{"id":"https://openalex.org/W2794554641","doi":"https://doi.org/10.1186/s12918-018-0558-x","title":"Systems biology as an emerging paradigm in transfusion medicine","display_name":"Systems biology as an emerging paradigm in transfusion medicine","publication_year":2018,"publication_date":"2018-03-07","ids":{"openalex":"https://openalex.org/W2794554641","doi":"https://doi.org/10.1186/s12918-018-0558-x","mag":"2794554641","pmid":"https://pubmed.ncbi.nlm.nih.gov/29514691"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-018-0558-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0558-x","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0558-x","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0558-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082126398","display_name":"James T. Yurkovich","orcid":"https://orcid.org/0000-0002-9403-509X"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James T. Yurkovich","raw_affiliation_strings":["Bioinformatics and Systems Biology Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093, USA","Department Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Systems Biology Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026633794","display_name":"Aarash Bordbar","orcid":"https://orcid.org/0000-0001-6460-6771"},"institutions":[{"id":"https://openalex.org/I4210086236","display_name":"Sinopia Biosciences (United States)","ror":"https://ror.org/000jtf850","country_code":"US","type":"company","lineage":["https://openalex.org/I4210086236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aarash Bordbar","raw_affiliation_strings":["Sinopia Biosciences, 600 W Broadway Suite 700, San Diego, 92101, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sinopia Biosciences, 600 W Broadway Suite 700, San Diego, 92101, USA","institution_ids":["https://openalex.org/I4210086236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021035939","display_name":"\u00d3lafur E. Sigurj\u00f3nsson","orcid":"https://orcid.org/0000-0002-4968-842X"},"institutions":[{"id":"https://openalex.org/I123185442","display_name":"Reykjav\u00edk University","ror":"https://ror.org/05d2kyx68","country_code":"IS","type":"education","lineage":["https://openalex.org/I123185442"]},{"id":"https://openalex.org/I4210106610","display_name":"National University Hospital of Iceland","ror":"https://ror.org/011k7k191","country_code":"IS","type":"funder","lineage":["https://openalex.org/I4210106610"]}],"countries":["IS"],"is_corresponding":false,"raw_author_name":"\u00d3lafur E. Sigurj\u00f3nsson","raw_affiliation_strings":["School of Science and Engineering, Reykjav\u00edk University, Hringbraut 101, Reykjav\u00edk, 101, Iceland","The Blood Bank, Landsp\u00edtali-University Hospital, 9500 Gilman Drive, Reykjav\u00edk, 101, Iceland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Science and Engineering, Reykjav\u00edk University, Hringbraut 101, Reykjav\u00edk, 101, Iceland","institution_ids":["https://openalex.org/I123185442"]},{"raw_affiliation_string":"The Blood Bank, Landsp\u00edtali-University Hospital, 9500 Gilman Drive, Reykjav\u00edk, 101, Iceland","institution_ids":["https://openalex.org/I123185442","https://openalex.org/I4210106610"]}]},{"author_position":"last","author":{"id":null,"display_name":"Bernhard O. Palsson","orcid":"https://orcid.org/0000-0002-9403-509X"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210133661","display_name":"La Jolla Bioengineering Institute","ror":"https://ror.org/03sgbh608","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210133661"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernhard O. Palsson","raw_affiliation_strings":["Bioinformatics and Systems Biology Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093, USA. palsson@ucsd.edu","Department Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093, USA. palsson@ucsd.edu","Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093, USA. palsson@ucsd.edu","Bioinformatics and Systems Biology Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093, USA"],"raw_orcid":"https://orcid.org/0000-0002-9403-509X","affiliations":[{"raw_affiliation_string":"Bioinformatics and Systems Biology Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093, USA. palsson@ucsd.edu","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093, USA. palsson@ucsd.edu","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210133661"]},{"raw_affiliation_string":"Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093, USA. palsson@ucsd.edu","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Bioinformatics and Systems Biology Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7423,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.69873356,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"12","issue":"1","first_page":"31","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9851999878883362,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9419999718666077,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.8557240962982178},{"id":"https://openalex.org/keywords/transfusion-medicine","display_name":"Transfusion