{"id":"https://openalex.org/W2805207360","doi":"https://doi.org/10.1186/s12918-018-0591-9","title":"Simulating heterogeneous populations using Boolean models","display_name":"Simulating heterogeneous populations using Boolean models","publication_year":2018,"publication_date":"2018-06-07","ids":{"openalex":"https://openalex.org/W2805207360","doi":"https://doi.org/10.1186/s12918-018-0591-9","mag":"2805207360","pmid":"https://pubmed.ncbi.nlm.nih.gov/29879983"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-018-0591-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0591-9","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12918-018-0591-9.pdf","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s12918-018-0591-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025083984","display_name":"Brian C. Ross","orcid":"https://orcid.org/0000-0003-2432-4678"},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian C. Ross","raw_affiliation_strings":["Computational Bioscience Program, University of Colorado Anschutz Medical Campus, 12801 E. 17th Ave., Aurora, CO, 80045, USA","Department of Pharmacology, University of Colorado Anschutz Medical Campus, 12800 E. 19th Ave., Aurora, CO, 80045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Bioscience Program, University of Colorado Anschutz Medical Campus, 12801 E. 17th Ave., Aurora, CO, 80045, USA","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Department of Pharmacology, University of Colorado Anschutz Medical Campus, 12800 E. 19th Ave., Aurora, CO, 80045, USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043032665","display_name":"Mayla R. Boguslav","orcid":"https://orcid.org/0000-0003-0439-3107"},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mayla Boguslav","raw_affiliation_strings":["Computational Bioscience Program, University of Colorado Anschutz Medical Campus, 12801 E. 17th Ave., Aurora, CO, 80045, USA","Department of Pharmacology, University of Colorado Anschutz Medical Campus, 12800 E. 19th Ave., Aurora, CO, 80045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Bioscience Program, University of Colorado Anschutz Medical Campus, 12801 E. 17th Ave., Aurora, CO, 80045, USA","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Department of Pharmacology, University of Colorado Anschutz Medical Campus, 12800 E. 19th Ave., Aurora, CO, 80045, USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016229192","display_name":"Holly Weeks","orcid":null},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holly Weeks","raw_affiliation_strings":["Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, 13001 E. 17th Place, Aurora, CO, 80045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, 13001 E. 17th Place, Aurora, CO, 80045, USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035378993","display_name":"James C. Costello","orcid":"https://orcid.org/0000-0003-3158-9682"},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James C. Costello","raw_affiliation_strings":["Computational Bioscience Program, University of Colorado Anschutz Medical Campus, 12801 E. 17th Ave., Aurora, CO, 80045, USA. james.costello@ucdenver.edu","Department of Pharmacology, University of Colorado Anschutz Medical Campus, 12800 E. 19th Ave., Aurora, CO, 80045, USA. james.costello@ucdenver.edu","Department of Pharmacology, University of Colorado Anschutz Medical Campus, 12800 E. 19th Ave., Aurora, CO, 80045, USA"],"raw_orcid":"https://orcid.org/0000-0003-3158-9682","affiliations":[{"raw_affiliation_string":"Computational Bioscience Program, University of Colorado Anschutz Medical Campus, 12801 E. 17th Ave., Aurora, CO, 80045, USA. james.costello@ucdenver.edu","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Department of Pharmacology, University of Colorado Anschutz Medical Campus, 12800 E. 19th Ave., Aurora, CO, 80045, USA. james.costello@ucdenver.edu","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Department of Pharmacology, University of Colorado Anschutz Medical Campus, 12800 E. 19th Ave., Aurora, CO, 80045, USA","institution_ids":["https://openalex.org/I51713134"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035378993"],"corresponding_institution_ids":["https://openalex.org/I51713134"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":0.2472,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.51864983,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"12","issue":"1","first_page":"64","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.5616000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.5616000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.28189998865127563,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.025800000876188278,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/boolean-network","display_name":"Boolean