{"id":"https://openalex.org/W3091794033","doi":"https://doi.org/10.1186/s13040-020-00226-7","title":"Identification of microbial interaction network: zero-inflated latent Ising model based approach","display_name":"Identification of microbial interaction network: zero-inflated latent Ising model based approach","publication_year":2020,"publication_date":"2020-10-07","ids":{"openalex":"https://openalex.org/W3091794033","doi":"https://doi.org/10.1186/s13040-020-00226-7","mag":"3091794033","pmid":"https://pubmed.ncbi.nlm.nih.gov/33042226"},"language":"en","primary_location":{"id":"doi:10.1186/s13040-020-00226-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-020-00226-7","pdf_url":"https://biodatamining.biomedcentral.com/track/pdf/10.1186/s13040-020-00226-7","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://biodatamining.biomedcentral.com/track/pdf/10.1186/s13040-020-00226-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102025249","display_name":"Jie Zhou","orcid":"https://orcid.org/0000-0002-4097-2459"},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Zhou","raw_affiliation_strings":["Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Hanover, NH USA","Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Hanover, NH USA","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034353426","display_name":"Weston D. Viles","orcid":null},"institutions":[{"id":"https://openalex.org/I73443619","display_name":"University of Southern Maine","ror":"https://ror.org/03ke6tv85","country_code":"US","type":"education","lineage":["https://openalex.org/I2802397601","https://openalex.org/I73443619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weston D. Viles","raw_affiliation_strings":["Department of Mathematics and Statistics, University of Southern Maine, Portland, ME USA","Department of Mathematics and Statistics, University of Southern Maine, Portland, ME, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, University of Southern Maine, Portland, ME USA","institution_ids":["https://openalex.org/I73443619"]},{"raw_affiliation_string":"Department of Mathematics and Statistics, University of Southern Maine, Portland, ME, USA","institution_ids":["https://openalex.org/I73443619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028348918","display_name":"Boran Lu","orcid":null},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boran Lu","raw_affiliation_strings":["Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Hanover, NH USA","Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Hanover, NH USA","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100363804","display_name":"Zhigang Li","orcid":"https://orcid.org/0000-0002-6224-1833"},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhigang Li","raw_affiliation_strings":["Department of Biostatistics, University of Florida, Gainesville, FL USA","Department of Biostatistics, University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Florida, Gainesville, FL USA","institution_ids":["https://openalex.org/I33213144","https://openalex.org/I2800717037"]},{"raw_affiliation_string":"Department of Biostatistics, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073357411","display_name":"Juliette C. Madan","orcid":"https://orcid.org/0000-0003-0542-1368"},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juliette C. Madan","raw_affiliation_strings":["Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH USA","Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH USA","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062649421","display_name":"Margaret R. Karagas","orcid":"https://orcid.org/0000-0002-6398-7362"},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret R. Karagas","raw_affiliation_strings":["Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH USA","Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH USA","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008965974","display_name":"Jiang Gui","orcid":"https://orcid.org/0000-0001-5377-8914"},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiang Gui","raw_affiliation_strings":["Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Hanover, NH USA","Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Hanover, NH USA","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088186295","display_name":"Anne G. Hoen","orcid":"https://orcid.org/0000-0003-0035-8689"},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anne G. Hoen","raw_affiliation_strings":["Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Hanover, NH USA","Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH USA","Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA"],"raw_orcid":"https://orcid.org/0000-0002-0617-0196","affiliations":[{"raw_affiliation_string":"Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Hanover, NH USA","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH USA","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA","institution_ids":["https://openalex.org/I107672454"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5088186295"],"corresponding_institution_ids":["https://openalex.org/I107672454"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.3255,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.56891447,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"13","issue":"1","first_page":"16","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.883400022983551,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.883400022983551,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13283","display_name":"Mental Health Research Topics","score":0.02410000003874302,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/graphical-model","display_name":"Graphical