{"id":"https://openalex.org/W2899088343","doi":"https://doi.org/10.1186/s12918-018-0606-6","title":"The anticancer mechanism investigation of Tanshinone IIA by pharmacological clustering in protein network","display_name":"The anticancer mechanism investigation of Tanshinone IIA by pharmacological clustering in protein network","publication_year":2018,"publication_date":"2018-10-29","ids":{"openalex":"https://openalex.org/W2899088343","doi":"https://doi.org/10.1186/s12918-018-0606-6","mag":"2899088343","pmid":"https://pubmed.ncbi.nlm.nih.gov/30373594"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-018-0606-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0606-6","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0606-6","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0606-6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006334465","display_name":"Yanfeng Cao","orcid":null},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan-feng Cao","raw_affiliation_strings":["Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, China","School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, China","institution_ids":["https://openalex.org/I17747738"]},{"raw_affiliation_string":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035381595","display_name":"Shifeng Wang","orcid":"https://orcid.org/0000-0001-6169-2598"},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shi-feng Wang","raw_affiliation_strings":["School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100407728","display_name":"Xi Li","orcid":"https://orcid.org/0000-0002-4999-8436"},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Li","raw_affiliation_strings":["School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100621557","display_name":"Yanling Zhang","orcid":"https://orcid.org/0000-0001-6344-8804"},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan-ling Zhang","raw_affiliation_strings":["School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. collean_zhang@163.com","School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. collean_zhang@163.com","institution_ids":["https://openalex.org/I17747738"]},{"raw_affiliation_string":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111419769","display_name":"Yanjiang Qiao","orcid":"https://orcid.org/0009-0006-8319-2846"},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan-jiang Qiao","raw_affiliation_strings":["School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. yjqiao@bucm.edu.cn","School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. yjqiao@bucm.edu.cn","institution_ids":["https://openalex.org/I17747738"]},{"raw_affiliation_string":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China","institution_ids":["https://openalex.org/I17747738"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100621557","https://openalex.org/A5111419769"],"corresponding_institution_ids":["https://openalex.org/I17747738"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":3.5898,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.91674009,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"12","issue":"1","first_page":"90","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.4645000100135803,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.4645000100135803,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.048500001430511475,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.04839999973773956,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kegg","display_name":"KEGG","score":0.7683611512184143},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.6043293476104736},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5373562574386597},{"id":"https://openalex.org/keywords/pi3k/akt/mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.4841119050979614},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.44925105571746826},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"Programmed cell death","score":0.4387006461620331},{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.43130651116371155},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.4096817672252655},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.39936205744743347},{"id":"https://openalex.org/keywords/gene-ontology","display_name":"Gene ontology","score":0.3901154696941376},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.3443004786968231},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3024202585220337},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.18819379806518555},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.14936774969100952},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1455492377281189}],"concepts":[{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.7683611512184143},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6043293476104736},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5373562574386597},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4841119050979614},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44925105571746826},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4387006461620331},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.43130651116371155},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4096817672252655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39936205744743347},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.3901154696941376},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3443004786968231},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3024202585220337},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.18819379806518555},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14936774969100952},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1455492377281189},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045784","descriptor_name":"Abietanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045784","descriptor_name":"Abietanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045784","descriptor_name":"Abietanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045784","descriptor_name":"Abietanes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D045784","descriptor_name":"Abietanes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D045784","descriptor_name":"Abietanes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12918-018-0606-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0606-6","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0606-6","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:30373594","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30373594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:2aa093adb4bf40889fe704ef9df87c16","is_oa":false,"landing_page_url":"https://doaj.org/article/2aa093adb4bf40889fe704ef9df87c16","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 12, Iss 1, Pp 1-12 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5161020","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6206912","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6206912","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6206912","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12918-018-0606-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0606-6","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0606-6","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8100000023841858,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2899088343.pdf","grobid_xml":"https://content.openalex.org/works/W2899088343.