{"id":"https://openalex.org/W2799113834","doi":"https://doi.org/10.1186/s12918-018-0578-6","title":"Putative human sperm Interactome: a networks study","display_name":"Putative human sperm Interactome: a networks study","publication_year":2018,"publication_date":"2018-04-11","ids":{"openalex":"https://openalex.org/W2799113834","doi":"https://doi.org/10.1186/s12918-018-0578-6","mag":"2799113834","pmid":"https://pubmed.ncbi.nlm.nih.gov/29642908"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-018-0578-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0578-6","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0578-6","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0578-6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017522731","display_name":"Alessandra Ordinelli","orcid":"https://orcid.org/0000-0003-1001-1590"},"institutions":[{"id":"https://openalex.org/I124326101","display_name":"University of Teramo","ror":"https://ror.org/01yetye73","country_code":"IT","type":"education","lineage":["https://openalex.org/I124326101"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Alessandra Ordinelli","raw_affiliation_strings":["Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy","institution_ids":["https://openalex.org/I124326101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040520015","display_name":"Nicola Bernab\u00f2","orcid":"https://orcid.org/0000-0001-5140-9656"},"institutions":[{"id":"https://openalex.org/I124326101","display_name":"University of Teramo","ror":"https://ror.org/01yetye73","country_code":"IT","type":"education","lineage":["https://openalex.org/I124326101"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nicola Bernab\u00f2","raw_affiliation_strings":["Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy. nbernabo@unite.it","Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy"],"raw_orcid":"https://orcid.org/0000-0001-5140-9656","affiliations":[{"raw_affiliation_string":"Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy. nbernabo@unite.it","institution_ids":["https://openalex.org/I124326101"]},{"raw_affiliation_string":"Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy","institution_ids":["https://openalex.org/I124326101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080977250","display_name":"Massimiliano Orsini","orcid":"https://orcid.org/0000-0003-0087-3349"},"institutions":[{"id":"https://openalex.org/I4210144814","display_name":"Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale","ror":"https://ror.org/04es49j42","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210144814"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimiliano Orsini","raw_affiliation_strings":["Istituto Zooprofilattico Sperimentale \"G. Caporale\", Teramo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Zooprofilattico Sperimentale \"G. Caporale\", Teramo, Italy","institution_ids":["https://openalex.org/I4210144814"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111959162","display_name":"Mauro Mattioli","orcid":null},"institutions":[{"id":"https://openalex.org/I124326101","display_name":"University of Teramo","ror":"https://ror.org/01yetye73","country_code":"IT","type":"education","lineage":["https://openalex.org/I124326101"]},{"id":"https://openalex.org/I4210144814","display_name":"Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale","ror":"https://ror.org/04es49j42","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210144814"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mauro Mattioli","raw_affiliation_strings":["Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy","Istituto Zooprofilattico Sperimentale \"G. Caporale\", Teramo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy","institution_ids":["https://openalex.org/I124326101"]},{"raw_affiliation_string":"Istituto Zooprofilattico Sperimentale \"G. Caporale\", Teramo, Italy","institution_ids":["https://openalex.org/I4210144814"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007088211","display_name":"Barbara Barboni","orcid":"https://orcid.org/0000-0003-0231-8066"},"institutions":[{"id":"https://openalex.org/I124326101","display_name":"University of Teramo","ror":"https://ror.org/01yetye73","country_code":"IT","type":"education","lineage":["https://openalex.org/I124326101"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Barbara