network","score":0.7302553057670593},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.6210229992866516},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6202752590179443},{"id":"https://openalex.org/keywords/boolean-function","display_name":"Boolean function","score":0.589966893196106},{"id":"https://openalex.org/keywords/boolean-model","display_name":"Boolean model","score":0.5353183150291443},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4997568130493164},{"id":"https://openalex.org/keywords/attractor","display_name":"Attractor","score":0.47166502475738525},{"id":"https://openalex.org/keywords/variety","display_name":"Variety (cybernetics)","score":0.4688224494457245},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.4327622950077057},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.31752586364746094},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2768709659576416},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.19348198175430298},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.17231976985931396},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.16828662157058716},{"id":"https://openalex.org/keywords/discrete-mathematics","display_name":"Discrete mathematics","score":0.10842618346214294}],"concepts":[{"id":"https://openalex.org/C134444547","wikidata":"https://www.wikidata.org/wiki/Q585230","display_name":"Boolean network","level":3,"score":0.7302553057670593},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6210229992866516},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6202752590179443},{"id":"https://openalex.org/C187455244","wikidata":"https://www.wikidata.org/wiki/Q942353","display_name":"Boolean function","level":2,"score":0.589966893196106},{"id":"https://openalex.org/C67499762","wikidata":"https://www.wikidata.org/wiki/Q4943358","display_name":"Boolean model","level":2,"score":0.5353183150291443},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4997568130493164},{"id":"https://openalex.org/C164380108","wikidata":"https://www.wikidata.org/wiki/Q507187","display_name":"Attractor","level":2,"score":0.47166502475738525},{"id":"https://openalex.org/C136197465","wikidata":"https://www.wikidata.org/wiki/Q1729295","display_name":"Variety (cybernetics)","level":2,"score":0.4688224494457245},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.4327622950077057},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.31752586364746094},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2768709659576416},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.19348198175430298},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.17231976985931396},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.16828662157058716},{"id":"https://openalex.org/C118615104","wikidata":"https://www.wikidata.org/wiki/Q121416","display_name":"Discrete mathematics","level":1,"score":0.10842618346214294},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12918-018-0591-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0591-9","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12918-018-0591-9.pdf","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:29879983","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29879983","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:bc52cd39a7f34333ae9d915fb8a5ecaf","is_oa":false,"landing_page_url":"https://doaj.org/article/bc52cd39a7f34333ae9d915fb8a5ecaf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 12, Iss 1, Pp 1-11 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4980848","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5992775","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5992775","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5992775","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12918-018-0591-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0591-9","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12918-018-0591-9.pdf","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G166213354","display_name":null,"funder_award_id":"T15 LM009451","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G6466343383","display_name":null,"funder_award_id":"LM009451","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G7325690727","display_name":null,"funder_award_id":"2T15LM009451","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8097271314","display_name":null,"funder_award_id":"LM009451","funder_id":"https://openalex.org/F4320308537","funder_display_name":"Boettcher Foundation"}],"funders":[{"id":"https://openalex.org/F4320308537","display_name":"Boettcher Foundation","ror":"https://ror.org/0277pn602"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2805207360.pdf","grobid_xml":"https://content.openalex.org/works/W2805207360.