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1500435219","https://openalex.org/W1508150867","https://openalex.org/W1793887838","https://openalex.org/W1821806054","https://openalex.org/W1875112053","https://openalex.org/W1899594293","https://openalex.org/W1965239527","https://openalex.org/W1965917470","https://openalex.org/W1968274640","https://openalex.org/W1969898574","https://openalex.org/W1971937094","https://openalex.org/W1973817878","https://openalex.org/W1975810019","https://openalex.org/W1986559713","https://openalex.org/W1988367097","https://openalex.org/W1989260237","https://openalex.org/W1989420121","https://openalex.org/W1989825144","https://openalex.org/W1998976498","https://openalex.org/W2027738761","https://openalex.org/W2034242967","https://openalex.org/W2047265596","https://openalex.org/W2049502294","https://openalex.org/W2052560004","https://openalex.org/W2059341900","https://openalex.org/W2065769502","https://openalex.org/W2081371959","https://openalex.org/W2081882557","https://openalex.org/W2087327923","https://openalex.org/W2096814387","https://openalex.org/W2100980426","https://openalex.org/W2107940486","https://openalex.org/W2116393378","https://openalex.org/W2117192334","https://openalex.org/W2118123066","https://openalex.org/W2136482486","https://openalex.org/W2154897810","https://openalex.org/W2283632926","https://openalex.org/W2345804659","https://openalex.org/W2362943692","https://openalex.org/W2383949387","https://openalex.org/W2419226942","https://openalex.org/W2560160975","https://openalex.org/W2586562686","https://openalex.org/W2591628935","https://openalex.org/W2600354172","https://openalex.org/W2728118235","https://openalex.org/W3103071483","https://openalex.org/W3143498183","https://openalex.org/W4213385752","https://openalex.org/W4238452917"],"related_works":["https://openalex.org/W2551839783","https://openalex.org/W4386401670","https://openalex.org/W2956207900","https://openalex.org/W2790781282","https://openalex.org/W2334025507","https://openalex.org/W4313887725","https://openalex.org/W1778138535","https://openalex.org/W1970486251","https://openalex.org/W4296124993","https://openalex.org/W4229451835"],"abstract_inverted_index":{"Cancer":[0],"is":[1],"the":[2,28,41,53,58,96,108,118,149,239,258,266,281,302,319,322,344],"second":[3],"most":[4],"common":[5],"cause":[6],"of":[7,13,43,61,82,169,208,247,268,305,321,347],"death":[8],"globally.":[9],"The":[10,102,235,244,261,310],"anticancer":[11,59,97,109,119,145,206,303,323],"effects":[12],"Tanshinone":[14],"II":[15,18,63,84,175,210,249,270,307,328],"A":[16,19,64,85,167,176,211,250,271,308,329],"(Tan":[17],")":[20],"has":[21],"been":[22],"confirmed":[23,238],"by":[24,113,125,173,184,326],"numerous":[25],"researches.":[26],"However,":[27],"underlying":[29],"mechanism":[30,60],"remained":[31],"to":[32,56,78,92,139,220],"be":[33],"integrated":[34],"in":[35,52,107,117,157,196,262],"systematic":[36,315,341],"format.":[37],"Systems":[38],"biology":[39],"embraced":[40],"complexity":[42],"cancer;":[44],"therefore,":[45],"a":[46,73,314,337],"system":[47],"study":[48,55,312,342],"approach":[49],"was":[50,76,90,99,241,255],"proposed":[51],"present":[54],"explore":[57],"Tan":[62,83,174,209,248,269,306,327],"based":[65,199],"on":[66,200,205,224,251,272,343],"network":[67],"pharmacology.":[68],"Agilent":[69],"Literature":[70],"Search":[71],"(ALS),":[72],"text-mining":[74],"tool,":[75],"used":[77],"pull":[79],"protein":[80,185,331],"targets":[81],".":[86],"Then,":[87],"pharmacological":[88],"clustering":[89,188],"applied":[91],"classify":[93],"obtained":[94,112],"hits,":[95],"module":[98,110,120],"analysed":[100],"further.":[101],"top":[103],"ten":[104],"essential":[105],"nodes":[106],"were":[111,121,137,151,165,177,182,212,217,285],"ClusterONE.":[114],"Functional":[115],"units":[116,216],"catalogued":[122],"and":[123,132,181,232,277,294,350],"validated":[124],"Gene":[126,201],"Ontology":[127],"(GO)":[128],"analysis.":[129],"Meanwhile,":[130],"KEGG":[131],"Cell":[133],"Signalling":[134],"Technology":[135],"Pathway":[136],"employed":[138],"provide":[140],"pathway":[141,254],"data":[142],"for":[143,257,317,340],"potential":[144],"pathways":[146,150,204,324],"construction.":[147],"Finally,":[148],"plotted":[152],"using":[153],"Cytoscape":[154],"3.5.1.":[155],"Furthermore,":[156],"vitro":[158,263],"experiments":[159,264],"with":[160],"five":[161],"carcinoma":[162],"cell":[163,230,233,279],"lines":[164],"conducted.":[166],"total":[168],"258":[170],"proteins":[171,192],"regulated":[172,325],"identified":[178],"through":[179],"ALS":[180],"visualized":[183],"network.":[186,332],"Pharmacological":[187],"further":[189,300],"sorted":[190],"68":[191],"that":[193],"intimately":[194],"involved":[195],"cancer":[197],"pathogenesis":[198],"Ontology.":[202],"Subsequently,":[203],"effect":[207,304],"delineated.":[213],"Five":[214],"functional":[215],"clarified":[218],"according":[219],"literature:":[221],"including":[222],"regulation":[223],"apoptosis,":[225],"proliferation,":[226],"sustained":[227],"angiogenesis,":[228],"autophagic":[229],"death,":[231],"cycle.":[234],"GO":[236],"analysis":[237],"classification":[240],"statistically":[242],"significant.":[243],"inhibiting":[245],"influence":[246],"p70":[252],"S6K/mTOR":[253],"revealed":[256],"first":[259],"time.":[260],"displayed":[265],"selectivity":[267],"HeLa,":[273],"MDA-MB-231,":[274],"HepG2,":[275],"A549,":[276],"ACHN":[278],"lines,":[280],"IC":[282],"50":[283],"values":[284,346],"0.54":[286],"\u03bcM,":[287,289,291,296],"4.63":[288],"1.42":[290],"17.30":[292],"\u03bcM":[293],"204.00":[295],"respectively.":[297],"This":[298],"result":[299],"reinforced":[301],"treatment.":[309],"current":[311],"provides":[313],"methodology":[316],"discovering":[318],"coordination":[320],"via":[330],"And":[333],"it":[334],"also":[335],"offers":[336],"valuable":[338],"guidance":[339],"therapeutic":[345],"other":[348],"herbs":[349],"their":[351],"active":[352],"compounds.":[353]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2018-11-09T00:00:00"}
