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.12110161781311035},{"id":"https://openalex.org/keywords/infectious-disease","display_name":"Infectious disease (medical specialty)","score":0.0662798285484314},{"id":"https://openalex.org/keywords/outbreak","display_name":"Outbreak","score":0.06329822540283203},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.06295889616012573}],"concepts":[{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.8217760324478149},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.7264530658721924},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.5601562857627869},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.5541427135467529},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4847230911254883},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.36017340421676636},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2660960853099823},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2645449936389923},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12110161781311035},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0662798285484314},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.06329822540283203},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06295889616012573},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s13040-020-00227-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-020-00227-6","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/s13040-020-00227-6","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},{"id":"pmid:33082858","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33082858","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData mining","raw_type":null},{"id":"pmh:oai:doaj.org/article:4b180292efe24b5e9b1fdd4f440c3cd4","is_oa":true,"landing_page_url":"https://doaj.org/article/4b180292efe24b5e9b1fdd4f440c3cd4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Mining, Vol 13, Iss 1, Pp 1-23 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7563914","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7563914","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Min","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s13040-020-00227-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-020-00227-6","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/s13040-020-00227-6","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5799999833106995,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2071443865","display_name":null,"funder_award_id":"201805","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5672331592","display_name":null,"funder_award_id":"81973814","funder_id":"https://openalex.org/F4320335578","funder_display_name":"NSAF Joint Fund"},{"id":"https://openalex.org/G6322278640","display_name":null,"funder_award_id":"81973814","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326532","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95"},{"id":"https://openalex.org/F4320326710","display_name":"Traditional Chinese Medicine Bureau of Guangdong Province","ror":"https://ror.org/05vkkzf98"},{"id":"https://openalex.org/F4320328715","display_name":"Guangzhou University","ror":"https://ror.org/05ar8rn06"},{"id":"https://openalex.org/F4320335578","display_name":"NSAF Joint Fund","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3093259931.pdf","grobid_xml":"https://content.openalex.org/works/W3093259931.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W102230927","https://openalex.org/W978308701","https://openalex.org/W1589349659","https://openalex.org/W1971054351","https://openalex.org/W1999328570","https://openalex.org/W2015328086","https://openalex.org/W2026199442","https://openalex.org/W2033591223","https://openalex.org/W2035618305","https://openalex.org/W2044986214","https://openalex.org/W2061786382","https://openalex.org/W2082976004","https://openalex.org/W2085887280","https://openalex.org/W2086303909","https://openalex.org/W2103017472","https://openalex.org/W2103912979","https://openalex.org/W2113143567","https://openalex.org/W2134967712","https://openalex.org/W2138793275","https://openalex.org/W2142237411","https://openalex.org/W2152026276","https://openalex.org/W2169589032","https://openalex.org/W2255243349","https://openalex.org/W2326277133","https://openalex.org/W2522948738","https://openalex.org/W2537623931","https://openalex.org/W2571641922","https://openalex.org/W2613279343","https://openalex.org/W2747699571","https://openalex.org/W2761146002","https://openalex.org/W2784713136","https://openalex.org/W2806098891","https://openalex.org/W2884979872","https://openalex.org/W2885560675","https://openalex.org/W2946412700","https://openalex.org/W2948924403","https://openalex.org/W2969970076","https://openalex.org/W3001118548","https://openalex.org/W3001465255","https://openalex.org/W3002108456","https://openalex.org/W3003217347","https://openalex.org/W3003322996","https://openalex.org/W3004280078","https://openalex.org/W3005153693","https://openalex.org/W3005409321","https://openalex.org/W3006390878","https://openalex.org/W3007437518","https://openalex.org/W3007940623","https://openalex.org/W3008396685","https://openalex.org/W3009656185","https://openalex.org/W3009912996","https://openalex.org/W3010497490","https://openalex.org/W3011072970","https://openalex.org/W3011176674","https://openalex.org/W3012424007","https://openalex.org/W3013503430","https://openalex.org/W3019096936","https://openalex.org/W3022285953","https://openalex.org/W3026002191","https://openalex.org/W3027024458","https://openalex.org/W3028765292","https://openalex.org/W3034111647","https://openalex.org/W3035212040","https://openalex.org/W3039084627"],"related_works":["https://openalex.org/W3036314