Barboni","raw_affiliation_strings":["Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy","institution_ids":["https://openalex.org/I124326101"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5017522731"],"corresponding_institution_ids":["https://openalex.org/I124326101"],"apc_list":null,"apc_paid":null,"fwci":1.478,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.82850883,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"12","issue":"1","first_page":"52","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.2061000019311905,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.2061000019311905,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.05380000174045563,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.052000001072883606,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sperm","display_name":"Sperm","score":0.7666090726852417},{"id":"https://openalex.org/keywords/interactome","display_name":"Interactome","score":0.7147880792617798},{"id":"https://openalex.org/keywords/capacitation","display_name":"Capacitation","score":0.6589549779891968},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.611966609954834},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4971180260181427},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.45447713136672974},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4461810290813446},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.32581818103790283},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19437724351882935},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1469665765762329}],"concepts":[{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.7666090726852417},{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.7147880792617798},{"id":"https://openalex.org/C2780301668","wikidata":"https://www.wikidata.org/wiki/Q1728362","display_name":"Capacitation","level":3,"score":0.6589549779891968},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.611966609954834},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4971180260181427},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45447713136672974},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4461810290813446},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32581818103790283},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19437724351882935},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1469665765762329}],"mesh":[{"descriptor_ui":"D005298","descriptor_name":"Fertility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005298","descriptor_name":"Fertility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005298","descriptor_name":"Fertility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1186/s12918-018-0578-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0578-6","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0578-6","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:29642908","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29642908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:ae19de5aac924f3398afe7a1aa97c9fb","is_oa":false,"landing_page_url":"https://doaj.org/article/ae19de5aac924f3398afe7a1aa97c9fb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 12, Iss 1, Pp 1-10 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4834677","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5896140","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5896140","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5896140","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmh:oai:research.unite.it:11575/102977","is_oa":false,"landing_page_url":"http://www.biomedcentral.com/bmcsystbiol/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401171","display_name":"UniTERAMO Research Catalog (University of Teramo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I124326101","host_organization_name":"University of Teramo","host_organization_lineage":["https://openalex.org/I124326101"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s12918-018-0578-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0578-6","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0578-6","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2799113834.pdf","grobid_xml":"https://content.openalex.org/works/W2799113834.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W976841414","https://openalex.org/W1605832750","https://openalex.org/W1902504254","https://openalex.org/W1971335425","https://openalex.org/W1977886386","https://openalex.org/W1979125224","https://openalex.org/W1979697362","https://openalex.org/W1997314907","https://openalex.org/W2006179085","https://openalex.org/W2008620264","https://openalex.org/W2012501909","https://openalex.org/W2012704409","https://openalex.org/W2012852001","https://openalex.org/W2017648700","https://openalex.org/W2018049970","https://openalex.org/W2033553393","https://openalex.org/W2040080912","https://openalex.org/W2056728757","https://openalex.org/W2070607055","https://openalex.org/W2096253