{"id":"https://openalex.org/W2781012674","doi":"https://doi.org/10.1186/s12918-018-0554-1","title":"Systems biology analysis of mitogen activated protein kinase inhibitor resistance in malignant melanoma","display_name":"Systems biology analysis of mitogen activated protein kinase inhibitor resistance in malignant melanoma","publication_year":2018,"publication_date":"2018-04-03","ids":{"openalex":"https://openalex.org/W2781012674","doi":"https://doi.org/10.1186/s12918-018-0554-1","mag":"2781012674","pmid":"https://pubmed.ncbi.nlm.nih.gov/29615030"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-018-0554-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0554-1","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0554-1","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0554-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063057443","display_name":"Helma Zecena","orcid":null},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helma Zecena","raw_affiliation_strings":["Systems Biology and Cancer Metabolism, Program for Quantitative Systems Biology, University of California Merced, 2500 North Lake Road, Merced, CA, 95343, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology and Cancer Metabolism, Program for Quantitative Systems Biology, University of California Merced, 2500 North Lake Road, Merced, CA, 95343, USA","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077505885","display_name":"Daniel M. Tveit","orcid":null},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Tveit","raw_affiliation_strings":["Systems Biology and Cancer Metabolism, Program for Quantitative Systems Biology, University of California Merced, 2500 North Lake Road, Merced, CA, 95343, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology and Cancer Metabolism, Program for Quantitative Systems Biology, University of California Merced, 2500 North Lake Road, Merced, CA, 95343, USA","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100338344","display_name":"Zi Wang","orcid":"https://orcid.org/0000-0003-3892-827X"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Zi Wang","raw_affiliation_strings":["Department of Medicine, School of Medicine, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, 92697, USA","The State Key Laboratory of Medical Genetics and School of Life Sciences, Department of Molecular Biology, Central South University, Changsha, 410078, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, School of Medicine, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, 92697, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"The State Key Laboratory of Medical Genetics and School of Life Sciences, Department of Molecular Biology, Central South University, Changsha, 410078, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087131854","display_name":"Ahmed Farhat","orcid":"https://orcid.org/0000-0003-2945-1780"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmed Farhat","raw_affiliation_strings":["Department of Medicine, School of Medicine, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, School of Medicine, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040899406","display_name":"Parvita Panchal","orcid":null},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Parvita Panchal","raw_affiliation_strings":["Department of Medicine, School of Medicine, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, School of Medicine, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100374917","display_name":"Jing Liu","orcid":"https://orcid.org/0000-0001-5588-3865"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Jing Liu","raw_affiliation_strings":["Department of Medicine, School of Medicine, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, 92697, USA","The State Key Laboratory of Medical Genetics and School of Life Sciences, Department of Molecular Biology, Central South University, Changsha, 410078, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, School of Medicine, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, 92697, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"The State Key Laboratory of Medical Genetics and School of Life Sciences, Department of Molecular Biology, Central South University, Changsha, 410078, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062036720","display_name":"Simar Singh","orcid":"https://orcid.org/0000-0001-5785-8292"},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simar J. Singh","raw_affiliation_strings":["Systems Biology and Cancer Metabolism, Program for Quantitative Systems Biology, University of California Merced, 2500 North Lake Road, Merced, CA, 95343, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology and Cancer Metabolism, Program for Quantitative Systems Biology, University of California Merced, 2500 North Lake Road, Merced, CA, 95343, USA","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021867782","display_name":"Amandeep Sanghera","orcid":null},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amandeep Sanghera","raw_affiliation_strings":["Systems Biology and Cancer Metabolism, Program for Quantitative Systems Biology, University of California Merced, 2500 North Lake Road, Merced, CA, 