{"id":"https://openalex.org/W2939796484","doi":"https://doi.org/10.1186/s12918-019-0703-1","title":"Adaptive information processing of network modules to dynamic and spatial stimuli","display_name":"Adaptive information processing of network modules to dynamic and spatial stimuli","publication_year":2019,"publication_date":"2019-03-14","ids":{"openalex":"https://openalex.org/W2939796484","doi":"https://doi.org/10.1186/s12918-019-0703-1","mag":"2939796484","pmid":"https://pubmed.ncbi.nlm.nih.gov/30866946"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-019-0703-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-019-0703-1","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-019-0703-1","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-019-0703-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050190007","display_name":"J. Krishnan","orcid":"https://orcid.org/0000-0001-6196-2033"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"J. Krishnan","raw_affiliation_strings":["Department of Chemical Engineering, Centre for Process Systems Engineering, Imperial College London, South Kensington, London, SW7 2AZ, UK. j.krishnan@imperial.ac.uk","Department of Chemical Engineering, Centre for Process Systems Engineering, Imperial College London, London, UK"],"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Centre for Process Systems Engineering, Imperial College London, South Kensington, London, SW7 2AZ, UK. j.krishnan@imperial.ac.uk","institution_ids":[]},{"raw_affiliation_string":"Department of Chemical Engineering, Centre for Process Systems Engineering, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013470797","display_name":"Ioannis N. Floros","orcid":null},"institutions":[{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","GR"],"is_corresponding":false,"raw_author_name":"Ioannis Floros","raw_affiliation_strings":["Department of Chemical Engineering, Centre for Process Systems Engineering, Imperial College London, South Kensington, London, SW7 2AZ, UK","National Centre of Scientific Research \"Demokritos\", Athens, Greece","National Centre of Scientific Research \u201cDemokritos\u201d, Athens, Greece","Department of Chemical Engineering, Centre for Process Systems Engineering, Imperial College London, London, UK"],"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Centre for Process Systems Engineering, Imperial College London, South Kensington, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"National Centre of Scientific Research \"Demokritos\", Athens, Greece","institution_ids":["https://openalex.org/I203474044"]},{"raw_affiliation_string":"National Centre of Scientific Research \u201cDemokritos\u201d, Athens, Greece","institution_ids":["https://openalex.org/I203474044"]},{"raw_affiliation_string":"Department of Chemical Engineering, Centre for Process Systems Engineering, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050190007"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":null,"apc_paid":null,"fwci":1.5677,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.83353319,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"32","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10502","display_name":"Advanced Memory and Neural Computing","score":0.9921000003814697,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10502","display_name":"Advanced Memory and Neural Computing","score":0.9921000003814697,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12784","display_name":"Modular Robots and Swarm Intelligence","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13182","display_name":"Quantum-Dot Cellular Automata","score":0.949400007724762,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.614693284034729},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5133537650108337},{"id":"https://openalex.org/keywords/information-processing","display_name":"Information processing","score":0.504128098487854},{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.42929524183273315},{"id":"https://openalex.org/keywords/cognitive-science","display_name":"Cognitive science","score":0.3392651677131653},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3058757185935974},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23787909746170044},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.19394943118095398},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.1248835027217865}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.614693284034729},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5133537650108337},{"id":"https://openalex.org/C87868495","wikidata":"https://www.wikidata.org/wiki/Q750843","display_name":"Information processing","level":2,"score":0.504128098487854},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.42929524183273315},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.3392651677131653},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3058757185935974},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23787909746170044},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.19394943118095398},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1248835027217865}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004777","descriptor_name":"Environment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004777","descriptor_name":"Environment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004777","descriptor_name":"Environment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12918-019-0703-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-019-0703-1","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-019-0703-1","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:30866946","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30866946","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:d722e052951248cd820a0f234d709041","is_oa":true,"landing_page_url":"https://doaj.org/article/d722e052951248cd820a0f234d709041","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 