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W78272879","https://openalex.org/W110422944","https://openalex.org/W253803806","https://openalex.org/W1493523706","https://openalex.org/W1520434148","https://openalex.org/W1567580433","https://openalex.org/W1581408534","https://openalex.org/W1807981783","https://openalex.org/W1943756471","https://openalex.org/W1975274391","https://openalex.org/W1989298969","https://openalex.org/W2022313562","https://openalex.org/W2035036685","https://openalex.org/W2044433401","https://openalex.org/W2052252977","https://openalex.org/W2069739265","https://openalex.org/W2072891907","https://openalex.org/W2079583491","https://openalex.org/W2081781433","https://openalex.org/W2093144236","https://openalex.org/W2098739408","https://openalex.org/W2103723044","https://openalex.org/W2113268441","https://openalex.org/W2113465369","https://openalex.org/W2115276344","https://openalex.org/W2122902176","https://openalex.org/W2142400903","https://openalex.org/W2147450898","https://openalex.org/W2155898089","https://openalex.org/W2160533336","https://openalex.org/W2166214692","https://openalex.org/W2186373804","https://openalex.org/W2436013910","https://openalex.org/W2560208303","https://openalex.org/W3099614534","https://openalex.org/W4233961202","https://openalex.org/W4313314042"],"related_works":["https://openalex.org/W2972653083","https://openalex.org/W2101472055","https://openalex.org/W2061235113","https://openalex.org/W1968124963","https://openalex.org/W2789889436","https://openalex.org/W2963357480","https://openalex.org/W2159176187","https://openalex.org/W4302620569","https://openalex.org/W2509811556","https://openalex.org/W1979056074"],"abstract_inverted_index":{"Certain":[0],"biological":[1],"processes,":[2],"such":[3,32],"as":[4,143],"the":[5,69,94,106,113,117,135,137,141,166,195],"development":[6],"of":[7,27,46,61,96,116,140,162,198],"cancer":[8],"and":[9,176],"immune":[10],"activation,":[11],"can":[12,35,91,125,207],"be":[13,36,208],"controlled":[14],"by":[15,133,154],"rare":[16,33],"cellular":[17,81,174],"events":[18,34],"that":[19,66,79],"are":[20,83,213],"difficult":[21],"to":[22,104,157,188,219],"capture":[23],"computationally":[24],"through":[25],"simulations":[26],"individual":[28],"cells.":[29],"Information":[30],"about":[31],"gleaned":[37],"from":[38],"an":[39,73],"attractor":[40],"analysis,":[41],"for":[42,51,184],"which":[43,194],"a":[44,57,64,86,159,182,190],"variety":[45],"methods":[47],"exist":[48],"(in":[49],"particular":[50],"Boolean":[52,87,163,186],"models).":[53],"However,":[54],"explicitly":[55],"simulating":[56],"defined":[58],"mixed":[59],"population":[60,161,196],"cells":[62],"in":[63,128,193,202],"way":[65],"tracks":[67],"even":[68,112,210],"rarest":[70,114],"subpopulations":[71,218],"remains":[72],"open":[74],"challenge.":[75],"Here":[76],"we":[77],"show":[78],"when":[80,211],"states":[82,175],"described":[84],"using":[85,155,185],"network":[88,142],"model,":[89,136],"one":[90],"exactly":[92],"simulate":[93,158],"dynamics":[95],"non-interacting,":[97],"highly":[98],"heterogeneous":[99,160],"populations":[100],"directly,":[101],"without":[102],"having":[103],"model":[105,118,220],"various":[107],"subpopulations.":[108],"This":[109,205],"strategy":[110],"captures":[111],"outcomes":[115],"with":[119],"no":[120],"sampling":[121],"error.":[122],"Our":[123],"method":[124,153,183],"incorporate":[126],"heterogeneity":[127],"both":[129],"cell":[130],"state":[131],"and,":[132],"augmenting":[134],"underlying":[138],"rules":[139],"well":[144],"(e.g.,":[145],"introducing":[146],"loss-of-function":[147],"genetic":[148],"alterations).":[149],"We":[150,179],"demonstrate":[151],"our":[152],"it":[156],"networks":[164],"modeling":[165],"T-cell":[167],"receptor,":[168],"spanning":[169],"\u223c":[170],"10":[171],"20":[172],"distinct":[173,217],"mutational":[177],"profiles.":[178],"have":[180],"developed":[181],"models":[187],"perform":[189],"population-level":[191],"simulation,":[192],"consists":[197],"non-interacting":[199],"individuals":[200],"existing":[201],"different":[203],"states.":[204],"approach":[206],"used":[209],"there":[212],"far":[214],"too":[215],"many":[216],"individually.":[221]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}