{"id":"https://openalex.org/W2903925270","doi":"https://doi.org/10.1186/s12918-018-0667-6","title":"Qualitative modelling of the interplay of inflammatory status and butyrate in the human gut: a hypotheses about robust bi-stability","display_name":"Qualitative modelling of the interplay of inflammatory status and butyrate in the human gut: a hypotheses about robust bi-stability","publication_year":2018,"publication_date":"2018-12-01","ids":{"openalex":"https://openalex.org/W2903925270","doi":"https://doi.org/10.1186/s12918-018-0667-6","mag":"2903925270","pmid":"https://pubmed.ncbi.nlm.nih.gov/30558589"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-018-0667-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0667-6","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0667-6","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0667-6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051677560","display_name":"Gunter Neumann","orcid":null},"institutions":[{"id":"https://openalex.org/I26437253","display_name":"\u00d6rebro University","ror":"https://ror.org/05kytsw45","country_code":"SE","type":"education","lineage":["https://openalex.org/I26437253"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Gunter Neumann","raw_affiliation_strings":["School of Medical Health (MV), \u00d6rebro University, \u00d6rebro, 70182, Sweden"],"affiliations":[{"raw_affiliation_string":"School of Medical Health (MV), \u00d6rebro University, \u00d6rebro, 70182, Sweden","institution_ids":["https://openalex.org/I26437253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043925711","display_name":"Rebecca Wall","orcid":"https://orcid.org/0000-0002-6514-2718"},"institutions":[{"id":"https://openalex.org/I26437253","display_name":"\u00d6rebro University","ror":"https://ror.org/05kytsw45","country_code":"SE","type":"education","lineage":["https://openalex.org/I26437253"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Rebecca Wall","raw_affiliation_strings":["School of Medical Health (MV), \u00d6rebro University, \u00d6rebro, 70182, Sweden"],"affiliations":[{"raw_affiliation_string":"School of Medical Health (MV), \u00d6rebro University, \u00d6rebro, 70182, Sweden","institution_ids":["https://openalex.org/I26437253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089290023","display_name":"Ignacio Rangel","orcid":"https://orcid.org/0000-0003-3383-9219"},"institutions":[{"id":"https://openalex.org/I26437253","display_name":"\u00d6rebro University","ror":"https://ror.org/05kytsw45","country_code":"SE","type":"education","lineage":["https://openalex.org/I26437253"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ignacio Rangel","raw_affiliation_strings":["School of Medical Health (MV), \u00d6rebro University, \u00d6rebro, 70182, Sweden"],"affiliations":[{"raw_affiliation_string":"School of Medical Health (MV), \u00d6rebro University, \u00d6rebro, 70182, Sweden","institution_ids":["https://openalex.org/I26437253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028328418","display_name":"Tatiana M. Marques","orcid":"https://orcid.org/0000-0001-8591-0799"},"institutions":[{"id":"https://openalex.org/I26437253","display_name":"\u00d6rebro University","ror":"https://ror.org/05kytsw45","country_code":"SE","type":"education","lineage":["https://openalex.org/I26437253"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Tatiana M. Marques","raw_affiliation_strings":["School of Medical Health (MV), \u00d6rebro University, \u00d6rebro, 70182, Sweden"],"affiliations":[{"raw_affiliation_string":"School of Medical Health (MV), \u00d6rebro University, \u00d6rebro, 70182, Sweden","institution_ids":["https://openalex.org/I26437253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065327075","display_name":"Dirk Repsilber","orcid":"https://orcid.org/0000-0002-7173-5579"},"institutions":[{"id":"https://openalex.org/I26437253","display_name":"\u00d6rebro University","ror":"https://ror.org/05kytsw45","country_code":"SE","type":"education","lineage":["https://openalex.org/I26437253"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Dirk Repsilber","raw_affiliation_strings":["School of Medical Health (MV), \u00d6rebro University, \u00d6rebro, 70182, Sweden. dirk.repsilber@oru.se","School of Medical Health (MV), \u00d6rebro University, \u00d6rebro, 70182, Sweden"],"affiliations":[{"raw_affiliation_string":"School of Medical Health (MV), \u00d6rebro University, \u00d6rebro, 70182, Sweden. dirk.repsilber@oru.se","institution_ids":[]},{"raw_affiliation_string":"School of Medical Health (MV), \u00d6rebro University, \u00d6rebro, 70182, Sweden","institution_ids":["https://openalex.org/I26437253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5051677560"],"corresponding_institution_ids":["https://openalex.org/I26437253"],"apc_list":null,"apc_paid":{"value":2125,"currency":"EUR","value_usd":2291},"fwci":0.4639,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.64349635,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"12","issue":"1","first_page":"144","last_page":"144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.9908999800682068,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.666752815246582},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.5161769986152649},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5136094093322754},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5104430913925171},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3078743517398834},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