model","score":0.5334708094596863},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.520110011100769},{"id":"https://openalex.org/keywords/gut-flora","display_name":"Gut flora","score":0.48235195875167847},{"id":"https://openalex.org/keywords/mixture-model","display_name":"Mixture model","score":0.43814465403556824},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3725346326828003},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3337186574935913},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.31548652052879333},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.29070568084716797}],"concepts":[{"id":"https://openalex.org/C155846161","wikidata":"https://www.wikidata.org/wiki/Q1143367","display_name":"Graphical model","level":2,"score":0.5334708094596863},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.520110011100769},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.48235195875167847},{"id":"https://openalex.org/C61224824","wikidata":"https://www.wikidata.org/wiki/Q2260434","display_name":"Mixture model","level":2,"score":0.43814465403556824},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3725346326828003},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3337186574935913},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.31548652052879333},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.29070568084716797},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s13040-020-00226-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-020-00226-7","pdf_url":"https://biodatamining.biomedcentral.com/track/pdf/10.1186/s13040-020-00226-7","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},{"id":"pmid:33042226","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33042226","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData mining","raw_type":null},{"id":"pmh:oai:doaj.org/article:5031ecfb2929430a89712dc933daf13f","is_oa":true,"landing_page_url":"https://doaj.org/article/5031ecfb2929430a89712dc933daf13f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Mining, Vol 13, Iss 1, Pp 1-15 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7542390","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7542390","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Min","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s13040-020-00226-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13040-020-00226-7","pdf_url":"https://biodatamining.biomedcentral.com/track/pdf/10.1186/s13040-020-00226-7","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G181906898","display_name":null,"funder_award_id":"P01ES022832","funder_id":"https://openalex.org/F4320306107","funder_display_name":"U.S. Environmental Protection Agency"},{"id":"https://openalex.org/G2888156169","display_name":null,"funder_award_id":"UH3OD023275","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3490695784","display_name":null,"funder_award_id":"UG3/UH3OD023275","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3681109530","display_name":null,"funder_award_id":"P20GM104416","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4519590523","display_name":null,"funder_award_id":"R01 LM012012","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G5872326114","display_name":null,"funder_award_id":"UH3 OD023275","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6148147876","display_name":null,"funder_award_id":"UG3/UH3OD023275","funder_id":"https://openalex.org/F4320306107","funder_display_name":"U.S. Environmental Protection Agency"},{"id":"https://openalex.org/G6156100379","display_name":null,"funder_award_id":"R01 GM123014","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6362915941","display_name":null,"funder_award_id":"P30 CA023108","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6539703392","display_name":null,"funder_award_id":"P01ES022832","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6808659693","display_name":null,"funder_award_id":"P01 ES022832","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G7112160442","display_name":null,"funder_award_id":"P20 GM104416","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7584862991","display_name":null,"funder_award_id":"P42 ES007373","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G766807502","display_name":null,"funder_award_id":"RD83544201","funder_id":"https://openalex.org/F4320306107","funder_display_name":"U.S. Environmental Protection Agency"},{"id":"https://openalex.org/G7908535367","display_name":null,"funder_award_id":"R01LM012723","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G819391142","display_name":null,"funder_award_id":"RD83544201","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8207119146","display_name":null,"funder_award_id":"P20GM104416","funder_id":"https://openalex.org/F4320306107","funder_display_name":"U.S. Environmental Protection Agency"},{"id":"https://openalex.org/G8558333783","display_name":null,"funder_award_id":"R01 LM012723","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G996038514","display_name":null,"funder_award_id":"P42ES007373","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306107","display_name":"U.S. Environmental Protection Agency","ror":"https://ror.org/03tns0030"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3091794033.pdf","grobid_xml":"https://content.openalex.org/works/W3091794033.