{"id":"https://openalex.org/W2883499473","doi":"https://doi.org/10.1186/s12918-018-0603-9","title":"A quantitative systems pharmacology (QSP) model for Pneumocystis treatment in mice","display_name":"A quantitative systems pharmacology (QSP) model for Pneumocystis treatment in mice","publication_year":2018,"publication_date":"2018-07-17","ids":{"openalex":"https://openalex.org/W2883499473","doi":"https://doi.org/10.1186/s12918-018-0603-9","mag":"2883499473","pmid":"https://pubmed.ncbi.nlm.nih.gov/30016951"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-018-0603-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0603-9","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0603-9","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0603-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101422397","display_name":"Guan\u2010Sheng Liu","orcid":"https://orcid.org/0000-0003-3255-2777"},"institutions":[{"id":"https://openalex.org/I4210149307","display_name":"Sabin Vaccine Institute","ror":"https://ror.org/042te9f59","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210149307"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guan-Sheng Liu","raw_affiliation_strings":["Department of Pharmacology and Systems Physiology, College of Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH, 45267-0576, USA","Department of Pharmacology and Systems Physiology, College of Medicine, University of Cincinnati, Cincinnati, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Systems Physiology, College of Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH, 45267-0576, USA","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I4210149307"]},{"raw_affiliation_string":"Department of Pharmacology and Systems Physiology, College of Medicine, University of Cincinnati, Cincinnati, USA","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014243011","display_name":"Richard Ballweg","orcid":"https://orcid.org/0000-0001-7872-2941"},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I4210149307","display_name":"Sabin Vaccine Institute","ror":"https://ror.org/042te9f59","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210149307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Ballweg","raw_affiliation_strings":["Department of Pharmacology and Systems Physiology, College of Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH, 45267-0576, USA","Department of Pharmacology and Systems Physiology, College of Medicine, University of Cincinnati, Cincinnati, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Systems Physiology, College of Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH, 45267-0576, USA","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I4210149307"]},{"raw_affiliation_string":"Department of Pharmacology and Systems Physiology, College of Medicine, University of Cincinnati, Cincinnati, USA","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108448394","display_name":"Alan Ashbaugh","orcid":null},"institutions":[{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Ashbaugh","raw_affiliation_strings":["Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH, USA","Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, USA"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH, USA","institution_ids":["https://openalex.org/I92156820"]},{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, USA","institution_ids":["https://openalex.org/I92156820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002416203","display_name":"Yin Zhang","orcid":"https://orcid.org/0000-0002-6127-7535"},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yin Zhang","raw_affiliation_strings":["Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA","Division of Biostatistics and Epidemiology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, USA"],"affiliations":[{"raw_affiliation_string":"Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Division of Biostatistics and Epidemiology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055848320","display_name":"Joseph Facciolo","orcid":null},"institutions":[{"id":"https://openalex.org/I4210149307","display_name":"Sabin Vaccine Institute","ror":"https://ror.org/042te9f59","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210149307"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Facciolo","raw_affiliation_strings":["Department of Pharmacology and Systems Physiology, College of Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH, 45267-0576, USA","Department of Pharmacology and Systems Physiology, College of Medicine, University of Cincinnati, Cincinnati, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Systems Physiology, College of Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH, 45267-0576, USA","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I4210149307"]},{"raw_affiliation_string":"Department of Pharmacology and Systems Physiology, College of Medicine, University of Cincinnati, Cincinnati, USA","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007219416","display_name":"Melanie T. Cushion","orcid":"https://orcid.org/0000-0001-6621-2784"},"institutions":[{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melanie T. Cushion","raw_affiliation_strings":["Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH, USA","Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, USA"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH, USA","institution_ids":["https://openalex.org/I92156820"]},{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, USA","institution_ids":["https://openalex.org/I92156820"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003112405","display_name":"Tongli Zhang","orcid":"https://orcid.org/0000-0003-1773-6279"},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tongli Zhang","raw_affiliation_strings":["Department of Pharmacology and Systems Physiology, College of Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH, 45267-0576, USA. zhangtl@ucmail.uc.edu","Department of Pharmacology and Systems Physiology, College of Medicine, University of Cincinnati, Cincinnati, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Systems Physiology, College of Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH, 45267-0576, USA. zhangtl@ucmail.uc.edu","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology and Systems Physiology, College of Medicine, University of