13, Iss 1, Pp 1-26 (2019)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5413494","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6417070","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/70148","is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/70148","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/s12918-019-0703-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-019-0703-1","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-019-0703-1","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10","score":0.6899999976158142}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2939796484.pdf","grobid_xml":"https://content.openalex.org/works/W2939796484.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W5842570","https://openalex.org/W574446616","https://openalex.org/W1964393785","https://openalex.org/W1964508389","https://openalex.org/W1971158145","https://openalex.org/W1974137633","https://openalex.org/W1975351609","https://openalex.org/W1985732712","https://openalex.org/W1990476699","https://openalex.org/W1991932257","https://openalex.org/W2003917394","https://openalex.org/W2005615084","https://openalex.org/W2015244769","https://openalex.org/W2020808454","https://openalex.org/W2022844999","https://openalex.org/W2028175152","https://openalex.org/W2037906405","https://openalex.org/W2041603328","https://openalex.org/W2042102692","https://openalex.org/W2046140095","https://openalex.org/W2047365291","https://openalex.org/W2053345816","https://openalex.org/W2056861732","https://openalex.org/W2057513094","https://openalex.org/W2066718612","https://openalex.org/W2068887765","https://openalex.org/W2071794568","https://openalex.org/W2072284983","https://openalex.org/W2072454019","https://openalex.org/W2073571012","https://openalex.org/W2073694964","https://openalex.org/W2076496720","https://openalex.org/W2081191373","https://openalex.org/W2084977635","https://openalex.org/W2087538969","https://openalex.org/W2090415492","https://openalex.org/W2100149477","https://openalex.org/W2106133729","https://openalex.org/W2106362845","https://openalex.org/W2117056464","https://openalex.org/W2120170134","https://openalex.org/W2123834061","https://openalex.org/W2123973944","https://openalex.org/W2131456214","https://openalex.org/W2131591423","https://openalex.org/W2133254839","https://openalex.org/W2133403209","https://openalex.org/W2135415852","https://openalex.org/W2141851583","https://openalex.org/W2141977920","https://openalex.org/W2149109097","https://openalex.org/W2151366879","https://openalex.org/W2152750766","https://openalex.org/W2162647894","https://openalex.org/W2164495477","https://openalex.org/W2166884834","https://openalex.org/W2247294682","https://openalex.org/W2276582555","https://openalex.org/W2338895903","https://openalex.org/W2343828220","https://openalex.org/W2418779518","https://openalex.org/W2472786230","https://openalex.org/W2515930553","https://openalex.org/W2750346291","https://openalex.org/W2964163153"],"related_works":["https://openalex.org/W2997567050","https://openalex.org/W1483272040","https://openalex.org/W4283377908","https://openalex.org/W1533421371","https://openalex.org/W2003050223","https://openalex.org/W2091777911","https://openalex.org/W2766405861","https://openalex.org/W2360975119","https://openalex.org/W2372487155","https://openalex.org/W2280156463"],"abstract_inverted_index":{"By":[0],"studying":[1],"a":[2,11,93],"range":[3,12],"of":[4,13,21,29,71,75,83,85,99,112],"network":[5],"circuits/motifs":[6],"on":[7,15],"one":[8],"hand":[9],"and":[10,32,43,66,89,101,114,116],"stimuli":[14,79],"the":[16,108],"other,":[17],"we":[18],"isolate":[19],"characteristics":[20],"these":[22],"circuits":[23,82],"(structural)":[24],"which":[25],"enable":[26,63],"different":[27],"degrees":[28],"exact":[30],"adaptive":[31,100],"homeostatic":[33,64,102,119],"behaviour":[34,65,103],"in":[35,87,104,117],"such":[36],"stimuli,":[37],"how":[38],"they":[39],"may":[40,60],"be":[41],"combined,":[42],"also":[44,52],"identify":[45],"cases":[46],"associated":[47,55,68],"with":[48,56,69,81],"non-homeostatic":[49],"behaviour.":[50],"We":[51],"reveal":[53],"constraints":[54,67],"locations":[57],"where":[58],"signals":[59],"act":[61],"to":[62],"augmentations":[70],"circuits.":[72,121],"This":[73],"consideration":[74],"multiple":[76],"experimentally/naturally":[77],"relevant":[78],"along":[80],"adaptation":[84,113],"relevance":[86],"natural":[88,105],"engineered":[90],"biology,":[91],"provides":[92],"platform":[94],"for":[95],"deepening":[96],"our":[97],"understanding":[98],"systems,":[106],"bridging":[107],"gap":[109],"between":[110],"models":[111],"experiments":[115],"engineering":[118],"synthetic":[120]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