.16562408208847046}],"concepts":[{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.666752815246582},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.5161769986152649},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5136094093322754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5104430913925171},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3078743517398834},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.16562408208847046}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002087","descriptor_name":"Butyrates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002087","descriptor_name":"Butyrates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002087","descriptor_name":"Butyrates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12918-018-0667-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0667-6","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0667-6","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:30558589","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30558589","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:b4920a236e9741c687770b2a6c7a5fdd","is_oa":true,"landing_page_url":"https://doaj.org/article/b4920a236e9741c687770b2a6c7a5fdd","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 12, Iss 1, Pp 1-11 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5267400","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6296070","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6296070","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6296070","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12918-018-0667-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0667-6","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0667-6","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321975","display_name":"\u00d6rebro Universitet","ror":"https://ror.org/05kytsw45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2903925270.pdf","grobid_xml":"https://content.openalex.org/works/W2903925270.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1596321532","https://openalex.org/W1793035576","https://openalex.org/W1800141310","https://openalex.org/W1868036258","https://openalex.org/W1934624334","https://openalex.org/W1967139826","https://openalex.org/W1972266008","https://openalex.org/W2000864811","https://openalex.org/W2005301170","https://openalex.org/W2009170813","https://openalex.org/W2009707322","https://openalex.org/W2019610958","https://openalex.org/W2027621512","https://openalex.org/W2029751554","https://openalex.org/W2032230795","https://openalex.org/W2042684473","https://openalex.org/W2050609241","https://openalex.org/W2051312690","https://openalex.org/W2057411492","https://openalex.org/W2062661305","https://openalex.org/W2065725792","https://openalex.org/W2069506614","https://openalex.org/W2069507800","https://openalex.org/W2076386438","https://openalex.org/W2087292184","https://openalex.org/W2088170171","https://openalex.org/W2089187598","https://openalex.org/W2095481371","https://openalex.org/W2097788076","https://openalex.org/W2098209207","https://openalex.org/W2102288941","https://openalex.org/W2106528813","https://openalex.org/W2111913995","https://openalex.org/W2114089110","https://openalex.org/W2114755316","https://openalex.org/W2115450300","https://openalex.org/W2121167265","https://openalex.org/W2127511909","https://openalex.org/W2128992702","https://openalex.org/W2133547370","https://openalex.org/W2135989088","https://openalex.org/W2140937256","https://openalex.org/W2145366310","https://openalex.org/W2152200355","https://openalex.org/W2152751713","https://openalex.org/W2155770880","https://openalex.org/W2161238054","https://openalex.org/W2163878401","https://openalex.org/W2166562121","https://openalex.org/W2171742795","https://openalex.org/W2274927794","https://openalex.org/W2277409206","https://openalex.org/W2310441748","https://openalex.org/W2335805754","https://openalex.org/W2409656339","https://openalex.org/W2411288489","https://openalex.org/W2597800471","https://openalex.org/W2891545181","https://openalex.org/W2896296657","https://openalex.org/W2969892420","https://openalex.org/W6652808489"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W5284979","https://openalex.org/W4245853730"],"abstract_inverted_index":{"Interpreting":[0],"the":[1,11,18,28,44,51,64,72,75,83],"results":[2],"of":[3,14,27,50,58,63,67,74,86],"this":[4],"qualitative":[5,65],"model":[6],"allows":[7],"formulating":[8],"hypotheses":[9,77],"about":[10,33],"switch-like":[12,48],"character":[13,66],"inflammatory":[15,91],"regulation":[16],"in":[17,40,43],"gut":[19],"epithelium,":[20],"involving":[21],"bacterial":[22,41],"products":[23],"as":[24,80,82],"constitutive":[25],"parts":[26],"system.":[29],"We":[30],"also":[31],"speculate":[32],"possible":[34],"explanations":[35],"for":[36,71],"observed":[37],"bimodal":[38],"distributions":[39],"compositions":[42],"human":[45],"gut.":[46],"The":[47],"behaviour":[49],"system":[52],"proved":[53],"to":[54,89],"be":[55],"mostly":[56],"independent":[57],"parameter":[59],"choices.":[60],"Further":[61],"implications":[62],"our":[68],"modeling":[69],"approach":[70],"robustness":[73],"proposed":[76],"are":[78],"discussed,":[79],"well":[81],"pronounced":[84],"role":[85],"butyrate":[87],"compared":[88],"other":[90],"regulators,":[92],"especially":[93],"LPS,":[94],"NF-":[95],"\u03baB":[96],"and":[97],"cytokines.":[98]},"counts_by_year":[{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}