Cincinnati, Cincinnati, USA","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5003112405"],"corresponding_institution_ids":["https://openalex.org/I63135867"],"apc_list":null,"apc_paid":null,"fwci":0.8101,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.7386171,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"12","issue":"1","first_page":"77","last_page":"77"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12369","display_name":"Pneumocystis jirovecii pneumonia detection and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12369","display_name":"Pneumocystis jirovecii pneumonia detection and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-pharmacology","display_name":"Systems pharmacology","score":0.5817848443984985},{"id":"https://openalex.org/keywords/pneumocystis-pneumonia","display_name":"Pneumocystis pneumonia","score":0.5493700504302979},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.45553162693977356},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"Pharmacokinetics","score":0.44719386100769043},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.42868390679359436},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3751959502696991},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.3428957462310791},{"id":"https://openalex.org/keywords/pneumocystis-jirovecii","display_name":"Pneumocystis jirovecii","score":0.2521156668663025},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.2230347990989685},{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.21753793954849243},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.19957250356674194}],"concepts":[{"id":"https://openalex.org/C2779446555","wikidata":"https://www.wikidata.org/wiki/Q7663877","display_name":"Systems pharmacology","level":3,"score":0.5817848443984985},{"id":"https://openalex.org/C2777160144","wikidata":"https://www.wikidata.org/wiki/Q15401586","display_name":"Pneumocystis pneumonia","level":4,"score":0.5493700504302979},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.45553162693977356},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.44719386100769043},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42868390679359436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3751959502696991},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3428957462310791},{"id":"https://openalex.org/C2777559004","wikidata":"https://www.wikidata.org/wiki/Q134478","display_name":"Pneumocystis jirovecii","level":3,"score":0.2521156668663025},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2230347990989685},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.21753793954849243},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19957250356674194}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011010","descriptor_name":"Pneumocystis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011010","descriptor_name":"Pneumocystis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011010","descriptor_name":"Pneumocystis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12918-018-0603-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0603-9","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0603-9","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:30016951","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30016951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:a540d8d278ef4dd39ae44a8d24e7621b","is_oa":true,"landing_page_url":"https://doaj.org/article/a540d8d278ef4dd39ae44a8d24e7621b","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 12, Iss 1, Pp 1-12 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5006411","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6050661","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12918-018-0603-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0603-9","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0603-9","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1361052422","display_name":null,"funder_award_id":"Merit","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G996879696","display_name":null,"funder_award_id":"I01BX000523","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2883499473.pdf","grobid_xml":"https://content.openalex.org/works/W2883499473.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W207124023","https://openalex.org/W293301321","https://openalex.org/W1171027907","https://openalex.org/W1554237150","https://openalex.org/W1628859045","https://openalex.org/W1702314691","https://openalex.org/W1709109739","https://openalex.org/W1911541991","https://openalex.org/W1977176762","https://openalex.org/W1989445468","https://openalex.org/W2002049350","https://openalex.org/W2009965521","https://openalex.org/W2021697524","https://openalex.org/W2036199624","https://openalex.org/W2038167571","https://openalex.org/W2038691499","https://openalex.org/W2040614564","https://openalex.org/W2043572962","https://openalex.org/W2050099555","https://openalex.org/W2057531115","https://openalex.org/W2093471017","https://openalex.org/W2103798138","https://openalex.org/W2114330722","https://openalex.org/W2116758955","https://openalex.org/W2118479851","https://openalex.org/W2137119350","https://openalex.org/W2146907515","https://openalex.org/W2147335917","https://openalex.org/W2149555509","https://openalex.org/W2149868870","https://openalex.org/W2150393707","https://openalex.org/W2152390411","https://openalex.org/W2152689602","https://openalex.org/W2158552630","https://openalex.org/W2161143301","https://openalex.org/W2162824813","https://openalex.org/W2166117980","https://openalex.org/W2169830276","https://openalex.org/W2305072984","https://openalex.org/W2521450174","https://openalex.org/W2551340690","https://openalex.org/W2742389367","https://openalex.org/W2743900293","https://openalex.org/W2749642217","https://openalex.org/W6608501443","https://openalex.org/W6637258463"],"related_works":["https://openalex.org/W2559094151","https://openalex.org/W2132914709","https://openalex.org/W2898595765","https://openalex.org/W2997274725","https://openalex.org/W2153121902","https://openalex.org/W2096630686","https://openalex.org/W4366086369","https://openalex.org/W3173171686","https://openalex.org/W2098178401","https://openalex.org/W2099561845"],"abstract_inverted_index":{"We":[0],"developed":[1],"and":[2,11],"validated":[3],"a":[4],"QSP":[5],"model":[6],"that":[7],"integrates":[8],"available":[9],"data":[10],"promises":[12],"to":[13],"facilitate":[14],"the":[15],"design":[16],"of":[17],"future":[18],"therapies":[19],"against":[20],"PCP.":[21]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}