801","https://openalex.org/W2105258629","https://openalex.org/W2108726522","https://openalex.org/W2114343065","https://openalex.org/W2114995396","https://openalex.org/W2119052115","https://openalex.org/W2128070048","https://openalex.org/W2128469364","https://openalex.org/W2138240713","https://openalex.org/W2141232122","https://openalex.org/W2143736326","https://openalex.org/W2150318080","https://openalex.org/W2152871729","https://openalex.org/W2157364297","https://openalex.org/W2163438679","https://openalex.org/W2163480486","https://openalex.org/W2179991501","https://openalex.org/W2318816788","https://openalex.org/W2321931302","https://openalex.org/W2343477951","https://openalex.org/W2479606858","https://openalex.org/W2525574134","https://openalex.org/W2525665778","https://openalex.org/W2532967803","https://openalex.org/W2561718059"],"related_works":["https://openalex.org/W1980835909","https://openalex.org/W2102525950","https://openalex.org/W2375901088","https://openalex.org/W2145902169","https://openalex.org/W2051038137","https://openalex.org/W2318476861","https://openalex.org/W2389928464","https://openalex.org/W2061686998","https://openalex.org/W3201167239","https://openalex.org/W1969624149"],"abstract_inverted_index":{"BACKGROUND:":[0],"For":[1,261],"over":[2],"sixty":[3],"years,":[4],"it":[5,155],"has":[6,156],"been":[7,157],"known":[8],"that":[9,82,134,142,213,223],"mammalian":[10],"spermatozoa":[11],"immediately":[12],"after":[13,24],"ejaculation":[14],"are":[15,115,125,136,143,224],"virtually":[16],"infertile.":[17],"They":[18],"became":[19],"able":[20,76],"to":[21,31,72,77,120,138,145,150,159,175,187,226,284],"fertilize":[22],"only":[23],"they":[25,38,135],"reside":[26],"for":[27],"long":[28],"time":[29,264],"(hours":[30],"days)":[32],"within":[33],"female":[34,55],"genital":[35],"tract":[36],"where":[37],"complete":[39],"their":[40],"functional":[41],"maturation,":[42],"the":[43,51,54,79,91,104,121,161,168,177,189,203,255,262,285],"capacitation.":[44],"This":[45,171,274],"process":[46],"is":[47],"finely":[48],"regulated":[49],"by":[50,127],"interaction":[52,81],"with":[53],"environment":[56],"and":[57,67,97,113,124,141,148,167,186,198,246,281],"involves,":[58],"in":[59,107,181,221,233,290],"spermatozoa,":[60,288],"a":[61,74,267],"myriad":[62],"of":[63,69,192,205,239,257,287],"molecules":[64,218],"as":[65,237],"messengers":[66],"target":[68],"signals.":[70],"Since,":[71],"date,":[73],"model":[75],"represent":[78,217],"molecular":[80],"characterize":[83],"sperm":[84,183,234,258,272],"physiology":[85],"does":[86],"not":[87,228,231],"exist,":[88],"we":[89,211,265],"realized":[90],"Human":[92],"Sperm":[93],"Interactme":[94],"Network3.0":[95],"(HSIN3.0)":[96],"its":[98],"main":[99],"component":[100],"(HSNI3.0_MC),":[101],"starting":[102],"from":[103,207],"pathway":[105],"active":[106,180,232],"male":[108],"germ":[109],"cells.":[110],"RESULTS:":[111],"HSIN3.0":[112],"HSIN3.0_MC":[114],"scale":[116],"free":[117],"networks,":[118],"adherent":[119],"Barabasi-Albert":[122],"model,":[123],"characterised":[126],"an":[128],"ultra-small":[129],"world":[130],"topology.":[131],"We":[132],"found":[133,212],"resistant":[137],"random":[139],"attacks":[140],"designed":[144],"respond":[146],"quickly":[147],"specifically":[149,219],"external":[151],"inputs.":[152],"In":[153],"addition,":[154],"possible":[158],"identify":[160],"most":[162],"connected":[163],"nodes":[164,216],"(the":[165],"hubs)":[166],"bottlenecks":[169],"nodes.":[170],"result":[172,275],"allowed":[173],"us":[174],"explore":[176],"control":[178,238],"mechanisms":[179],"driving":[182],"biochemical":[184],"machinery":[185],"verify":[188],"different":[190],"levels":[191],"controls:":[193],"party":[194],"vs.":[195,200],"date":[196],"hubs":[197,199],"bottlenecks,":[201],"thanks":[202],"availability":[204],"data":[206],"KO":[208],"mice.":[209],"Finally,":[210],"several":[214],"key":[215],"involved":[220],"function":[222],"thought":[225],"be":[227],"present":[229,266],"or":[230,292],"cells,":[235],"such":[236],"cell":[240],"cycle,":[241],"proteins":[242],"synthesis,":[243],"nuclear":[244],"trafficking,":[245],"immune":[247],"response,":[248],"thus":[249],"potentially":[250],"open":[251],"new":[252],"perspectives":[253],"on":[254],"study":[256],"biology.":[259],"CONCLUSIONS:":[260],"first":[263],"network":[268],"representing":[269],"putative":[270],"human":[271],"interactome.":[273],"gives":[276],"very":[277],"intriguing":[278],"biological":[279],"information":[280],"could":[282],"contribute":[283],"knowledge":[286],"either":[289],"physiological":[291],"pathological":[293],"conditions.":[294]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}