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W563824333","https://openalex.org/W958079127","https://openalex.org/W1523266228","https://openalex.org/W1605035807","https://openalex.org/W1735309556","https://openalex.org/W1765176027","https://openalex.org/W1933293707","https://openalex.org/W1966623514","https://openalex.org/W1983314776","https://openalex.org/W2010824638","https://openalex.org/W2011312755","https://openalex.org/W2027297424","https://openalex.org/W2032259302","https://openalex.org/W2040847667","https://openalex.org/W2044712133","https://openalex.org/W2052639391","https://openalex.org/W2077514957","https://openalex.org/W2078183728","https://openalex.org/W2088170171","https://openalex.org/W2088192427","https://openalex.org/W2097360283","https://openalex.org/W2102760656","https://openalex.org/W2106398669","https://openalex.org/W2112408821","https://openalex.org/W2113977541","https://openalex.org/W2114104545","https://openalex.org/W2128208871","https://openalex.org/W2132555912","https://openalex.org/W2147109452","https://openalex.org/W2152239989","https://openalex.org/W2156591001","https://openalex.org/W2157258388","https://openalex.org/W2159793005","https://openalex.org/W2163903604","https://openalex.org/W2312839476","https://openalex.org/W2334099820","https://openalex.org/W2401404581","https://openalex.org/W2416379413","https://openalex.org/W2464722113","https://openalex.org/W2485626290","https://openalex.org/W2573450200","https://openalex.org/W2618341198","https://openalex.org/W2695942126","https://openalex.org/W2769209214","https://openalex.org/W2769542288","https://openalex.org/W2769942785","https://openalex.org/W2904250115","https://openalex.org/W2971439707","https://openalex.org/W3098834468","https://openalex.org/W3098888484","https://openalex.org/W3125096521","https://openalex.org/W3142520071","https://openalex.org/W4210823377","https://openalex.org/W4293052541","https://openalex.org/W4294541781","https://openalex.org/W4300625937"],"related_works":["https://openalex.org/W2109986081","https://openalex.org/W4297589944","https://openalex.org/W2417308975","https://openalex.org/W2964129930","https://openalex.org/W4368755698","https://openalex.org/W4285040766","https://openalex.org/W1975321310","https://openalex.org/W4388627352","https://openalex.org/W1952261593","https://openalex.org/W4290803287"],"abstract_inverted_index":{"BACKGROUND:":[0],"Throughout":[1],"their":[2],"lifespans,":[3],"humans":[4],"continually":[5],"interact":[6],"with":[7,177,317],"the":[8,19,28,32,39,42,78,82,99,115,136,147,192,196,201,206,220,225,241,246,254,291,336],"microbial":[9,103,337],"world,":[10],"including":[11],"those":[12,250],"organisms":[13],"which":[14,113,240],"live":[15],"in":[16,23,48,239,265,273,339],"and":[17,35,54,58,69,76,89,126,138,158,184,210,231,287],"on":[18,122],"human":[20,43,266],"body.":[21],"Research":[22],"this":[24,85],"domain":[25],"has":[26,269],"revealed":[27],"extensive":[29],"links":[30],"between":[31,81],"human-associated":[33],"microbiota":[34,40,165,223,282],"health.":[36],"In":[37,84],"particular,":[38],"of":[41,102,117,150,216,281],"gut":[44,164,222],"plays":[45],"essential":[46],"roles":[47],"digestion,":[49],"nutrient":[50],"metabolism,":[51],"immune":[52],"maturation":[53],"homeostasis,":[55],"neurological":[56],"signaling,":[57],"endocrine":[59],"regulation.":[60],"Microbial":[61],"interaction":[62,104,338],"networks":[63,228],"are":[64,70,175],"frequently":[65],"estimated":[66,227],"from":[67,167,179,229,251,322],"data":[68,95,157],"an":[71,162,310],"indispensable":[72],"tool":[73],"for":[74,92,146,296],"representing":[75],"understanding":[77],"conditional":[79,292],"correlation":[80,293],"microbes.":[83],"high-dimensional":[86],"setting,":[87],"zero-inflation":[88,139],"unit-sum":[90,137],"constraint":[91],"relative":[93,118,279],"abundance":[94,119,280],"pose":[96],"challenges":[97],"to":[98,131,161,213,235,244,315,334],"reliable":[100],"estimation":[101],"networks.":[105],"METHODS":[106],"AND":[107],"RESULTS:":[108],"(ZILI)":[109],"model":[110,148,182,187,308,329],"is":[111,144,153,191,211,261],"proposed":[112,145,303],"assumes":[114],"distribution":[116],"relies":[120],"only":[121],"finite":[123],"latent":[124],"states":[125],"provides":[127,309],"a":[128,214,257],"novel":[129],"way":[130,314],"solve":[132],"issues":[133],"induced":[134,277],"by":[135,278],"constrains.":[140],"A":[141],"two-step":[142,202],"algorithm":[143,203],"selection":[149],"ZILI.":[151],"ZILI":[152,190,232,242,307,323],"evaluated":[154],"through":[155],"simulated":[156],"subsequently":[159],"applied":[160],"infant":[163,221],"dataset":[166],"New":[168],"Hampshire":[169],"Birth":[170],"Cohort":[171],"Study.":[172],"The":[173,302,320],"results":[174,178,321],"compared":[176],"Gaussian":[180],"graphical":[181,207],"(GGM)":[183],"dichotomous":[185],"Ising":[186],"(DIS).":[188],"Providing":[189],"true":[193],"data-generating":[194],"model,":[195],"simulation":[197],"studies":[198],"show":[199],"that":[200],"can":[204,330],"identify":[205],"structure":[208],"effectively":[209],"robust":[212],"range":[215],"parameter":[217],"settings.":[218],"For":[219],"dataset,":[224],"final":[226],"GGM":[230],"turn":[233],"out":[234],"have":[236,324],"significant":[237],"overlap":[238],"tends":[243],"select":[245],"sparser":[247],"network":[248],"than":[249],"GGM.":[252,301],"From":[253],"shared":[255],"subnetwork,":[256],"hub":[258],"taxon":[259],"Lachnospiraceae":[260],"identified":[262],"whose":[263],"involvement":[264],"disease":[267],"development":[268],"been":[270],"discovered":[271],"recently":[272],"literature.":[274],"CONCLUSIONS:":[275],"Constrains":[276],"such":[283,299],"as":[284,300],"zero":[285],"inflation":[286],"unit":[288],"sum":[289],"render":[290],"analysis":[294],"unreliable":[295],"conventional":[297],"methods":[298],"optimal":[304],"categoricalization":[305],"based":[306],"alternative":[311],"yet":[312],"elegant":[313],"deal":[316],"these":[318],"difficulties.":[319],"reasonable":[325],"biological":[326],"interpretation.":[327],"This":[328],"also":[331],"be":[332],"used":[333],"study":[335],"other":[340],"body":[341],"parts.":[342]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2}],"updated_date":"2026-06-15T08:34:33.830935","created_date":"2025-10-10T00:00:00"}