95343, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology and Cancer Metabolism, Program for Quantitative Systems Biology, University of California Merced, 2500 North Lake Road, Merced, CA, 95343, USA","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013180172","display_name":"Ajay Bainiwal","orcid":null},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ajay Bainiwal","raw_affiliation_strings":["Systems Biology and Cancer Metabolism, Program for Quantitative Systems Biology, University of California Merced, 2500 North Lake Road, Merced, CA, 95343, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology and Cancer Metabolism, Program for Quantitative Systems Biology, University of California Merced, 2500 North Lake Road, Merced, CA, 95343, USA","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038881888","display_name":"Shuan Y. Teo","orcid":null},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuan Y. Teo","raw_affiliation_strings":["Systems Biology and Cancer Metabolism, Program for Quantitative Systems Biology, University of California Merced, 2500 North Lake Road, Merced, CA, 95343, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology and Cancer Metabolism, Program for Quantitative Systems Biology, University of California Merced, 2500 North Lake Road, Merced, CA, 95343, USA","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060872059","display_name":"Frank L. Meyskens","orcid":"https://orcid.org/0000-0002-8827-4334"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank L. Meyskens","raw_affiliation_strings":["Department of Medicine, School of Medicine, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, School of Medicine, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100415350","display_name":"Feng Liu","orcid":"https://orcid.org/0000-0003-3963-0651"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Feng Liu-Smith","raw_affiliation_strings":["Department of Epidemiology, School of Medicine, University of California, Irvine, CA, 92697, USA. liufe@uci.edu","Department of Medicine, School of Medicine, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, 92697, USA. liufe@uci.edu","Department of Medicine, School of Medicine, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, School of Medicine, University of California, Irvine, CA, 92697, USA. liufe@uci.edu","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Medicine, School of Medicine, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, 92697, USA. liufe@uci.edu","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Medicine, School of Medicine, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047057665","display_name":"Fabian V. Filipp","orcid":"https://orcid.org/0000-0001-9889-5727"},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fabian V. Filipp","raw_affiliation_strings":["Systems Biology and Cancer Metabolism, Program for Quantitative Systems Biology, University of California Merced, 2500 North Lake Road, Merced, CA, 95343, USA. filipp@ucmerced.edu","Systems Biology and Cancer Metabolism, Program for Quantitative Systems Biology, University of California Merced, 2500 North Lake Road, Merced, CA, 95343, USA"],"raw_orcid":"https://orcid.org/0000-0001-9889-5727","affiliations":[{"raw_affiliation_string":"Systems Biology and Cancer Metabolism, Program for Quantitative Systems Biology, University of California Merced, 2500 North Lake Road, Merced, CA, 95343, USA. filipp@ucmerced.edu","institution_ids":["https://openalex.org/I156087764"]},{"raw_affiliation_string":"Systems Biology and Cancer Metabolism, Program for Quantitative Systems Biology, University of California Merced, 2500 North Lake Road, Merced, CA, 95343, USA","institution_ids":["https://openalex.org/I156087764"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5047057665","https://openalex.org/A5100415350"],"corresponding_institution_ids":["https://openalex.org/I156087764","https://openalex.org/I204250578"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":2.307,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.89210802,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"33","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vemurafenib","display_name":"Vemurafenib","score":0.8458538055419922},{"id":"https://openalex.org/keywords/mapk/erk-pathway","display_name":"MAPK/ERK pathway","score":0.7625381946563721},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6734570264816284},{"id":"https://openalex.org/keywords/downregulation-and-upregulation","display_name":"Downregulation and upregulation","score":0.6313719153404236},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.6261259317398071},{"id":"https://openalex.org/keywords/melanoma","display_name":"Melanoma","score":0.5625572204589844},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.539837121963501},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.5160803198814392},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"Protein kinase A","score":0.4908903241157532},{"id":"https://openalex.org/keywords/cell-growth","display_name":"Cell