medicine","score":0.8203598260879517},{"id":"https://openalex.org/keywords/systems-medicine","display_name":"Systems medicine","score":0.6172952651977539},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5847257971763611},{"id":"https://openalex.org/keywords/modelling-biological-systems","display_name":"Modelling biological systems","score":0.46489468216896057},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.4594799280166626},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3922054171562195},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3831852078437805},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.352209210395813},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.33567678928375244},{"id":"https://openalex.org/keywords/blood-transfusion","display_name":"Blood transfusion","score":0.3107566833496094},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.18706583976745605}],"concepts":[{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.8557240962982178},{"id":"https://openalex.org/C79592252","wikidata":"https://www.wikidata.org/wiki/Q1318451","display_name":"Transfusion medicine","level":3,"score":0.8203598260879517},{"id":"https://openalex.org/C36415437","wikidata":"https://www.wikidata.org/wiki/Q7663871","display_name":"Systems medicine","level":3,"score":0.6172952651977539},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5847257971763611},{"id":"https://openalex.org/C137866125","wikidata":"https://www.wikidata.org/wiki/Q4299308","display_name":"Modelling biological systems","level":3,"score":0.46489468216896057},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4594799280166626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3922054171562195},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3831852078437805},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.352209210395813},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33567678928375244},{"id":"https://openalex.org/C2780014101","wikidata":"https://www.wikidata.org/wiki/Q183605","display_name":"Blood transfusion","level":2,"score":0.3107566833496094},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18706583976745605},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D064826","descriptor_name":"Transfusion Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D064826","descriptor_name":"Transfusion Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D064826","descriptor_name":"Transfusion Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1186/s12918-018-0558-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0558-x","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0558-x","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:29514691","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29514691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:ark:/13030/qt5tx9220z","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:doaj.org/article:cd33fd6c0cbb42fea197b93d2fea4d39","is_oa":false,"landing_page_url":"https://doaj.org/article/cd33fd6c0cbb42fea197b93d2fea4d39","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 12, Iss 1, Pp 1-9 (2018)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt5tx9220z","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/5tx9220z","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC systems biology, vol 12, iss 1","raw_type":"article"},{"id":"pmh:oai:opinvisindi.is:20.500.11815/1312","is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.11815/1312","pdf_url":null,"source":{"id":"https://openalex.org/S4306401866","display_name":"Opin v\u00edsindi (Opin v\u00edsindi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5842607","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5842607","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmh:oai:www.hirsla.lsh.is:2336/620562","is_oa":false,"landing_page_url":"http://hdl.handle.net/2336/620562","pdf_url":null,"source":{"id":"https://openalex.org/S4306401083","display_name":"Hirsla (Landsp\u00edtali University Hospital)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210106610","host_organization_name":"National University Hospital of Iceland","host_organization_lineage":["https://openalex.org/I4210106610"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/s12918-018-0558-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0558-x","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0558-x","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5199999809265137}],"awards":[{"id":"https://openalex.org/G675271601","display_name":null,"funder_award_id":"R43HL123074","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7330341858","display_name":null,"funder_award_id":"ERC 232816","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"},{"id":"https://openalex.org/G8476348301","display_name":null,"funder_award_id":"NHLBI R43HL123074","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320322367","display_name":"Landsp\u00edtali H\u00e1sk\u00f3lasj\u00fakrah\u00fas","ror":"https://ror.org/011k7k191"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2794554641.pdf","grobid_xml":"https://content.openalex.org/works/W2794554641.