732","https://openalex.org/W3009669391","https://openalex.org/W3176864053","https://openalex.org/W4206669628","https://openalex.org/W3171943759","https://openalex.org/W4292098121","https://openalex.org/W3154141118","https://openalex.org/W4388896133","https://openalex.org/W3031607536","https://openalex.org/W3198183218"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Chinese":[2,57],"medicine":[3],"Xuebijing":[4],"(XBJ)":[5],"has":[6],"proven":[7],"to":[8,40,61,89,97,105,118,132,150,302,359],"be":[9,272],"effective":[10,375],"in":[11,103,148,278,447,462,476],"the":[12,22,42,63,75,86,98,143,291,316,372,414,438,442,448,457,472],"treatment":[13,34,449],"of":[14,28,46,66,110,138,162,171,193,196,236,297,323,352,381,395,417,445,450,460,471],"mild":[15],"coronavirus":[16],"disease":[17,72,101],"2019":[18],"(COVID-19)":[19],"cases.":[20],"But":[21],"bioactive":[23],"compounds":[24],"and":[25,33,58,79,94,125,130,145,159,164,179,234,262,269,283,304,307,349,404,408,423,431,452,465],"potential":[26,43,107,139,189,355,435,473],"mechanisms":[27,45,444],"XBJ":[29,47,310,396,446,461],"for":[30,182],"COVID-19":[31,49,71,100,190,463],"prevention":[32],"are":[35],"unclear.":[36],"This":[37],"study":[38,426],"aimed":[39],"examine":[41],"effector":[44,92,173,191,364,458,474],"on":[48,51,401,420,441],"based":[50],"network":[52,124,135],"pharmacology.":[53],"Methods":[54],"We":[55,141,175,186],"searched":[56],"international":[59],"papers":[60],"obtain":[62,106],"active":[64,393],"ingredients":[65,376,394,430],"XBJ.":[67,111,194],"Then,":[68],"we":[69,84],"compiled":[70],"targets":[73,93,102,109,192,422,433],"from":[74],"GeneCards":[76],"gene":[77,152],"database":[78,88],"via":[80],"literature":[81],"searches.":[82],"Next,":[83],"used":[85,117,142,176],"SwissTargetPrediction":[87],"predict":[90],"XBJ\u2019s":[91,172],"map":[95],"them":[96],"abovementioned":[99],"order":[104],"therapeutic":[108,313],"Cytoscape":[112,149],"software":[113,181],"version":[114],"3.7.0":[115],"was":[116],"construct":[119,361],"a":[120,362,378,468],"\u201cXBJ":[121],"active-compound-potential-effector":[122],"target\u201d":[123],"protein-protein":[126],"interaction":[127],"(PPI)":[128],"network,":[129],"then":[131],"carry":[133],"out":[134],"topology":[136],"analysis":[137,158,170],"targets.":[140,174,275,390],"ClueGO":[144],"CluePedia":[146],"plugins":[147],"conduct":[151],"ontology":[153],"(GO)":[154],"biological":[155],"process":[156],"(BP)":[157],"Kyoto":[160],"Encyclopedia":[161],"Genes":[163],"Genomes":[165],"(KEGG)":[166],"signaling":[167,294,357],"pathway":[168],"enrichment":[169],"AutoDock":[177],"vina":[178],"PyMOL":[180],"molecular":[183,367],"docking.":[184],"Results":[185],"obtained":[187],"144":[188],"Fourteen":[195],"these":[197],"targets-glyceraldehyde":[198],"3-phosphate":[199],"dehydrogenase":[200],"(":[201,205,211,218,225,229,239,247,253,259,285,333,338],"GAPDH":[202],"),":[203,207,213,220,227,231,241,249,255,261],"albumin":[204],"ALB":[206],"tumor":[208],"necrosis":[209],"factor":[210,216,321,343],"TNF":[212],"epidermal":[214],"growth":[215,342],"receptor":[217,257,293,346,354],"EGFR":[219],"mitogen-activated":[221],"protein":[222],"kinase":[223,281,336],"1":[224,258,282],"MAPK1":[226],"Caspase-3":[228],"CASP3":[230],"signal":[232],"transducer":[233],"activator":[235],"transcription":[237],"3":[238],"STAT3":[240],"MAPK8":[242],",":[243,251,287,329],"prostaglandin-endoperoxide":[244],"synthase":[245],"2":[246,284],"PTGS2":[248],"JUN":[250],"interleukin-2":[252],"IL-2":[254],"estrogen":[256],"ESR1":[260],"MAPK14":[263],"had":[264,377],"degree":[265],"values":[266],">":[267],"40":[268],"therefore":[270],"could":[271,455],"considered":[273],"key":[274,429],"They":[276],"participated":[277],"extracellular":[279],"signal\u2013regulated":[280],"ERK1":[286],"ERK2":[288],")":[289],"cascade,":[290],"T-cell":[292],"pathway,":[295],"activation":[296],"MAPK":[298,328],"activity,":[299,437],"cellular":[300],"response":[301],"lipopolysaccharide,":[303],"other":[305],"inflammation-":[306],"immune-related":[308],"BPs.":[309],"exerted":[311],"its":[312],"effects":[314,416],"through":[315],"renin-angiotensin":[317],"system":[318],"(RAS),":[319],"nuclear":[320],"\u03ba-light-chain-enhancer":[322],"activated":[324],"B":[325,337],"cells":[326],"(NF-\u03baB),":[327],"phosphatidylinositol-4,":[330],"5-bisphosphate":[331],"3-kinase":[332],"PI3K":[334],")-protein":[335],"Akt":[339],")-vascular":[340],"endothelial":[341],"(VEGF),":[344],"toll-like":[345],"(TLR),":[347],"TNF,":[348],"inflammatory-mediator":[350],"regulation":[351],"transient":[353],"(TRP)":[356],"pathways":[358],"ultimately":[360],"\u201cdrug-ingredient-target-pathway\u201d":[363],"network.":[365],"The":[366,392],"docking":[368,379],"results":[369],"showed":[370],"that":[371,428],"core":[373],"18":[374],"score":[380],"less":[382],"than":[383],"\u2212":[384],"4.0":[385],"with":[386],"those":[387,466],"top":[388],"10":[389],"Conclusion":[391],"regulated":[397],"different":[398,402,418],"genes,":[399],"acted":[400],"pathways,":[403],"synergistically":[405],"produced":[406],"anti-inflammatory":[407],"immune-regulatory":[409],"effects,":[410],"which":[411],"fully":[412],"demonstrated":[413,427],"synergistic":[415],"components":[419],"multiple":[421],"pathways.":[424],"Our":[425],"their":[432],"have":[434],"binding":[436],"existing":[439],"studies":[440],"pharmacological":[443],"sepsis":[451],"severe":[453],"pneumonia,":[454],"explain":[456],"mechanism":[459,475],"treatment,":[464],"provided":[467],"preliminary":[469],"examination":[470],"this":[477],"disease.":[478]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":1}],"updated_date":"2026-07-29T09:40:50.615796","created_date":"2025-10-10T00:00:00"}