growth","score":0.41323134303092957},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.41320565342903137},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17298075556755066},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12036183476448059}],"concepts":[{"id":"https://openalex.org/C2776131300","wikidata":"https://www.wikidata.org/wiki/Q423111","display_name":"Vemurafenib","level":4,"score":0.8458538055419922},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.7625381946563721},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6734570264816284},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6313719153404236},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6261259317398071},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5625572204589844},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.539837121963501},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5160803198814392},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4908903241157532},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.41323134303092957},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41320565342903137},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17298075556755066},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12036183476448059},{"id":"https://openalex.org/C2994587330","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Metastatic melanoma","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/s12918-018-0554-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0554-1","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0554-1","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:29615030","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29615030","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:ark:/13030/qt7r05d128","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:doaj.org/article:e38c05a11bde455b8317197d3d13cebf","is_oa":false,"landing_page_url":"https://doaj.org/article/e38c05a11bde455b8317197d3d13cebf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 12, Iss 1, Pp 1-12 (2018)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt7r05d128","is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/7r05d128","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC systems biology, vol 12, iss 1","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4797764","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5883534","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:qt7r05d128","is_oa":true,"landing_page_url":"http://www.escholarship.org/uc/item/7r05d128","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Zecena, H; Tveit, D; Wang, Z; Farhat, A; Panchal, P; Liu, J; \u00c2\u00a0et al.(2018). Systems biology analysis of mitogen activated protein kinase inhibitor resistance in malignant melanoma. BMC SYSTEMS BIOLOGY, 12. doi: 10.1186/s12918-018-0554-1. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7r05d128","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12918-018-0554-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0554-1","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-018-0554-1","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.800000011920929,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1058714210","display_name":null,"funder_award_id":"K07 CA160756","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1080478560","display_name":null,"funder_award_id":"UL1 TR001414","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G510962456","display_name":null,"funder_award_id":"CA160756","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5514792281","display_name":null,"funder_award_id":"CA154887","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6807040102","display_name":null,"funder_award_id":"K99 CA154887","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G991492426","display_name":null,"funder_award_id":"R00 CA154887","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320314070","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142"},{"id":"https://openalex.org/F4320315321","display_name":"Cancer Research Coordinating Committee","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2781012674.pdf","grobid_xml":"https://content.openalex.org/works/W2781012674.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1640505003","https://openalex.org/W1764134105","https://openalex.org/W1834835434","https://openalex.org/W1965370740","https://openalex.org/W1997074238","https://openalex.org/W2002034430","https://openalex.org/W2009562082","https://openalex.org/W2015009944","https://openalex.org/W2017187984","https://openalex.org/W2032211985","https://openalex.org/W2040286515","https://openalex.org/W2041255253","https://openalex.org/W2043058822","https://openalex.org/W2052917253","https://openalex.org/W2053977768","https://openalex.org/W2060573548","https://openalex.org/W2061339803","https://openalex.org/W2072363222","https://openalex.org/W2080534618","https://openalex.org/W2082456282","https://openalex.org/W2083435672","https://openalex.org/W2096387850","https://openalex.org/W2100305481","https://openalex.org/W2102838769","https://openalex.org/W2103557568","https://openalex.org/W2105660237","https://openalex.org/W2106448082","https://openalex.org/W2108537717","https://openalex.org/W2112132009","https://openalex.org/W2114104545","https://openalex.org/W2122252204","https://openalex.org/W2123106337","https://openalex.org/W2128542677","https://openalex.org/W2128635872","https://openalex.org/W2130410032","https://openalex.org/W2131040858","https://openalex.org/W2136474966","https://openalex.org/W2154196978","https://openalex.org/W2156078931","https://openalex.org/W2159220884","https://openalex.org/W2163188200","https://openalex.org/W2170551349","https://openalex.org/W2176310149","https://openalex.org/W2260446271","https://openalex.org/W2291929727","https://openalex.org/W2342564029","https://openalex.org/W2472780937","https://openalex.org/W2482247668","https://openalex.org/W2592680049","https://openalex.org/W2781012674","https://openalex.org/W2787145482","https://openalex.org/W2889440592","https://openalex.org/W2951110639","https://openalex.org/W4293247451"],"related_works":["https://openalex.org/W2796527216","https://openalex.org/W2404580886","https://openalex.org/W2528389484","https://openalex.org/W2922270413","https://openalex.org/W1988432435","https://openalex.org/W3092419705","https://openalex.org/W2912365614","https://openalex.org/W4292434921","https://openalex.org/W4244963342","https://openalex.org/W2792952928"],"abstract_inverted_index":{"BACKGROUND:":[0],"Kinase":[1],"inhibition":[2],"in":[3,52,60,68,132,182,216,244,307],"the":[4,23,74,102,252],"mitogen":[5],"activated":[6],"protein":[7],"kinase":[8],"(MAPK)":[9],"pathway":[10,120,254],"is":[11,268],"a":[12,248,271],"standard":[13],"therapy":[14],"for":[15,270,300],"cancer":[16],"patients":[17],"with":[18,207],"activating":[19,144],"BRAF":[20,75,145,178],"mutations.":[21],"However,":[22],"anti-tumorigenic":[24],"effect":[25],"and":[26,32,39,86,96,119,130,138,147,159,171,185,201,220,238,282,304],"clinical":[27,71],"benefit":[28],"are":[29,34],"only":[30],"transient,":[31],"tumors":[33],"prone":[35],"to":[36,70,124],"treatment":[37,117],"resistance":[38,59,118,243],"relapse.":[40],"To":[41],"elucidate":[42],"mechanistic":[43,233],"insights":[44],"into":[45,235],"drug":[46],"resistance,":[47],"we":[48],"have":[49,143],"established":[50,229],"an":[51],"vitro":[53],"cellular":[54,65,189,230,236],"model":[55,66],"of":[56,73,90,104,108,116,153,167,264,273,286,292],"MAPK":[57,92,161,192,208,253],"inhibitor":[58,193,242,260],"malignant":[61,245,305],"melanoma.":[62,246],"METHODS:":[63],"The":[64,113,228,262],"evolved":[67],"response":[69],"dosage":[72],"inhibitor,":[76],"vemurafenib,":[77],"PLX4032.":[78],"We":[79],"conducted":[80],"transcriptomic":[81],"expression":[82],"profiling":[83],"using":[84],"RNA-Seq":[85],"RT-qPCR":[87],"arrays.":[88],"Pathways":[89],"melanogenesis,":[91,202],"signaling,":[93],"cell":[94,141,302],"cycle,":[95],"metabolism":[97,187],"were":[98],"significantly":[99],"enriched":[100],"among":[101],"set":[103,272],"differentially":[105],"expressed":[106],"genes":[107,298],"vemurafenib-resistant":[109],"cells":[110,198],"vs":[111],"control.":[112],"underlying":[114],"mechanism":[115],"rewiring":[121,257],"was":[122],"uncovered":[123],"be":[125],"based":[126],"on":[127],"non-genomic":[128],"adaptation":[129],"validated":[131],"two":[133],"distinct":[134],"melanoma":[135],"models,":[136],"SK-MEL-28":[137],"A375.":[139],"Both":[140],"lines":[142],"mutations":[146],"display":[148],"metastatic":[149],"potential.":[150],"RESULTS:":[151],"Downregulation":[152],"dual":[154],"specific":[155],"phosphatases,":[156],"tumor":[157,301],"suppressors,":[158],"negative":[160],"regulators":[162],"reengages":[163],"mitogenic":[164,287],"signaling.":[165,209],"Upregulation":[166],"growth":[168],"factors,":[169],"cytokines,":[170],"cognate":[172],"receptors":[173],"triggers":[174],"signaling":[175],"pathways":[176,203],"circumventing":[177],"blockage.":[179],"Further,":[180],"changes":[181,237],"amino":[183],"acid":[184],"one-carbon":[186],"support":[188],"proliferation":[190],"despite":[191],"treatment.":[194],"In":[195],"addition,":[196],"treatment-resistant":[197],"upregulate":[199],"pigmentation":[200],"which":[204,277],"partially":[205],"overlap":[206],"Upstream":[210],"regulator":[211],"analysis":[212],"discovered":[213],"significant":[214],"perturbation":[215],"oncogenic":[217],"forkhead":[218],"box":[219],"hypoxia":[221],"inducible":[222],"factor":[223],"family":[224],"transcription":[225],"factors.":[226],"CONCLUSIONS:":[227],"models":[231],"offer":[232],"insight":[234],"therapeutic":[239],"targets":[240],"under":[241],"At":[247],"systems":[249],"biology":[250],"level,":[251],"undergoes":[255],"major":[256],"while":[258],"acquiring":[259],"resistance.":[261],"outcome":[263],"this":[265],"transcriptional":[266,274],"plasticity":[267],"selection":[269],"master":[275],"regulators,":[276],"circumvent":[278],"upstream":[279],"targeted":[280],"kinases":[281],"provide":[283],"alternative":[284],"routes":[285],"activation.":[288],"A":[289],"fine-woven":[290],"network":[291],"redundant":[293],"signals":[294],"maintains":[295],"similar":[296],"effector":[297],"allowing":[299],"survival":[303],"progression":[306],"therapy-resistant":[308],"cancer.":[309]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":11}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}