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W31192654","https://openalex.org/W153791596","https://openalex.org/W1491559148","https://openalex.org/W1530835588","https://openalex.org/W1532434329","https://openalex.org/W1543292456","https://openalex.org/W1551870152","https://openalex.org/W1572028876","https://openalex.org/W1582684391","https://openalex.org/W1661767063","https://openalex.org/W1664312070","https://openalex.org/W1860450641","https://openalex.org/W1946741439","https://openalex.org/W1969218538","https://openalex.org/W1982297646","https://openalex.org/W1984000875","https://openalex.org/W1984074561","https://openalex.org/W1985783895","https://openalex.org/W1992927602","https://openalex.org/W1997062226","https://openalex.org/W2015780328","https://openalex.org/W2031258198","https://openalex.org/W2033778280","https://openalex.org/W2034931345","https://openalex.org/W2039562389","https://openalex.org/W2043016160","https://openalex.org/W2044154435","https://openalex.org/W2044683058","https://openalex.org/W2045642520","https://openalex.org/W2054715966","https://openalex.org/W2056037296","https://openalex.org/W2065219073","https://openalex.org/W2067059164","https://openalex.org/W2067520432","https://openalex.org/W2075796888","https://openalex.org/W2082382448","https://openalex.org/W2085434605","https://openalex.org/W2085993965","https://openalex.org/W2094024424","https://openalex.org/W2099545760","https://openalex.org/W2104108767","https://openalex.org/W2109414887","https://openalex.org/W2116407433","https://openalex.org/W2123775239","https://openalex.org/W2132066552","https://openalex.org/W2132218677","https://openalex.org/W2143784594","https://openalex.org/W2147651841","https://openalex.org/W2148260610","https://openalex.org/W2151218107","https://openalex.org/W2154717205","https://openalex.org/W2194318288","https://openalex.org/W2210974969","https://openalex.org/W2235759113","https://openalex.org/W2293817669","https://openalex.org/W2311054803","https://openalex.org/W2338391427","https://openalex.org/W2360226239","https://openalex.org/W2412317313","https://openalex.org/W2461866271","https://openalex.org/W2471444529","https://openalex.org/W2495368724","https://openalex.org/W2507939969","https://openalex.org/W2548952244","https://openalex.org/W2552606985","https://openalex.org/W2591786337","https://openalex.org/W2592379136","https://openalex.org/W2600816175","https://openalex.org/W2604657987","https://openalex.org/W2614353632","https://openalex.org/W2747965822","https://openalex.org/W2763014033","https://openalex.org/W2763693830","https://openalex.org/W2765876921","https://openalex.org/W2766399257","https://openalex.org/W2791231307","https://openalex.org/W2951452972","https://openalex.org/W2952564192","https://openalex.org/W2972897244","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4386563820","https://openalex.org/W2169478906","https://openalex.org/W2185904291","https://openalex.org/W4233388905","https://openalex.org/W2140327348","https://openalex.org/W2034718166","https://openalex.org/W2057769265","https://openalex.org/W3199870583","https://openalex.org/W1511119527","https://openalex.org/W2794554641"],"abstract_inverted_index":{"Blood":[0],"transfusions":[1],"are":[2],"an":[3,49],"important":[4],"part":[5],"of":[6,21,56,67,81,92,104,122,129,140,149,152,163],"modern":[7],"medicine,":[8,77],"delivering":[9],"approximately":[10],"85":[11],"million":[12],"blood":[13,40,94],"units":[14],"to":[15,26,72,106,126,155],"patients":[16],"annually.":[17],"Recently,":[18],"the":[19,29,43,54,65,79,88,107,112,120,127,137,147],"field":[20],"transfusion":[22,76,132],"medicine":[23,133],"has":[24,70],"started":[25],"benefit":[27],"from":[28,146],"\"omic\"":[30],"data":[31,124],"revolution":[32],"and":[33,159],"corresponding":[34],"systems":[35,57,68,157],"biology":[36,58,69,158],"analytics.":[37],"The":[38],"red":[39,93],"cell":[41],"is":[42,135],"simplest":[44],"human":[45],"cell,":[46],"making":[47],"it":[48],"accessible":[50],"starting":[51],"point":[52,162],"for":[53],"application":[55],"approaches.In":[59],"this":[60],"review,":[61],"we":[62,117],"discuss":[63],"how":[64,101,119],"use":[66],"led":[71,125],"significant":[73],"contributions":[74],"in":[75,136],"including":[78],"identification":[80,128],"three":[82],"distinct":[83],"metabolic":[84,114],"states":[85],"that":[86],"define":[87],"baseline":[89],"decay":[90],"process":[91],"cells":[95],"during":[96],"storage.":[97],"We":[98],"then":[99],"describe":[100],"a":[102,141,150,160],"series":[103],"perturbations":[105],"standard":[108],"storage":[109],"conditions":[110],"characterized":[111],"underlying":[113],"phenotypes.":[115],"Finally,":[116],"show":[118],"analysis":[121],"high-dimensional":[123],"predictive":[130],"biomarkers.The":[131],"community":[134],"early":[138],"stages":[139],"paradigm":[142],"shift,":[143],"moving":[144],"away":[145],"measurement":[148],"handful":[151],"chosen":[153],"variables":[154],"embracing":[156],"cell-scale":[161],"view.":[164]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}